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Vapor resection: a good alternative to standard loop resection in the management of prostates >40 cc.

BACKGROUND AND PURPOSES: The morbidity of transurethral vesection of the prostate (TURP) necessitates constant attempts at modifications to … sodium postoperatively in the two groups was not statistically significant. The complications were dysuria in six patients lasting for a month and one capsular perforation in Group and incontinence lasting for 6 months in two patients and stricture in one patient in Group 2. The efficacy, assessed with IPSS, Q(max), and residual urine volume, was compara …

Борьба с раком, токсичностью и вторичным риском заболевания протонной радиацией для стадии I-IIB семинома.

ЦЕЛЬ: Цель этого исследования заключалась в том, чтобы сообщать о результатах борьбы с раком и токсичности после протонной радиационной терапии (RT) в яично-полиномической полуномии и сопоставлять риски вторичной злокачественности (SMN) с альтернативами лечения на основе фотонов. МЕТОДЫ И МАТЕРИАЛЫ: В одном учреждении ретроспективно анализировались пациенты, страдающие яичекой полуномой стадии I-IIB с протоном RT. Были рассчитаны оценочные показатели < < Каплан-Мейер > > для обеспечения выживания без болезней и общего выживания. Токсичность была оценена с использованием версии общи

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… Genitourinary toxicities were least common (urinary frequency: n = 2 [8.3%]; all G1) or never reported (ie, dysuria). … The most common acute toxicity was G1 nausea (70.8%), which is consistent with 3D-CRT prospective data. 3 , 5 In a recent retrospective comparison study between proton RT (n = 11) and 3D-CRT (n = 44), most acute toxicities (fatigue, nausea/vomiting, and dysuria) were not significantly different between …

A Rare Case of Gastrointestinal Amyloidosis Due to Monoclonal Gammopathy of Undetermined Significance.

Amyloidosis of the gastrointestinal (GI) tract is caused by the deposition of fibrils made of serum proteins into extracellular spaces. It is an uncommon disease with a poor prognosis, requiring prompt diagnosis and treatment. Treatment for amyloid light chain (AL)-type amyloidosis involves supportive care as well as addressing any underlying plasma cell dyscrasias. We present the case of a 64-year-old female diagnosed with AL-type GI amyloidosis with associated monoclonal gammopathy of undetermined significance. Unfortunately, the treatment was initiated nine months after the initial presenta

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… year-old female with a past medical history significant for hypertension, chronic obstructive pulmonary disease, systolic congestive heart failure, depression, gastroesophageal reflux disease, hyperlipidemia, hypothyroidism, and anxiety presented to the emergency department (ED) complaining of dyspnea, dysuria … Discussion Our patient initially presented with dyspnea, dysuria, fatigue, and right lower quadrant pain but later also presented with hematemesis, weight loss, melanotic stool, and tongue swelling. These later presentations signified manifestations of her disease. …

'Targeted top down' approach for the investigation of UTI: A 10-year follow-up study in a cohort of 1000 children.

INTRODUCTION: Investigations following urinary tract infection (UTI) aim to identify children who are prone to renal scarring, which may be … ere discharged from the UTI clinic: 47 of them re-presented - 40 with recurrent UTIs and seven with dysuria. Thirty-five of the 47 children who re-presented with urological symptoms underwent a DMSA scan, which showed scarring in three (6%). DISCUSSION: Only 12% of children have a significant radiological abnormality picked up on investigation following …

Urethral injection therapy for urinary incontinence in women.

BACKGROUND: Periurethral or transurethral injection of bulking agents is a minimally invasive surgical procedure used for the treatment of s … his was sustained, and the treatment was associated with high levels of postoperative retention and dysuria. Greater symptomatic improvement was observed with surgical treatments, though the advantages need to be set against likely higher risks. No clear-cut conclusions could be drawn from trials comparing alternative agents, although dextranomer hyaluron …

Excision versus colorectal resection in deep endometriosis infiltrating the rectum: 5-year follow-up of patients enrolled in a randomized controlled trial.

STUDY QUESTION: Is there a difference in functional outcomes and recurrence rate between conservative versus radical rectal surgery in patie … ipation (1 stool/>5 consecutive days), frequent bowel movements (≥3 stools/day), anal incontinence, dysuria or bladder atony requiring self-catheterization 24 months postoperatively. Secondary endpoints were values taken from the Knowles-Eccersley-Scott-symptom questionnaire (KESS), the gastrointestinal quality of life index (GIQLI), the Wexner scale, the …

Mutations in immunodeficiency-related genes may increase the risk of infection after CAR-T-cell therapy: a report of two cases.

BackgroundChimeric antigen receptor T-cell therapy (CAR-T) has yielded unprecedented efficacy in B-cell malignancies. With the increasing use of CAR-T-cell therapy, infection has become one of the major concerns after CAR-T-cell infusion. Some patients even develop refractory or recurrent infections, posing challenges in treatment, prophylactic, and monitoring strategies. However, the mechanisms underlying the development of these infections were not clear.Case presentationWe report two cases of infection after CAR-T-cell therapy. Patient 1, diagnosed with multiple myeloma, received anti-B-cel

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… CAR chimeric antigen receptor, G-CSF granulocyte colony-stimulating factor, NK natural killer The patient complained of dysuria without fever on Day 25, which was considered a urinary tract infection. … The symptom of dysuria then gradually resolved; however, the patient developed refractory hypokalaemia even when the dosage of amphotericin B liposomes was reduced. From Day 56, the antifungal agent was changed back to micafungin since the patient had no more complaints (Fig. 1 A). …

[Application of modified urethral separation method in artificial urethral sphincter implantation and its influence on intraoperative urethral pressure profilometry].

Objective: To explore the application of modified urethral separation method in artificial urethral sphincter (AUS) implantation in patients … uding 2 cases of painless hematuria, 1 case of infection, 1 case of urethral erosion, and 1 case of dysuria. Except for one patient who experienced urethral erosion and had his sleeve removed, the remaining four patients regained social urination control with active support treatment, and no symptoms recurred until the last follow-up. Conclusion: The modi …

A multicenter retrospective cohort study comparing urethral diverticulectomy with and without pubovaginal sling.

BACKGROUND: Urethral diverticulum is a rare entity and requires a high suspicion for diagnosis based on symptoms and physical exam with conf … pubovaginal sling group had greater preoperative stress urinary incontinence (71% vs 33%; P<.0001), dysuria (47% vs 30%; P=.002), and recurrent urinary tract infection (49% vs 33%; P=.004). The addition of a pubovaginal sling at the time of diverticulectomy significantly improved the odds of stress urinary incontinence resolution after adjusting for prior …

Surgical management of urethral prolapse in girls: 13 years' experience.

UNLABELLED: Study Type - Therapy (case series) Level of Evidence 4 What's known on the subject? and What does the study add? Urethral prolap … factors, management and outcomes. RESULTS: Presenting symptoms were: mass (n= 8), bleeding (n= 6), dysuria/straining at micturition (n= 6), discharge (n= 1) and constipation (n= 1). In all, 13 patients were managed conservatively because their symptoms were mild. Seven patients underwent prolapse reduction under general anaesthetic (GA). In one patient, …

Focal therapy for localised unifocal and multifocal prostate cancer: a prospective development study.

BACKGROUND: Radical whole-gland therapy can lead to significant genitourinary and rectal side-effects for men with localised prostate cancer … hospital admission. Nine men (22%, 95% CI 11-38) had self-resolving, mild to moderate, intermittent dysuria (median duration 5·0 days [IQR 2·5-18·5]). Urinary debris occurred in 14 men (34%, 95% CI 20-51), with a median duration of 14·5 days (IQR 6·0-16·5). Urinary tract infection was noted in seven men (17%, 95% CI 7-32). Median overall International Ind …

Infectious Diseases

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… 38.3 °C [≥101 °F], duration ≥3 weeks for outpatients or ≥3 days for inpatients fever , NYD —persistent fever that has not yet met the definition for FUO Clinical Features HISTORY —pattern and duration of fever, associated symptoms (cough, dyspnea, hemoptysis, chest pain, diarrhea, abdominal pain, dysuria … positive 4.2 0.3 APPROACH —“four symptoms (dysuria, frequency, hematuria, back pain) and one sign (CVA tenderness) increased the probability of UTI and may effectively rule in if all present. …

Проблемы с диагностикой и оказанием неотложной медицинской помощи в случае быстро прогрессирующего заболевания лёгких, вторичного и многократного заболевания миеломой.

Одновременное представление множественной миеломы (ММ) и межститиальной болезни легких (МЛ) остается исключительно редким, при этом ограниченная литература описывает оптимальные стратегии управления для этой двойной патологии. Мы сообщаем о сложном случае 62-year-old Мужчина с недавно поставленным диагнозом MM с цитогенетикой промежуточного риска (del13q, набирающий 1q), который одновременно представил быстро прогрессирующий ILD, демонстрирующий обычную интерститальную пневмонию (МСАГВ). Пациентка 6-month Клинический курс был отмечен участием многих организаций, периодическими инфекциями, тром

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… Case presentation A 62-year-old male, controlled hypertensive, presented to the medicine outpatient with lower urinary tract symptoms (dysuria, increased urinary frequency, nocturia) and nocturnal cough. He had a long-standing history of bilateral ankle pain (8 years’ duration). … However, one week later, he presented again with fever and dysuria. Urine culture revealed Klebsiella pneumoniae. Despite outpatient antibiotic therapy, symptoms persisted, requiring admission for intravenous antibiotics. …

Infectious Diseases

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… , ≥38.3°C [≥101°F], duration ≥3 weeks for outpatients or ≥3 days for inpatients fever, NYD —persistent fever that has not yet met the definition for FUO Clinical Features HISTORY —pattern and duration of fever, associated symptoms (cough, dyspnea, hemoptysis, chest pain, diarrhea, abdominal pain, dysuria … Chronic schistosomiasis with granuloma formation is due to host’s immune response to schistosome eggs, leading to hepatic (cirrhosis), intestinal (diarrhea, occult blood, fibrosis) or genitourinary tract symptoms (hematuria, dysuria, calcification, fibrosis), and rarely CNS (seizures, focal deficit, …

Stevens Johnson Syndrome: Past, Present, and Future Directions Gynecologic Manifestations and Management in SJS/TEN.

UNLABELLED: Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are severe mucocutaneous hypersensitivity disorders characterized by sudden onset epidermal necrosis. Acute manifestations of SJS/TEN often include vulvovaginal erosions, ulcerations, vaginal discharge, bleeding, vaginal pain, dysuria, and urinary retention. If not treated, this can lead to complications such as vulvovaginal adhesions, vaginal stenosis or dryness, pain, dyspareunia, bleeding, and adenosis. Even with adequate treatment, there are lasting impacts including difficulty with vaginal exams and psychologi…

Serotonin and Norepinephrine Reuptake Inhibitors.

This chapter covers antidepressants that fall into the class of serotonin (5-HT) and norepinephrine (NE) reuptake inhibitors. That is, they … thway for clearance is direct conjugation and renal elimination. As with other drugs in this class, dysuria is a common, troublesome, and dose-dependent adverse effect (occurring in up to 7% of patients). High-dose milnacipran has been reported to cause blood pressure and pulse elevations. Levomilnacipran is the levorotary enantiomer of milnacipran, and i …

Intravesical gemcitabine therapy for non-muscle invasive bladder cancer (NMIBC): a systematic review.

•  Intravesical immunotherapy or chemotherapy for non-muscle invasive bladder cancer is a well-established treatment for preventing or delay … re similar with respective recurrence rates of 25% and 30% (P= 0.92) and overall progression equal. Dysuria (12.5% vs 45%, P < 0.05) and frequency (10% vs 45%, P < 0.001) were significantly less with gemcitabine. •  In a second trial of high-risk patients the recurrence rate was significantly greater with gemcitabine compared with BCG (53.1% vs 28.1%, P= …

Trans-obturator urethral sling for the surgical correction of female stress urinary incontinence: outside-in (Monarc) versus inside-out (TVT-O). Are the two ways reassuring?

INTRODUCTION: In 2001, the trans-obturator route was proposed for the surgical positioning of tape with a view to avoiding the retropubic sp … e de novo symptoms included one case of imperious urges to urinate in the TVT-O group and objective dysuria in two cases in the MON group versus seven in the TVT-O group. There was no statistically significant between-group difference in the complications. No tape exposure was observed. Overall, the recovery rate was 90% at 1 year for MON versus 94% for T …

Acute genitourinary toxicity after high-dose-rate (HDR) brachytherapy combined with hypofractionated external-beam radiation therapy for localized prostate cancer: correlation between the urethral dose in HDR brachytherapy and the severity of acute genitourinary toxicity.

PURPOSE: Several investigations have revealed that the alpha/beta ratio for prostate cancer is atypically low, and that hypofractionation or … ch and Treatment of Cancer toxicity criteria. RESULTS: The main symptoms of acute GU toxicity were dysuria and increase in urinary frequency or nocturia. The grade distribution of acute GU toxicity in the patients was as follows: Grade 0-1, 39 patients (56%), and Grade 2-4, 31 patients (44%). One patient who developed acute urinary obstruction was classi …

Oral gepotidacin versus nitrofurantoin in patients with uncomplicated urinary tract infection (EAGLE-2 and EAGLE-3): two randomised, controlled, double-blind, double-dummy, phase 3, non-inferiority trials.

BACKGROUND: Gepotidacin is a novel, bactericidal, first-in-class triazaacenaphthylene antibiotic that inhibits bacterial DNA replication by … t birth, non-pregnant, aged 12 years or older, weighing 40 kg or more, with two or more symptoms of dysuria, frequency, urgency, or lower abdominal pain, and with evidence of urinary nitrite, pyuria, or both were eligible for inclusion. Patients were randomly assigned (1:1) centrally by interactive response technology to receive oral gepotidacin (1500 mg …