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Cross-cultural development of an item list for computer-adaptive testing of fatigue in oncological patients.

IntroductionWithin an ongoing project of the EORTC Quality of Life Group, we are developing computerized adaptive test (CAT) measures for the QLQ-C30 scales. These new CAT measures are conceptualised to reflect the same constructs as the QLQ-C30 scales. Accordingly, the Fatigue-CAT is intended to capture physical and general fatigue.MethodsThe EORTC approach to CAT development comprises four phases (literature search, operationalisation, pre-testing, and field testing). Phases I-III are described in detail in this paper. A literature search for fatigue items was performed in major medical data

Research trends of acupuncture therapy for painful peripheral nervous system diseases from 2004 to 2023: a bibliometric and meta-analysis.

BackgroundPeripheral nervous system diseases (PNSD) have represented a major global health burden, leading to significant economic impacts and diminished productivity. This bibliometric analysis was performed to summarize the current research trends and hotspots over the past two decades, aiming to provide a comprehensive perspective for future research.MethodsAll data were sourced from the Web of Science Core Collection (WoSCC) on March 1, 2024, for publications between January 1, 2004, and December 31, 2023. Data visualization and analyses, including descriptive statistics, co-occurrence map

A scoping review on the surgical management of metastatic bone disease of the extremities.

BACKGROUND: Management of metastatic bone disease of the extremities (MBD-E) is challenging, and surgical directions pose significant implications for overall patient morbidity and mortality. Recent literature reviews on the surgical management of MBD-E present a paucity of high-level evidence and global inconsistencies in study design. In order to steer productive research, a scoping review was performed to map and assess critical knowledge gaps. METHODS: The Arksey and O'Malley framework for scoping studies was followed. A comprehensive literature search identified a large body of literatur

Using a digital patient powered research network to identify outcomes of importance to patients with multiple myeloma.

BACKGROUND: Social media platforms give patients a voice by allowing them to discuss their health and connect with others. These unfiltered and genuine reports offer direct access to what matters most to patients. Exploring the patient-reported outcomes discussed in these platforms reveal clinical insights and behavioral patterns of the real-world patient journey. This research study reviewed health-related quality of life (HRQoL) concepts reported by patients with multiple myeloma (MM). METHODS: Data were obtained using the Belong.life patient-powered research network (PPRN) using social med

Метод пилатеса как биопсихосоциальное вмешательство на современном рабочем месте: систематический обзор физических, психических и профессиональных пособий.

Справочная информация/задачи: На здоровье и производительности рабочей силы существенно сказываются связанные с работой расстройства мускулоскелета (ВМСД) и профессиональный стресс. Цель этого систематического обзора заключалась в обобщении данных об эффективности метода пилатеса как биопсихосоциального вмешательства для работников, а также в изучении его воздействия на физические, психологические и профессиональные результаты. Методы: Был проведен систематический поиск по основным электронным базам данных и поисковым системам (PubMed, Scopus, Web of Science, PEDro и Google Scientific) после P

Development and validation of a patient-reported outcome tool to assess cancer-related financial toxicity in Italy: a protocol.

IntroductionFinancial toxicity (FT) is a well-recognised problem in oncology. US-based studies have shown that: (a) cancer patients have a 2.7 times risk of bankruptcy; (b) patients who declare bankruptcy have a 79% greater hazard of death; (c) financial burden significantly impairs quality of life (QoL) and (d) reduces compliance and adherence to treatment prescriptions. The aim of the project is to develop and validate a patient-reported-outcome (PRO) measure to assess FT of cancer patients in Italy, where, despite the universal health coverage provided by the National Health Service, FT is

Exploring cancer care needs for Latinx adults: a qualitative evaluation.

PurposeLatinx adults with cancer, as compared with non-Latinx White adults, are diagnosed with more advanced stages and experience worse quality of life. Identifying barriers in cancer care among low-income Latinx adults is crucial to designing and implementing culturally appropriate interventions. The objective of this study was to explore the specific barriers encountered by Latinx adults after a cancer diagnosis and perspectives on the use of community health workers (CHWs) to address these barriers.MethodsWe conducted semi-structured qualitative interviews with low-income Latinx adults wit

Effectiveness of bilingual health education on obesity and dietary behaviors in Mongolian adolescents: a six-month intervention study.

BackgroundObesity among adolescents has become a global public health concern. Previous studies have shown that multidimensional interventions, such as school-based programs, health education, and guidance on diet and physical activity, effectively improve obesity in adolescents. However, there is a lack of research on bilingual health education interventions in minority language environments in rural and pastoral areas of China. Based on a 2023 field survey of students from three Mongolian middle schools in Ar Horqin Banner, Chifeng City, Inner Mongolia, this study evaluated the effect of a 6

Навязчивое сексуальное поведение и проблематичное использование порнографии: всеобъемлющий, междисциплинарный и экспертный обзор описательной информации с указанием предлагаемых направлений будущей деятельности.

СПРАВОЧНАЯ ИНФОРМАЦИЯ И МАТЕРИАЛЫ: Характер и классификация дисрегулированного сексуального поведения по-прежнему широко обсуждаются. Сексуальные расстройства, связанные с сексуальным поведением, и проблематичное использование порнографии (PUP) two Наиболее часто изученные конструкции в этой области, каждая из которых имеет значительные последствия для психического здоровья, межличностного функционирования и более широкого благосостояния. Хотя научные результаты по этим темам за последнее десятилетие быстро расширились, в последних обзорах основное внимание, как правило, уделялось конкретным п

Early Palliative Care in Advanced Hematologic Malignancies: A Systematic Review of Patient-Centered Outcomes.

Background: Patients with hematologic malignancy (HM) experience high symptom burden (SB) and diminished quality of life (QOL). While early palliative care (EPC) benefits solid tumors, its impact in HM remains uncertain. Objectives: To systematically review the effects of EPC on patient-centered outcomes in individuals with HM. Methods: MEDLINE, Web of Science, Cochrane Library, and Scopus were searched for English-language articles published between 2020 and 2024. Eligible studies included adults with advanced HM receiving EPC compared with usual care, reporting outcomes on SB, QOL, place of

The Korea National Disability Registration System.

The Korea National Disability Registration System (KNDRS) was established in 1989 to provide social welfare benefits based on predefined criteria for disability registration and an objective medical assessment using a disability grading system. Disability registration requires (1) a medical examination by a qualified specialist physician and (2) a medical advisory meeting to review the degree of disability. Medical institutions and specialists for the diagnosis of disabilities are legally stipulated, and medical records for a specified period are required to support the diagnosis. The number o

Artificial intelligence for risk assessment and outcome prediction in malignant haematology.

Risk stratification is the backbone of clinical decision-making for patients with haematological malignancies. Models currently used in routine clinical practice often rely on static rules, conventional statistics and expert consensus. While pragmatic and accessible, these models fail to capture the complex biological interactions and patient heterogeneity, especially as data dimensionality grows given the availability of more comprehensive molecular analysis. Artificial intelligence (AI), particularly machine learning (ML), offers the potential to process such high-dimensional data, uncover l

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… Transformer | Neural network architecture is designed to process sequential data (text, genomic sequences) using attention mechanisms rather than recurrence, being the foundation of modern large language models. … Large language model (LLM) | Transformer‐based model trained on massive text datasets to understand and generate human language. LLMs can be adapted to biomedical texts for literature synthesis or report generation. …

A tailored maturity model for REDCap-based patient-facing technology: revealing development stages and guiding future evolution.

ObjectivesThis integrative review aims to analyze the REDCap-based patient-facing technologies (PFTs) and propose a tailored maturity model to characterize their development stages, challenges, and future evolution toward intelligent, proactive care.Materials and methodsFollowing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a focused search of PubMed, Web of Science, and Embase identified relevant studies. Data were analyzed using aggregate and thematic synthesis. Combining literature evidence with pilot case insights, a tailored maturity model wa

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… Key challenges include data protection, especially when integrating external large language models, algorithmic transparency, and clinical liability. Safe deployment ultimately demands clear policies, rigorous validation, and regulatory review. … The future landscape of large language models in medicine. Commun Med (Lond). 2023;3:141. 10.1038/s43856-023-00370-1 6. Dang A, Arora D, Rane P. Role of digital therapeutics and the changing future of healthcare. J Family Med Prim Care. 2020;9:2207-2213. 10.4103/jfmpc.jfmpc_105_20 7. …

BioBERT-powered synergy: advanced bibliometric and molecular insights into prostate cancer bone metastasis.

BACKGROUND: Prostate cancer (PC) is a leading cause of male cancer mortality, with bone metastasis (BM) being a frequent and debilitating complication. Despite therapeutic advancements, the molecular mechanisms underlying BM remain poorly understood. This study aims to bridge this gap by integrating bibliometric analysis with bioinformatics to provide a comprehensive overview of the academic trends and molecular profiles associated with prostate cancer bone metastasis (PCBM). METHODS: We conducted a bibliometric analysis to identify key contributors in PCBM research from 2004 to 2024 with adv

Artificial intelligence in immunotherapy: revolutionizing diagnostic and therapeutic applications in cancer and autoimmune diseases.

Artificial intelligence (AI) is increasingly advancing precision immunotherapy by integrating high-dimensional biomedical data to support diagnosis, treatment selection, and longitudinal monitoring in both cancer and autoimmune diseases. This review summarizes AI applications in biomarker discovery, prediction of immune checkpoint inhibitor (ICI) response and toxicity, neoantigen prioritization, CAR-T cell optimization, and therapeutic antibody engineering. In oncology, multimodal models combining multi-omics, medical imaging, and clinical variables improve patient stratification and non-invas

Алгоритмы машинного обучения для виртуального раннего обнаружения и выявления нейродегенеративных и нейрокогнитивных расстройств: систематический обзор.

Происхождение и аналоговые расстройства (например, болезнь Альцгеймера, болезнь Паркинсона) приводят к нейронной потере; нейрокогнитивные расстройства (например, бред, слабоумие) свидетельствуют о когнитивном упадке. Раннее обнаружение имеет решающее значение для эффективного управления. Машинное обучение помогает в более точном выявлении заболеваний, потенциально преобразуя медицинское обслуживание. В рамках этого всеобъемлющего систематического обзора обсуждается вопрос о том, каким образом машинное обучение (ML) может способствовать раннему выявлению этих расстройств, превосходя при этом тр

Свойства измерений и их применение WHODAS 2.0 в многоразовом склерозе: систематический обзор.

Фон/задачи: Множественный склероз (МС) влияет на моторное, когнитивное, психологическое и социальное функционирование, которое не в полной мере фиксируется на основе нарушений. В ходе этого систематического обзора была проведена оценка свойств измерений и их применения в соответствии с графиком Всемирной организации здравоохранения по оценке инвалидности (WHODAS) 2.0 для взрослых с МЗ в исследовательских и клинических контекстах. Методы: с момента создания библиотеки Пубмед/МЕДЛИН, Эмбазы, Скопуса, Сети науки и Кокрана до 25 мая 2026 года был проведен обыск. В ходе соответствующих экспертных и

За пределами здоровых границ: контрольные интервалы для населения и индивидуального медицинского анализа речи.

Интервалы справочной информации (РИ) являются хорошо зарекомендовавшим себя клиническим инструментом для определения здоровых границ лабораторных измерений. В последнее время они применяются к акустическим особенностям, извлекаемым из речи, в целях обеспечения транспарентности и агностической оценки симптомов. Мы оцениваем потенциал и ограничения RI в трех наборах данных: чистые, лабораторные записи людей с множественным склерозом (PwMS) и два шумных набора данных, ориентированных на респираторные симптомы и стресс, связанный с работой, которые собираются в условиях повседневной жизни. Что кас

Obesity definition, diagnosis, bias, standard operating procedures (SOPs), and telehealth: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2022.

BackgroundThe Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) regarding definition, diagnosis, bias, standard operating procedures (SOPs) and telehealth is intended to provide clinicians an overview of obesity medicine and provide basic organizational tools towards establishing, directing, managing, and maintaining an obesity medical practice.MethodsThis CPS is based upon published scientific citations, clinical perspectives of OMA authors, and peer review by Obesity Medicine Association leadership.ResultsOMA has defined obesity as: "A chronic, progressive, relapsing, and

When Cancer Clots: An Extensive Radiologic Analysis of Cancer-Associated Thromboembolism.

Cancer-associated thrombosis (CAT) is a leading cause of morbidity and mortality in patients with malignancy, yet its imaging manifestations extend far beyond the conventional diagnosis of deep vein thrombosis and pulmonary embolism. This comprehensive review examines the full spectrum of CAT as encountered by radiologists, from routine venous thromboembolism to unusual-site thromboses, arterial thromboembolic events, catheter-related complications, and endovascular management strategies. Patients with cancer face a four- to seven-fold increased risk of venous thromboembolism compared with the

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… Large Language Models Large language models (LLMs), appear to be a versatile tool in radiology, with applications extending substantially beyond image interpretation and radiomics into integration of clinical history, knowledge retrieval and consequent decision support [ 86 , 87 ]. … language model ML | Machine learning MR | Magnetic resonance MRA | Magnetic resonance angiography MRPA | Magnetic resonance pulmonary angiography MRV | Magnetic resonance venography NBTE | Nonbacterial thrombotic endocarditis PE | Pulmonary embolism PERT | Pulmonary Embolism Response Team PICC | Peripherally …