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The effectiveness of traditional Chinese medicine fumigation and washing nursing care after arthroscopic debridement of Knee Osteoarthritis: A protocol for systematic review and meta-analysis.

BACKGROUND: Knee Osteoarthritis (KOA) is a degenerative osteoarthrosis with knee joint pain as the main symptom. In recent years, arthroscopic removal of loose body and repair of meniscus have become common methods for the treatment of KOA. However, postoperative pain, swelling and limited joint movement affect the functional recovery of knee joint and the effect of surgical treatment. Early postoperative control of pain and swelling is of great significance to improve the curative effect of arthroscopic debridement and promote the recovery of knee joint function. In recent years, many clinica…

Knotless anchors offer better prevention of meniscal excursion than knotted anchors: An experimental study of the bovine knee.

OBJECTIVE: Due to the biomechanical importance of the meniscal root ligament, several surgical techniques have been defined in order to treat meniscal root tear. Different application techniques have different levels of difficulty. We aimed to find a stronger and simpler repair technique. METHODS: Sixteen bovine knee joints were prepared. The posterior root of the medial meniscus was dissected and repaired with one of two different techniques. The knees in group 1 ("knotted group") were repaired with the knotted suture anchor technique, and the knees in group 2 ("knotless group") were repaire…

[Myofascial trigger point: an indicator of acupoint sensitization].

OBJECTIVE: The present study is to investigate the characteristic distribution of primary pain points and referred pain areas in patients wi … occurred in the medial area of the knee. In 127 patients with lateral collateral ligament, lateral meniscus lesion, iliotibial band tendonitis, popliteus or triceps tendinitis, the pain spots were found in the lateral region of the knee. In 28 patients with posterior cruciate ligament injury or popliteal fossa tendonitis, the local pain was found to be at …

Loganin ameliorates cartilage degeneration and osteoarthritis development in an osteoarthritis mouse model through inhibition of NF-κB activity and pyroptosis in chondrocytes.

ETHNOPHARMACOLOGICAL RELEVANCE: Corni Fructus (CF), the red fruit of Cornus officinalis Siebold & Zucc, has been used both as food and medic … ms involved in the OA protective effects. MATERIALS AND METHODS: The destabilization of the medial meniscus (DMM) procedure was performed on the right knee of 8-week-old C57BL/6 male mice. 30 or 100 μg/ml of loganin was then injected into articular space twice a week for 8 and 12-week. Safranin O/Fast green staining, H&E staining, micro-CT analysis were p …

Alpha-Mangostin protects rat articular chondrocytes against IL-1β-induced inflammation and slows the progression of osteoarthritis in a rat model.

Osteoarthritis (OA) is a joint disease characterized by inflammation and cartilage degradation. α-Mangostin (α-MG), which can be isolated from the fruit of the tropical evergreen tree Garcinia mangostana-L, is known to have anti-inflammatory properties. The aim of the study was to investigate the use of α-MG in the treatment of OA, using both rat chondrocytes and an OA rat model induced by destabilization of the medial meniscus (DMM). Rat chondrocytes were pretreated with α-MG (0, 1.25, 2.5, and 5.0μg/ml for 24h) prior to stimulation with interleukin-1β (IL-1β) (10ng/ml for 24h). Nitric oxide …

Baseline predictors of health-related quality of life after anterior cruciate ligament reconstruction: a longitudinal analysis of a multicenter cohort at two and six years.

BACKGROUND: Limited information exists regarding predictors of general quality of life following anterior cruciate ligament (ACL) reconstruc … higher baseline PCS score, younger age, lower baseline body mass index, having >50% of the lateral meniscus excised, or having no treatment done on a lateral meniscal tear. In contrast, significant predictors of a lower PCS score were a shorter follow-up time since surgery, revision ACL reconstruction, smoking at baseline, fewer years of education, and ch …

A preliminary study of joint surface changes after an intraarticular fracture: a sheep model of a tibia fracture with weight bearing after internal fixation.

OBJECTIVE: To evaluate the changes in the articular cartilage and subchondral bone after an osteotomy designed to simulate an articular frac … ls tester with pressure-sensitive film to record joint contact pressures above and below the medial meniscus. SETTING: The studies were performed in the research laboratories of the Orthopaedic Laboratory at Harborview Medical Center in Seattle, Washington and the Madigan Army Medical Center in Tacoma, Washington. ANIMALS: Twelve adult domestic sheep. I …

Nucleic acid aptamers in orthopedic diseases: promising therapeutic agents for bone disorders.

Precision medicine has become a cornerstone in modern therapeutic strategies, with nucleic acid aptamers emerging as pivotal tools due to their unique properties. These oligonucleotide fragments, selected through the Systematic Evolution of Ligands by Exponential Enrichment process, exhibit high affinity and specificity toward their targets, such as DNA, RNA, proteins, and other biomolecules. Nucleic acid aptamers offer significant advantages over traditional therapeutic agents, including superior biological stability, minimal immunogenicity, and the capacity for universal chemical modificatio

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… In meniscus research, aptamers may be utilized to recognize and target specific biomarkers of meniscus injury or degeneration, thereby facilitating early diagnosis and treatment of the condition. … It presents a potential alternative for meniscus tissue regeneration and a ready-made cell-guided meniscus product for clinical applications. …

Perioperative low-level light therapy for ocular surface protection in patients undergoing Femto-LASIK: a prospective double-masked, randomized controlled study.

BACKGROUND: Dry eye disease (DED) is among the most common complications experienced after femtosecond laser-assisted in situ keratomileusis … baseline (T0), and 1 week (T1), 1 month (T2), and 3 months (T3) postoperatively. Outcomes were tear meniscus height (TMH), Schirmer test values, and Dry Eye Questionnaire-5 (DEQ-5) scores, noninvasive tear break-up time (NIBUT), and interferometry. RESULTS: Forty eyes of 40 patients (mean age: 34.58 ± 5.67 years) were analyzed. In the LLLT group, tear fil …

FBXO7 protects against osteoarthritis by promoting IL-6 ubiquitination and inhibiting JAK1/STAT3 signaling.

OBJECTIVE AND DESIGN: Osteoarthritis (OA) is a chronic degenerative disease marked by cartilage destruction and subchondral bone remodeling, … stigated FBXO7 expression in articular cartilage from OA patients and destabilization of the medial meniscus (DMM)-induced OA mice using transcriptomic analysis, histology, and immunohistochemistry. Functional studies were performed using human chondrocytes and SW-1353 cells to assess the effects of FBXO7 overexpression and knockdown on cell viability, pro …

Lateral Tibial Posterior Slope Induces Anterior Tibial Translation While Lateral-Medial Slope Difference Induces Internal Rotation: A Cadaveric Biomechanical Study.

BACKGROUND: Posterior tibial slope (PTS) influences tibiofemoral kinematics and anterior cruciate ligament (ACL) function. While previous st … on the medial and lateral tibial plateaus with a custom cutting guide, preserving key ligament and meniscus root attachments. Medial and lateral PTS were independently adjusted to -5°, 0°, +5°, and +10°, resulting in medial and lateral PTS ranging from -5° to +10°, using 3-dimensionally printed wedges. Repeated-measures analyses of variance, post hoc t te …

Lower Extremity Injuries in Elite Snowsport Athletes: A Retrospective Survey.

Background/Objectives: Lower extremity injuries represent a major health concern in elite snowsport disciplines, where high mechanical loads … ver, patellar tendinitis, hamstring strains, calf strains, Achilles ruptures, anterior tibial pain, meniscus tears, and hip injuries were frequently observed in injury patterns. Conclusions: Ankle sprains were the most frequent lower extremity injury in elite snowsport athletes, whereas medial tibial stress syndrome (MTSS) and anterior cruciate ligament (A …

Data-Driven Characterization of Knee Structures Using Non-Negative Matrix Factorization of 3D Multi-Echo UTE MRI.

T2* quantification based on multi-echo ultrashort echo time (UTE) MRI has been widely proposed for knee tissue characterization, yet accurat … on between asymptomatic and impaired knee tissues, particularly in the posterior horn of the medial meniscus and the anterior cruciate ligament, and consequently holds promise for more objective diagnosis and monitoring of internal knee derangements.

Association of the glucose metabolism continuum (fasting plasma glucose/HbA1c) with tear-film stability and secretion: ocular surface evidence across non-diabetes, prediabetes, and diabetes.

BACKGROUND: Whether gradations in glycemia across non-diabetes, prediabetes, and diabetes relate to tear-film homeostasis and dry eye diseas … TBUT), ocular surface disease index (OSDI), National Eye Institute (NEI) staining, meiboscore, tear meniscus height, bulbar redness, tear osmolarity, and matrix metalloproteinase-9 (MMP-9). DED was defined as OSDI ≥13 plus ≥1 sign [NIBUT <10 s, osmolarity ≥308 mOsm/L or intereye difference ≥8 mOsm/L, or NEI staining score ≥2 (beyond trace)]. Multivariable …

Lower limb kinematic changes during stair navigation 3 and 5 months after anterior cruciate ligament reconstruction: A longitudinal analysis in real-world settings.

BACKGROUND: Despite advancements in anterior cruciate ligament reconstruction (ACLR), achieving symmetrical movement patterns during stair n … s, bone-patellar tendon-bone, or quadriceps). Exclusion criteria were multiligament injuries, major meniscus injuries, other concomitant injuries, or previous knee surgeries. An additional group of matched healthy controls (n = 16) was also recruited. SETTING: Public health care campus. INTERVENTIONS: N/A. MAIN OUTCOME MEASURES: Maximum and minimum join …

Intermediate Duration Outcomes After Hamstring Anterior Cruciate Ligament Reconstruction Comparing Adolescents With and Without Suture Tape Reinforcement.

BACKGROUND: Suture tape reinforcement (STR) as an adjunct to hamstring anterior cruciate ligament (ACL) reconstruction in adolescent athlete … ient-reported ability to return to pre-injury level of sport. Complications included graft failure, meniscus pathology, arthrofibrosis, STR failure, or feelings of knee instability. RESULTS: Forty-two patients (21 STR and 21 no-STR) had completed PROs at a mean of 5.1 ± 1.2 years (STR mean 6.2 ± 0.3 years versus no-STR mean 3.9 ± 0.7 years; P < .001). Non …

Postoperative Rehabilitation Protocol After Isolated Meniscal Repair: A Systematic Review.

BACKGROUND: The meniscus plays a critical role in knee stability and load distribution, with meniscal tears often resulting from trauma or degeneration. Rehabilitation protocols after meniscal repair lack standardization, particularly regarding weightbearing restrictions and their effect on outcomes. HYPOTHESIS/PURPOSE: This systematic review hypothesizes that accelerated weightbearing protocols after isolated meniscal repair would lead to improved patient-reported outcomes and comparable failure rates relative to restricted rehabilitation protocols. The purpose was to evaluate the influence …

Dual-Root Repair of Concomitant Medial and Lateral Meniscal Root Tears Improves Patient-Reported Outcomes Whereas Isolated Single-Root Repair or No Repair Does Not.

PURPOSE: To compare patient-reported outcomes (PROs), survivorship, and demographic characteristics of patients with medial and lateral meni … oups depending on whether they had both meniscal roots repaired (dual-repair group) or they had one meniscus repaired, underwent partial meniscectomy, or underwent no meniscal repair (non-dual-repair group). Statistical analysis was completed to determine between-group differences in patient demographic characteristics and PROs. RESULTS: This study includ …

Immune rejection of orthopedic tissue allograft scoping review: Are we missing a cause of graft/procedural failure? Current concepts.

Allograft transplants are commonly used in orthopedics. Unlike other transplanted tissues, orthopedic tissue allografts are not human leukocyte antigen (HLA)-matched. The clinical impact of the immune response to allografts is poorly understood. Recent experience with allograft failures and reactions to anterior cruciate ligaments (ACL), medial patellofemoral ligament (MPFL), osteochondral, and meniscus transplants raises concern. This scoping review examines the literature on immunologic rejection of orthopedic tissue allograft using PubMed, Embase, Web of Science, and Scopus for studies desc…

Risk factors and nomogram-based prediction of dry eye disease following intraocular lens implantation in cataract patients.

BACKGROUND: Postoperative dry eye disease (DED) is a common complication following cataract surgery with intraocular lens (IOL) implantation … oup (n = 218) based on clinical evaluation, including the Ocular Surface Disease Index (OSDI), tear meniscus height (TMH), tear film break-up time (BUT), Schirmer I test (SIt), and fluorescein staining (FL) scores. Risk factors were identified using univariate and multivariate logistic regression analyses. A nomogram was constructed from significant predic …