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Palliative patients who may benefit from intranasal delivery of symptomatic drugs: a two-center observational study evaluated the administration of morphine and dexamethasone in Polish hospices.

IntroductionPatients receiving hospice care at the end of life often suffer from a variety of ailments. They may need medication to alleviate symptoms for the rest of their lives. The most common and recommended way to take opioids and steroids is orally. Less frequently, the subcutaneous or intravenous routes are used. The intranasal route is a relatively uncommon but interesting alternative for administering drugs.AimThe study aims to identify hospice patients who may benefit from changing the standard opioid and steroid administration route to intranasal delivery.Material and methodsThe ele

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… author’s/self-created questionnaire to assess problems with taking medications Route of drug delivery | Difficulties in administering medication | Tick if applicable Oral | Obstruction of the gastrointestinal tract—symptoms or diagnosis | Feeding by nasogastric tube or PEG (percutaneous endoscopic gastrostomy … Less common reasons included generalized edema and/or cachexia (13%), liver failure (11%), vomiting (6%), presence of a PEG (percutaneous endoscopic gastrostomy) 5%, and gastrointestinal obstruction (1%) (Fig. 3 ). …

[A-56-year-old woman with parkinsonism, whose mother had Parkinson's disease].

We report a 56-year-old woman with progressive gait disturbance. Her mother had Parkinson's disease with onset at age 70. She died at age 74 … igh-density lesions in the posterior parietal lobes. She developed dysphagia for which she required gastrostomy. She was transferred to another hospital but her clinical condition deteriorated further. On December 22, 1999, she developed fever and dyspnea and was admitted to our service again. She developed cardial arrest at the emergency room from hypoxia. S …

Giant Mandibular Ameloblastoma with Rare Hypercalcemia: A Case Report and Literature Review.

Ameloblastoma is the most common benign odontogenic tumor with local invasion and high recurrence, which generally occurs in the jaw bones. Hypercalcemia is a common paraneoplastic syndrome that is commonly observed in patients with malignancies but rarely encountered in patients with benign tumors. Thus far, not many cases of ameloblastoma with hypercalcemia have been reported, and the pathogenic mechanism has not been studied in depth. This paper presents a case report of a 26-year-old male diagnosed with giant ameloblastoma of the mandible, accompanied by rare hypercalcemia. Additionally, a

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… He received a series of interventions to improve the systemic conditions, including blood transfusion, gastrostomy, and oral beraprost sodium therapy; however, these measures yielded limited efficacy. … concentration by diuresis (furosemide, 20 mg, QD or BID) and calcitonin (Miacacic, 100 IU, QD or BID); (2) improving anemia by iron supplementation (Rifeinen, 150 mg, BID), and red blood cell transfusions before operation (400 mL); and (3) improving cachexia by enteral nutrition therapy (oral feeds or via gastrostomy …

Interventions for dysphagia and nutritional support in acute and subacute stroke.

BACKGROUND: Dysphagia (swallowing problems) are common after stroke and can cause chest infection and malnutrition. Dysphagic, and malnouris … 423; OR 0.52; 95% CI 0.30 to 0.88; P = 0.01; I(2) = 22%). Route of feeding: percutaneous endoscopic gastrostomy (PEG) and nasogastric tube (NGT) feeding did not differ for case fatality or the composite outcome of death or dependency, but PEG was associated with fewer treatment failures (t = 3; n = 72; OR 0.09; 95% CI 0.01 to 0.51; P = 0.007; I(2) = 0%) and g …

2021 Scientific Session of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), Las Vegas, Nevada, 31 August–3 September 2021: Video Loops

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… The obstruction was caused by intact pseudocapsule requiring surgical resection and placement of a feeding gastrostomy tube. We present pre-op endoscopic and esophageal manometry images and intra-operative findings on laparoscopy and gastroscopy. … A 48 year old female with a remote history of roux-en-Y gastric bypass and subsequent reversal and gastrostomy tube placement presented with a gastrocutaneous fistula and gastrogastrostomy stenosis, which required repeat dilations and stenting. …

[Clinical effectiveness of fecal microbiota transplantation combined with nutritional support and psychological intervention in patients with "Tetralogy of Tongji"].

Objective: To summarize and analyze the clinical effect of fecal microbiota transplantation (FMT) combined with nutritional support and psyc … ectious diseases, life-threatening systemic comorbidities, intorlerate to nasojejunal, percutaneous gastrostomy / jejunostomy or FMT. The clinical data of 43 patients at Shanghai Tenth People's Hospital exhibiting the "Tetralogy of Tongji" and who received microflora transplantation combined with nutritional support and psychotherapy from June 2017 to June 20 …

AGA Clinical Practice Update on Endoscopic Management of Perforations in Gastrointestinal Tract: Expert Review.

BEST PRACTICE ADVICE 1: For all procedures, especially procedures carrying an increased risk for perforation, a thorough discussion between … , stricture incision, thermal coagulation for hemostasis or tumor ablation, percutaneous endoscopic gastrostomy, ampullectomy, endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), endoluminal stenting with self-expanding metal stent (SEMS), full-thickness endoscopic resection, endoscopic retrograde cholangiopancreatography (ERCP) in sur …

Effect of exercise training on functional capacity & quality of life in head & neck cancer patients receiving chemoradiotherapy.

Background & objectivesPatients with head and neck cancer (HNC) undergoing chemoradiotherapy (CRT) suffer from fatigue causing a decrease in functional capacity and quality of life (QoL). Limited research in the field of exercise training among these patients demanded the need for this study to assess the effects of exercise training on functional capacity and quality of life.MethodsA randomized controlled trial was conducted on 48 patients with HNC undergoing CRT. The exercise group received an individually tailored, supervised, exercise programme for six weeks, while the control group did no

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… Patients usually depend on soft or liquid diet and in majority of the cases require a gastrostomy tube for feeding due to oral mucositis 2 . Fatigue and depression lead to physical inactivity in HNC patients. …

Antibiotic prophylaxis for the prevention of methicillin-resistant Staphylococcus aureus (MRSA) related complications in surgical patients.

BACKGROUND: Risk of methicillin-resistant Staphylococcus aureus (MRSA) infection after surgery is generally low, but affects up to 33% of pa … ctions compared with placebo in people without malignant disease undergoing percutaneous endoscopic gastrostomy insertion, although this may be due to decreasing overall infection thereby preventing wounds from becoming secondarily infected with MRSA. There is currently no other evidence to suggest that using a combination of multiple prophylactic antibiotics …

Nutritional Issues and Self-care Measures Adopted by Cancer Patients Attending a University Hospital in Turkey.

ObjectiveThis study aimed to assess the nutritional status of cancer patients and the self-care measures they adopted as a response to nutritional problems.MethodsThis descriptive study included seventy cancer patients staying in the oncology and internal disease clinics of a university hospital in Turkey. Data were collected using a questionnaire with 29 questions.ResultsThe mean age of participants was 40.2 ± 1.82 years. Approximately, 62.9% of the patients ate only half of the meals offered to them, 65.7% experienced weight loss, and 45.7% had difficulty eating their meals on their own. Mor

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… Prophylactic gastrostomy tubes in patients undergoing intensive irradiation for cancer of the head and neck. Arch Otolaryngol Head Neck Surg. 1998;124:871–5. doi: 10.1001/archotol.124.8.871. 18. Isenring E, Elia M. …

Interventional radiology in the elderly.

Interventional radiological percutaneous procedures are becoming all the more important in the curative or palliative management of elderly frail patients with multiple underlying comorbidities. They may serve either as alternative primary minimally invasive therapies or adjuncts to traditional surgical treatments. The present report provides a concise review of the most important interventional radiological procedures with a special focus on the treatment of the primary debilitating pathologies of the elderly population. The authors elaborate on the scientific evidence and latest developments

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… uncovered stents may be as high as 60%, and is usually treated with repeat co-axial placement of another stent. 34 , 35 Other delayed complications are mostly device-related and may include stent migration, stent torsion, stent fracture or tracheoesophageal fistulation. 35 , 37 Of note, percutaneous gastrostomy … Disruption of normal swallowing in the elderly because of stroke or degenerative neurological conditions is another indication of the procedure. 38 , 39 With a combination of ultrasound and X-ray guided gastropexy various types of gastrostomy or gastrojejunostomy tubes may be inserted. …

Canine Gastric Cancer: Current Treatment Approaches.

Human gastric cancer (GC) ranks as the fifth most prevalent cancer worldwide, and is the third leading cause of cancer-related death. The incidence of GC is lower in dogs than in humans, accounting for less than 1% of all canine malignancies. In recent years, efforts have been made to understand the pathogenesis of GC and in find an appropriate therapy to maximize curative results, such as adjuvant chemotherapy treatments in addition to surgery. Although surgery is the first-line treatment, it is associated with several complications. In terms of chemotherapeutic intervention, canine gastric c

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… complications, such as a major hemorrhage and a 2nd-degree atrioventricular block, and had a survival time of 49 days; (d) the last two dogs exhibited major postoperative complications—one presented severe pancreatitis and intermittent hypoglycemia and survived 258 days, while the other pulled out the gastrostomy … Metastasis of gastric adenocarcinoma to the abdominal wall following placement of a gastrostomy tube in a dog Can. Vet. J. 2005 46 641 643 16152722 PMC1168882 28. Reiss K.A. Calvert A.H. O’Dwyer P.J. Platinum Analogs Cancer Principles & Practice of Oncology 11th ed. DeVita V.T. Lawrence T.S. …

The profile of the onco-hematology patient in the palliative care: 4 years of experience.

OBJECTIVES: Most of the palliative care (PC) patients have oncologic diseases, being hematologic tumors a small part of them. According to the literature, onco-hematologic (OH) patients should be individualized from those with solid tumors for the specialized care required along their disease course. This study aims to review the casuistry of OH patients referred to PC in a specialized oncologic hospital and help to understand better how hematologists can improve the care of these patients. METHODS: We analyzed all OH patients referred to the PC service in 1 oncologic hospital along 42 months

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… biopsies and myelograms, positron emission tomography, magnetic resonance imaging studies, transthoracic echocardiograms, lumbar punctures, biopsies or cytology, and bronchofibroscopy), diminishing that frequency as the patients were mainly cared by the PC team (responsible for all percutaneous endoscopic gastrostomy …

Macroglossia due to Systemic Amyloidosis: Is There a Role for Radiotherapy?

BACKGROUND: Macroglossia due to amyloid depositions can cause cosmetic problems and functional disability, and can lead to life-threatening airway obstruction. Management of macroglossia in systemic amyloidosis is controversial, and the role of surgery is unclear. CASE DESCRIPTION: We present a case of a 66-year-old woman affected by macroglossia due to light chain amyloidosis who presented with eating and breathing difficulties. Because of prior successful results of radiotherapy for localized amyloid disease, our patient was treated with external beam radiation therapy (20 Gy in 10 fraction

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… Therefore, tracheostomy and gastrostomy or jejunostomy for enteral alimentation are the only approaches available for the majority of patients affected by systemic amyloidosis [ 1 , 5 ]. The role of radiation therapy in the management of macroglossia secondary to amyloid has not been reported. …

Картирование ухода в конце жизни для пациентов с неврологическими заболеваниями на немецких хоспезах: обследование распространенности точечных заболеваний.

ОБРАЩЕНИЕ: Доступ пациентов с неврологическими заболеваниями к паллиативной помощи по-прежнему ограничен. К числу факторов, способствующих этому, относятся трудности с прогнозированием траекторий заболеваний, ограниченность ресурсов для долгосрочного ухода и трудности с выявлением фазы завершения жизни, которая зачастую усугубляется коммуникационными и когнитивными нарушениями. МЕТОДЫ: Мы провели национальное обследование точечной распространенности среди германских стационарных хоспей с использованием онлайнового вопросника. Результаты: доля ответивших 44%, с 83% - наличие у участников хоспей

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… Control in the absence of choice: A qualitative study on decision-making about gastrostomy in people with amyotrophic lateral sclerosis, caregivers, and healthcare professionals. PLoS One. 2023;18:e0290508. doi: 10.1371/journal.pone.0290508. …

Adult-Onset Cerebral Adrenoleukodystrophy Without Adrenal Gland Involvement.

X-linked adrenoleukodystrophy (X-ALD) is a metabolic disorder characterized by endocrine and neurological degeneration. A rare and variegated entity in adults, diagnosis is often a significant challenge and can lead to extensive testing, including invasive procedures if clinical suspicion is not high. We present the case of a 46-year-old-male with neurological dysfunction that is uncommon in X-ALD with preserved adrenocortical function. Initially misdiagnosed with multiple sclerosis, the patient faced a significant neurological and cognitive decline in a short follow-up time frame, ultimately

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… He was evaluated by a gastroenterologist and underwent a percutaneous endoscopic gastrostomy tube placement and now requires continuous skilled nursing care. He cannot perform activities of daily living independently. …

The Proceedings of the 19th International Cancer Imaging Society Meeting and Annual Teaching Course : Verona, Italy. 7 - 9 October 2019.

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Осложнения периферального нерва в результате применения лекарств для потери веса: систематический обзор.

ЦЕНТРАЛЬНАЯ ИНФОРМАЦИЯ: Существует глобальная эпидемия ожирения, и в этом контексте разработка новых агентов для снижения веса является своевременной. Поступали сообщения о периферийных осложнениях нервной системы, и это исследование было направлено на систематический анализ всех сообщенных случаев, связанных с лекарственными препаратами, используемыми для снижения веса. МЕТОДЫ: Был проведен систематический поиск баз данных PubMed, Embase и CINAHL с момента создания по 30 июня 2026 года в целях выявления исследований, в которых сообщается о новых или ухудшающихся периферийных осложнениях нервн

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… Despite cessation of semaglutide, she continued to deteriorate requiring gastrostomy and eventually tracheostomy. …

Refractory Hyperammonemic Encephalopathy as a Paraneoplastic Presentation of Fibrolamellar Hepatocellular Carcinoma: A Case Report.

BACKGROUND Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare liver malignancy affecting adolescents and young adults without underlying liver disease. Hyperammonemic encephalopathy (HAE) is an uncommon but severe complication in advanced FLHCC, resulting from progressive hepatic dysfunction or tumor-related metabolic derangements. Early recognition is essential to prevent neurologic decline and improve outcomes. CASE REPORT A 24-year-old man with metastatic FLHCC presented with worsening confusion for 1 month. His prior treatments included transarterial radioembolization, multiple resec

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… On physical examination, he was cachectic, had a percutaneous gastrostomy tube, was oriented only to person, and demonstrated asterixis (grade 2 encephalopathy). …

Benefit of Reducing Body Weight Loss with A Nutritional Support Pathway in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.

BackgroundThis retrospective, historically controlled investigative study examined the benefit of a nutritional support pathway that included nutritional education before the start of conditioning and emphasized oral nutrition in response to nutrition-related adverse events in patients undergoing hematopoietic stem cell transplantation (HSCT).Material and methodsParticipants were patients undergoing allogeneic HSCT; 46 were in the control group (i.e., did not follow our nutritional pathway) and 36 were in the group that underwent nutritional intervention (enhanced nutrition group). We compared

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… content_id=1 39 Whelan K Schneider SM Mechanisms, prevention, and management of diarrhea in enteral nutrition Curr Opin Gastroenterol 2011 27 152 59 21191288 10.1097/MOG.0b013e32834353cb 40 Gomes CA Jr Andriolo RB Bennett C Percutaneous endoscopic gastrostomy versus nasogastric tube feeding for adults …