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Cabozantinib Cutaneous Toxicity-Comprehensive Review.

BackgroundIn the context of modern cancer therapy, the management of adverse effects of systemic therapies can lead to the avoidance of underdosing and withdrawal and increases in the quality of the therapeutic act and the quality of life. This review offers an overview of the skin-related toxicities associated with Cabozantinib, a multikinase inhibitor (MKI) that is approved for treating advanced kidney cancer, hepatocellular carcinoma, and medullary thyroid cancer. It covers the most common dermatological side effects, such as palmar-plantar erythrodysesthesia, stomatitis, hair alterations,

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… In addition, to illustrate these adverse effects, we used images obtained with the informed consent of patients treated with Cabozantinib from the medical practice of the authors, the study being approved by the Ethical Committee of the Clinical Emergency County Hospital of Craiova, Romania (6344/8 February … Institutional Review Board Statement The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethical Committee of the Clinical Emergency County Hospital of Craiova, Romania (13837/29 March 2024). …

Development and 10-year history of a biosimilar: the example of Binocrit®.

Patent expirations for several biological products have prompted the development of alternative versions, termed 'biosimilars', which have comparable quality, safety and efficacy to a licensed biological medicine (also referred to as the 'reference' medicine). The first biosimilars developed in oncology were the supportive-care agents filgrastim and epoetin. Binocrit® (HX575) is a biosimilar version of epoetin alfa, indicated in the oncology setting for the treatment of chemotherapy-induced anemia (CIA). The process for development and approval of Binocrit® as a biosimilar included extensive a

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… A retrospective clinical audit has assessed the effectiveness of Binocrit ® for the treatment of CIA in patients ( n = 152) with solid tumors. 18 Data were collected from patients at five centers in Europe (one each in France, Italy, The Netherlands, Romania and Spain). … Versions of the study have also been taken up in Germany, Italy, Romania and Austria. …

Navigating the Diagnostic and Management Challenges of Suspected Cardiac Amyloidosis in Resource-Limited Settings: Ethiopia Experience.

This report discusses the diagnostic and therapeutic complexities encountered in resource-limited environments when assessing patients suspected of cardiac amyloidosis (CA). The study describes a case involving a patient who initially presented with heart failure symptoms and eventually received a CA diagnosis after 13 months and four primary physician visits, primarily based on discrepancies observed between electrocardiographic and echocardiographic findings, alongside elevated cardiac troponin levels. The case underscores the limited awareness of CA among primary healthcare providers in Eth

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… In Romania, the mean delay from the first presentation with cardiac symptoms to diagnosis was no longer than 24 months [ 3 ]. A study of patients at the UK National Amyloidosis Centre found a median diagnostic delay of 39 months [ 11 ]. … Major knowledge gaps were identified in different surveys among primary care providers in the United States and practicing cardiologists in the United Arab Emirates, Kuwait, Bahrain, Qatar, Oman, and Romania and health care providers in Egypt that range from lack of awareness among health care providers …

Epoetin Theta with a New Dosing Schedule in Anaemic Cancer Patients Receiving Nonplatinum-Based Chemotherapy: A Randomised Controlled Trial.

INTRODUCTION: Recombinant human erythropoietin (r-HuEPO) is used to treat symptomatic anaemia due to chemotherapy. A new r-HuEPO, Epoetin theta (Eporatio®), was investigated and compared to placebo in a randomised, double-blind clinical trial in adult cancer patients receiving nonplatinum-based chemotherapy. The primary efficacy endpoint was the responder rate (complete haemoglobin (Hb) response, i.e., Hb increase ≥2 g/dl) without the benefit of a transfusion within the previous 4 weeks. RESEARCH DESIGN AND METHODS: 186 patients were randomised to s.c. treatment for 12 weeks with either Epoeti

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… The study protocol, amendments, informed consent documents and other relevant study-related documents were reviewed and approved by independent ethics committees of all participating countries (Argentina, Belarus, Brazil, Bulgaria, Chile, India, Moldova, Romania, Russia, Ukraine). … Corcimaru Chisinau; Romania: C. Volovat Iasi, G. Barca Bucuresti, R. Stoia Bucuresti, E. Gheorghita Brasov, R-G. Mihaila Sibiu, M. Gavanescu Targu Jiu; Russia: D. Korman Moscow, E. Voznyi Moscow, V. Ivanova Moscow, L. Neluybina Moscow, O. Rukavitsin Moscow, I. Zyuzgin Saint Petersburg, B. …

Бремя наследственного транстиретинового амилоида на качество жизни.

ВВЕДЕНИЕ: амилоидоз наследственного транстиретина (ХАТТР) является прогрессивным, дегенеративным заболеванием с периферической нейропатией, кардиомиопатией и другими клиническими проявлениями. В этом исследовании рассматривается воздействие амилоидоз hATTR на качество жизни (QOL). МЕТОДЫ: Удельный QOL, измеряемый с помощью Norfolk QOL-Diabetic Neuropathy, сопоставлялся между пациентами с амилоидозом HATTR и пациентами с типом 2 диабет, в то время как общий QOL, измеряемый с помощью 36-item Вариант обследования состояния здоровья в краткой форме 2 (В тыс.SF-36v2), были сопоставлены между пациен

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… Type 2 Diabetes Sample Also included in the analysis comparing Norfolk QOL‐DN scores is a sample of patients with type 2 diabetes described by Veresiu et al . 15 This sample consisted of 20,469 patients from Romania (mean age 60.9 years; 53% female) who consented to participate in a cross‐sectional … It is possible that, due to cultural differences, responses on the Norfolk QOL‐DN may differ between the DN participants in the Eastern European country of Romania (as in the study by Veresiu et al . 15 ) and patients enrolled in the NEURO‐TTR study who lived in 10 countries (Argentina, Brazil, France …

Indocyanine Green (ICG) and Colorectal Surgery: A Literature Review on Qualitative and Quantitative Methods of Usage.

Background: Due to its many benefits, indocyanine green (ICG) has gained progressive popularity in operating rooms (ORs) globally. This literature review examines its qualitative and quantitative usage in surgical treatment. Method: Relevant terms were searched in five international databases (1. Pubmed, 2. Sciencedirect, 3. Scopus, 4. Oxfordjournals, 5. Reaxys) for a comprehensive literature review. The main benefits of using ICG in colorectal surgery are: intraoperative fluorescence angiography; fluorescence-guided lymph node involvement detection and the sentinel technique; the fluorescent

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… Funding Statement This research was published with the full financial support provided by the National Society of Medical Oncology in Romania ( https://snomr.ro ). … TP53 somatic mutations and LOH profile in colorectal cancer in Romania. Rom. Biotechnol. Lett. 2018;23:13530. 104. Xie T., Qi Y., Li Y., Zhang F., Li W., Zhong D., Tang Z., Zhou M. …

New approaches to divorce with children: A problem of public health.

This broad review elaborates on the most up-to-date knowledge on biochemical and psychobiological aspects of parental loss and other childhood adversities during divorce involving minor children. So far, divorce involving minor children was unfortunately considered by authorities only as a purely juridical problem, and this approach has often allowed a completely different approach according to the Courts. Now, scientific research, also making use of animal models, is demonstrating the biological basis of the problem and the indisputable consequences on the well-being and health of children. T

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… Physical shared custody <15% | Physical shared custody <30% | Physical shared custody >30% Italy, Switzerland, Greece, Austria, Germany | France, Spain | Sweden, Belgium, Denmark Czech Republic, Slovakia | | UK, Romania | | Portugal | | Figure 1. … Hildegunde Suenderhauf, Luteran University of Nurnberg, Germany; Dr Catalin Bogdan, Vice President of European Platform for Joint Custody “Colibri,” Romania; Prof. Alessando Salvatoni, Insubria University, Italy; and Mrs Marcelle Holloway, European Commission, Ispra, Italy. …

Empirical antimicrobial treatment in haemato-/oncological patients with neutropenic sepsis.

Neutropenic sepsis in haemato-/oncological patients is a medical emergency, as infections may show a fulminant clinical course. Early differentiation between sepsis and febrile neutropenic response often proves to be challenging. To assess the severity of the illness, different tools, which are discussed in this article, are available. Once the diagnosis has been established, the correct use of early empirical antibiotic and antifungal treatment is key in improving patient survival. Therefore, profound knowledge of local resistance patterns is mandatory and carefully designed antibiotic regime

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… For example, methicillin-resistant Staphylococcus aureus (MRSA) only plays a minor role in Austria, France, UK, Germany and the Scandinavian countries, while Hungary, Romania or Greece (among others) show dramatic resistance rates between 20% and 57%. 10 In the USA and Canada, MRSA rates show a steady … From all available data, worldwide highest prevalence estimates of MRSA (resistance rates >50%) are found in Colombia, Malta, Romania, Iraq, Hong Kong, Singapore, Japan and South Korea. 13 Regarding Gram negatives, resistance to third-generation cephalosporins in Escherichia coli ranges between 5.7% …

Relative Risk of Death in Bulgarian Cancer Patients during the Initial Waves of the COVID-19 Pandemic.

BackgroundThe COVID-19 pandemic has led to millions of documented deaths worldwide, with diverse distribution among countries. Surprisingly, Bulgaria, a middle-income European Union member state, ranked highest in COVID-19 mortality. This study aims to assess whether Bulgarian cancer patients experienced a higher relative risk (RR) of death compared to the general Bulgarian population during the pandemic.Materials and methodsData from the Bulgarian National Statistical Institute and the Bulgarian National Cancer Registry were analyzed to estimate monthly RR of death in cancer patients compared

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… This amount was slightly higher than the identical measure in Romania, which was EUR 36 per capita but more than four-fold lower than the Europe average expenditure of EUR 195 per capita [ 10 ]. … A comparison of health system responses to COVID-19 in Bulgaria, Croatia and Romania in 2020 Health Policy 2022 126 456 464 10.1016/j.healthpol.2022.02.003 35221121 PMC8851743 24. Steinert J.I. Sternberg H. Prince H. Fasolo B. Galizzi M.M. Büthe T. Veltri G.A. …

Epidemiology of osteoporotic fracture in Kazakhstan and development of a country specific FRAX model.

UNLABELLED: Retrospective and prospective population-based survey in a region of the Republic of Kazakhstan determined the incidence of fractures at the hip, proximal humerus and distal forearm. The hip fracture rates were used to create a FRAX® model to enhance fracture risk assessment in Kazakhstan. OBJECTIVE: This paper describes the epidemiology of osteoporotic fractures in the Republic of Kazakhstan that was used to develop a country specific FRAX® tool for fracture prediction. METHODS: We carried out a retrospective population-based survey in Taldykorgan in the Republic of Kazakhstan r

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… | 3.6 Canada | 15.5 | 5.8 Greece | 15.4 | 6.8 UK | 14.4 | 5.0 Portugal | 13.7 | 4.8 Finland | 12.9 | 6.0 Kazakhstan b | 12.6 | 6.0 Spain | 12.6 | 4.2 Bulgaria | 11.2 | 4.4 Hungary | 10.8 | 4.2 Mexico c | 10.6 | 5.0 Poland d | 10.1 | 4.2 Moldova e | 9.3 | 5.7 Russia f | 7.7 | 3.8 Serbia | 7.6 | 3.7 Romania … Incidence of hip fracture in Romania and the development of a Romanian FRAX model. Calcif Tiss Int. 2013;92:429–436. doi: 10.1007/s00223-013-9697-7. 25. …

Mitigating Doxorubicin-Induced Cardiotoxicity through Quercetin Intervention: An Experimental Study in Rats.

Doxorubicin (DOX) is an effective anticancer drug, but its use is limited by dose-dependent heart toxicity. Quercetin is a natural antioxidant frequently studied for its beneficial properties. Moreover, a wide range of dietary supplements are available for human use. This in vivo study aimed to explore the potential cardioprotective effects of quercetin in chronic DOX treatment. A total of 32 Wistar rats were randomly divided into four groups: control, DOX, DOX/Q-50, and DOX/Q-100, treated with saline, 2.5 mg/kg body-weight DOX, 2.5 mg/kg body-weight DOX + 50 mg quercetin, and 2.5 mg/kg body-w

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… Study Design This analytical, experimental study was performed on 32 Wistar rats weighing 150–250 g, which were housed in the animal facility of “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania with stable temperatures of 23 ± 2 °C and a 12 h dark/light cycle, and received … Funding Statement This research was funded by “Iuliu Hatieganu” University of Medicine and Pharmacy Cluj-Napoca, Romania, grant number 1529/13/18.01.2019. …

[Tricophyton rubrum in a case of tinea unguium phenotypic mycological diagnostic algorithm and its limits].

Trichophyton rubrum is the most common dermatophyte isolated from human dermatophytosis. We present the mycological diagnosis algorithm and results in an onychomycosis case--tinea unguium. Biological samples have been inoculated on both usual and special culture media and incubated at both 30 degrees C and 37 degrees C for a period of fourteen days. Based on the macroscopic and microscopic characters and on the physiological and biochemical tests results, we identified a Trichophyton rubrum granular type dermatophyte. We are discussing phenotypic mycological diagnosis limits and molecular diag

[Biotherapeutic use of yeasts--importance of probiotic products].

Besides their important biotechnological and industrial applications, yeasts have been used during the last years, in obtaining probiotic products, along with lactic acid bacteria and various enzymes. Our study deals with some aspects regarding the use of yeasts as animal and human probiotics, and their possible mechanisms of action. Also, we present information on probiotic products synthesized by international and national companies. Finally, there are described future prospective of research concerning the applications of recombinant yeast strains as basis for obtaining new bio-drugs. In co

[Antibiotic resistance patterns in Acinetobacter spp. strains isolated from hospital environment].

INTRODUCTION: The Acinetobacter species are ubiquitary germs isolated more and more frequently, Acinetobacter baumannii being currently considered the second strictly aerobic microorganism involved in the ethiology of severe nosocomial infections. Acinetobacter baumannii is usually encountered in surgery and intensive care units, especially in patients with depressed immunity, in which various locations are possible, the most frequvent being the respiratory tract infections, urinary tract infections and bacteriemia. MATERIAL AND METHOD: The study used 52 strains of Acinetobacter spp. isolated

[Giardia lamblia and duodenal involvement].

UNLABELLED: Giardia lamblia (GL) is one of the causes of diarrhoea. GL is a frequent parasite in our country. In the literature, endoscopic aspects of Giardia duodenitis are mentioned. Some authors tried even to make the diagnosis on endoscopic criteria. AIM: The purpose of the study is to find the endoscopic and histopathology changes produced by giardiasis. METHODS: 214 patients entered this study and underwent upper digestive endoscopy. Duodenal and gastric multiple biopsies were taken. Biopsies were stained with hematoxylin-eosine for Helicobacter pylori and Giemsa for Giardia lamblia. C

[Study of antibiotic influence on adherence capacity of gram positive and gram negative bacteria to the cellular substrate].

Bacterial adherence to the cellular substrate (skin and mucosa) represents a precondition of infectious pathology. It was demonstrated that bacteria which adhere and form biofilms on catheters and other inert materials used in medicine are resistant to the therapeutic antibiotic concentrations being protected by the biofilm mathrix and generating severe and hard to treat infections. There are only few studies on the influence of antibiotics on the bacterial adhesins synthesis and bacterial adherence to the cellular substrate. The purpose of this study was to investigate the influence of subinh

[Correlation between multiple antibiotic resistance and heavy-metal tolerance among some E.coli strains isolated from polluted waters].

Self-transmissible plasmids conferring multiple antibiotic resistance are wide-spread in coliforms populations. In soil and water, multiple antibiotic resistance is clearly associated with resistance/tolerance to heavy-metals (Hg2+, Cu2+, Pb2+, Zn2+, Ca2+). For different genera the genes for heavy-metals resistance are often plasmid encoded. Since these genes are clustered on the same plasmids, heavy-metals and drugs are environmental factors which exert a selective pressure for the populations of these plasmid-harboring bacteria. The aim of this preliminary study was to find possible correlat