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Финголимод, связанный с криптококковым менингитом у пациента с множественным склерозом: доклад о деле и обзор литературы.

У 65-летней женщины с множественным склерозом появились головные боли и судороги. Культура цереброспиновой жидкости (CSF) указывает на неоформаны криптококка. Анализ литературы по 20 случаям криптококкового менингита показал, что головная боль является наиболее распространенным первоначальным симптомом, и все случаи были положительными для сыворотки и/или криптококковых антигенов CSF.

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… Adenosine deaminase (ADA) levels were within the normal range at 4.2 IU/L, and both Treponema pallidum antibody and oligoclonal bands were negative. Blood was also positive for cryptococcal antigen (1:1024); however, blood cultures were negative. Cryptococcal meningitis was diagnosed. …

Adverse Reaction to COVID-19 mRNA Vaccination in a Patient With VEXAS Syndrome.

VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a rare genetic disorder originating from a somatic mutation in the hematopoietic stem cells. This syndrome was first described in 2020 and carries many clinical features that other conditions cannot explain. Widespread autoinflammation is the primary process the disease presents, with high morbidity and mortality in those who show signs of bone marrow failure. Treatment is complex, and response to current therapies is poor. Long-term prognosis carries a mortality of 50%. In addition, the advancement of new-generation

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… Reference values | Units B2GP1 IgM Ab | 76.8 | <20 | U/mL Lupus anticoagulant | Negative | Negative | Anticardiolipin IgM Ab | 19 | <20 | GPL-U/mL ANA | Non-reactive | Non-reactive | RF | 22 | 0-30 | IU/mL anti-CCP IgG Ab | 22 | 0-30 | U ANCA | Negative | <1:20 | HLA-B27 | Negative | Negative | Treponema …

Genome-wide association study of periodontal pathogen colonization.

Pathological shifts of the human microbiome are characteristic of many diseases, including chronic periodontitis. To date, there is limited evidence on host genetic risk loci associated with periodontal pathogen colonization. We conducted a genome-wide association (GWA) study among 1,020 white participants of the Atherosclerosis Risk in Communities Study, whose periodontal diagnosis ranged from healthy to severe chronic periodontitis, and for whom "checkerboard" DNA-DNA hybridization quantification of 8 periodontal pathogens was performed. We examined 3 traits: "high red" and "high orange" bac

Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis.

Periodontitis is a polymicrobial infectious disease characterized by alveolar bone loss. Systemic diseases or local infections, such as diabetes, postmenopausal osteoporosis, obesity, and inflammatory bowel disease, promote the development and progression of periodontitis. Accumulating evidences have revealed the pivotal effects of gut microbiota on bone health via gut-alveolar-bone axis. Gut pathogens or metabolites may translocate to distant alveolar bone via circulation and regulate bone homeostasis. In addition, gut pathogens can induce aberrant gut immune responses and subsequent homing o

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… The interactions between host immune responses and periodontal pathogens, such as Porphyromonas gingivalis , Treponema denticola , and Tannerella forsythia , contribute to the pathogenesis of periodontitis ( Frederick et al., 2011 ; Silva et al., 2015 ). … Molecular Signaling Mechanisms of the Periopathogen, Treponema Denticola. J. Dent. Res. 90 (10), 1155–1163. doi: 10.1177/0022034511402994 Frost G., Sleeth M. L., Sahuri-Arisoylu M., Lizarbe B., Cerdan S., Brody L., et al. (2014). …

Высокоагрессивный множественный склероз релапсируется во время беременности после инфекции SARS-COV-2: Case Report and Licture Review.

Мы сообщаем о сложном случае с 32-летней ранее здоровой беременной женщиной при 17+2-недельной беременности с новым диагнозом исключительно высокоактивного релапсирующего множественного склероза (RRMS), спровоцированного интенсивным острым респираторным синдромом коронавируса 2 (SARS-COV-2). Замечательными клиническими характеристиками были быстрое ухудшение клинического состояния, серьезность и характер симптомов, включая спастическую тетраплегию, диспнею, дисфагию, анартхрию и синдром сильной боли, что привело к необходимости интенсивной терапии и механической вентиляции в течение 24 часов.

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… serum 3.6 31.01.2024 (External laboratory analysis) TBE IgG/IgM Negative   West-Nil IgG/IgM Negative   Japanese encephalitis IgG/IgM Negative   Yellow fever IgG/IgM Negative   Dengue type 1-4 IgG/IgM Negative   Mycoplasma pneumoniae IgG/IgM Negative   Borrelia burgdorferi IgG/IgM Negative   Treponema …

Ось Гут-Брэйна в нейродегенерации: механистические связи между дисбиозом и нейроатологией.

& ЦЕЛЬ: Ось кишечника по сути представляет собой two- система связи, которая физически соединяет мозг с кишечным трактом. Связь поддерживается через ряд путей, включая нейронные, эндокринные и иммунные пути. Гут дисбиоз, который объясняется как дисбаланс в микробном сообществе, связан с причинно-следственной связью различных нейродегенеративных расстройств, таких, как болезнь Альцгеймера, болезнь Паркинсона и множественный склероз. Однако патологические механизмы в мозге известны лишь частично. В настоящем обзоре описывается процесс кишечного дисбиоза и нейродегенерации с подробным описанием ф

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… Additionally, other microorganisms linked to neurodegenerative diseases include Treponema denticola, which produces dentilisin that may damage neural tissue, and Fusobacterium nucleatum, which is associated with colorectal cancer and Alzheimer's disease and promotes neuroinflammation. … Pharmacother 2025 184 117905 10.1016/j.biopha.2025.117905 39933444 32 Shawkatova I Durmanova V Javor J Alzheimer's disease and Porphyromonas gingivalis: exploring the links Life (Basel) 2025 15 1 96 10.3390/life15010096 39860036 PMC11766648 33 Ganther S Godovikova V Seshadrinathan S Kapila YL Fenno JC Treponema …

Association of HSV-1 and Reduced Oral Bacteriota Diversity with Chemotherapy-Induced Oral Mucositis in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation.

Oral mucositis (OM) is a common complication of chemotherapy and remains a significant unmet need. The aim of this study was to investigate the role of oral bacteriota and HSV-1 in OM. Forty-six patients admitted for autologous hematopoietic stem cell transplantation were longitudinally evaluated for OM, Candida, HSV-1, and leukocyte count, and buccal mucosal bacterial samples were obtained during their admission period. The bacterial communities collected at the baseline and post-chemotherapy, chosen from the time with the highest severity, were analyzed by sequencing the 16S rRNA gene. Twent

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… Hong et al. [ 20 ] reported correlations of OM severity with the enrichment of F. nucleatum , Treponema maltophilum , Clostridiales HOT093, and Prevotella oris , but the depletion of 29 species in patients who received 5-fluorouracil- or doxorubicin-based chemotherapy. …

Периодическое заболевание и нейроинфламмация при множественном склерозе: систематический обзор текущих данных.

Множественный склероз (MS) — хроническое, иммунопосредованное неврологическое расстройство, характеризующееся обезвоживанием и нейродегенерацией. Появляющиеся данные свидетельствуют о наличии связи между MS и периодонтальными заболеваниями (PD) через общие иммуновоспалительные пути. В ходе этого обзора оценивается связь между периодонтальными заболеваниями и множественным склерозом с уделением особого внимания взаимодействию между иммунной и воспалением и клинической корреляции. Несмотря на появляющиеся данные, прочность связей остается неясной из-за методологической неоднородности. AIM: Обзор

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… During periodontal infections, the virulence factors released by Porphyromonas gingivalis and Treponema denticola produce lipopolysaccharides (LPS) that drive additional immune responses, possibly related to CNS inflammation ( 29 , 30 ). …

Тенденции и &lt; &lt; горячие точки &gt; &gt; в глобальных исследованиях галитоса: библиометрический анализ 2010 в адрес 2025.

Цель настоящего исследования заключается в использовании библиометрических методов для изучения глобальной англоязычной литературы по галитозу с целью выявления горячих точек для исследований и определения возможных направлений будущих исследований в этой области. 2010 по июль 2025. Библиометрический анализ проводился с использованием базы данных Medpulse и пакета программного обеспечения R, включая статистический анализ литературных данных, а также тематических и совместных анализов. 1634 статьи, представляющие вклад соответствующих авторов 19 - страны, в которых ведущую роль в выпуске публик

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… Halitosis is primarily caused by volatile sulfur compounds produced by anaerobic bacteria like Porphyromonas gingivalis and Treponema denticola in the mouth. [ 21 ] In the investigation of pathological mechanisms, although there is a foundational understanding of the relationship between oral microbial …

Molecular Mechanisms Leading from Periodontal Disease to Cancer.

Periodontitis is prevalent in half of the adult population and raises critical health concerns as it has been recently associated with an increased risk of cancer. While information about the topic remains somewhat scarce, a deeper understanding of the underlying mechanistic pathways promoting neoplasia in periodontitis patients is of fundamental importance. This manuscript presents the literature as well as a panel of tables and figures on the molecular mechanisms of Porphyromonas gingivalis and Fusobacterium nucleatum, two main oral pathogens in periodontitis pathology, involved in instigati

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… Treponema denticola , Porphyromonas gingivalis and Tanneralla forsythia , also known as red-complex triad, are common in periodontal disease [ 5 , 6 ]. … The authors explored the mechanism behind those carcinogenic features specifically for Treponema denticola ( T. denticola ), however, as those oral pathogens behave similarly, we thought it would be worth mentioning the pathways discovered for T. denticola as they may also be exploited by P. gingivalis …

Гипоксия стимулирует развитие множественного склероза, улучшая воспаление активации в макрофаге с инфекцией Porphyromonas gingivalis.

Porphyromonas gingivalis (Pg) — грамм-отрицательный анаэробный бактерий, ведущий патоген, вызывающий периодонтит. Он скрывает несколько факторов вирулентности, включая гингипатины, липополизакариды (LPS) и внешние мембранные везикли (OMVs), которые могут привести к высвобождению таких подстрекательских цитокинов, как интерлейкин (IL)-1β, альфа-фактор некроза опухоли (TNFα) и IL-6, посредством воспламенительной активации и сигнала рецептора толль-подобных (TLR). Мы продемонстрировали, что инфекция Pg в условиях гипоксики усиливает воспаление NLRP3 в макрофаге. Кроме того, мы заметили, что регул

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… A bacterial group known as the “red complex,” which includes Porphyromonas gingivalis , Treponema denticola , and Tannerella forsythia , is recognized as a major contributor to periodontitis [ 5 ]. …

Understanding the Mechanisms of Diet and Outcomes in Colon, Prostate, and Breast Cancer; Malignant Gliomas; and Cancer Patients on Immunotherapy.

Cancer patients often ask which foods would be best to consume to improve outcomes. This is a difficult question to answer as there are no case-controlled, prospective studies that control for confounding factors. Therefore, a literature review utilizing PubMed was conducted with the goal to find evidence-based support for certain diets in specific cancer patients-specifically, we reviewed data for colon cancer, prostate cancer, breast cancer, malignant gliomas, and cancer patients on immunotherapy. Improved outcomes in colon cancer and patients on immunotherapy were found with high-fiber diet

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… presence of CRC, certain bacterial species ( Fusobacteria, Alistipes, Porphyromonadaceae, Coriobacteridae, Staphylococcaceae, Akkermansia spp. and Methanobacteriales ) are noted to be predominant and other species ( Bifidobacterium, Lactobacillus, Ruminococcus, Faecalibacterium spp., Roseburia, and Treponema …

Nontraumatic Spinal Cord Injury: Epidemiology, Etiology and Management.

The spinal cord is a conduit within the central nervous system (CNS) that provides ongoing communication between the brain and the rest of the body, conveying complex sensory and motor information necessary for safety, movement, reflexes, and optimization of autonomic function. After a traumatic spinal cord injury (SCI), supraspinal influences on the peripheral nervous system and autonomic nervous system (ANS) are disrupted, leading to spastic paralysis, sympathetic blunting, and parasympathetic dominance, resulting in cardiac dysrhythmias, systemic hypotension, bronchoconstriction, copious re

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… Neurosyphilis Mycobacterium treponema pallidum is responsible for the development of syphilis. While rarely seen given improved detection and treatment of syphilis, neurosyphilis is the neurological manifestation of long-term, untreated syphilis [ 64 , 65 ]. …

Potential Role of Oral Microbiota in Medication-Related Osteonecrosis of the Jaw in Cancer Patients: A Narrative Review.

Medication-related osteonecrosis of the jaw (MRONJ) is a severe complication frequently observed in cancer patients undergoing antiresorptive therapies, such as bisphosphonates and denosumab. Emerging evidence suggests that dysbiosis of the oral microbiota plays a pivotal role in the pathogenesis of MRONJ. The complex interplay between microbial communities, host immune responses, and the effects of cancer treatments creates an environment conducive to pathogenic colonization, chronic inflammation, and impaired bone healing, which are the key hallmarks of MRONJ. Chemotherapy, radiotherapy, and

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… Another noteworthy pathogen, Treponema denticola , exacerbates tissue destruction and further hinders wound healing, particularly in conjunction with other microbes. This complex interplay of bacterial infections underscores the multifactorial nature of MRONJ. …

Medication-Related Osteonecrosis of the Jaw: A Systematic Review and a Bioinformatic Analysis.

The objective was to evaluate the current evidence regarding the etiology of medication-related osteonecrosis of the jaw (MRONJ). This study systematically reviewed the literature by searching PubMed, Web of Science, and ProQuest databases for genes, proteins, and microRNAs associated with MRONJ from the earliest records through April 2023. Conference abstracts, letters, review articles, non-human studies, and non-English publications were excluded. Twelve studies meeting the inclusion criteria involving exposure of human oral mucosa, blood, serum, saliva, or adjacent bone or periodontium to a

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… Porphyromonas, Treponema, and Mogibacterium Promote Il8/Ifnγ/Tnfα-Based pro-Inflammation in Patients with Medication-Related Osteonecrosis of the Jaw. J. Oral Microbiol. 2021;13:1851112. doi: 10.1080/20002297.2020.1851112. 52. Liu H., Li D., Zhang Y., Li M. …

Host impairments in patients with neoplastic diseases.

Healthy individuals possess an immune system comprising physical barriers, innate and acquired immunity as well as the indigenous microflora that populate the body surfaces. The immune system maintains constant vigilance over the body at the cellular level as well as at the interface between the host integument and the resident microflora. However, neoplastic diseases and their treatment often lead to impaired immunity resulting in an increased risk of infections due to viruses, bacteria, fungi, and protozoa. This chapter explores the various aspects of host impairment focusing on the componen

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… Spirochetes Treponema spp. Mycoplasma Mycoplasma spp. M. salivarium Yeasts Candida spp. … . | Spirochetes | Treponema spp. | Mycoplasma | Mycoplasma spp. | M. salivarium Yeasts | Candida spp. | C. albicans The Lung The lung appears to be particularly vulnerable to damage by cytotoxic chemotherapy and irradiation and is exquisitely susceptible to infection. …

Treatment of Stage 2 Medication-Induced Osteonecrosis of the Jaw: A Case Series.

Medication-induced jaw osteonecrosis (MRONJ) is a rare and serious disease with a negative impact on patients' quality of life, whose exact cause remains unclear and which may have a multifactorial origin. Although there are different therapeutic protocols, there is still no consensus. This case series evaluated three patients diagnosed with staged 2 MRONJ treated at the University of Murcia dental clinic according to the protocols described by the Spanish Society of Oral and Maxillofacial Surgery and the American Association of Oral and Maxillofacial Surgeons. Within 12 months of the applicat

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… The antibiotic administered should cover Actinomyces, Fusobacterium, Eikenella, Bacillus, Staphylococcus, Streptococcus and Treponemas [ 39 ]. …

A Retrospective Observational Study of Risk Factors for Denosumab-Related Osteonecrosis of the Jaw in Patients with Bone Metastases from Solid Cancers.

This single-center retrospective observational study aimed to identify risk factors for developing denosumab-related osteonecrosis of the jaw (DRONJ) in stage IV solid cancer patients with bone metastases. In total, 123 consecutive patients who had received 120 mg of denosumab every 4 weeks at least twice between July 2014 and October 2018 were included. We surveyed their demographics, medical history, blood test, underlying disease, and intraoral findings. Fourteen patients (11.4%) developed DRONJ within a mean denosumab administration period of 4 months (range: 2-52 months). Univariate analy

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… Eight dominant taxa were identified at the genus level, namely Porphyromonas , Lactobacillus, Tannerella, Prevotella, Actinomyces, Treponema, Streptococcus , and Fusobacterium . …

Clinical and Histopathological Aspects of MRONJ in Cancer Patients.

Medication-related osteonecrosis of the jaw (MRONJ) is a major complication of bisphosphonate treatment in cancer patients, and its etiology is not completely clarified. The study's goal is to find connections between the clinical and histopathological characteristics of osteonecrosis and bisphosphonates in a cohort of cancer patients who had osteonecrosis treated surgically. The retrospective study includes 51 patients of both sexes, aged 46 to 85 years, who underwent surgical treatment for MRONJ in two oral and maxillofacial surgery clinics (Craiova and Constanța). Demographic, clinical, and

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… The antibiotic prescribed should cover Actinomyces , Fusobacterium , Eikenella , Bacillus , Staphylococcus , Streptococcus , and Treponemas [ 35 ]. …

Medication-Related Osteonecrosis of the Jaw: Successful Medical Management of Complex Maxillary Alveolus with Sinus Involvement.

Medication-related osteonecrosis of the jaw (MRONJ) in cancer patients presents a considerable challenge in management. Current management is primarily based on interventions in a limited number of cases assessing a single approach. Medical management typically is reported to include antimicrobial therapy with or without surgery. Advances in the understanding of pathogenesis have led to the investigation of additional medical interventions for early-stage necrosis. We present 3 patients with advanced-stage MRONJ of the maxilla using combined medical modalities including antimicrobial therapy,

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… Efficacy of antimicrobial photodynamic and photobiomodulation therapy against Treponema denticola, fusobacterium nucleatum and human beta defensin-2 levels in patients with gingivitis undergoing fixed orthodontic treatment: a clinic-laboratory study. …