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Immunoexpression of C4 Binding Protein in Oral Leukoplakia and Oral Squamous Cell Carcinoma.

INTRODUCTION: Today there are approximately one million people with dementia in Germany. If current demographic trends continue, this number … sults in favour of the respective interventions, and three studies (ergotherapy, aroma therapy, and music/massage) report positive effects with respect to all of the endpoints measured. Six publications present economic results for usual-care-concepts. One study reports additional costs of 16 GBP (24.03 Euro (2006)) per patient per week for occupational …

The effectiveness of non-pharmacological pain management in relieving chronic pain for children and adolescents.

BACKGROUND: There is accumulating evidence that recurring pain symptoms in children are becoming a serious health concern. Children and adol … straction & guided imagery), meditation, progressive muscle relaxation, self-hypnosis, biofeedback, music therapy, and dance training. TYPES OF OUTCOME MEASURES: The primary outcome measures included: (1) Behavioral variables, such as pain behavior, cognitive coping and appraisal, psychiatric reaction (anxiety and depression), and social activities, (2 …

Stroke rehabilitation.

Stroke is a common, serious, and disabling global health-care problem, and rehabilitation is a major part of patient care. There is evidence to support rehabilitation in well coordinated multidisciplinary stroke units or through provision of early supported provision of discharge teams. Potentially beneficial treatment options for motor recovery of the arm include constraint-induced movement therapy and robotics. Promising interventions that could be beneficial to improve aspects of gait include fitness training, high-intensity therapy, and repetitive-task training. Repetitive-task training mi

Обзор воздействия терапии платформы (DMT) на сопутствующие клинические симптомы множественного склероза.

Лица с множественным склерозом (PwMS) испытывают различные симптомы, часто влияющие на клинические решения. Симптомы, включая когнитивные недостатки, боль, усталость и депрессию, оказывают глубокое воздействие на качество жизни (QoL). Лекарства для борьбы с заболеваниями (ДМТ) ориентированы главным образом на сокращение случаев рецидивов и замедление прогресса; однако их способность смягчать симптомы менее известна. В настоящем обзоре сведены воедино нынешние данные о роли платформы DMT (Glatiramer Acetate (GA), Interferon (IFN), Dimetil Fumarate (DMF), Terifluномид (TER)) в отношении сопутств

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… Ziemssen (2016); 28 Observational, non-interventional, open-label study, 170 sites from Germany PwMS (n=754); (n=709 [95.6%] had RRMS) Treatment naive (de novo) or previously treated with immunomodulatory drugs or mitoxantrone GA 20 mg/mL subcutaneously once daily for 2 years MUSIC PASAT MUSIC-Cognition … Ziemssen (2016); 28 Observational, non-interventional, open-label study, 170 sites from Germany | PwMS (n=754); (n=709 [95.6%] had RRMS) Treatment naive (de novo) or previously treated with immunomodulatory drugs or mitoxantrone | GA 20 mg/mL subcutaneously once daily for 2 years | MUSIC PASAT | MUSIC-Cognition …

Peri-transplant psychosocial factors and neutrophil recovery following hematopoietic stem cell transplantation.

ObjectiveMultiple psychosocial factors appear to affect cancer progression in various populations; however, research investigating the relationship between psychosocial factors and outcomes following hematopoietic stem cell transplantation (HCT) is scarce. Subject to adverse immunological and psychological conditions, HCT patients may be especially vulnerable to psychosomatic health sequelae; therefore, we studied whether optimism and anxiety influence the pertinent clinical outcome of days to neutrophil engraftment (DTE).Method54 adults undergoing either autologous or allogeneic HCT completed

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… These psychosocial measures were utilized as part of a music therapy intervention study in which 32 participants were randomized to the music therapy intervention and 32 randomized to an expressive reading arm; both groups received the same time and attention support. … While the initial study was a randomized controlled trial evaluating the efficacy of music therapy, both treatment arms were an active intervention (music therapy vs. expressive reading), and there were no differences in psychosocial or other outcomes between groups. …

Benzodiazepine and zolpidem prescriptions during autologous stem cell transplantation.

Multiple myeloma patients undergoing autologous stem cell transplantation (ASCT) may receive benzodiazepine or zolpidem-class (B/Z) medications despite their risks in older patients. Of 205 myeloma patients (36% aged 65+) who underwent ASCT at our institution between 2017 and 2018, we found that B/Z prescription rates for anxiety/insomnia rose significantly from 26% before ASCT to 38% at discharge and 39% at Day +100. B/Z initiation while hospitalized was a strong predictor of B/Z persistence at Day +100. Our findings highlight the role of these potentially inappropriate medications during hos

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… Several integrative strategies have been shown to be feasible during ASCT hospitalizations, for example: (a) music therapy, with patient‐selected live music performances and patient participation, if possible; (b) acupuncture needle insertion into the skin by trained acupuncturists; and even (c) programmed … Music therapy for symptom management after autologous stem cell transplantation: results from a randomized study. Biol Blood Marrow Transplant. 2017;23(9):1567‐72. 12. Deng G, Giralt S, Chung DJ, Landau H, Siman J, Search B, et al. …

Patient's satisfaction, acceptability, and feasibility of virtual reality for pain and anxiety management during bone marrow biopsy.

ObjectiveThis study aims to access the feasibility of using Virtual Reality during bone marrow biopsy, as well as patient-reported acceptability and satisfaction in reducing pain and anxiety for patients with hematologic malignancies.Methods and analysisIn this is pilot study, fifteen patients were required from hematological department of Hedi Chaker university hospital, Tunisia. Only descriptive statistical analyses were performed. The primary outcomes were technique's feasibility, participants' acceptability and satisfaction through passive health care observation during intervention and by

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… The available scenarios are composed of visual content, such as animals or nature scenes, associated with audio content, including Quran recitations or relaxing music. Scenarios’ durations range from 10 to 30 minutes. … Virtual reality and music therapy as distraction interventions to alleviate anxiety and improve mood states in breast cancer patients during chemotherapy. J Cell Physiol. 2020;235(6):5353–5362. doi: 10.1002/jcp.29422 11. Bani Mohammad E, Ahmad M.. …

[Can one talk of benzodiazepine "drunkenness"? About acute benzodiazepine intoxication, without suicidal or mortiferous tendencies].

BACKGROUNDS: When we refer to "drunkenness", more often than not, we think of alcohol or cannabis being the instigator rather than pharmacological drugs, even if outside the toxic origins, "drunkenness" may also occur without any substance intake: one can be drunk on love, poetry, music and even mania. Benzodiazepine "drunkenness" is not a classical notion in medicine. But the concept of addictology allows one to enlarge different approaches and to consider the relationship with psychoactive substances according to the same references. So, in a single fashion, between use and misuse, is it pos…

Mindfulness vs. sleep education during autologous hematopoietic cell transplantation for multiple myeloma: Feasibility of a randomized controlled pilot study.

BackgroundSleep disturbance is common in patients receiving hematopoietic stem cell transplantation (HCT). Mindfulness-based interventions (MBIs) can improve sleep quality during and following cancer treatment by reducing treatment-related symptoms and enhancing immune function.MethodsWe conducted a randomized controlled pilot study investigating the feasibility of implementing Mindfulness Awareness Practices for Insomnia (MAP-I) in patients with multiple myeloma (MM) undergoing autologous HCT. Patients were randomized to receive either MAP-I or a Sleep Health Education (SHE) intervention, bot

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… Similarly, a study examining a cognitive behavioral music therapy intervention on post-HCT fatigue reported that 11 out of 36 eligible patients (30.5%) completed the intervention [ 45 ]. … However, there are somewhat fewer required participant activities, and the music therapy MBI is delivered in person [ 49 ], similar to Bauer-Wu et al. (2008) and Compernolle and Sledge (2020). …

Adapting Yoga Therapy to Meet the Needs of Inpatients Undergoing Hematopoietic Stem Cell Transplantation: Insights From an International, Multisite, Qualitative Study.

PurposeYoga therapy (YT) is a growing mind-body approach in oncology. However, its integration into hematopoietic stem cell transplantation (HSCT) remains limited, particularly in non-Western and resource-constrained settings. This formative qualitative study aimed to explore the lived experiences of HSCT patients in the United States, India, and Tanzania to inform the development of a culturally adapted YT protocol.MethodsFifteen post-HSCT adult participants were recruited from three international cancer centers using purposive sampling. Semistructured interviews were conducted in participant

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… Multidisciplinary integrative services, such as massage, music therapy, nutrition, psycho-oncology, and physiotherapy, are available. HCG, India HCG is South Asia's largest oncology network, with over 18 centers in India, including one center in Africa, treating 100,000 new patients annually. … Engagement in stress management activities, such as walking, reading, listening to music, or chess, also supported psychological well-being, although this theme was less prevalent at MNH. …

Risk factors associated with suicidal ideation among cancer patients: a systematic review and meta-analysis.

ObjectiveThe objective of this review was to provide a comprehensive summary and analysis of the risk factors associated with suicidal ideation among cancer patients.MethodsThis review adhered to the PICO/S framework and guidelines outlined in the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) framework (PROSPERO CRD42023433639). We searched Web of Science, PubMed, Embase, Scopus, PsycINFO, and Cochrane Library from the establishment date of the databases until June 9, 2023 for observational studies that reveal risk factors associated with suicidal ideation among ca

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… Based on previous research into risk factors for suicidal ideation, researchers have proposed various psychological interventions, including mindfulness meditation ( Boyle et al., 2017 ) and music intervention ( Trigueros-Murillo et al., 2023 ). … Some studies have demonstrated that music intervention exerts a substantial positive influence on anxiety, depression, pain, fatigue, and overall quality of life ( Bulotiene and Pociute, 2019 ). …

Guided imagery for treating hypertension in pregnancy.

BACKGROUND: Hypertension (high blood pressure) in pregnancy carries a high risk of maternal morbidity and mortality. Although antihypertensi … son with no intervention or other non-pharmacological treatments for hypertension (e.g. quiet rest, music therapy, aromatherapy, relaxation therapy, acupuncture, acupressure, massage, device-guided slow breathing, hypnosis, physical exercise, and yoga). DATA COLLECTION AND ANALYSIS: Three review authors independently assessed the trials for inclusion, …

Recent advances in the detection and management of motor dysfunction in Alzheimer's disease.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder primarily characterized by cognitive decline. However, there is growing … that integrates motor and cognitive exercises (dual-task training) may provide additional benefits. Music therapy has also been shown to positively influence cognitive status, emotional well-being, and quality of life in older adults with early-stage dementia.10 Motor impairments are increasingly recognized as early markers of disease progression and cr …

Interventions for fatigue in people with kidney failure requiring dialysis.

BACKGROUND: Fatigue is a common and debilitating symptom in people receiving dialysis that is associated with an increased risk of death, ca … atigue-related outcomes, including non-physiological neutral amino acid, relaxation with or without music therapy, meditation, exercise with nandrolone, nutritional supplementation, cognitive-behavioural therapy, ESAs, frequent HD sections, home blood pressure monitoring, blood flow rate reduction, serotonin reuptake inhibitor, beta-blockers, anabolic s …

Концептуализация комплексного ухода за многими миеломами: роль питания, дополнительных услуг и дополнительных услуг.

Множественная миелома (ММ) — вторая по распространенности гематологическая гелингология, масштабы которой в последние годы значительно возросли. Прогноз ММ радикально изменился с введением новых лекарственных средств, повышающих ожидаемую продолжительность жизни; рецидивы являются обычным явлением во время болезни и характеризуются увеличением числа отказов от лечения. Кроме того, пациенты ММ сталкиваются с проблемами, связанными с качеством жизни, в то время как обычное лечение может быть ограничено. Это включает боль в костях и диализ из-за осложнений острой почечной недостаточности. Поэтому

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… Bates and colleagues explored the impact of music therapy considered by some scholars in the context of mind–body medicine, while others categorize it independently among the art therapies discipline. … The RCT explored symptom management following ASCT in patients with lymphoma or MM and found that the patients receiving music therapy used significantly less narcotic pain medication [ 108 ]. …

Effects of non-pharmacological interventions on depressive and anxiety symptoms in pregnant women: a systematic review and network meta-analysis.

BACKGROUND: Given the distinctive physiological characteristics of pregnant women, non-pharmacological therapies are increasingly being used … py, relaxation, mind-body exercise, psychotherapy, foetal movement counting, physical exercise, and music). Among the studies included in this analysis, 73 studies exhibited a low risk of bias, 9 studies had an unclear risk of bias, and 19 studies demonstrated a high risk of bias. The results indicate that, for both high-risk pregnancy population and he …

Personally tailored activities for improving psychosocial outcomes for people with dementia in community settings.

BACKGROUND: People with dementia living in the community, that is in their own homes, are often not engaged in meaningful activities. Activi … for an individual activity plan. We did not include interventions offering a single activity (e.g. music or reminiscence) or activities that were not tailored to the individual's interests or preferences. Control groups received usual care or an active control intervention. DATA COLLECTION AND ANALYSIS: Two review authors independently checked the art …

Virtual reality hypnosis during protective isolation: a parallel group randomized trial.

BACKGROUND: Patients in protective isolation often develop symptoms of anxiety. Virtual reality therapy and hypnosis could be of benefit to these patients, as both have been shown to relieve anxiety in a hospital setting. In this study, we investigated the use of virtual reality hypnosis (VRH), which induces a state of hypnosis. The primary aim was to determine whether VRH would reduce patients' anxiety during protective isolation. The secondary aim was to determine whether it would also relieve any pain. METHODS: This parallel group, open-label, single-center randomized trial included adult

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… Patients can often choose one of several appealing settings, such as a tropical beach or snowy mountains, and calming music may be played. … It would be helpful to carry out further work to identify patients who would benefit the most from VRH, and to optimize the virtual reality scenery, background music, and voice-over to maximize the effectiveness. …

Стратегии охраны мозга у лиц среднего возраста с незначительным нейрокогнитивным расстройством: аналитическая оценка.

Здравоохранение мозга означает оптимальное функционирование и целостность мозга, определяемые сложными когнитивными, психологическими и социальными детерминантами. Лица с легким нейрокогнитивным расстройством (mNCD) подвергаются повышенному риску развития слабоумия. Первостепенное состояние мозга имеет важное значение на протяжении всей жизни, особенно в период среднего возраста, когда риск для здоровья часто возникает наряду с тяжелыми жизненными обязанностями. В международных рамочных программах особое внимание уделяется изменению факторов риска на протяжении всей жизни в целях снижения риск

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… (around 13–16 per arm) reflect the challenge of enrolling and keeping patients with HD in lengthy interventions | Interventions were highly personalised, e.g., music therapy sessions were customised to each patient’s musical preferences. … A randomized clinical trial to evaluate the efficacy of cognitive rehabilitation and music therapy in mild cognitive impairment in Huntington’s disease," (in English) J Neurol. 2025;272(3) doi: 10.1007/s00415-025-12927-2. Article. 50. Currenti W., et al. …

Умственные меры по охране психического здоровья взрослых работников: обзор.

Справочная информация: Цель этого аналитического обзора заключалась в выявлении и обобщении данных о мерах, принимаемых на основе сознательности и направленных на достижение результатов в области психического здоровья работающих взрослых. Методы: Был проведен всеобъемлющий поиск four электронные базы данных (PubMed, Scopus, Web of Science и OT проситель) до октября 2025. Обзор проводился в соответствии с руководящими принципами ПРИСМА-СКР. Методологическое качество оценивалось с использованием классификации Оксфордского центра научно обоснованной медицины (OCEBM). Протокол был в перспективе за

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… The interventions employed various mindfulness-based protocols, including MBSR, MBSC, MBOT, app-based meditation (e.g., Headspace ® ), psychoeducational stress management programs, and mindfulness combined with music therapy. 3.4. … The effect of mindfulness-based breathing and music therapy on nurses’ stress and psychological well-being during COVID-19. Holist. Nurs. Pract. 2022;36:156–165. doi: 10.1097/HNP.0000000000000511. 29. …