Результаты поиска

Novel Carbon Dots Derived from Glycyrrhizae Radix et Rhizoma and Their Anti-Gastric Ulcer Effect.

Glycyrrhizae Radix et Rhizoma (GRR) is one of the commonly used traditional Chinese medicines in clinical practice, which has been applied to treat digestive system diseases for hundreds of years. GRR is preferred for anti-gastric ulcer, however, the main active compounds are still unknown. In this study, GRR was used as precursor to synthesize carbon dots (CDs) by a environment-friendly one-step pyrolysis process. GRR-CDs were characterized by using transmission electron microscopy, high-resolution TEM, fourier transform infrared, ultraviolet-visible and fluorescence spectroscopy, X-ray photo

Impact of nano-conjugate on Drosophila for early diagnosis of Alzheimer's disease.

Alzheimer's disease (AD) is an irreversible neurodegenerative disease. Recent identification of AD biomarkers has led to the diagnosis of AD before the onset of dementia. It has been shown that Drosophila melanogaster is a valuable model for studying human neurodegeneration, including AD. According to its properties, curcumin shows promising potential for the diagnosis of AD. In order to improve its use, new formulations, including nanotechnology-based delivery systems, have been applied. The current study aims to diagnose AD by detecting the accumulation of amyloid beta-peptide via carbon-dot

Efficient core shell structured dual response ratiometric fluorescence probe for determination of H2O2 and glucose via etching of silver nanoprisms.

A simple and sensitive inner filter effect and charge transfer dual response ratiometric fluorescent probe (D-RFP) for sensing glucose was developed based on etching of silver nanoprisms (Ag NPRs). The D-RFP was proposed by hybridizing red emitting CdTe QDs and blue emitting CDs into core-shell structured silica nanoparticles. In this design, when mixed Ag NPRs with the D-RFP, QDs which embedded in silica nanoparticles can be quenched by Ag NPRs via inner filter effect. Ag NPRs can be effectively etched to silver ions by H2O2 which can bind with CDs and quench CDs by charge transfer. The etchi

Photoelectrochemistry of free-base-porphyrin-functionalized zinc oxide nanoparticles and their applications in biosensing.

The photoelectrochemical properties of free-base-porphyrin-functionalized zinc oxide nanoparticles were studied. A universal photoelectrochemical biosensing platform was constructed on indium tin oxide (ITO) by using the functional nanohybrid. The nanohybrid was synthesized by means of dentate binding of ZnO nanoparticles with carboxylic groups of 4,4',4'',4'''-(21H,23H-porphine-5,10,15,20-tetrayl)tetrakis(benzoic acid) (TCPP), and characterized with scanning electron microscopy, contact angle measurement, and spectral techniques. The nanohybrid-coated ITO electrode showed an efficient photocu

Fluorescent nanocrystals reveal regulated portals of entry into and between the cells of Hydra.

Initially viewed as innovative carriers for biomedical applications, with unique photophysical properties and great versatility to be decorated at their surface with suitable molecules, nanoparticles can also play active roles in mediating biological effects, suggesting the need to deeply investigate the mechanisms underlying cell-nanoparticle interaction and to identify the molecular players. Here we show that the cell uptake of fluorescent CdSe/CdS quantum rods (QRs) by Hydra vulgaris, a simple model organism at the base of metazoan evolution, can be tuned by modifying nanoparticle surface c

Photoluminescence and raman study of CdS-Al2O3 nanocomposite films prepared by sol-gel techniques.

The optical and microstructural properties of CdS-Al2O3 nanocomposite (CdS-Al2O3 = 20:80 to 50:50) thin films synthesized by sol-gel techniques were studied. Optical transmission spectra indicated a marked blue shift of the absorption edge due to quantum confinement. Band gaps of CdS-Al2O3 nanocomposites were found to vary in the range 3.69-2.61 eV. The sizes of the nanocrystals, estimated from the blue shift (0.2-1.2 eV) of the absorption edges and transmission electron microscopy, were found to vary in the range 2.8-7.0 nm. X-ray diffraction studies showed reflections from (111), (200), (220

A crosslinking network and nanoconfinement synergistic strategy for achieving white-light excited long-lived room-temperature phosphorescence in transparent aqueous carbon dot solutions.

Aqueous phosphorescent carbon dots (CDs) have shown great promise for solution-based practical applications. However, dissolved oxygen in water can severely quench triplet excitons, resulting in unstable phosphorescence emission in aqueous solution. Moreover, most reported aqueous phosphorescent CDs mainly rely on UV excitation and exhibit turbid colloidal solutions. Herein, we for the first time report that white light excitable high-transparency aqueous room-temperature phosphorescence (RTP) CD-based nanomaterials (N,P-CDs@SiO2) can be rationally designed and synthesized via a crosslinking n

Optimized melanin production from marine-associated Bacillus sp. EGY7 as a sustainable precursor of carbon dots for biomedical applications.

Melanin, a multifunctional biopigment with photoprotective, antioxidant, and therapeutic properties, is limited by scarce sustainable sources and poor aqueous solubility. In this study, melanin production from a newly isolated marine-associated Bacillus sp. EGY7 was optimized using a Box-Behnken design, achieving a yield of 0.208 g/L. The microbial melanin was subsequently hydrothermally converted into water-dispersible melanin-derived carbon dots (MCDs) with quasi-spherical morphology, particle size of 9-15 nm, and a quantum yield of 5.05 ± 0.31%. The MCDs exhibit strong UV absorption, tunabl

From concepts to devices: the odyssey of 3d transition metal catalysts in photocatalytic CO2 conversion.

The rapid increase in atmospheric CO2 concentrations driven by human activity necessitates the development of sustainable mitigation strateg … issues, hybrid systems that couple molecular catalysts with semiconductors such as carbon nitride, quantum dots, metal oxides, chalcogenides, and perovskites have been developed, offering improved light harvesting, charge transfer, and robustness. Further incorporation into porous crystalline frameworks, including metal-organic frameworks (MOFs) and covalent- …

Phage-based biosensors for Cancer biomarker detection and diagnosis.

Early cancer identification is necessary to reduce mortality. Traditional methods for identifying cancers can be problematic. Tissue biopsie … ive detection of circulating tumor cells and cancer biomarkers. Optical biosensors utilizing either quantum dots or liquid crystals can provide up to 20-fold greater sensitivity than ELISA tests. Acoustic biosensors utilizing piezoelectric resonators can deliver results rapidly (< 5 min) and portably. In addition, arrays of phage can be utilized in conjunction …

Simultaneous Localization of Electrons/Holes by Surface Cationic Dangling-Bonds/Vacancies for Synergistically Boosting Photocatalytic Activity.

Simultaneous localization of photoelectrons and holes into different surface defects on a single-component photocatalyst is an ideal strategy for maximizing photocatalytic activity yet remains a huge challenge. We propose a novel concept of creating two distinct defects, cationic dangling bonds and vacancies, on the surface of frequently used CdSe and CdS quantum dots (QDs) for simultaneously confining the photoelectrons and holes to boost the photocatalytic activity. The coexisting cationic dangling bonds and vacancies left by a simple acid-etching of QDs localize photoelectrons and holes, re…

High-Yield ReS2 Photodetector Array Enabled by Dry-Released Self-Rolled-Up Microtubes and Enhanced through Scalable MoS2 QDs.

Three-dimensional (3D) self-rolled-up microarchitectures present a promising avenue to enhance the performance of low-dimensional material-b … its planar counterpart. Furthermore, a mixed-dimensional heterojunction formed by integrating MoS2 quantum dots (QDs) onto ReS2 results in more than 3-fold and 2-fold improvements in photocurrent and responsivity (R), respectively. The devices also exhibit fast responses (4 ms/6 ms), along with excellent stability and robustness. The finite element simulation …

Nanomaterial-Assisted Physical Mass Loading and Signal Amplification Strategies for Exosome Isolation and Sensing in Liquid Biopsy: A Review.

Exosomes and small extracellular vesicles are promising liquid-biopsy biomarkers because they carry molecular information from their cells o … ic nanoparticles, magnetic systems, metal-organic frameworks, carbon and two-dimensional materials, quantum dots, upconversion nanomaterials, DNA nanostructures, and polymer-based platforms. The gap between analytical sensitivity and clinical utility, including separation purity, recovery, biological heterogeneity, pre-analytical variability, interference from …

Enhanced Room-Temperature Phosphorescence from Carbon Dots Embedded in a Robust SiO2 Matrix.

Carbon dots (CDs) represent a rapidly advancing class of fluorescent nanomaterials. Due to the dominant nonradiative decay channels of the triplet excited state of CDs, these materials generally exhibit no observable phosphorescence (PH) or delayed fluorescence. Here, we report the development of a sustainable and efficient room-temperature phosphorescence (RTP) material by embedding CDs into a covalently bonded silica matrix, with both components derived from a previously unreported biomass precursor. Our effort has focused on stabilizing triplet excited states of CDs by constructing hybrid s

A self-powered photoelectrochemical sensor with ultra-low background based on ZnIn2S4@CdS photoanode and Bi2WO6 photocathode for BACE1 detection.

Self-powered photoelectrochemical (PEC) sensing features no external power supply, fast response, strong anti-interference and high sensitivity, providing a powerful strategy for ultrasensitive detection of β-site amyloid precursor protein cleaving enzyme 1 (BACE1), a key biomarker for early Alzheimer's disease (AD). In this work, a dual-photoelectrode self-powered PEC biosensor with ultralow background signal was constructed. ZnIn2S4 was grown in situ on fluorine-doped tin oxide (FTO) via hydrothermal reaction, and CdS quantum dots were loaded through successive ionic layer adsorption and rea…

Emerging Combinatorial Drug Delivery Strategies for Breast Cancer: A Comprehensive Review.

Breast cancer remains the second most prevalent cancer among women in the United States. Despite advancements in surgical, radiological, and … somes, polymeric micelles, and nanoparticles (organic, inorganic, gold, magnetic, carbon-based, and quantum dots) are examined as innovative strategies for enhancing drug delivery efficacy. Furthermore, stimuli-responsive DDSs, including reactive oxygen species (ROS), enzyme-, and hypoxia- responsive systems, are presented as cutting-edge approaches to overcom …

Nanomedicine in the Fight Against Multidrug-Resistant Infections: A Review on Emerging Strategies and Translational Prospects.

The global rise of multidrug-resistant (MDR) bacteria has rendered numerous traditional antibiotics ineffective, posing a major threat to pu … applications, nanomedicine-based diagnostic platforms including magnetic nanoparticles, biosensors, quantum dots (QDs), and graphene-based transistors enable rapid and sensitive detection of MDR pathogens and resistance genes, facilitating timely intervention and personalized treatment approaches in resource-limited settings. Despite these advances, significan …

Green "turn-off" luminescent nanosensor for the sensitive analysis of finerenone in various matrices: application of recent greenness assessment techniques.

Finerenone (FNR) is an innovative FDA-approved selective non-steroidal mineralocorticoid receptor antagonist utilized in kidney failure. This study utilizes eco-friendly nitrogen and sulfur co-doped carbon quantum dots (N,S-CQDs), fluorescent nanomaterials, to introduce a sensitive and environmentally sustainable spectrofluorometric platform for the analysis of FNR. Water-soluble N,S-CQDs were prepared from green precursors (citric acid and glutathione) using a straightforward and eco-friendly hydrothermal technique. The intrinsic fluorescence of the fluorophore was monitored at λ em = 419 nm …

Наноматериалы: обзор текущих тенденций и будущих перспектив лечения неврологических расстройств.

Всемирная организация здравоохранения (ВОЗ) определила неврологические расстройства (НД) в качестве одной из основных проблем в области здравоохранения во всем мире, что приводит к высоким уровням смертности. ND - это условия, влияющие на центральные и периферийные нервные системы, включая мозг, спинной мозг, краниальные нервы, периферийные нервы, нервные корни, нервно-мышечные соединения и мышцы. К числу этих неврологических заболеваний относятся болезнь Альцгеймера, болезнь Паркинсона, глиома/рак мозга, болезнь Хантингтона, амиотропический боковой склероз, множественный склероз, нейроинфекци

Совпадение в аннотации оригинала
The World Health Organization (WHO) has identified neurological disorders (NDs) as one of the major health concerns worldwide, resulting in … logies of inorganic and organic nanomaterials are increasingly employed for treating NDs, including quantum dots, dendrimers, metal nanoparticles, polymeric nanoparticles, liposomes, carbon nanotubes, metal oxide nanoparticles, and micelles. Their exceptional properties such as sensitivity, selectivity, and potential to bypass the BBB make them suitable for bo …

Establishment of a stem cell administration imaging method in bleomycin-induced pulmonary fibrosis mouse models.

Pulmonary fibrosis is a progressive disease caused by interstitial inflammation. Treatments are extremely scarce; therapeutic drugs and tran … his study, we administered mouse adipose tissue-derived mesenchymal stem cells (mASCs) labeled with quantum dots (QDs; 8.0 nM) to a mouse model of bleomycin-induced pulmonary fibrosis in an effort to clarify the relationship between in vivo dynamics and therapeutic efficacy. These QD-labeled mASCs were injected into the trachea of C57BL/6 mice seven days after …