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Immune effector cell-associated neurotoxicity syndrome following CAR T-cell therapy: a review of recent advances.

BACKGROUND: Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment landscape for hematologic malignancies. However, immune effector cell-associated neurotoxicity syndrome (ICANS) remains a significant and potentially lethal complication, affecting approximately 27% to 65% of patients and challenging the therapeutic risk-benefit profile. MAIN BODY: This review synthesizes recent advances in the epidemiology, pathophysiology, diagnosis, and management of ICANS. Incidence varies significantly by product design, with anti-CD19 therapies and CD28-containing constructs demonstr

Sinking Skin Flap Syndrome After Decompressive Hemicraniectomy in a Patient With Calvarial Multiple Myeloma Who Underwent a Lumbar Puncture: A Case Report.

Sinking skin flap syndrome (SSFS) or "syndrome of the trephined" is a rare complication that can occur after decompressive craniectomy. Disabling neurologic deficits, as well as the impairment of overall mental status with the development of a concave deformity and relaxation of the skin flap, are frequently observed. This usually develops several weeks to months after craniectomy. The pathophysiology of the syndrome includes cerebrospinal fluid (CSF) hypovolemia and the development of an atmospheric pressure gradient that can be worsened by CSF diversion, dehydration, and change in position s

Solitary Cervical Plasmacytoma Presenting as Acute Quadriparesis Following a Recent Cerebral Infarct: A Case Report.

Solitary plasmacytoma of bone (SPB) is a rare plasma-cell neoplasm that can cause acute neurological compromise, especially when involving the cervical spine. We report a 59-year-old male with a recent right hemispheric hemorrhagic infarct who developed rapidly progressive quadriparesis and urinary retention 15 days later. Neurological examination showed spastic quadriparesis with a C5 sensory level. MRI and CT revealed a pathological C4-C5 wedge compression fracture with cord compression. Emergency anterior C4-C5 corpectomy with fusion was performed. Intraoperative tissue culture grew Staphyl

An unusual case of aggressive endometrial adenocarcinoma metastasis to the clivus: illustrative case.

BackgroundThough endometrial carcinomas are a relatively common cancer of the female genitourinary tract, they rarely metastasize. Similarly, clival metastases make up a tiny fraction of all brain metastases. To the authors' knowledge, an endometrial carcinoma clival metastasis has never been described in the literature; therefore, the authors present the following unusual case of a 69-year-old female with a history of an initially grade 2 endometrial adenocarcinoma that metastasized to her clivus.ObservationsEndometrial carcinoma has the potential to metastasize to the clivus.LessonsEndometri

СНМИКОН 2024 Резюме

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Safety and feasibility of outpatient autologous stem cell transplantation in pediatric patients with primary central nervous system tumors.

High-dose chemotherapy with autologous hematopoietic stem cell transplantation (autoHSCT) is a well-established treatment for pediatric central nervous system (CNS) tumors. Given the risks of toxicity and infection, pediatric autoHSCT has been historically performed on hospitalized children. As our practice evolved, some patients were transplanted as outpatients. We performed a retrospective cohort analysis of 37 patients who received 90 transplant procedures (49 outpatient and 41 inpatient) at Children's Hospital Colorado. The most common primary diagnosis was medulloblastoma (51.4%). Of the

Paraparesis and Disseminated Osteolytic Lesions Revealing Cholangiocarcinoma: A Case Report.

Bone metastases in cholangiocarcinoma are uncommon. We report the case of a patient with disseminated osteolytic lesions who was admitted to the Neurology Department for progressive paraparesis. On the computed tomography examination, specific features for cholangiocarcinoma were described, confirmed later by the histopathological aspect of the bone lesions.

Совпадение в полном тексте источника
… Figure 1: Cerebral CT scan – bone window: osteolytic lesion in the left frontal bone. The first neurosurgical consult recommended a spine MRI exam. However, this was not possible due to the non-MRI compatible right femoral metallic plate. …

Adult-Onset Hyperammonemia: Case Report and Review of Literature.

INTRODUCTION: Hyperammonemia is a life-threatening condition most associated with liver disease, though non-cirrhotic causes are increasingly recognized. CASE PRESENTATION: We report an 18-year-old female presenting with 1 week of progressive confusion, abdominal pain, and nausea. Initial evaluation showed normal routine laboratories but markedly elevated ammonia and respiratory alkalosis. She rapidly deteriorated, requiring intubation and intensive care. Ammonia peaked at 795 µg/dL and improved rapidly after urgent venous hemofiltration and medical therapy, with full neurological recovery by

Важное значение акромагалоидных физических свойств для клинической практики.

Акромагали и гигантизм - это гормональные расстройства, которые возникают в результате гиперсекретирования хронического роста гормона. Псевдоним префикса используется для описания определенного клинического состояния без четко подтвержденной характеристики патофизиологического механизма и основных биохимических характеристик; псевдоакромегалы или акромигалоидизм соответствуют определению, приведенному выше. В данном случае мы попытаемся представить краткий обзор диагностической оценки акромигалоидной физической внешности при обсуждении two - случаи пациентов, которые имеют такие же клинические

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… He had deep nasolabial folds, bulbous nose, blepharophimosis, drooping of eyelids, and enlarged frontal bones. The teeth were spread apart and he had a very deep voice. The most important symptom was macroglossia, which caused his reduced quality of life. …

Diffuse large B cell lymphoma originating from the maxillary sinus with skin metastases: A case report and review of literature.

BackgroundDiffuse large B-cell lymphoma (DLBCL) is the most common type of malignant lymphoma (ML), accounting for 30%-40% of cases of non-Hodgkin's lymphoma (NHL) in adults. Primary paranasal sinus lymphoma is a rare presentation of extranodal NHL that accounts for only 0.17% of all lymphomas. ML from the maxillary sinus (MS) is a particularly rare presentation, and is thus often difficult to diagnose. We have reported the first known case of DLBCL originating from the MS with rapidly occurrent multiple skin metastasis.Case summaryAn 81-year-old Japanese man visited our hospital due to contin

Single-stage 360° Reconstruction in a Case of Solitary Vertebral Plasmacytoma of L3 vertebra - A Case Report.

INTRODUCTION: Aneurysmal bone cyst (ABC) is a benign intraosseous lesion, usually seen before the age of 20 years and is a lesion filled with blood cavities causing a blowout distension of the bone. It constitutes to about 1% of benign bone tumors. Although benign, a large lesion is liable to develop pathological fracture, so needs prompt addressal. Surgical resection or curettage in large lesions can lead to bone defects, deformities, and even functional abnormalities, especially in children. This article describes a large aggressive ABC of proximal metaphyseodiaphyseal region of proximal hum

Потенциальные цели микроглии в лечении нейродегенеративных заболеваний: механизм и терапевтические последствия.

В случае различных нейродегенеративных расстройств активируются микроглиальные клетки. Кроме того, дисфункциональная и гиперактивированная микроглия инициирует митохондриальную автофагию, окислительный стресс и патологическое накопление белка, заканчивающееся нейроинфламмацией, которая усугубляет повреждения допаминергических нейронов и вносит значительный вклад в патологию нейродегенеративного расстройства. Микроглиальная чрезмерная активация тесно связана с секрецией провоспалительных цитокинов, фагоцитозом травмированных нейронов и модуляцией нейротоксичной среды. В этом обзоре резюмируется

Osteomyelitis of the Jaw in COVID-19 Patients: A Rare Condition With a High Risk for Severe Complications.

Osteomyelitis of the jaw is an uncommon infection that arises from the flora of the oral cavity or sinuses and affects immunocompromised and polymorbid patients. Treatment includes surgical debridement and long regiments of broad-spectrum antibiotics. We present three cases of complicated jaw osteomyelitis presented with concurrent COVID-19 infection, including only two reported cases of odontogenic COVID-related osteomyelitis. The two mandibular cases were patients in their 30s with no comorbidities. The first case was an asymptomatic COVID-19-positive patient who developed an odontogenic inf

Двусторонний призыв в качестве первоначального проявления множественной миэломы с участием орбиты: обзор дела и литературы.

Орбитальная плазмоцитома (OP) представляет собой редкое экстрамуллярное проявление множественной миэломы (MM), которое, как правило, представляется в одностороннем порядке в ходе ранее диагностированной болезни. Двусторонний ФП как первоначальное проявление MM является чрезвычайно редким явлением. Мы сообщали о 40-летней женщине, у которой был быстрый двусторонний протез, нарушение зрения и повреждение окулярной поверхности. Краниоорбитальная съемка продемонстрировала двусторонние внекональные массы и диффузные литические повреждения. Иммуноэлектропоресис выявил моноклональную ига каппу, а апп

ИАНКОН 2023 Выдержки из плаката

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Ocrelizumab-Induced Hemophagocytic Lymphohistiocytosis: A Case Report.

Hemophagocytic lymphohistiocytosis (HLH) is an uncommon disorder marked by severe immune system dysfunction and excessive inflammation. Its clinical features often mimic those of severe sepsis, including persistent high fevers, multiorgan failure, cytopenia, and coagulation abnormalities. HLH can be triggered by infections, malignancies, rheumatological disorders, genetic factors, and medications, particularly those that cause immunosuppression. Ocrelizumab, an anti-CD20 monoclonal antibody used in the treatment of multiple sclerosis, has been associated with rare immune-mediated complications

Резюме АОКНМБ и СНМИКС 2025

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Unraveling Molecular and Genetic Insights into Neurodegenerative Diseases: Advances in Understanding Alzheimer's, Parkinson's, and Huntington's Diseases and Amyotrophic Lateral Sclerosis.

Neurodegenerative diseases are, according to recent studies, one of the main causes of disability and death worldwide. Interest in molecular genetics has started to experience exponential growth thanks to numerous advancements in technology, shifts in the understanding of the disease as a phenomenon, and the change in the perspective regarding gene editing and the advantages of this action. The aim of this paper is to analyze the newest approaches in genetics and molecular sciences regarding four of the most important neurodegenerative disorders: Alzheimer's disease, Parkinson's disease, Hunti

Persistent lactic acidosis in ALK-positive anaplastic large cell lymphoma: a case report and literature review.

Lactic acidosis is common in the ICU, but malignancy-associated type B lactic acidosis mediated by the clinical Warburg effect (CWE) is uncommon and easily missed when infection or organ dysfunction dominates the presentation. We report a 35-year-old man with a month of fever and progressive dyspnea who presented with persistent hyperlactatemia (peak 15.46 mmol/L) and markedly elevated LDH despite stable hemodynamics. Imaging revealed generalized lymphadenopathy, multifocal osteolytic lesions, and bilateral pleural effusions; infectious studies were unrevealing apart from chronic hepatitis B.

Predicting which patients with cancer will see a psychiatrist or counsellor from their initial oncology consultation document using natural language processing.

BackgroundPatients with cancer often have unmet psychosocial needs. Early detection of who requires referral to a counsellor or psychiatrist may improve their care. This work used natural language processing to predict which patients will see a counsellor or psychiatrist from a patient's initial oncology consultation document. We believe this is the first use of artificial intelligence to predict psychiatric outcomes from non-psychiatric medical documents.MethodsThis retrospective prognostic study used data from 47,625 patients at BC Cancer. We analyzed initial oncology consultation documents