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Availability of secondary healthcare data for conducting pharmacoepidemiology studies in Colombia: A systematic review.

Real-world evidence (RWE) is emerging as a fundamental component of the post-marketing evaluation of medicinal products. Even though the focus on RWE studies has increased in Colombia, the availability of secondary data sources to perform this type of research is not well documented. Thus, we aimed at identifying and characterizing secondary data sources available in Colombia. We performed a systematic literature review on PubMed, EMBASE, and VHL using a combination of controlled vocabulary and keywords for the concepts of electronic health records, epidemiologic studies and Colombia. A total

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… Machado‐Alba JE, Medina‐Morales DA, Echeverri‐Cataño LF. Comparison of medication adherence in diabetes mellitus patients on human versus analogue insulins. Expert Opin Drug Saf. 2017;16:133‐137. 108. Machado‐Alba JE, Medina‐Morales DA, Echeverri‐Cataño LF. … Machado‐Alba JE, Morales Plaza CD, Solarte Gómez MJ. Antidepressant prescription patterns in patients affiliated with the general social security health system of Colombia. Rev Panam Salud Publica. 2011;30:461‐468. 135. Machado‐Alba JE, Morales‐Plaza CD. …

Haematological nurses' experiences about palliative care trajectories of patients with life-threatening haematological malignancies: A qualitative study.

AimsTo explore haematological nurses' experiences about the palliative care trajectories of patients with life-threatening haematological malignancies.DesignA qualitative study with a descriptive and explorative design.MethodsData were collected through 12 individual semi-structured interviews of nurses who work with patients with haematological malignancies from four hospitals in Norway. The data were analysed using systematic text condensation. The study was reported according to the Consolidated Criteria for Reporting Qualitative Research checklist.ResultsThree categories emerged from the d

Аспекты достоинства в семьях, обеспечивающих уход за лицами, страдающими множественным склерозом.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Основное внимание в этом исследовании уделяется сохранению достоинства и посягательству на достоинство членов семьи, обеспечивающих уход за лицами, страдающими множественным склерозом. АИМ: Цель исследования заключалась в углублении понимания того, как семьи, ухаживающие за лицами, страдающими множественным склерозом, воспринимают сохранение или лишение их достоинства. Применялся герменевый подход. МЕТОДЫ ИССЛЕДОВАНИЙ: Авторы провели научные опросы в форме бесед с восемью лицами, обеспечивающими уход за членами семьи. АНАЛИЗ И МЕТОДЫ ТОЛКОВАНИЯ: Нашим компасом и руководс

Resuscitating Patient Rights during the Pandemic: COVID-19 and the Risk of Resurgent Paternalism.

The COVID-19 Pandemic a stress test for clinical medicine and medical ethics, with a confluence over questions of the proportionality of resuscitation. Drawing upon his experience as a clinical ethicist during the surge in New York City during the Spring of 2020, the author considers how attitudes regarding resuscitation have evolved since the inception of do-not-resuscitate (DNR) orders decades ago. Sharing a personal narrative about a DNR quandry he encountered as a medical intern, the author considers the balance of patient rights versus clinical discretion, warning about the risk of resurg

Perspectives on the DNR decision process: A survey of nurses and physicians in hematology and oncology.

IntroductionIn cancer care, do-not-resuscitate (DNR) decisions are made frequently; i.e., decisions not to start the heart in the event of a cardiac arrest. A DNR decision can be a complex process involving nurses and physicians with a wide variety of experiences and perspectives. Previous studies have shown different perceptions of the DNR decision process among nurses and physicians, e.g. concerning patient involvement and information. DNR decisions have also been reported to be unclear and documentation inconsistent.ObjectiveThe aim was to investigate how important and how likely to happen

Advancements in Biomarkers and Molecular Targets in Hematological Neoplasias.

Hematological neoplasias are among the most common cancers worldwide, and the number of new cases has been on the rise since 1990, reaching 1 [...].

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… In T-cell acute lymphoblastic leukemia (T-ALL), Villa-Morales et al. [ 11 ] investigated if NRF2 activation may constitute a prognostic biomarker. … The article of Villa-Morales et al. analyzed a publicly available T-cell acute lymphoblastic leukemia gene expression database that revealed a correlation between NFE2L2 expression and the TLX3 molecular subgroup of T-ALL, which was already associated with poor outcomes. …

Tarasca: ritual monster of Spain.

Let us now revisit our original assumptions. First, we note that for the participants in Hacinas Carnival the Tarasca is a figure of fun and joy, but it also exudes a strain of aggressive misogyny that many female residents, not to mention tourists, find somewhat unsettling. In the spirit of feminist currents in Spain, a group of young women protested in 1992 to town officials and, when rebuffed, sought to build their own female monster, which they intended to use to attack boys and men. While their plan was never carried out, and indeed met with stiff opposition from officialdom and, especial

Baby doe redux? The Department of Health and Human Services and the Born-Alive Infants Protection Act of 2002: a cautionary note on normative neonatal practice.

The Born-Alive Infants Protection Act (BAIPA), passed by Congress in 2002, has attracted little publicity. Its purposes were, in part, "to repudiate the flawed notion that a child's entitlement to the protections of the law is dependent on whether that child's mother or others want him or her." Understood as antiabortion rhetoric, the bill raised little concern among physicians at the time of legislative hearings and passed in both Houses by overwhelming majorities, hardly suggesting contentious legislation. After its signing into law, the Neonatal Resuscitation Program (NRP) Steering Committe

Rare disease patients protection: theoretical discussion and institutional construction of orphan drug designation in China.

Orphan drugs play a vital role, often described as the "public goods of public goods." As a result, they demand robust policy support. Among these, the designation of orphan drugs serves as the pivotal and core element of the national incentive mechanism for such drugs. The designation of orphan drugs is a prerequisite and a key system to determine whether pharmaceutical enterprises are eligible to access policy support, which directly determines the effective output of orphan drugs and the fairness of public policies. However, there is still an urgent need to explore this system in China theo

Patient Perspectives on Health Insurance Design: A Mixed-Methods Analysis.

There remains a persistent lack of patient-centered evidence on insurance reform and real-world experiences of patients with chronic disease. This study gathered insights around insurance design from chronic disease beneficiaries. This mixed-methods analysis comprised an online survey and virtual focus group sessions (August to December 2023) involving US residents with chronic disease and health insurance. Patients' perspectives on insurance design were explored. Survey data were analyzed descriptively. Key themes were identified from focus group transcripts and direct observations. In total,

Cultural adaptation and validation of the Sinhala version of the spiritual needs assessment for patients (S-SNAP) questionnaire.

BackgroundSpiritual support for patients and caregivers of critically ill patients is associated with improved quality of life. This aspect, however, is not incorporated into the current care pathways in Sri Lanka. The Spiritual Needs Assessment for Patients (SNAP) questionnaire, comprised of 3 domains: psychosocial, spiritual and religious, gives a platform for clinicians to assess the spiritual needs of those patients. This study presents the results of validation of the Sinhala version of the SNAP (S-SNAP) questionnaire.MethodsThe SNAP was translated from English to Sinhala using the standa

The effect of the holy Quran recitation and listening on anxiety, stress, and depression: A scoping review on outcomes.

Background and aimAnxiety, stress, and depressive disorders as common mental health problems have adverse effects in different populations. Holy Quran recitation and listening can help reduce these disorders. Therefore, the aim of this study was to investigate the effect of the Holy Quran on anxiety, stress, and depression.Materials and methodsTo retrieve eligible studies, we searched PubMed, Web of Science, and Scopus databases. The articles were screened and chosen by three researchers. The selection of studies and the data extraction from the studies were done by three researchers using the

Does Therapeutic Repurposing in Cancer Meet the Expectations of Having Drugs at a Lower Price?

Therapeutic repurposing emerged as an alternative to the traditional drug discovery and development model (DDD) of new molecular entities (NMEs). It was anticipated that by being faster, safer, and cheaper, the development would result in lower-cost drugs. As defined in this work, a repurposed cancer drug is one approved by a health regulatory authority against a non-cancer indication that then gains new approval for cancer. With this definition, only three drugs are repurposed for cancer: Bacillus Calmette-Guerin (BCG) vaccine (superficial bladder cancer, thalidomide [multiple myeloma], and p

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… Based on these observations, Morales, a urologist in Canada published the first use of intravesical BCG against superficial bladder cancer in 1976 [ 53 ]. In 1997, the FDA approved the general use of intravesical BCG (TICE BCG) in patients with superficial bladder tumors. … Morales A, Eidinger D, Bruce AW. Intracavitary Bacillus Calmette–Guerin in the treatment of superficial bladder tumors. J Urol. 1976;116(2):180–182. doi: 10.1016/S0022-5347(17)58737-6. 54. Herr HW, Morales A. History of Bacillus Calmette–Guerin and bladder cancer: an immunotherapy success story. …

Отвращение от мастурбации и гиперсексуальности

Несмотря на отсутствие данных о негативном воздействии мастурбации на здоровье, воздержание от мастурбации часто рекомендуется в качестве стратегии улучшения сексуального саморегулирования. Мы приняли рамки предполагаемых проблем с порнографией, чтобы собрать первые намеки на то, является ли воздержание от мастурбации результатом психологической и поведенческих циаддикций или противоречивых взглядов. В онлайновом опросе, проведенном с помощью нетематического " Reddit " (n = 1063), большинство участников сообщили о том, что они пытались избежать мастурбации. Как видно из корреляции ну

Психиатрические результаты первого two спустя годы после октября 7 - нападения: систематический обзор последствий посттравматического стресса, беспокойства, депрессии и наркомании.

ЦЕЛИ: октябрь 7 :: нападения и последовавшая за ними война создали условия для устойчивой, многоплановой травмы. В настоящем систематическом обзоре обобщаются результаты исследований, проведенных в ходе первого обзора. two годы войны, чтобы прояснить раннее распространение симптомов посттравматического стресса (ПТСС), тревоги, депрессии и связанных с наркоманией последствий среди израильского населения. МЕТОДЫ: ПОСЛЕ ПРИСМА 2020 :: были проведены обыски по ПубМеду, Психиндо, Скопусу и веб-сайту науки с целью выявления исследований, опубликованных в период с октября 7, 2023 и октябрь 7, 2025 (з

Medical Machiavellianism: the tradeoff between benefit and harm with targeted chemotherapy.

Machiavellianism is a word synonymous with the phrase "the end justifies the means", and in this article we have coined the term Medical Machiavellianism to describe the 'cruel-to-be-kind' administration of toxic chemotherapeutic agents in apparent violation of the precept first do no harm, while acknowledging the 'dirty hands' dilemma of having to decide between and choose the lesser of two evils in the setting of advanced cancer--i.e. to treat or not to treat. The perception that 'targeted' therapies are relatively non-toxic and therefore respect the Hippocratic First Commandment by virtue o

Euthanasia as a safeguard for living: Anticipation and incurable cancer in a Colombian context.

This article builds on years of ethnographic conversations I sustained with my father, 89, who lives in Colombia. Soon after getting diagnosed with an incurable Multiple Myeloma-a cancer known for unleashing prolonged and painful agonies-he withdrew from oncology treatments and secured access to euthanasia (assisted-dying) on his own, bypassing medico-insurance guidelines created to regulate this medical practice and prevent abuses. Eight years after withdrawing treatments, my dad is still alive. His case shines a light on how securing access to euthanasia may have had unintended therapeutic e

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… In the United States, discussions about euthanasia have evolved into a modern form of medical ethics, emphasizing the moral aspects of the patient‐physician relationship and the central value of individual liberty within the medical‐legal framework. … Herrera‐Morales . 2016 . “ Reflections on Euthanasia in Colombia .” Colombian Journal of Anesthesiology 44 ( 4 ): 324 – 329 . 10.1016/j.rcae.2016.06.007 . Republica de Colombia, Ministerio de Salud y Protección Social . 2015a . …

Ретроспективное когортное исследование по вопросу о смертности от щелочной фосфаты и СИС при множественной миеломе.

Алькалин фосфатаза имеет другое клиническое значение в миеломе, чем в других новообразованиях. Изменения уровней щелочного фосфатаза могут служить хорошим прогнозом для пациентов с множественным миэломой в отделении интенсивной терапии. Однако данных о взаимосвязи между щелочной фосфатазой и смертностью у пациентов с множественной миеломой в СИС не имеется. Было проведено ретроспективное когортное исследование с участием 161 Участники получили доступ к базе данных " Medical Information Mart for Inтенциальный уход " ( " Медицинская информация для интенсивной терапии " ). Коэ

'It gives you an understanding you can't get from any book.' The relationship between medical students' and doctors' personal illness experiences and their performance: a qualitative and quantitative study.

BackgroundAnecdotes abound about doctors' personal illness experiences and the effect they have on their empathy and care of patients. We formally investigated the relationship between doctors' and medical students' personal illness experiences, their examination results, preparedness for clinical practice, learning and professional attitudes and behaviour towards patients.MethodsNewly-qualified UK doctors in 2005 (n = 2062/4784), and two cohorts of students at one London medical school (n = 640/749) participated in the quantitative arm of the study. 37 Consultants, 1 Specialist Registrar, 2 C

Инвентаризация поведения мужчин, имеющих сексуальные отношения с мужчинами: бифакторная проверка, диагностика IRT и клинические отсечки.

Справочная информация: Навязчивые сексуальные расстройства широко распространены среди мужчин, вступающих в половые отношения с мужчинами (МСМ), и связаны с неблагоприятными последствиями для здоровья, однако в этой области крайне не хватает проверенных инструментов оценки. Цель этого исследования состояла в том, чтобы адаптировать Инвентарь Гиперсексуального поведения (ГБИ) среди португальских МШМ (N = 1116 из четырех исследований). Метод и результаты: После перевода и адаптации (Study 1a/1b) в аналитическом анализе факторов была предложена двухфакторная структура инструмента (Study 2). Кроме