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A novel arthroscopically assisted reduction technique for three patterns of posterolateral tibial plateau fractures.

BACKGROUND: Posterolateral tibial plateau fractures (PTPF) remain a challenge for orthopedics surgeons because the special anatomical struct … gament (ACL) injuries including the ACL tibial attachment ruptures occurred in 16 patients (51.6%), meniscus lesions happened in 19 patients (61.3%), medial collateral ligament (MCL) injuries were founded in 13 patients (41.9%). The number of ACL injuries including the ACL tibial attachment ruptures in the PI fracture pattern (12 cases) is significantly hi …

Preservation Methods Influence the Biomechanical Properties of Human Lateral Menisci: An Ex Vivo Comparative Study of 3 Methods.

BACKGROUND: Three main meniscal preservation methods have been used over the past decade: cryopreservation, freezing, and freezing with gamma irradiation. HYPOTHESIS: All 3 preservation methods will result in similar biomechanical properties as defined by tensile and compression testing. STUDY DESIGN: Controlled laboratory study. METHODS: A total of 24 human lateral menisci were collected from patients who underwent total knee arthroplasty. Inclusion criteria were patients younger than 70 years with primary unilateral (medial) femorotibial knee osteoarthritis. Each meniscus was divided into…

Reoperation Rates After Combined Anterior Cruciate Ligament and Anterolateral Ligament Reconstruction: A Series of 548 Patients From the SANTI Study Group With a Minimum Follow-up of 2 Years.

BACKGROUND: Early clinical results of anterolateral ligament (ALL) reconstruction are promising, but concerns exist due to high rates of com … index procedure. There were 63 reoperations for ipsilateral, non-graft rupture-related indications (meniscus, n = 30; arthrofibrosis, n = 22; removal of hardware, n = 4; deep infection, n = 3; arthroscopic lavage without infection, n = 4). The only specific complications related to the ALL procedure (n = 3) were all related to femoral hardware that require …

[Clinical research of popliteal cyst excision combined with debridement of the knee under arthroscopy with local anesthesia].

OBJECTIVE: To evaluate the clinical effects of popliteal cyst excision combined with debridement of the knee under arthroscopy with local an … with the disease, 52 patients were diagnosed as popliteal cyst before operation; 23 cases of simple meniscus injury or cartilage injury, 18 cases of osteoarthritis, 7 cases of cruciate ligament injury, 2 cases of gouty arthritis, 1 case of rheumatoid arthritis, 1 case of pigmented villonodular arthritis. The preoperative clinical manifestations involved kn …

Weekly injections of Hylan G-F 20 delay cartilage degeneration in partial meniscectomized rat knees.

BACKGROUND: Cross-linked hyaluronan--also called Hylan G-F 20--is a medical device developed to treat osteoarthritis of the knee. However, it is still controversial whether Hylan G-F 20 has a cartilage protective effect in trauma-induced osteoarthritis. We investigated whether Hylan G-F 20 delayed osteoarthritis progression in a partial meniscectomized rat model. METHODS: Lewis rats were used for the experiments. The anterior medial meniscus was resected at the level of the medial collateral ligament in both knees. From 1 week after the surgery, 50 μl of Hylan G-F 20 was injected weekly into …

Experimental osteoarthritis models in mice.

Osteoarthritis (OA) is a slowly progressing, degenerative disorder of synovial joints culminating in the irreversible destruction of articul … s models. The most common two methods for surgical induction are: (1) destabilization of the medial meniscus (DMM) and (2) anterior cruciate ligament transection (ACLT). In the DMM model, the medial meniscotibial ligament is transected while in the ACLT model the anterior cruciate ligament is destroyed. In the third, chemical induced instability method, in …

Femoral Tunnel Drilling Method: Risk of Reoperation and Revision After Anterior Cruciate Ligament Reconstruction.

BACKGROUND: The femoral tunnel in anterior cruciate ligament reconstruction (ACLR) can be created by the transtibial (TT) or tibial-independent (TI) methods. An anatomically located femoral tunnel can be more consistently achieved by TI methods, which include the anteromedial portal and lateral (outside-in, retrodrill) techniques. Nonanatomic graft placement in ACLR can result in postoperative instability and meniscal or chondral injury. An anatomically located graft is subjected to higher postoperative physiologic forces than one placed nonanatomically. PURPOSE: To examine isolated primary A

Repeated exposure to high-frequency low-amplitude vibration induces degeneration of murine intervertebral discs and knee joints.

OBJECTIVE: High-frequency, low-amplitude whole-body vibration (WBV) is being used to treat a range of musculoskeletal disorders; however, there is surprisingly limited knowledge regarding its effect(s) on joint tissues. This study was undertaken to examine the effects of repeated exposure to WBV on bone and joint tissues in an in vivo mouse model. METHODS: Ten-week-old male mice were exposed to vertical sinusoidal vibration under conditions that mimic those used clinically in humans (30 minutes per day, 5 days per week, at 45 Hz with peak acceleration at 0.3g). Following WBV, skeletal tissues

The expression of proinflammatory cytokines and matrix metalloproteinases in the synovial membranes of patients with osteoarthritis compared with traumatic knee disorders.

PURPOSE: The aim of this study was to evaluate a subset of matrix metalloproteinases (MMPs) and proinflammatory cytokines within the synovium, from traumatic knee disorders (TKDs) and nontraumatic osteoarthritis (OA). METHODS: MMP-1, MMP-3, interleukin 1beta, and tumor necrosis factor (TNF) alpha gene expression was quantified by use of TaqMan-based real-time polymerase chain reaction (Applied Biosystems, Foster City, CA) in synovial tissue samples obtained from 12 patients with OA and 32 with TKDs. In addition, the levels of serum inflammatory parameter C-reactive protein (CRP) were recorded

Commercially available bioinks and state-of-the-art lab-made formulations for bone tissue engineering: A comprehensive review.

Bioprinting and bioinks are two of the game changers in bone tissue engineering. This review presents different bioprinting technologies including extrusion-based, inkjet-based, laser-assisted, light-based, and hybrid technologies with their own strengths and weaknesses. This review will aid researchers in the selection and assessment of the bioink; the discussion ranges from commercially available bioinks to custom lab-made formulations mainly based on natural polymers, such as agarose, alginate, gelatin, collagen, and chitosan, designed for bone tissue engineering. The review is centered on

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… For meniscus repair, two studies investigated the use of Lifeink®200 by Advanced Biomatrix to fabricate 3D bioprinted meniscus-regenerative scaffolds. One study took place in 2022 when Stocco et al. explored the use of Lifeink®200 to develop a 3D bioprinted meniscus-regenerative scaffold [ 164 ]. … The authors used magnetic resonance imaging data from a healthy volunteer for the medial meniscus, that was processed to create a 3D model, and the meniscus was printed in a rectilinear filling pattern with 50 % infill density in a layer-by-layer method. …

Leptin drives osteoarthritis pain through sensory neuron reprogramming independent of cartilage signaling.

OBJECTIVE: Pain in osteoarthritis (OA) is often discordant with structural joint damage, particularly in obesity-associated OA, where adipos … ptor knockout mice (Aggrecan-CreERT2;LepRfl/fl), were challenged with destabilization of the medial meniscus (DMM) surgery to induce OA. Pain-related behaviors, joint pathology, serum cytokines, and lumbar dorsal root ganglia (DRG) transcriptomes were assessed. Human DRG cultures treated with leptin underwent transcriptomic profiling. Secondary analyses of …

Novel Interlinked Suspensory Fixation Technique Demonstrates Excellent Biomechanics and Improves Patient Outcomes in Anterior Cruciate Ligament (ACL) Reconstruction With Quadriceps Tendon Autograft.

Introduction Quadriceps tendon (QT) autografts are a versatile option for primary anterior cruciate ligament reconstruction (ACLR) due to lo … ected for patients undergoing primary ACLR with this graft preparation, with or without concomitant meniscus treatment. Patient-reported outcome measures (PROMs) and range of motion (ROM) data were retrospectively collected from the medical record. Results  Five QT grafts underwent biomechanical testing. The mean elongation was 4.16±0.42 mm over 2000 cycle …

Increased Preoperative Lateral Anterior Tibial Subluxation by Magnetic Resonance Imaging Is Associated With Increased Knee Laxity After Anatomical Anterior Cruciate Ligament Reconstruction.

PURPOSE: To clarify the correlation between postoperative anterior tibial subluxation (ATS) and clinical outcomes and identify the factors t … c ACL deficiency (>3 months from injury) (estimate = 0.594, 95% CI [0.047-1.140], P = .033), medial meniscus lesions ((estimate = 0.627, 95% CI [0.076-1.178], P = .026), and preoperative medial ATS (estimate = 0.394, 95% CI [0.292-0.495], P < .001) as independent risk factors for postoperative medial ATS and the preoperative lateral ATS (estimate = 0.313, …

Comparative return to play and performance outcomes following lower extremity injuries in European professional soccer: a systematic review and meta-analysis.

BACKGROUND: Lower extremity injuries are common in professional soccer and can significantly impact return to play (RTP) and player performa … RTPR of 70% to 78% and RTPT of 119-161 days, with significant short-term reductions in performance. Meniscus and medial collateral ligament (MCL) injuries demonstrated lower RTPR (approximately 70%) but shorter recovery timelines. Adductor and hamstring injuries were associated with the shortest RTPT (approximately 15-24 days) and minimal long-term perform …

Integrated prioritization of candidate quality markers for Smilacis Chinae Rhizoma under the five-principle framework through chemical profiling, effectiveness evaluation, and bionic sensing.

ETHNOPHARMACOLOGICAL RELEVANCE: Smilacis Chinae Rhizoma (SCR), the dried rhizome of Smilax china L., is a traditional Chinese medicinal herb … , and fresh-to-processed matching. Effectiveness was assessed using a destabilization of the medial meniscus-induced osteoarthritis (OA) model, network pharmacology, molecular docking, interleukin-1β-induced chondrocytes, and molecular dynamics (MD) simulation. TCM relevance was evaluated by electronic tongue and electronic nose analyses. RESULTS: A total …

Circular RNA circ_0003423 Promotes Osteoarthritis Progression by Sponging miR-330-5p to Upregulate TWIST1-Mediated Chondrocyte Inflammation and Extracellular Matrix Degradation.

Osteoarthritis (OA) is a debilitating degenerative joint disease characterized by progressive articular cartilage destruction, persistent in … levels were measured by ELISA. An OA mouse model was established via destabilization of the medial meniscus (DMM), and Circ_0003423 was silenced by intra-articular injection of lentiviral shRNA to validate In vivo findings. Circ_0003423 was significantly upregulated in OA cartilage and IL-1β-stimulated chondrocytes. Silencing Circ_0003423 rescued IL-1β-in …

Maternal omega-6 to omega-3 conversion reduces osteoarthritis pain-related behaviors in adult female offspring.

BACKGROUND: A parental high-fat diet (HFD) enriched in inflammatory omega-6 polyunsaturated fatty acids (n-6 PUFAs) increases the severity o … ulthood for metabolic and musculoskeletal outcomes 12-weeks following destabilization of the medial meniscus (DMM) surgery. RESULTS: WT fetal offspring from fat-1 dams had increased circulating levels of the anti-inflammatory cytokine IL-4 and decreased levels of the inflammatory cytokine TNFα, indicating a less inflammatory systemic environment than offsp …

Impact of Suture Configurations for Posterior Horn Meniscal Repair on Postoperative Stability and Reoperation Rates in Patients Undergoing Concurrent Anterior Cruciate Ligament Reconstruction: A Retrospective Comparative Study.

BACKGROUND: Posterior horn meniscal tears often accompany ACL injuries, requiring surgical repair to preserve knee function and prevent oste … -rank P = 0.024). Horizontal suture configuration (HR 2.84, 95% CI 1.32-6.14; P = 0.008) and medial meniscus location (HR 2.42, 95% CI 1.18-4.96; P = 0.014) were independent risk factors for failure, whereas tear length, chronicity, and bucket-handle tear pattern were not independently associated after adjustment. CONCLUSIONS: Combined vertical-horizontal …

Double-bundle ACL and ALL reconstruction results in less femoral posterolateral bundle tunnel widening than outside-in double-bundle ACL reconstruction.

PurposeTo compare the clinical and radiological results of two double-bundle (DB) anterior cruciate ligament reconstruction (ACLR) technique … ) and who received outside-in DB ACLR (non-ALLR group) were enrolled. Age, BMI, follow-up duration, meniscus repair, laterality, and knee range of motion (ROM) were collected. Lysholm, Tegner scale, and radiological results were compared.ResultsThirty-four and 33 patients were enrolled in the ALLR and non-ALLR groups. Patient demographics were similar betw …

Complete ACL injuries are associated with higher static tibial subluxation than partial ACL injuries or intact ACLs measured on MRI.

PURPOSE: To investigate static tibial subluxation on magnetic resonance imaging (MRI) as a potential method to quantify rotatory knee instab … red ACL-augmentation. The control group with an intraoperatively confirmed intact ACL (i-ACL) and a meniscus injury was 1:1 matched to p-ACL-I considering age, sex and body mass index (BMI). Static tibial subluxation in the medial (MC) and lateral compartment (LC) was measured on preoperative MRI. Intraclass correlation coefficients (ICC) were calculated f …