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Co-research in the development of AI and digital health tools for cancer management and care: a systematic review.

BackgroundParticipatory approaches (including co-research, co-design, Patient and Public Involvement [PPI], and Participatory Action Research [PAR]) are increasingly being incorporated into digital health innovation. However, their application in cancer-related digital and Artificial Intelligence (AI) tool lifecycle remains insufficiently synthesised, limiting understanding of how participatory approaches influence ethical outcomes, trust, and the real-world implementation of these technologies. This review moves beyond documenting participatory approaches to critically examine how far partici

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… Adler RF Morales P Sotelo J Magasi S Developing an mHealth app for cancer survivors with disabilities JMIR Form Res 2022 6 e37706 10.2196/37706 35881439 PMC9364172 Adler RF, Morales P, Sotelo J, Magasi S. Developing an mHealth app for cancer survivors with disabilities. …

Healing Environments for Cancer Care: Toward a Patient-Centered Design Guideline for Inpatient Settings.

ObjectivesThis study proposes an evidence-based design guideline for oncology inpatient rooms that addresses the physical, emotional, and psychosocial needs of cancer patients.BackgroundCancer inpatients frequently experience long hospital stays with emotional vulnerability and clinical stress. Growing evidence suggests environmental design can shape patient experience, comfort, and recovery. Yet, current literature lacks an integrated framework for the spatial and sensory needs of this population.MethodA systematic literature review was conducted across Web of Science, Scopus, and PubMed. Fro

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… Processes that actively involve patients, such as serving on design juries or engaging in participatory photography, lead to greater satisfaction and foster a powerful sense of ownership and morale among both patients and staff (Studies 3 and 32). … Spiritual assessment of patients with cancer: The moral authority, vocational, aesthetic, social, and transcendent model. Oncology Nursing Forum, 33(4), 745–751. 10.1188/06.onf.745-751 Smith R., Watkins N. (2016). Therapeutic environments . …

Diagnostic and prognostic value of cardiac imaging in amyloidosis.

Amyloidosis is an infiltrative disease caused by extracellular protein deposition that has accumulated a lot of scientific production in recent years. Different types of amyloidosis can affect the heart. Transthyretin amyloidosis and light chain amyloidosis are the two most common types of cardiac amyloidosis. These entities have a poor prognosis, so accurate diagnostic techniques are imperative for determining an early therapeutic approach. Recent advances in cardiac imaging and diagnostic strategies show that these tools are safe and can avoid the use of invasive diagnostic techniques to his

Revolutionizing Allogeneic Graft Tolerance Through Chimeric Antigen Receptor-T Regulatory Cells.

Background/Objectives: Organ transplantation is a life-saving intervention for patients with terminal organ failure, but long-term success is hindered by graft rejection and dependence on lifelong immunosuppressants. These drugs pose risks such as opportunistic infections and malignancies. Chimeric antigen receptor (CAR) technology, originally developed for cancer immunotherapy, has been adapted to regulatory T cells (Tregs) to enhance their antigen-specific immunosuppressive function. This systematic review evaluates the preclinical development of CAR-Tregs in promoting graft tolerance and su

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… Simultaneously, there are also other commercial alternatives, such as the protocol validated by Marín Morales et al., 2019 used to compare the efficacy of the CliniMacs Prodigy ® (Miltenyi Biotec, NRW, Germany) to the G-REX ® platform for Treg expansion [ 45 ]. … Marín Morales J.M. Münch N. Peter K. Freund D. Oelschlägel U. Hölig K. Böhm T. Flach A.C. Keßler J. Bonifacio E. Automated Clinical Grade Expansion of Regulatory T Cells in a Fully Closed System Front. Immunol. 2019 10 38 10.3389/fimmu.2019.00038 30778344 PMC6369367 46. Long A.H. Haso W.M. …

Couples Coping With Hematological Cancer: Support Within and Outside the Couple - Findings From a Qualitative Analysis of Dyadic Interviews.

ObjectiveCancer affects the patients as well as their partners. Couples use different strategies to cope with cancer and the associated burden: individual coping, dyadic coping, and support from the social network and from professional health care. The aim of this qualitative dyadic interviews is to gain a deeper and more differentiated understanding of the support system inside and outside of the couple.MethodsTen heterosexual couples (patients: seven men and three women) with different ages (patients: range = 22-75; spouses: range = 22-74), different hematological cancer (e.g., acute myeloid

Oral manifestations and dental management in patients undergoing CAR-T cell therapy: a retrospective observational study.

Chimeric antigen receptor T-cell (CAR-T) therapy has emerged as a highly effective treatment for refractory and relapsed hematologic malignancies. Despite its clinical benefits, CAR-T therapy is associated with a unique toxicity profile, including cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), and prolonged immunosuppression. Oral complications in this population remain underreported. This retrospective case series was aimed at describing oral manifestations and dental management in patients undergoing CAR-T therapy at a tertiary referral cente

Posterior vertebral column resection: Exploring practical uses in clinical settings.

BACKGROUND: The purpose of this study was to present our experience in patients who had been treated with posterior vertebral column resection (PVCR) for various spinal deformities. METHODS: Thirty-seven patients who performed PVCR between 2015 and 2018 were evaluated retrospectively. The mean follow-up period was 24 months (range: 12-50 months). The demographic data of the patients, mean blood loss, amount of blood replacement, duration of operation, intensive care and hospitalization period, PVCR level, instrumentation level, amount of preoperative curvature, amount of postoperative curvatu

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… Morales Codina AM, Martín-Benlloch JA, Valverde Belda D, Muñoz Donat S, Sánchez Monzó C, Aguirre García R, et al. Comparison of smith-petersen, pedicle subtraction osteotomy and vertebral column resection for the correctıon of sagittal imbalance. 2013;12:319–21. 6. …

:: позитивная психотерапия, призванная повысить терпимость к бедам и уменьшить чувство запугиваемости у пациентов с множественным склерозом.

Множественный склероз является центральным нейрогенным демиелинирующим заболеванием. Это one из наиболее распространенных неврологических заболеваний у людей и является самым изнурительным в юном возрасте. Симптомы множественного склероза включают проблемы зрения, проблемы баланса, головокружение, сенсорные расстройства, хроническую нейропатию и усталость. МАТЕРИАЛЫ И МЕТОДЫ: квазиэкспериментальное исследование с предварительным испытанием, посттестированием и one- была проведена последующая работа с целью оценки эффективности позитивной психотерапии с точки зрения терпимого отношения к бедств

Perspectives to mitigate payer uncertainty in health technology assessment of novel oncology drugs.

Reimbursement decisions on new oncology drugs are now often made while uncertainty remains about a drug's risk-benefit profile. One consequence of this is a delay in patient access to valuable new medicines. We share our perspectives on strategies to mitigate sources of uncertainty in the health technology assessment process. These include flexible approaches for evaluating the additional benefit, such as better use of surrogate endpoints and health-related quality of life data, and renewed research efforts to define the optimal target population and generate real-world evidence post-authorisa

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… Sola-Morales has consulted for most of the multinational pharmaceutical companies, including all ‘top 10’. He has received fees and honoraria for such consultancies, and is currently engaged in several projects with many of these companies. …

Cancer Treatment near the End-of-Life Becomes More Aggressive: Changes in Trend during 10 Years at a Single Institute.

PurposeThe purpose of this study was to investigate and compare cancer treatment near the end-of-life (EOL) over a 10-year period.Materials and methodsPatients with advanced solid cancer at Seoul National University Hospital who received palliative chemotherapy and had died were enrolled. We categorized the consecutive patients according to two time periods: 2002 (n=57) and 2012 (n=206). Aggressiveness of cancer treatment near the EOL was evaluated.ResultsThe median patient age was 62, and 65.4% of patients (n=172) were male. Time from the last chemotherapy to death (TCD) was found to have bee

Seroepidemiology of Toxoplasma gondii infection in psychiatric inpatients in a northern Mexican city.

BACKGROUND: Patients with psychiatric disorders were found to show a high seroprevalence of Toxoplasma gondii infection. There is scarce information about the epidemiology of T. gondii infection in psychiatric patients in Mexico. Therefore, we sought to determine the prevalence of T. gondii infection and associated socio-demographic, clinical and behavioural characteristics in a population of psychiatric patients in Durango City, Mexico. Seroprevalence in patients was compared with that obtained in a control population. METHODS: One hundred and thirty seven inpatients of a public psychiatric

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… Ehecatl Duran-Morales, Email: cets_dgo@yahoo.com. Sergio Estrada-Martínez, Email: sem@mexico.com. Sergio-Arturo Martínez-García, Email: sergiomicro@gmail.com. Oliver Liesenfeld, Email: oliver.liesenfeld@charite.de. References …

Rendezvous of Cancer Patients with Logistic and Socioeconomic Challenges during COVID-19 Pandemic: A Case Series.

The coronavirus disease 2019 pandemic has shaken the health-care infrastructure worldwide and has led to enormous challenges for cancer patients. They are suffering on various fronts during this pandemic, especially the often overlooked ones such as logistic and socioeconomic. Through the case series, we have highlighted the various components of these challenges the cancer patients are facing and tried to emphasize that the health-care setups and government along with nongovernmental organizations have to come on the forefront to help the patients mitigate these challenges.

Indocyanine Green (ICG) and Colorectal Surgery: A Literature Review on Qualitative and Quantitative Methods of Usage.

Background: Due to its many benefits, indocyanine green (ICG) has gained progressive popularity in operating rooms (ORs) globally. This literature review examines its qualitative and quantitative usage in surgical treatment. Method: Relevant terms were searched in five international databases (1. Pubmed, 2. Sciencedirect, 3. Scopus, 4. Oxfordjournals, 5. Reaxys) for a comprehensive literature review. The main benefits of using ICG in colorectal surgery are: intraoperative fluorescence angiography; fluorescence-guided lymph node involvement detection and the sentinel technique; the fluorescent

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… Morales-Conde S., Licardie E., Alarcón I., Balla A. Indocyanine green (ICG) fluorescence guide for the use and indications in general surgery: Recommendations based on the descriptive review of the literature and the analysis of experience. … Gomez-Rosado J.C., Valdes-Hernandez J., Cintas-Catena J., Cano-Matias A., Perez-Sanchez A., Del Rio-Lafuente F.J., Torres-Arcos C., Lara-Fernandez Y., Capitan-Morales L.C., Oliva-Mompean F. …

Artificial Intelligence-Augmented Propensity Score, Cost Effectiveness and Computational Ethical Analysis of Cardiac Arrest and Active Cancer with Novel Mortality Predictive Score.

Background and objectives: Little is known about outcome improvements and disparities in cardiac arrest and active cancer. We performed the first known AI and propensity score (PS)-augmented clinical, cost-effectiveness, and computational ethical analysis of cardio-oncology cardiac arrests including left heart catheterization (LHC)-related mortality reduction and related disparities. Materials and methods: A nationally representative cohort analysis was performed for mortality and cost by active cancer using the largest United States all-payer inpatient dataset, the National Inpatient Sample,

FDA approved drugs with pharmacotherapeutic potential for SARS-CoV-2 (COVID-19) therapy.

In December 2019, a novel SARS-CoV-2 coronavirus emerged, causing an outbreak of life-threatening pneumonia in the Hubei province, China, and has now spread worldwide, causing a pandemic. The urgent need to control the disease, combined with the lack of specific and effective treatment modalities, call for the use of FDA-approved agents that have shown efficacy against similar pathogens. Chloroquine, remdesivir, lopinavir/ritonavir or ribavirin have all been successful in inhibiting SARS-CoV-2 in vitro. The initial results of a number of clinical trials involving various protocols of administr

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… However, the results of the recent animal and human studies do not support this theory ( Cappuccio and Siani, 2020 ; Sriram and Insel, 2020 ; Morales et al., 2020 ; Fosbøl et al., 2020 ; Alexandre et al., 2020 ). … Morales D.R., et al. Renin-angiotensin system blockers and susceptibility to COVID-19: a multinational open science cohort study. medRxiv : the preprint server for health sciences. 2020 p. 2020.06.11.20125849. Morse J.S., et al. …

MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applications.

MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two relevant classes of non-coding RNAs (ncRNAs) that play a pivotal role in a number of molecular processes through different epigenetic regulatory mechanisms of gene expression. As a matter of fact, the altered expression of these types of RNAs leads to the development and progression of a varied range of multifactorial human diseases. Several recent reports elucidated that miRNA and lncRNAs have been implicated in pancreatic cancer (PC). For instance, dysregulation of such ncRNAs has been found to be associated with chemoresistance,

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… Paul S., Ruiz-Manriquez L.M., Ledesma-Pacheco S.J., Benavides-Aguilar J.A., Torres-Copado A., Morales-Rodríguez J.I., De Donato M., Srivastava A. Roles of microRNAs in chronic pediatric diseases and their use as potential biomarkers: a review. Arch. Biochem. … Ruiz-Manriquez L.M., Carrasco-Morales O., Sanchez Z E.A., Osorio-Perez S.M., Estrada-Meza C., Pathak S., Banerjee A., Bandyopadhyay A., Duttaroy A.K., Paul S. MicroRNA-mediated regulation of key signaling pathways in hepatocellular carcinoma: a mechanistic insight. Front. …

Mitochondrial Determinants of Anti-Cancer Drug-Induced Cardiotoxicity.

Mitochondria are key organelles for the maintenance of myocardial tissue homeostasis, playing a pivotal role in adenosine triphosphate (ATP) production, calcium signaling, redox homeostasis, and thermogenesis, as well as in the regulation of crucial pathways involved in cell survival. On this basis, it is not surprising that structural and functional impairments of mitochondria can lead to contractile dysfunction, and have been widely implicated in the onset of diverse cardiovascular diseases, including ischemic cardiomyopathy, heart failure, and stroke. Several studies support mitochondrial t

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… Morales M. Ramos C. Hasson D. Sotomayor C.G. Henriquez P. … Morales-Ruiz M. Perea R.J. Monzó M. Esteve J. …

Редактор специального выпуска : Множественный склероз: от диагностических биомаркеров до воображаемых и клинических прогнозов

Множественный склероз (MS) представляет собой хроническое, нейро-воспалительное и нейродегенеративное заболевание центральной нервной системы (CNS), которое может вызывать множество физических и когнитивных расстройств [...]

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… Morales S. Naranjo V. Sempere A.P. Contribution of Gray Matter Atrophy and White Matter Damage to Cognitive Impairment in Mildly Disabled Relapsing-Remitting Multiple Sclerosis Patients Diagnostics 2021 11 578 10.3390/diagnostics11030578 33807060 PMC8005138 6. Poulsen E.N. Olsson A. Gustavsen S. …

Превышение зависимости от предыдущих ожиданий при пересылке множественных склерозов.

Когнитивное расстройство является общей и недействующей особенностью множественного склероза (МС). Байезийские модели восприятия и действий обеспечивают мощную основу для понимания того, как познавательные процессы изменяются в НР. В этом исследовании по контролю мы использовали модель временнóго воспроизведения в байесовской системе для выявления когнитивной дисфункции у пациентов с релапсирующим MS, используя модифицированную байезскую модель наблюдателя, которая разделяет время на сенсорные измерения, оценки и моторные ступени. Как НР, так и контрольные группы переоценивали короткие промежу

Repurposing drugs for highly prevalent diseases: pentoxifylline, an old drug and a new opportunity for diabetic kidney disease.

Diabetic kidney disease is one of the most frequent complications in patients with diabetes and constitutes a major cause of end-stage kidney disease. The prevalence of diabetic kidney disease continues to increase as a result of the growing epidemic of diabetes and obesity. Therefore, there is mounting urgency to design and optimize novel strategies and drugs that delay the progression of this pathology and contain this trend. The new approaches should go beyond the current therapy focussed on the control of traditional risk factors such as hyperglycaemia and hypertension. In this scenario, d

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… Sarafidis P, Ferro CJ, Morales Eet al. SGLT-2 inhibitors and GLP-1 receptor agonists for nephroprotection and cardioprotection in patients with diabetes mellitus and chronic kidney disease. A consensus statement by the EURECA-m and the DIABESITY working groups of the ERA-EDTA. … Dávila-Esqueda ME, Martínez-Morales F. Pentoxifylline diminishes the oxidative damage to renal tissue induced by streptozotocin in the rat. Exp Diabesity Res 2004; 5: 245–251 117. Navarro-González JF, Mora-Fernández C. The role of inflammatory cytokines in diabetic nephropathy. …