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Panton-Valentine Leukocidin-Secreting Staphylococcus aureus Pneumonia Complicating COVID-19.

Necrotizing pneumonia induced by Panton-Valentine leukocidin-secreting Staphylococcus aureus is a rare but life-threatening infection that has been described in patients after they had influenza. We report a fatal case of this superinfection in a young adult who had coronavirus disease.

Early and longitudinal evaluations of treated infants and children and untreated historical patients with congenital toxoplasmosis: the Chicago Collaborative Treatment Trial.

Between December 1981 and May 1991, 44 infants and children with congenital toxoplasmosis were referred to our study group. A uniform approach to evaluation and therapy was developed and is described herein along with the clinical characteristics of these infants and children. In addition, case histories that illustrate especially important clinical features or previously undescribed findings are presented. Factors that contributed to the more severe disabilities included delayed diagnosis and initiation of therapy; prolonged, concomitant neonatal hypoxia and hypoglycemia; profound visual impa

First isolation and molecular characterization of Toxoplasma gondii strains from human congenital toxoplasmosis cases in Monastir, Tunisia.

Toxoplasma gondii is a protozoon parasite that can cause severe clinical problems such as congenital toxoplasmosis. The distribution of T. gondii genotypes varies from one geographic area to another. So far, little is known about the parasite genotypes in Tunisia, North Africa. The present study aimed isolating and genotyping T. gondii from the amniotic fluid (AF) and placenta of pregnant women in Monastir, Tunisia. Amniotic fluid and/or placenta from 80 women who acquired toxoplasma infection during pregnancy were tested by PCR and/or mouse bioassay. Genotyping of T. gondii isolates from thes

Prevention and treatment of cryptosporidiosis in immunocompromised patients.

BACKGROUND: Cryptosporidiosis is a disease that causes diarrhoea lasting about one to two weeks, sometimes extending up to 2.5 months among … itological clearance of 0.26 (95% CI 0.09-0.80) based on a single study. The single study comparing spiramycin with placebo found no significant difference in reduction of the duration of hospitalisation (mean difference -0.40 days (95% CI -6.62-5.82)) or in mortality between the two arms of the trial (RR 0.43 (95% CI 0.04-4.35)). One study assessed the role …

[Sampling study on practitioners' attitude to the prevention of infectious endocarditis].

UNLABELLED: BACKGROUNDS AND METHODS: The opinions and the experience of Veneto practitioners about prevention of infective endocarditis were … gentamycin (61.3%). On the contrary, most responders would prescribe neither tetracycline (73%) nor spiramycin (69.8%). There is no prevailing trend to the employ of oral cephalosporins. The 90.3% of the practitioners think that infective endocarditis can be a quite interesting and useful subject for an up-to-date course.

[Management of cervical cellulitis with and without mediastinal extension: report of 17 cases].

OBJECTIVES: Cervical cellulitis is infrequent but serious. The aim of our study was to describe the way we care and to identify certain factors that promote the development of such a condition. PATIENTS AND METHODS: We conducted a retrospective study covering the period 2004 to 2009 and included patients with cervical cellulitis with or without mediastinal extension surgically supported by ENT department of the University Hospital of Dijon. Data were collected clinical, radiological, treatment, type of surgery and complications. RESULTS: Seventeen patients met our inclusion criteria, four of

Review of Myeloma Therapies and Their Potential for Oral and Maxillofacial Side Effects.

Myeloma is a common haematological malignancy in which adverse skeletal related events are frequently seen. Over recent years, treatment for myeloma has evolved leading to improved survival. Antiresorptive therapy is an important adjunct therapy to reduce the risk of bone fractures and to improve the quality of life for myeloma patients; however, this has the potential for unwanted side effects in the oral cavity and maxillofacial region. Osteonecrosis of the jaw related to antiresorptive medications and other myeloma therapies is not uncommon. This review serves to highlight the risk of osteo

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… Different types of antibiotics have been recommended including penicillin, metronidazole, clindamycin, doxycycline, erythromycin, and spiramycin [ 3 , 55 ]. … Clinical Experience with Spiramycin in Bisphosphonate-Associated Osteonecrosis of the Jaw. Int. J. Immunopathol. Pharmacol. 2010;23:619–626. doi: 10.1177/039463201002300224. 57. …

[Postnatal follow-up of infants born to mothers with certain Toxoplasma gondii infection: evaluation of prenatal management].

UNLABELLED: The clinical management of perinatal toxoplasmosis involves a gynaecologist during pregnancy and a neonatologist after delivery. Then, in the absence of a uniform approach, early evaluation of infected infants requires a thorough long-term follow-up also in asymptomatic children, who have to be observed for at least one year due to unpredictable sequelae in later life. We retrospectively analyzed pregnancy management of 54 women with certain infection from Toxoplasma gondii (TG) and prospectively enrolled their infants to compare prenatal management with postnatal clinical outcome.

Lactic acidosis and hypoglycemia as markers of disease progression of multiple myeloma: A case report.

Case report: A 64-year-old man was hospitalized in the intensive care unit with pneumonia, lactic acidosis, and hypoglycemia. Investigations revealed a kappa light chain multiple myeloma. The patient underwent chemotherapy by bortezomib, lenalidomide, and dexamethasone. Serum lactate level and glycemia normalized. Evaluation at day 28 showed a disease progression. Lenalidomide was switched for daratumumab, bortezomib, and dexamethasone. In front of the inefficiency of the chemotherapy, the patient underwent third-line chemotherapy by melphalan. There was a correlation between the evolution of

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… Broad‐spectrum antibiotics (cefotaxime and spiramycine) were administered. Three days after the admission in ICU, the patient's condition worsened. A rapidly extensive pulmonary infection was suspected, that required intubation, mechanical ventilation, and norepinephrine infusion. …

Intestinal Coccidian Infections in Cancer Patients: A Case Series.

Introduction Coccidian protozoa and microsporidian fungi are opportunistic pathogens increasingly implicated in infections in immunosuppressed individuals. These parasites typically infect the intestinal epithelium, resulting in secretory diarrhea and malabsorption. The disease burden and timeline are both greater and longer among immunosuppressed patients. Therapeutic options for immunocompromised individuals are limited. As a result, we wanted to better characterize the disease course and treatment efficacy of these parasitic gastrointestinal infections. Methods We performed a single-center,

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… While nitazoxanide is the first-line treatment, replacement or supplementation with azithromycin, paromomycin, rifaximin, or spiramycin may be possible [ 10 ]. …

Estimation of Abbreviated Cyclosporine A Area under the Concentration-Time Curve in Allogenic Stem Cell Transplantation after Oral Administration.

Measurements of Cyclosporine (CsA) systemic exposure permit its dose adjustment in allogenic stem cell transplantation recipients to prevent graft-versus-host disease. CsA LSSs were developed and validated from 60 ASCT patients via multiple linear regressions. All whole-blood samples were analyzed by fluorescence polarization immunoassay (FPIA-Axym). The 10 models that have used CsA concentrations at a single time point did not have a good fit with AUC(0-12) (R(2) < 0.90). C(2) and C(4) were the time points that correlated best with AUC(0-12 h), R(2) were respectively 0.848, and 0.897. The LSS

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… All patients received oral antimicrobial prophylaxis with amoxicillin or spiramycin, fluconazole, and acyclovir. …

Abstracts from the 8th Drug Hypersensitivity Meeting (DHM)

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… 0.78 PRISTINAMYCINE SPIRAMYCINE ® 0.75 VIBRAMYCINE TEMODAL ® 0.78 TEXODIL VIBRAMYCINE ® 0.75 SPIRAMYCINE Table 1 Results Drug at risk for confusion | MATCH SCORE | Inducing drug ACIDRINE ® | 0.72 | ADIAZINE ADENYL | 0.71 | GARDENAL ADEPAL ® | 0.79 | ALEPSAL ADEPAL ® | 0.71 | GARDENAL ARESTAL ® | 0.74 … | 0.78 | PRISTINAMYCINE SPIRAMYCINE ® | 0.75 | VIBRAMYCINE TEMODAL ® | 0.78 | TEXODIL VIBRAMYCINE ® | 0.75 | SPIRAMYCINE Conclusion We confirm that some CADR may be due to drug substitution favored by LASA. …

Drug Repurposing of Selected Antibiotics: An Emerging Approach in Cancer Drug Discovery.

Drug repurposing is a method of investigating new therapeutic applications for previously approved medications. This repurposing approach to "old" medications is now highly efficient, simple to arrange, and cost-effective and poses little risk of failure in treating a variety of disorders, including cancer. Drug repurposing for cancer therapy is currently a key topic of study. It is a way of exploring recent therapeutic applications for already-existing drugs. Theoretically, the repurposing strategy has various advantages over the recognized challenges of creating new molecular entities, inclu

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… . | ( 28 ) (b) Azithromycin (c) Clarithromycin (d) Dirithromycin (e) Roxithromycin (f) Flurithromycin (g) Josamycin (h) Rokitamycin (i) Kitasamycin (j) Mirosamycin (k) Oleandomycin (l) Rosaramicin (m) Spiramycin (n) Tylosin 7. | Glycopeptide | (a) Vancomycin | Glycopeptides inhibit the synthesis of cell … Separation and determination of the macrolide antibiotics (erythromycin, spiramycin and Oleandomycin) by capillary electrophoresis coupled with fast reductive voltammetric detection . J. …

ECC-4 Abstracts

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… Antimicrobials tested included penicillin (PEN), amoxicillin (AMO), erythromycin (ERY), azithromycin (AZI), clarithromycin (CLA), midecamycin (MID), spiramycin (SPI), clindamycin (CLI), levofloxacin (LEV), vancomycin (VAN), rifampicin (RIF), tetracycline (TET) and co-trimoxazole (SXT). …

P941 – P1197

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… Conclusion: As previously described, therapy with spiramycin may modify IgG antibody response and IgG avidity maturation in pregnant women. … The reason for the delay in serological response may be reduction of parasitic load in early treated infections due to the effect of spiramycin on trophozoite stage. The antibody rebound observed after delivery and therapy interruption may thus also be explained. …

Potential drug development and therapeutic approaches for clinical intervention in COVID-19.

While the vaccination is now available to many countries and will slowly dissipate to others, effective therapeutics for COVID-19 is still illusive. The SARS-CoV-2 pandemic has posed an unprecedented challenge to researchers, scientists, and clinicians and affected the wellbeing of millions of people worldwide. Since the beginning of the pandemic, a multitude of existing anti-viral, antibiotic, antimalarial, and anticancer drugs have been tested, and some have shown potency in the treatment and management of COVID-19, albeit others failed to leave any positive impact and a few also became cont

Proceedings of Reanimation 2022, the French Intensive Care Society International Congress.

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