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Real-Life Use of Ceftolozane/Tazobactam for the Treatment of Bloodstream Infection Due to Pseudomonas aeruginosa in Neutropenic Hematologic Patients: a Matched Control Study (ZENITH Study).

We sought to assess the characteristics and outcomes of neutropenic hematologic patients with Pseudomonas aeruginosa (PA) bloodstream infection (BSI) treated with ceftolozane-tazobactam (C/T). We conducted a multicenter, international, matched-cohort study of PA BSI episodes in neutropenic hematologic patients who received C/T. Controls were patients with PA BSI treated with other antibiotics. Risk factors for overall 7-day and 30-day case fatality rates were analyzed. We compared 44 cases with 88 controls. Overall, 91% of episodes were caused by multidrug-resistant (MDR) strains. An endogenou

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… Chemother 64 : e02291-19 . doi: 10.1128/AAC.02291-19 . 31932379 PMC7179316 33 Gudiol C , Albasanz-Puig A , Laporte-Amargós J , Pallarès N , Mussetti A , Ruiz-Camps I , Puerta-Alcalde P , Abdala E , Oltolini C , Akova M , Montejo M , Mikulska M , Martín-Dávila P , Herrera F , Gasch O , Drgona L , Paz Morales … H , Brunel A-S , García E , Isler B , Kern WV , Morales I , Maestro-de la Calle G , Montero M , Kanj SS , Sipahi OR , Calik S , Márquez-Gómez I , Marin JI , Gomes MZR , Hemmatti P , Araos R , Peghin M , del Pozo JL , Yáñez L , Tilley R , Manzur A , Novo A , Carratalà J , IRONIC Study Group . 2020 . …

High Mortality of HLH in ICU Regardless Etiology or Treatment.

Background: Adult hemophagocytic lymphohistiocytosis (HLH) is highly lethal in the ICU. The diagnostic and therapeutic emergency that HLH represents is compounded by its unknown pathophysiological mechanisms. Here, we report on a large cohort of adult HLH in the ICU (ICU-HLH). We analyzed prognostic factors associated with mortality to define the diagnostic and therapeutic challenges in this specific population. Methods: This retrospective study included adult patients diagnosed with HLH in four ICUs in Marseille, France between 2010 and 2020. Patients who fulfilled the HLH-2004 criteria (≥ 4/

International Congress on Academic Medicine: 2025 medical education abstracts.

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Ensuring the Safety of Hospitalized Oncology Patients During a Pandemic.

Patients with hematologic malignancies present a unique set of circumstances during the COVID-19 pandemic; they are at increased risk of complications and death from COVID-19 infection, but the treatment of their cancer cannot be delayed. This article highlights some of the practice changes made by an inpatient hematology/oncology advanced practice provider team at a large academic institution in Philadelphia, Pennsylvania, at both a hospital-wide and service level. Practice changes have included restructuring the rounding process, imposing visitor restrictions, adjusting blood transfusion par

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… Having a manager who prioritized communication and strategies to provide support to staff was critical to maintaining team morale during this difficult and unprecedented time. …

Integration of exercise prescription into medical provision as a treatment for non-communicable diseases: A scoping review.

BackgroundThe purpose of this scoping review is to stimulate interest and to raise awareness, among researchers, healthcare practitioners, and policymakers regarding the current scientific literature related to exercise prescription for non-communicable diseases (NCDs). Exercise prescription is a safe and cost-effective method that enables physicians to use exercise as a complementary addition to NCDs management and treatment.MethodsThis scoping review followed the PRISMA Extension Guidelines for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Using this framework, we considered infor

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… Morales JS, Padilla JR, Valenzuela PL, Santana-Sosa E, Rincón-Castanedo C, Santos-Lozano A, et al. Inhospital exercise training in children with cancer: does it work for all? Front Pediatr. (2018) 6:1–8. doi: 10.3389/fped.2018.00404 45. … Morales JS, Santana-Sosa E, Santos-Lozano A, Baño-Rodrigo A, Valenzuela PL, Rincón-Castanedo C, et al. Inhospital exercise benefits in childhood cancer: a prospective cohort study. Scand J Med Sci Sports. (2020) 30:126–34. doi: 10.1111/sms.13545, PMID: 46. …

Interventional radiology in the elderly.

Interventional radiological percutaneous procedures are becoming all the more important in the curative or palliative management of elderly frail patients with multiple underlying comorbidities. They may serve either as alternative primary minimally invasive therapies or adjuncts to traditional surgical treatments. The present report provides a concise review of the most important interventional radiological procedures with a special focus on the treatment of the primary debilitating pathologies of the elderly population. The authors elaborate on the scientific evidence and latest developments

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… Fotiadis NI, Sabharwal T, Morales JP, Hodgson DJ, O’Brien TS, Adam A. Combined percutaneous radiofrequency ablation and ethanol injection of renal tumours: midterm results. Eur Urol. 2007;52(3):777–784. doi: 10.1016/j.eururo.2007.03.063. 19. Lewin JS, Nour SG, Connell CF, et al. … Sabharwal T, Morales JP, Salter R, Adam A. Esophageal cancer: self-expanding metallic stents. Abdom Imaging. 2005;30:456–464. doi: 10.1007/s00261-004-0277-1. 34. Lowe AS, Sheridan MB. Esophageal stenting. Semin Intervent Rad. 2004;21(3):157–166. doi: 10.1055/s-2004-860874. 35. Lee SH. …

Incidence and survival of transthyretin amyloid cardiomyopathy from a French nationwide study of in- and out-patient databases.

BACKGROUND: Precise data about ATTR-CM incidence rates at national level are scarce. Consequently, this study aimed to estimate the annual incidence and survival of transthyretin amyloid cardiomyopathy (ATTR-CM) in France between 2011 and 2019 using real world data. We used the French nationwide exhaustive data (SNDS database) gathering in- and out-patient claims. As there is no specific ICD-10 marker code for ATTR-CM, diagnosis required both amyloidosis (identified by E85. ICD-10 code or a tafamidis meglumine delivery) and a cardiovascular condition (identified by ICD-10 or medical procedure

Генетика и чжэнь-цзю-терапия города

В статье обосновывается тезис о прикладном, практическом характере генетики города (как и генетики в целом). Рассмотрено несколько примеров из практики управления развитием городов в различных регионах. Сделан вывод о том, что метод городской акупунктуры может быть эффективным только случае, если проект точечного воздействия опирается на образы города, генетически заложенные в его историю и структуру.

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… SolΑ-Morales de M. (2008). A Matter of Things. London: NAi Uitgevers. TED conferences (2007, March). Jaime Lerner singing about the city. https://www.ted.com/talks/jaime_lerner_a_song_of_the_city?lan- guage=ru#t-744786 The Guardian (2016, May 6). … https://www.academia.edu/22298104/Urban_Acupuncture_and_its_ Practices_in_China_and_Egypt 2. de Solà-Morales M. A Matter of Things. London: NAi Uitgevers, 2008. – 208 pp. 3. …

Поэтапное сокращение сотрудничества между людьми.

Сотрудничество между людьми носит динамичный характер и зачастую сокращается даже при наличии благоприятных условий conditions1-4. Многие из существующих теорий объясняют уменьшение масштабов сотрудничества с точки зрения стратегического поведения или обучения, сформулированного как свидетельство рационального поведения или продвижения в направлении rationality5-9. Здесь мы показываем, что одним из ключевых источников долгосрочного спада являются отклонения от рационального поведения, которые систематически меняются с течением времени. Мы анализируем естественную социальную дилемму на местах,

Использование машинного обучения с помощью краткого перечня симптомов для просмотра Comorbid Disabilities: A account of Principle Study.

ВВЕДЕНИЕ: Психические расстройства являются основными причинами заболеваемости во всем мире и часто связаны с потреблением психоактивных веществ и другими видами наркотического поведения. Однако многие лица, находящиеся в психиатрических учреждениях, не проходят проверку на наличие зависимости. Общие психопатологические меры, такие, как краткий список симптомов (BSI), могут дать ценное представление о риске наркомании. В этом исследовании рассматривается вопрос о том, могут ли модели машинного обучения использовать реакцию БСИ для прогнозирования проблемного потребления веществ (алкоголь, нарк

Самочувственное оральное здоровье у гемато-онкологических пациентов и связь с качеством жизни.

ЦЕЛЬ: Оценить самосообщенное состояние орального и перорального здоровья пациентов, у которых диагностируется гемато-онкологическое заболевание. ПАТИЕНТЫ И МЕТОДЫ: Данные собирались с помощью цифрового вопросника в сотрудничестве с голландской организацией пациентов " Гематон " . Вопросники EORTC-QLQ-C30, EORTC-QLQ-OH15, сокращенный Ксеростомический кадастр (XI) и OHIP-14 были использованы. Результаты: Seven hundred five (Включены пациенты)52.5% женщины среднего возраста 63.2 ± 10.1). Большинство из них были диагностированы 2 много лет назад86%) и прошли курс лечения (81%) за свою бо

Ультразвуковые характеристики развития в Гвинейских свиньях: сходства с беременностью человека.

ИСТОРИЯ ВОПРОСА: Биометрические исследования и анализ кровотока имеют основополагающее значение для оценки развития фетоплацета во время беременности. Гвинейские свиньи были предложены в качестве хорошей модели для изучения развития плода и связанных с этим осложнений, связанных с гестацией; однако продольный рост и изменения кровотока в утробе не были должным образом описаны. Цель этого исследования состояла в том, чтобы описать рост плода и плаценты и кровотечение основных внутриматочных сосудистых кроватей в ходе обычной беременности среди свиней-мореносцев, а также обсудить актуальность эт

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… Guinea Pig and Human Doppler Ultrasound Comparison of PI of UA, PI of MCA, and CPR as a percentage of pregnancy for our guinea pig data and human published studies (Medina-Castro et al. [ 24 , 25 ], Parra-Cordero et al. [ 26 ], Arduini et al. [ 27 ], Seffah et al. [ 28 ], Bahlmann et al. [ 29 ], Morales-Roselló … Morales-Roselló J. Khalil A. Morlando M. Hervás-Marín D. Perales-Marín A. Doppler Reference Values of the Fetal Vertebral and Middle Cerebral Arteries, at 19–41 Weeks Gestation J. Matern. Fetal Neonatal Med. 2015 28 338 343 10.3109/14767058.2014.916680 24749804 31. Ebbing C. Rasmussen S. …

Simultaneous Onset of Haematological Malignancy and COVID: An Epicovideha Survey.

Background: The outcome of patients with simultaneous diagnosis of haematological malignancies (HM) and COVID-19 is unknown and there are no specific treatment guidelines. Methods: We describe the clinical features and outcome of a cohort of 450 patients with simultaneous diagnosis of HM and COVID-19 registered in the EPICOVIDEHA registry between March 2020 to February 2022. Results: Acute leukaemia and lymphoma were the most frequent HM (35.8% and 35.1%, respectively). Overall, 343 (76.2%) patients received treatment for HM, which was delayed for longer than one month since diagnosis in 57 (1

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… Morales M.-D. Frequency, Clinical Characteristics and Outcome of Adults With Acute Lymphoblastic Leukemia and COVID 19 Infection in the First vs. Second Pandemic Wave in Spain Clin. Lymphoma Myeloma Leuk. 2021 21 e801 e809 10.1016/j.clml.2021.06.024 34376375 PMC8286547 17. Chiaretti S. … Morales M.D. Benzo G. Gómez-Catalan I. Coll R. De La Fuente I. Luna A. Risk factors and outcome of COVID-19 in patients with haematological malignancies Exp. Hematol. Oncol. 2020 9 21 10.1186/s40164-020-00177-z 32864192 PMC7445734 21. Stahl M. Narendra V. Jee J. Derkach A. Maloy M. Geyer M.B. …

The penumbra of thalidomide, the litigation culture and the licensing of pharmaceuticals.

Fifty years ago several thousand children were born with severe limb defects after their mothers had been given thalidomide in pregnancy. This tragedy caused procedures for licensing new medicines to become much stricter. Where, nevertheless, significant side effects were found it became common to sue for damages. These consequences have caused possibly an even greater disaster damaging many more people and threatening ruin to health services everywhere. The huge increase in both time and cost in bringing medicines to market is increasing their price to unsupportable levels; and only wealthy c

CBD promotes antitumor activity by modulating tumor immune microenvironment in HPV associated head and neck squamous cell carcinoma.

IntroductionMarijuana use is associated with HPV-positive head and neck squamous cell carcinoma (HNSCC). However, cannabinoid use continues to increase in the US general population for recreational purposes as well as in cancer patients for palliative care. In this study, we explored the role of cannabidiol (CBD) in promoting anti-tumor activity by modulating immune response in HPV-positive HNSCC by using pre-clinical models.MethodsThe anti-proliferative effect of CBD on HPV-positive HNSCC cells was evaluated through BrdU, apoptosis and migration analyses, followed by western blot analysis to

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… A study by García-Morales et al. showed that CBD was able to reduce the advancement of breast cancer tumors in vivo ( 69 ). In this study, we investigated the role of CBD in immune modulation in a tumor microenvironment by using a series of in vivo models of HNSCC. … Neuron . ( 2023 ) 111 ( 3 ): 302–27 . doi: 10.1016/j.neuron.2022.12.022 PMC9898277 36638804 69 García-Morales L Mendoza-Rodríguez MG Tapia Ramírez J Meza I . CBD inhibits in vivo development of human breast cancer tumors . …

Chronic stress and myeloid immunosuppression in cancer: A neuroimmune link to behavioral dysfunction.

Cancer progression is profoundly influenced by the complex interplay between the tumor microenvironment (TME), the immune system, and the patient's psychological state. This review delineates a critical pathway linking chronic stress to worsened cancer outcomes through inflammatory factors, anti-tumor immune suppression, and the induction of behavioral comorbidities. We postulate that sustained stress hormone signaling via the sympathetic nervous system and hypothalamic-pituitary-adrenal axis activation orchestrates a systemic immunosuppressive cascade. A central mechanism is the stress-induce

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… Morales-López C. Cruz-Robles M.E. Hernández-Cordero E.R. Russell S. Whitaker R. Bonilla-Claudio M. Chen D.T. Dutil J. Gaillard S.L. Yi J.S. Previs R.A. Armaiz-Pena G.N. … Morales-Lopez C. Cruz-Robles M.E. Hernandez-Cordero E.R. Russell S. Whitaker R. Bonilla-Claudio M. Chen D.T. Dutil J. Gaillard S.L. Yi J.S. Previs R.A. Armaiz-Pena G.N. …

Addressing clinical uncertainties in ATMP reimbursement: a review of methodological guidelines and European practice.

IntroductionAdvanced Therapy Medicinal Products (ATMPs) often present substantial clinical uncertainties at the time of reimbursement evaluation, particularly due to the lack of appropriate comparators and the absence of long-term clinical endpoints. This study primarily examined two methodological areas relevant to these challenges: indirect treatment comparisons (ITCs) and surrogate endpoints. In addition, the review was supplemented with an assessment of innovative trial designs to explore how emerging approaches may contribute to evidence generation for ATMPs.MethodsA structured literature

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… Sola-Morales O. Gianfrate F. Toumi M. Bucher H. C. ( 2022 ). Shaping a research agenda to ensure a successful European health technology assessment: insights generated during the inaugural convention of the European access academy . Health Econ. … Value Health 15 ( 6 ), 940 – 947 . 10.1016/j.jval.2012.05.004 22999145 Sola-Morales O. Volmer T. Mantovani L. ( 2019 ). Perspectives to mitigate payer uncertainty in health technology assessment of novel oncology drugs . J. Mark. …

The Effect of Exercise on Pain in People with Cancer: A Systematic Review with Meta-analysis.

IntroductionCancer-related pain is common and undertreated. Exercise is known to have a pain-relieving effect in non-cancer pain.ObjectivesThis systematic review aimed to evaluate (1) the effect of exercise on cancer-related pain in all cancers, and (2) whether the effect of exercise differed according to exercise mode, degree of supervision, intervention duration and timing (during or after cancer treatment), pain types, measurement tool and cancer type.MethodsElectronic searches were undertaken in six databases to identify exercise studies evaluating pain in people with cancer, published pri

Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis.

PurposeTo evaluate the effects of physical exercise on key clinical outcomes (such as quality of life (QoL), aerobic capacity, fatigue, and muscle strength) in patients undergoing haematopoietic stem cell transplantation.MethodsPRISMA systematic review and meta-analysis from inception to April 2025. PubMed, Embase, Cochrane Library, Web of Science and Scopus databases were searched for eligible studies. Methodological quality and risk of bias were evaluated with the Pedro scale and the Risk-Of-Bias Tool for randomized trials (ROB2.0) respectively.ResultsAn initial search retrieved 5217 article

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… Liang et al. reported a similar effect (SMD = 0.45; 95% CI 0.25–0.65), equivalent to an average gain of ~ 40 m in 6MWT distance [ 12 ], while Morales Rodríguez et al. [ 48 ] found a + 36 m increase ( p < 0.01). … Morales Rodríguez E Lorenzo Calvo J Granado-Peinado M Pérez-Bilbao T San Juan AF Effects of exercise programs on psychoemotional and quality-of-life factors in adult patients with cancer and hematopoietic stem cell transplantation or bone marrow transplantation: a systematic review Int J Environment …

Навязчивое сексуальное поведение может быть в большей степени похоже на состояние, чем на предательство: результаты трехлетнего продольного репрезентативного обследования.

ИСТОРИЯ ВОПРОСА О том, является ли принуждение к сексуальному поведению (CSB) устойчивым или переходным продольным курсом, является скудной и вызывает неоднозначные выводы, осложняющие его концептуализацию. Модель, включающая как специфические/стабильные факторы, так и факторы, характерные для конкретного состояния/окции, может уточнить направление и характер деятельности ЦСБ. Авторы преследовали цель определить долю различий в оценках ССБ, обусловленных специфическими/стабильными и государственными/окнесационными факторами, и проанализировать прочность авторегрессивного воздействия между посл