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Лечение пациентов с множественным склерозом во время COVID-19 и пандемии: оценка рекомендаций экспертов

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… By the end of February 2020 the first cases were reported in Latin-America ( Rodriguez-Morales et al., 2020 ). … 2020 Lancet London, England 10.1016/S0140-6736(20)30691-7 PMC7138169 32220278 Rodriguez-Morales A.J. Gallego V. Escalera-Antezana J.P. Méndez C.A. Zambrano L.I. Franco-Paredes C. Suárez J.A. Rodriguez-Enciso H.D. Balbin-Ramon G.J. Savio-Larriera E. Risquez A. Cimerman S. …

Clinical context and communication in shared decision-making about major surgery: Findings from a qualitative study with colorectal, orthopaedic and cardiac patients.

Increasing numbers of older people undergo major surgery in the United Kingdom (UK), with many at high risk of complications due to age, co-morbidities or frailty. This article reports on a study of such patients and their clinicians engaged in shared decision-making. Shared decision-making is a collaborative approach that seeks to value and centre patients' preferences, potentially addressing asymmetries of knowledge and power between clinicians and patients by countering medical authority with greater patient empowerment. We studied shared decision-making practices in the context of major su

Оценка и лечение агрессивного сексуального поведения: нынешние ограничения и потенциальные стратегии.

Несмотря на то, что в МКБ-11 была введена соответствующая классификация и симптоматика расстройства сексуального поведения (CSBD) по-прежнему противоречива. В этом обзоре мы изучили историю, эпидемиологический статус-кво, коморбиды, теории нейрофизики, текущие диагнозы и рекомендации по лечению для CSBD. Кроме того, мы подчеркнули недостатки текущих исследований и перспективы будущей работы. Селективные ингибиторы серотонина и налтрексон обычно используются в качестве "немаркированных" наркотиков. Диагностика и лечение пациентов, проходящих курс лечения, должны включать в себя биологические, п

Сексуальная диагностика после травматологического травматизма мозга и разрушения мозга: критический нарационный обзор нейробиологии, клинических фенотипов и управления.

Фон/цели: Приобретенная травма мозга (АБИ) может нарушить сексуальное регулирование, но в литературе не поддерживается ни одна связь между побочными повреждениями. В этом критическом обзоре дается оценка гиперсексуальности, сексуального лишения и редких парафических проявлений после травматической травмы мозга (ТБР) и инсульта, а также задается вопрос о том, насколько скудные, разнородные данные могут служить основой для пропорционального клинического ухода. Методы: была проведена проверка по Пубмеду/МЕДЛИНЕ, Скопу и Сети наук 6 Август 2026. Two Эксперты, проводящие обзор, проводят независимую

Клиническое описание и социально-демографическая характеристика лиц, страдающих киберсексуальной зависимостью, в рамках долгосрочных программ терапевтической поддержки.

ЦЕЛЬ: Киберсексуальная зависимость и гиперсексуальное поведение представляют собой растущие проблемы в области психического здоровья во всем мире. В ходе этого исследования были проанализированы социально-демографические и клинические характеристики когорты мужчин, проходящих курс лечения, а также была изучена взаимосвязь между продолжительностью терапевтической помощи и симптоматической строгостью. МЕТОД: В рамках программ терапевтической поддержки было проведено исследование по наблюдению, описательному и сквозному изучению с участием преимущественно мужской клинической группы (n = 27; 26 му

Incivility Is Associated with Burnout and Reduced Compassion Satisfaction: A Mixed-Method Study to Identify Causes of Burnout among Oncology Clinical Research Coordinators.

While oncology clinical research coordinators (CRCs) experience a combination of factors that are thought to put them at increased risk for burnout, very little research has been conducted to understand the risk factors associated with burnout among CRCs. We used a mixed-method approach, including self-report questionnaires to assess burnout and compassion satisfaction, as well as individual and interpersonal variables hypothesized to impact CRC well-being. We also conducted a focus group to gain a more nuanced understanding of coordinators' experiences around burnout, teamwork, resilience, an

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… Regarding interpersonal factors important to well-being, we were interested in CRCs experiences of incivility from their colleagues, leadership, and from patients, given the well-documented negative effects of incivility on morale and performance [ 28 , 29 ]. … The Blue Ridge Academic Health Group The Hidden Epidemic: The Moral Imperative for Academic Health Centers to Address Health Professional’s Well-Being 2017–2018. [(accessed on 10 January 2018)]. …

Alexithymia in multiple sclerosis: past, present and future.

Alexithymia denotes the "absence" of "words" for "emotion" and has its roots in the Greek words "a," "lexis," and "thymos." It is sometimes referred to as "emotional blindness," "blunted feeling," or "disrupted emotional awareness." The term "alexithymia" first appeared in the 1970s in the works of Sifneos, Nemiah, and colleagues. It entails difficulties in identifying and expressing emotions and an externally oriented thinking style. It is not a psychiatric disorder but rather a multidimensional personality trait or construct, appearing to be normally distributed in the general population, wi

Head-to-Head Comparison between FDG and 11C-Methionine in Multiple Myeloma: A Systematic Review.

The aim of this systematic review is to provide a comprehensive overview of the existing literature, comparing 18F-fluorodeoxyglucose (FDG) and 11C-methionine (MET) for the imaging of multiple myeloma (MM) with positron emission computed tomography (PET/CT). Relevant studies published from 2013 up to March 2023 were selected by searching Scopus, PubMed, and Web of Science. Selected imaging studies were analyzed using a modified version of the critical Appraisal Skills Programme (CASP). Ten studies encompassing 335 patients were selected. On a patient-based analysis, MET sensitivity ranged betw

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… Diagnostic and Prognostic Impact of FDG and MET-Derived Volumetric Parameters The diagnostic value of whole body tumor burden, assessed by both MET and FDG–PET in MM patients, was assessed by Morales-Lozano and coworkers in two distinct studies. … Morales-Lozano M.I., Viering O., Samnick S., Rodriguez-Otero P., Buck A.K., Marcos-Jubilar M., Rasche L., Prieto E., Kortüm K.M., San-Miguel J., et al. 18F-FDG and 11C-Methionine PET/CT in Newly Diagnosed Multiple Myeloma Patients: Comparison of Volume-Based PET Biomarkers. …

Cancer Mortality - China, 2018.

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Полуструктурированный клинический интервью для оценки компульсивного сексуального поведения (SSCI-CSB): Развитие, надежность и валидность.

Цели Оценка компульсивного сексуального поведения (КСП) требует тонких подходов к оценке, идеально через клинические интервью. Однако ни одно из нескольких доступных клинических интервью для КСП не продемонстрировало сильные психометрические свойства. Чтобы решить эту проблему, мы разработали Semi-Structured Clinical Interview for the assessment of CSB (SSCI-CSB), интервью, которое собирает информацию о проявлениях, симптомах и клиническом течении КСП. Цель этого исследования состояла в том, чтобы проанализировать его надежность и обоснованность в выборке пациентов, нуждающихся в лечении некон

Low awareness of medication-related osteonecrosis of the jaw among dentists: a systematic review with a medical and bioethical perspective.

INTRODUCTION: Medication-related osteonecrosis of the Jaw (MRONJ) is a serious adverse drug reaction that can seriously affect the quality of life of patients if not promptly diagnosed and treated. To date, preventive measures have been the most effective strategy for reducing the incidence of MRONJ. The role of dental practitioners in managing patients treated with Bone Modifying Agents (BMAs) varies across countries, with some healthcare systems providing a more structured approach than others. This systematic review aims to investigate the knowledge and awareness of MRONJ among dentists, in

Silent Conversations: Goals of Care and End-of-Life Quality in Relapsed High-Risk Leukemia.

BackgroundAdvanced practice providers (APPs) affect high-quality health care through leadership, evidence-based practice implementation, and quality improvement projects. When planning solutions to clinical problems, leadership must solicit APP input to promote success. Hematology patients are more likely to receive poor-quality end-of-life (EOL) care than those with solid tumors. Regardless of disease, aggressive EOL care is increasing despite evidence that it is often inconsistent with patients' goals of care (GOC). Data regarding this phenomenon in hematology specifically is lacking. The di

Smart Targeting To Improve Cancer Therapeutics.

Cancer is the second largest cause of death worldwide with the number of new cancer cases predicted to grow significantly in the next decades. Biotechnology and medicine can and should work hand-in-hand to improve cancer diagnosis and treatment efficacy. However, success has been frequently limited, in particular when treating late-stage solid tumors. There still is the need to develop smart and synergistic therapeutic approaches to achieve the synthesis of strong and effective drugs and delivery systems. Much interest has been paid to the development of smart drug delivery systems (drug-loade

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… Due to the FAR overexpression in different cancer types, Morales-Cruz et al designed a smart nanosized DDS of cytochrome c modified with PEG-FA. … Moraima Morales-Cruz and Yamixa Delgado are co-first authors. …

Which health technologies should be funded? A prioritization framework based explicitly on value for money.

UnlabelledBackgroundDeciding which health technologies to fund involves confronting some of the most difficult choices in medicine. As for other countries, the Israeli health system is faced each year with having to make these difficult decisions. The Public National Advisory Committee, known as 'the Basket Committee', selects new technologies for the basic list of health care that all Israelis are entitled to access, known as the 'health basket'. We introduce a framework for health technology prioritization based explicitly on value for money that enables the main variables considered by deci

Effect of exercise interventions on cognitive function in breast cancer patients and survivors: a systematic review with meta-analysis.

BackgroundExercise has been shown to facilitate cognitive function; however, data on changes in cognitive function in response to exercise interventions among breast cancer patients and survivors, who frequently experience cognitive impairment, have not been comprehensively synthesized. Therefore, this study aims to examine the impact of exercise interventions on cognitive function among breast cancer patients and survivors.MethodsElectronic databases including PubMed, Scopus, and Web of Science were searched from inception to December 25, 2024. A three-level meta-analysis was performed in R u

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… Galiano-Castillo N, Arroyo-Morales M, Lozano-Lozano M, Fernández-Lao C, Martín-Martín L, Del-Moral-Ávila R, et al. Effect of an internet-based telehealth system on functional capacity and cognition in breast cancer survivors: a secondary analysis of a randomized controlled trial. … Galiano-Castillo N, Cantarero-Villanueva I, Fernández-Lao C, Ariza-García A, Díaz-Rodríguez L, Del-Moral-Ávila R, et al. …

Combined Immune Defect in B-Cell Lymphoproliferative Disorders Is Associated with Severe Infection and Cancer Progression.

B cell chronic lymphoproliferative diseases (B-CLPD) are associated with secondary antibody deficiency and other innate and adaptive immune defects, whose impact on infectious risk has not been systematically addressed. We performed an immunological analysis of a cohort of 83 B-CLPD patients with recurrent and/or severe infections to ascertain the clinical relevance of the immune deficiency expression. B-cell defects were present in all patients. Patients with combined immune defect had a 3.69-fold higher risk for severe infection (p = 0.001) than those with predominantly antibody defect. Inte

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… Mateo Morales M. LLano Hernández K. Williams L.J. Rodríguez de Frías E. Evaluation of Polysaccharide Typhim vi Antibody Response as a Predictor of Humoral Immunodeficiency in Haematological Malignancies Clin. Immunol. 2019 210 108307 10.1016/j.clim.2019.108307 31760095 15. Watson E.K. Rose P.W. … Mateo Morales M. Rodríguez de la Peña A. Díez-Rivero C.M. Trained Immunity-Based Vaccine in B Cell Hematological Malignancies With Recurrent Infections: A New Therapeutic Approach Front. Immunol. 2021 11 611566 10.3389/fimmu.2020.611566 33679698 PMC7928395 28. Sánchez-Ramón S. Fernández-Paredes L. …

A Review of Trend of Nursing Theories related Caregivers in Korea.

BackgroundThe prevalence of chronic diseases has been rapidly increased due to population aging. As the duration of care needs increase, the caregivers' socioeconomic burdens have also increased.ObjectiveThis review examines the attributes of caregiving experience and quality of life of caregivers in Korea with a focus on the application of nursing theory.MethodWe reviewed studies on caregivers' caring for adult patients published till 2016 in 4 bio-medical research portal websites or data bases. A total of 1,939 studies were identified through the keyword search. One hundred forty five studie

A Comprehensive Review of Immunotherapy Clinical Trials for Metastatic Urothelial Carcinoma: Immune Checkpoint Inhibitors Alone or in Combination, Novel Antibodies, Cellular Therapies, and Vaccines.

Urothelial cancer is an immune-responsive cancer, but only a subset of patients benefits from immune checkpoint inhibition. Currently, single-agent immune checkpoint inhibitors (ICIs) and the combination of pembrolizumab with the antibody-drug conjugate enfortumab vedotin are approved to treat patients with metastatic UC (mUC). Approval of first-line nivolumab in combination with gemcitabine and cisplatin is expected imminently. Many treatment approaches are being investigated to better harness the immune system to fight mUC. In this review, we summarize the landmark clinical trials of ICIs th

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… Morales A., Eidinger D., Bruce A.W. Intracavitary Bacillus Calmette-Guerin in the treatment of superficial bladder tumors. J. Urol. 1976;116:180–182. doi: 10.1016/S0022-5347(17)58737-6. 4. … Powles T., Csőszi T., Özgüroğlu M., Matsubara N., Géczi L., Cheng S.Y., Fradet Y., Oudard S., Vulsteke C., Morales Barrera R., et al. …

Revolutionising health care: Exploring the latest advances in medical sciences.

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Accumulated incidence of falls in people hospitalised with cancer and related factors.

AimTo study the accumulated incidence of falls of people hospitalised with cancer and analyse the related intrinsic and extrinsic factors.DesignA prospective study of people hospitalised with cancer at the Catalan Institute of Oncology.MethodsIntrinsic factors and extrinsic factors related to the fall have been studied. The data were gathered from the clinical history and a specific adverse events notification programme and patients were followed during hospitalisation.ResultsA total of 117 of 6090 patients admitted during the period of study were included, with an accumulated incidence of fal

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… B. , & Morales‐Asencio , J. M. ( 2015 ). Validation of the STRATIFY falls risk‐assessment tool for acute‐care hospital patients and nursing home residents: Study protocol . Journal of Advanced Nursing , 71 ( 8 ), 1948 – 1957 . 10.1111/jan.12651 25778931 Breivik , H. , Borchgrevink , P. … J. , & Morales‐Asencio , J. M. ( 2020 ). Profile of the patient who suffers falls in the hospital environment: Multicenter study . Enfermería Clínica , 30 ( 4 ), 236 – 243 . 10.1016/j.enfcli.2019.05.005 31208928 Fino , P. C. , Horak , F. B. , El‐Gohary , M. , Guidarelli , C. , Medysky , M. …