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The statistical fragility of randomised controlled trials evaluating tranexamic acid against a saline control in total hip arthroplasty.

INTRODUCTION: This study applied the fragility index (FI), reverse fragility index (rFI), and fragility quotient (FQ) to evaluate the statis … CTs is statistically fragile, particularly among significant outcomes and those related to blood or platelet transfusion rates. We recommend combined reporting of p-values with FI and FQ metrics to help interpret clinical findings in RCT involving TXA use during THA.

Spleen volume-to-platelet count ratio correlates with portal pressure and is associated with blood loss in laparoscopic non-anatomical hepatectomy.

Portal hypertension increases bleeding risk during liver resection, but direct measurement is invasive and impractical in routine practice. Therefore, we investigated whether the spleen volume-to-platelet count ratio (SVPR), a non-invasive surrogate, correlates with portal pressure and is associated with blood loss during laparoscopic hepatectomy. The correlation between portal pressure and SVPR was examined in 20 patients undergoing open hepatectomy with direct portal pressure measurement. Receiver operating characteristic (ROC) curve analysis was used to determine the optimal SVPR cutoff for

Early and Long-Lasting Hematologic Recovery in a Young Adult With Severe Aplastic Anemia Treated With Romiplostim, Horse-Anti-Thymocyte Globulin (ATG), and Cyclosporine A: A Case Report.

Aplastic anemia (AA) is a rare but potentially life-threatening bone marrow failure syndrome, typically characterized by peripheral pancytopenia and marked marrow hypocellularity. In acquired cases, immune-mediated destruction of hematopoietic stem cells is the predominant mechanism; however, intrinsic stem cell defects may also contribute to marrow failure, particularly in inherited bone marrow failure syndromes. Other etiologies, such as drug-induced marrow suppression, viral infections, and radiation exposure, should also be considered in the differential diagnosis. We present the case of a

Unique Gender-Related Characteristics and Differences of Chronic Myeloid Leukemia Patients in Azerbaijan: A Retrospective Cohort Study.

OBJECTIVE: The objective of this study is to evaluate gender-related demographic, clinical, and molecular differences, and imatinib response in patients with chronic myeloid leukemia (CML) in Azerbaijan. SETTING: The study was carried out at National Hematology and Blood Transfusion Center, Baku, Azerbaijan. PERIOD: This is a retrospective data analysis carried out from January 2008 to December 2023. METHODS: A total of 763 patients with Ph+ CML were included. Case records were reviewed for demographic data, disease phase, risk group, clinical manifestation, molecular characteristics, and r

A tertiary care interventional study on autologous platelet-rich plasma regenerative therapy for Grade III knee osteoarthritis.

BACKGROUND: Platelet-rich plasma (PRP) therapy is widely used in regenerative medicine, with proven efficacy in mild-to-moderate knee osteoarthritis (OA). However, its role in advanced OA (Kellgren-Lawrence Grade III) remains uncertain. OBJECTIVE: The objective of the study was to evaluate the effectiveness of PRP therapy in reducing pain and improving function in patients with Grade III bilateral knee OA. METHODS: A prospective interventional study was conducted on 29 patients with Grade III bilateral knee OA. Each patient received four intra-articular PRP injections per knee (7-8 ml; 2-3 ×

Total Knee Arthroplasty in Patients with Primary Sjögren's Syndrome: A Retrospective Case-Control Study Matched Patients without Rheumatic Diseases.

Background: The number of patients with primary Sjögren’s syndrome (pSS) who require total knee arthroplasty (TKA) is expected to increase, … SS group had more patients with post-operative anemia and hypoalbuminemia and more patients needing platelet transfusion. There were no significant differences in other complications, the rates of 90-day readmission, or overall revision. By multivariate analysis, the influencing factor for anemia in pSS patients was lower preoperative hemoglobin (OR = 0.334, 95% CI (0 …

Thromboelastography-guided management of coagulopathy in neonates with congenital diaphragmatic hernia supported by extracorporeal membrane oxygenation.

PURPOSE: Congenital diaphragmatic hernia (CDH) can cause severe hemodynamic deterioration requiring support with extracorporeal membrane oxy … a were collected. We divided subjects into two groups pre-2015 and post-2015. RESULTS: After 2015, platelet transfusion was administered for a low maximum amplitude (MA) more frequently (77% compared to 65%, p = 0.0007). Cryoprecipitate was administered less frequently for a low alpha-angle (28% compared to 41%, p = 0.0016). There was no difference in fresh frozen pl …

Оценка риска вертикальной передачи денге: перспективное исследование.

Число случаев заболевания денге во всем мире быстро растет. Более глубокое понимание проблемы передачи денге может помочь повысить эффективность мер по решению этой серьезной проблемы в области здравоохранения. Вирус передается главным образом векторами. Вместе с тем существуют и другие способы передачи, в частности передача от матери ребенку или вертикальная передача. Мы изучили перспективную когорту из 54 женщин, которые забеременели во время эпидемии 2012 - 2013 годов во Французской Гвиане, для оценки коэффициента передачи инфекции от матери к ребенку и для оценки клинического и биологическ

Совпадение в аннотации оригинала
The incidence of dengue worldwide is increasing rapidly. A better understanding of dengue transmission may help improve interventions agains … were 52 births, including three newborns who presented neonatal dengue with warning signs requiring platelet transfusion. This quantification of the mother-to-child transmission of dengue highlights three points: first, vertical transmission of dengue is not negligible; second, it is more frequent when maternal dengue occurs late during pregnancy near delivery; and th …

A monocyte-TNF-endothelial activation axis in sickle transgenic mice: Therapeutic benefit from TNF blockade.

Elaboration of tumor necrosis factor (TNF) is a very early event in development of ischemia/reperfusion injury pathophysiology. Therefore, TNF may be a prominent mediator of endothelial cell and vascular wall dysfunction in sickle cell anemia, a hypothesis we addressed using NY1DD, S+SAntilles , and SS-BERK sickle transgenic mice. Transfusion experiments revealed participation of abnormally activated blood monocytes exerting an endothelial activating effect, dependent upon Egr-1 in both vessel wall and blood cells, and upon NFκB(p50) in a blood cell only. Involvement of TNF was identified by b

High rate of symptomatic cytomegalovirus infection in extremely low gestational age preterm infants of 22-24 weeks' gestation after transmission via breast milk.

BACKGROUND: Very immature preterm infants are at risk of developing symptomatic or severe infection if cytomegalovirus is transmitted via br … In 5 (45%) infants, thrombocytopenia was the only symptom and resolved without antiviral therapy or platelet transfusion. 6 (55%) infants developed sepsis-like disease with mildly elevated CRP values and showed signs of respiratory failure. 3 (27%) were able to be stabilized on CPAP, 3 (27%) had to be intubated and mechanically ventilated. 4 children were treated with …

Laparoscopic splenectomy is an effective and safe intervention for hypersplenism secondary to liver cirrhosis.

BACKGROUND: Laparoscopic splenectomy has become the standard procedure for the normal to moderately enlarged spleens. We performed this study to investigate the safety, feasibility, and effectiveness of laparoscopic splenectomy for hypersplenism secondary to liver cirrhosis. METHODS: We performed a retrospective chart review of 24 cases of laparoscopic splenectomy (group 1), 24 cases of open splenectomy (group 2) for hypersplenism secondary to liver cirrhosis, and 68 cases of laparoscopic splenectomy for immune thrombocytopenic purpura (group 3). We performed comparisons between groups 1 and

[Anaesthetic particularities for children with tumours].

OBJECTIVES: To present the more frequent solid tumors, that require a general anaesthesia and to describe the particularities of the anaesthetic management. DATA SOURCES AND EXTRACTION: The PUBMED database was searched for articles (1990 - 2005) combined with references analysis of major articles on the topics. DATA SYNTHESIS: Neoplasma is the first cause of paediatric death. In children less than 5 years of age, neuroblastoma and nephroblastoma are the more frequent of the tumour. The incidence of each pathology is low. However a general anaesthesia is required in numerous situations: bone

Gemcitabine combined with oxaliplatin (GEMOX) as second-line chemotherapy in patients with advanced ovarian cancer refractory or resistant to platinum and taxane.

OBJECTIVES: The aim of this multicenter feasibility study was to determine the toxicity profile and antitumor activity of the gemcitabine pl … mbocytopenia occurred in 14/20 of cases (70%); there were no symptomatic cases. 2 patients required platelet transfusion and 8 patients received hydrocortisone. The dose- limiting toxicity was thrombocytopenia. Combined grade 3/4 neutropenia was observed in 8/20 (40%) of cases (no sepsis was registered). Five patients were treated with recombinant erythropoietin becau …

[Prognostic factors in pediatric liver transplantation. Multivariate analysis].

AIM: To analyze independent risk factors associated with poor graft and patient survival in a series of 292 pediatric liver transplants (PLT … z-score recipient height, UNOS status, recipient and donor weight, transplant for immune hepatitis, platelet transfusion during the transplant, blood index > 4 during the surgery, type of arterial reconstruction, retransplantation and era of the transplant (first er: 1986-1990; 2nd. era: 1991-1995; 3rd. era: 1996-2000). Four of those variables are independent in the m …

Safety and efficacy of holmium: YAG laser lithotripsy in patients with bleeding diatheses.

PURPOSE: We assessed the safety and efficacy of ureteroscopy and holmium:YAG laser lithotripsy for treating upper urinary tract calculi in patients with known and uncorrected bleeding diathesis. MATERIALS AND METHODS: We retrospectively reviewed the charts at 2 tertiary stone centers to identify patients with known bleeding diathesis who were treated with holmium:YAG laser lithotripsy for upper urinary tract calculi. A total of 25 patients (29 upper urinary tract calculi) underwent ureteroscopic holmium laser lithotripsy. Bleeding diathesis involved warfarin administration for various conditi

Acute and long-term toxicities associated with gemtuzumab ozogamicin (Mylotarg) therapy of acute myeloid leukemia.

Gemtuzumab ozogamicin (Mylotarg) targets leukemia cells that express CD33 by means of a humanized anti-CD33 monoclonal antibody conjugated t … rophil count > or = 1500/microL, hemoglobin > or = 9 g/dL, and independence from red blood cell and platelet transfusion. Grade 3/4 acute toxicities included nausea or vomiting (11%); elevated serum aminotransferase enzyme (16%) and bilirubin (26%) levels; and infusion-related chills (9%), fever (6%), and hypotension (5%). As predicted with CD33-targeted therapy, most …

Vitamin D treatment in myelodysplastic syndromes.

Myelodysplastic syndromes (MDS) are a group of clonal disturbances with defective cellular differentiation. Vitamin D3 (VD) analogues can act on the differentiation and maturity of different cell lines. We studied the effects of VD on a series of patients with MDS in an open-design trial. Nineteen patients, 12 men and seven women, with MDS were included. Patients were 74.8 +/- 5.6 years (mean +/- SD), seven had refractory anaemia with ringed sideroblasts, five had refractory anaemia, one had refractory anaemia with excess of blasts and six had chronic myelomonocytic leukaemia. All the patients

Salvage chemotherapy with paclitaxel for recurrent oligodendrogliomas.

PURPOSE: A prospective phase II study of paclitaxel was performed in adult patients with recurrent hemispheric oligodendrogliomas. PATIENTS AND METHODS: Twenty adult patients (14 men and six women), ages 18 to 52 years (median, 40.5), with recurrent supratentorial hemispheric oligodendrogliomas were treated. All patients had previously been treated with surgery, involved-field radiotherapy (median dose, 55 Gy; range 54 to 55 Gy) and nitrosourea-based (procarbazine, lomustine [CCNU], and vincristine [PCV-3 regimen]) chemotherapy (median number of cycles, five; range, four to six). Fourteen pat

Distribution of HLA-A, B and DR genes and haplotypes in the Irish population.

The distribution of HLA phenotypes, genes and haplotypes in the normal population is of considerable importance in, for example, disease susceptibility studies, platelet transfusion support and transplantation. HLA population genetics studies have been carried out on numerous population samples, however, no major studies have been performed on Irish Caucasoids. We have analysed the HLA-A, B and DR phenotypes of 1,910 healthy unrelated Irish blood donors recruited onto the Irish Bone Marrow Donor Panel. HLA typing was performed by a combination of serology, the polymerase chain reaction with se…

Treatment of multiple myeloma with intensive chemotherapy followed by autologous BMT using marrow purged with 4-hydroperoxycyclophosphamide.

In August 1988 we began a program in which multiple myeloma patients achieving < or = 10% marrow plasma cells and > or = 50% reduction in pa … he median time to recovery of 0.5 x 10(9)/l neutrophils was 19 days (range 14 to 26) while the last platelet transfusion was given on a median of day 32 (range 10 to 46) post-BMT in the evaluable patients. The major non-hematologic toxicity was hepatic; two patients in complete remission died of hepatic veno-occlusive disease. Another patient succumbed to fungal infec …