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Эффективность образовательной программы по самоуправлению для лиц с множественным склерозом: предварительное исследование после тестирования.

Помимо фармакологической терапии, направленной на коррекцию заболеваний, имеющиеся данные свидетельствуют о том, что структурированные меры по самоуправлению могут оптимизировать функциональную независимость, уменьшить вторичные осложнения и повысить качество жизни. Вместе с тем по-прежнему ощущается нехватка данных, полученных от различных групп населения Ближнего Востока, особенно в отношении программ самостоятельного управления телемедициной. В связи с этим мы провели текущее исследование для оценки эффективности программы самостоятельного управления телемедициной по вопросам качества жизни

The predictors of spiritual dryness among Iranian cancer patients during the COVID-19 pandemic.

BackgroundSpiritual struggles affect the wellbeing of religious people. Among them are strugglers with God which is perceived as non-responsive and distant. These perceptions were so far analyzed predominantly in Western societies with a Christian background, but not in Muslims from Iran. The aim of this study was to determine the predictors of spiritual dryness among cancer patients in Iran during the COVID-19 pandemic.MethodsCross-sectional study with standardized questionnaires (i.e., Spiritual Dryness Scale, WHO-5, BMLSS-10, Awe/Gratitude Scale) among 490 cancer patients (mean age 49.50 ±

User experiences on implementation of patient reported outcome measures (PROMs)in a Haematological outpatient clinic.

BackgroundPROMs can help healthcare professionals gain an improved understanding of patients' physical burdens, functional levels, and (health-related) quality of life throughout disease and medical treatment. The aim of this study was to investigate the barriers and potential opportunities PROMs may present in a haematological outpatient clinic from three different perspectives: patients, nurses and haematologists.MethodsThe present study synthesizes three previously published studies that separately explored the experiences of patients, nurses and haematologists when implementing PROMs. The

Rolling contact fatigue dataset for AISI 52100 bearing steel balls under calcium grease lubrication.

Rolling contact fatigue (RCF) is a dominant failure mechanism in bearings; however, open-access datasets analyzing RCF under varying lubrication conditions remain scarce. This study aims to address this problem, in which AISI 52100 bearing steel balls were tested using a four-ball tribometer according to IP 300 standard. Three calcium-soap-thickened greases of National Lubricating Grease Institute (NLGI) grades 0, 00, and 000 were used and each was formulated with extreme-pressure additives. A total of 63 trials (21 per grade) were conducted at 1470 rpm, under a peak axial load of 5739 N. The

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… Morales-Espejel GE Gabelli A de Vries AJC A model for rolling bearing life with surface and subsurface survival—tribological effects Tribol. Trans. 2015 58 894 906 10.1080/10402004.2015.1025932 Morales-Espejel, G. E., Gabelli, A. & de Vries, A. J. C. …

A critical care outreach team under strain - Evaluation of the service provided to patients with haematological malignancy during the Covid-19 pandemic.

PurposeCritical Care Outreach Teams (CCOTs) have been associated with improved outcomes in patients with haematological malignancy (HM). This study aims to describe CCOT activation by patients with HM before and during the Covid-19 pandemic, assess amny association with worse outcomes, and examine the psychological impact on the CCOT.Materials and methodsA retrospective, mixed-methods analysis was performed in HM patients reviewed by the CCOT over a two-year period, 01 July 2019 to 31 May 2021.ResultsThe CCOT increased in size during the surge period and reviewed 238 HM patients, less than in

Oral toxicity produced by chemotherapy: A systematic review.

IntroductionAntineoplastic chemotherapy remains one of the most widely used management strategies in cancer, either alone or in combination with other types of treatment. The main inconvenience of chemotherapy is its lack of selectivity, since it acts upon both tumor cells and rapidly multiplying normal cells such as bone marrow cells, hair follicle cells and oral and gastrointestinal mucosal cells.Material and methodAn exhaustive search was made of the main oral toxic effects of chemotherapy in the PubMed-Medline, Cochrane Library and Scopus databases. A total of 1293 articles were identified

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… However, other investigators such as Avşar et al. ( 17 ) or Rojas-Morales et al. ( 19 ) have observed no significant variations following the administration of cytostatic agents. … Rojas-Morales T, Lugo Z, Santana Y, Navas R, Zambrano O, Viera N. Capacity buffer of the saliva in children and adolescents with cancer: Variations induced by the administration of Metotrexate or Cyclophosphamide. Med Oral Patol Oral Cir Bucal. 2005;10:E103–8. 20. Cowart BJ. …

Exploring the role of viral hepatitis in plasma cell disorders.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Rodriguez-Garcia A Linares M Morales ML . Efficacy of antiviral treatment in hepatitis C virus (HCV)-driven monoclonal gammopathies including myeloma . Front Immunol . 2021 ; 12 : 797209 . 35087522 10.3389/fimmu.2021.797209 PMC8786723 11. Becker N Schnitzler P Boffetta P . …

Acute lymphoblastic leukemia: an update on treatment and Brazilian perspective.

Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, representing a major global health concern, particularly in developing countries. This review provides an updated overview of the epidemiology, diagnosis, prognosis, treatment, and a Brazilian perspective for ALL. Despite advances in chemotherapy and immunotherapy, survival disparities remain challenging, driven by socioeconomic and healthcare access inequalities. Present diagnosis incorporates immunophenotyping, cytogenetics, and molecular biology for precise stratification and treatment planning. Treatment has evolved fr

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… Morales D, Loth G, Colturato VAR, Tavares RB, Lermontov S, Rodrigues AM, et al. Outcomes of hematopoietic stem cell transplantation in pediatric acute lymphoblastic leukemia: a multicenter Brazilian cohort study. Bone Marrow Transplant. (2025). doi: 10.1038/s41409-025-02676-1, PMID: 73. … Morales Saute JA, Picanço-Castro V, de Freitas Lopes AC, da Silva Júnior JB, Henriques Nehm J, Dos Santos Maciel F, et al. Clinical trials to gene therapy development and production in Brazil: a review. Lancet Regional Health - Americas. (2025) 43:100995. doi: 10.1016/j.lana.2025.100995, PMID: 88. …

Сексуальный и клинический профиль испаноязычных лиц с проблемным участием в сексуальной деятельности в Интернете: сравнение между субклиническими и клиническими группами.

С учетом быстрого роста цифровых технологий и последствий этой клинической картины все большую озабоченность вызывает проблематическое участие в онлайновой сексуальной деятельности (ОСА). Однако по-прежнему отсутствует консенсус в отношении нозологических и диагностических критериев этого формирующегося состояния. Хотя в ряде исследований были изучены характеристики и прогнозы проблемной КССА, лишь немногие из них опирались на клинические пробы или всеобъемлющие диагностические инструменты, охватывающие все существующие диагностические предложения. В рамках этого исследовательского исследовани

Mcl-1 downregulation enhances BCG treatment efficacy in bladder cancer by promoting macrophage polarization.

BackgroundBacillus Calmette-Guérin (BCG) is the primary method of postoperative perfusion treatment for bladder cancer. The myeloid cell leukemia gene-1 (Mcl-1) is closely associated with the development of malignant tumors. Previous research by our group has demonstrated that downregulating Mcl-1 using shRNA can enhance the efficacy of BCG treatment in bladder cancer. This study aims to investigate the impact of Mcl-1 downregulation in combination with BCG treatment on bladder cancer, macrophage polarization, and the underlying mechanism of action, with the goal of reducing recurrence and met

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… Since Morales et al. first suggested the use of BCG for treating bladder cancer in 1976, BCG therapy has emerged as a highly effective approach for non-muscle-invasive bladder cancer [ 31 ]. … Morales A, Eidinger D, Bruce AW. Intracavitary bacillus calmette-guerin in the treatment of superficial bladder tumors. J Urol. 1976;116(2):180–3. 32. Shpilsky GF, Takahashi H, Aristarkhova A, Weil M, Ng N, Nelson KJ, et al. …

Impact of Thrombopoietin Receptor Agonists on Pathophysiology of Pediatric Immune Thrombocytopenia.

Immune thrombocytopenia (ITP) in pediatric patients is a common cause of isolated thrombocytopenia. Various pathophysiological mechanisms are implicated in ITP pathogenesis, including the production of autoantibodies against components of platelets (PLTs) by B-cells, the activation of the complement system, phagocytosis by macrophages mediated by Fcγ receptors, the dysregulation of T cells, and reduced bone marrow megakaryopoiesis. ITP is commonly manifested with skin and mucosal bleeding, and it is a diagnosis of exclusion. In some ITP cases, the disease is self-limiting, and treatment is not

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… Tarantino M.D., Bussel J.B., Blanchette V.S., Despotovic J., Bennett C., Raj A., Williams B., Beam D., Morales J., Rose M.J., et al. Romiplostim in Children with Immune Thrombocytopenia: A Phase 3, Randomised, Double-Blind, Placebo-Controlled Study. … Kuter D.J., Ghanima W., Cooper N., Liebman H.A., Zhang L., Hu Y., Miyakawa Y., Morales Galindo L.E., Basquiera A.L., Tan C.W., et al. …

The indignities of shielding during the COVID-19 pandemic for people with sickle cell disorders: an interpretative phenomenological analysis.

This article seeks to understand the first-hand experiences of people with sickle cell, a recessively inherited blood disorder, who were identified as clinically extremely vulnerable during the COVID-19 pandemic. Part of a larger sequential mixed-methods study, this article uses a selective sample of eight qualitative semi-structured interviews, which were analysed using interpretative phenomenological analysis (IPA). The first stage of IPA focused on practical concerns participants had correlated to understanding shielding and their feelings about being identified as clinically extremely vuln

Immune Effector Cell-Associated HLH-like Syndrome: A Review of the Literature of an Increasingly Recognized Entity.

Since CAR-T cell therapy was initially approved in 2017, its use has become more prevalent and so have its side effects. CAR-T-related HLH, also named immune effector cell-associated HLH-like syndrome (IEC-HS), is a rare but fatal toxicity if not recognized promptly. We conducted a review of the literature in order to understand the prevalence of IEC-HS as well as clarify the evolution of the diagnostic criteria and treatment recommendations. IEC-HS occurrence varies between CAR-T cell products and the type of malignancy treated. Diagnosis can be challenging as there are no standardized diagno

Time Goes Back-Time Perspective in Polish Men with Compulsive Sexual Behavior Disorder and Risky Sexual Behavior.

Many relationships between time perspective and a propensity to engage in risky behaviors or developing addictions have been demonstrated. The aim of our study was to determine the differences in intensity of individual time perspectives in people with compulsive sexual behavior disorder (CSBD) and risky sexual behavior (RSB). The analysis includes 425 men: 98 CSBD (age M = 37.99 years), 63 RSB (age M = 35.70 years), 264 without CSBD and RSB features constituting the control group (age M = 35.08 years). We used the Zimbardo Time Perspective Inventory, the Sexual Addiction Screening Test-Revise

The Clinical Use of Stem Cell Research in Chronic Obstructive Pulmonary Disease: A Critical Analysis of Current Policies.

Chronic obstructive pulmonary disease (COPD) is a disorder affecting more than 200 million people around the world, resulting in three million deaths per year. COPD is characterized by the loss of lung tissue and airway remodelling, with chronic inflammation of the airways and progressive destruction of lung parenchyma. The use of stem cells may lead to regenerative processes that address biological damage. However, this approach raises ethical issues that need to be considered in clinical trials using stem cell therapy, such as informed consent, patient recruitment and harm minimization, as w

Serving Vietnam Veterans Hospitalized Outside the VA System: A Scoping Review of Presumptive Service-Related Illnesses and Presentations.

BackgroundRecent legislation, the MISSION Act and the PACT Act, expanded access to and utilization of non-Department of Veterans Affairs (VA) health care; more Veterans now receive care from non-VA healthcare providers. Hospitalists outside the VA may be less familiar with Veterans' service-related exposures and presumptive service-related conditions. We aimed to summarize research findings on service-related exposures and conditions among Vietnam War Veterans.MethodsUsing Arksey and O'Malley's methodological framework for scoping reviews, we searched PubMed, EMBASE, and Web of Science databas

Precision medicine and monoclonal antibodies: breach of promise?

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Bisphosphonate induced osteonecrosis of jaw in breast cancer patients: A systematic review.

BackgroundBisphosphonate therapy is widely used for the treatment of bone metastasis in breast cancer patients.AimThe aim of this study is to estimate the overall prevalence of bisphosphonate induced osteonecrosis of jaw (BONJ) in breast cancer patients with bone metastasis.Materials and methodsA literature review was conducted to search and evaluate all the articles that contained original data on the prevalence of BONJ in breast cancer patients from the year 2003-2009. Pubmed search terms used were bisphosphonate, osteonecrosis, breast cancer and jaw. Eleven publications that fulfilled the i

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… 16314295 10.1634/theoncologist.10-10-842 10 Sanna G Preda L Bruschini R Rocca MC Ferretti S Adamoli L Bisphosphonates and jaw osteonecrosis in patients with advanced breast cancer Ann Oncol 2006 17 1512 16 16936182 10.1093/annonc/mdl163 11 Aguiar Bujanda D Bohn Sarmiento U Cabrera Suarez MA Aguiar Morales …

Hemato- Oncology Care in COVID-19 Pandemic: Crisis within a Crisis.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Vaccination in Oncology Patients: Evidence, Clinical Challenges, and Future Directions.

This narrative review provides a comprehensive synthesis of patients with cancer disproportionately affected by vaccine-preventable infectious diseases due to malignancy-related immune dysfunction and treatment-induced immunosuppression. Vaccination represents a cornerstone of supportive care in oncology; however, vaccine uptake remains suboptimal and immune responses are frequently attenuated, particularly in patients with hematological malignancies and those receiving highly immunosuppressive therapies. This review provides a comprehensive synthesis of current evidence on vaccine immunogenic

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… Morales-Portillo A. Gonzalez-Alcaide M. Láinez-Ramos-Bossini A.J. Martínez-Ruiz V. Fernández-Martínez N.F. Martín-delosReyes L.M. Jiménez-Mejías E. Jiménez-Moleón J.J. High-dose versus standard-dose influenza vaccine in immunosuppressed adults: A systematic review and meta-analysis Clin. Infect. … Morales M. Ziv T. Arbel Y.S. Scarfò L. Efficacy of the BNT162b2 mRNA COVID-19 vaccine in patients with chronic lymphocytic leukemia Blood 2021 137 3165 3173 10.1182/blood.2021011568 33861303 PMC8061088 36. Van Oekelen O. Gleason C.R. Agte S. Srivastava K. Beach K.F. Aleman A. Kappes K. Banu R. …