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First-year treatment response predicts the following 5-year disease course in patients with relapsing-remitting multiple sclerosis.

Predicting long-term prognosis and choosing the appropriate therapeutic approach in patients with Multiple Sclerosis (MS) at the time of diagnosis is crucial in view of a personalized medicine. We investigated the impact of early therapeutic response on the 5-year prognosis of patients with relapsing-remitting MS (RRMS). We recruited patients from MSBase Registry covering the period between 1996 and 2022. All patients were diagnosed with RRMS and actively followed-up for at least 5 years to explore the following outcomes: clinical relapses, confirmed disability worsening (CDW) and improvement

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… Pia Amato, Daniele Spitaleri, Vincent Van Pesch, Richard Macdonell, Elisabetta Cartechini, Koen de Gans, Mark Slee, Tamara Castillo-Triviño, Aysun Soysal, Yara Fragoso†, Jose Luis Sanchez-Menoyo, Guy Laureys, Liesbeth Van Hijfte, Pamela McCombe, Ayse Altintas, Bianca Weinstock-Guttman, Eduardo Aguera-Morales … Dr Aguera-Morales has received honoraria as a speaker and for serving on scientific advisory boards from Biogen, Merck, Novartis and Sanofi-Genzyme. …

Impact of Adding a Rapid PCR-Based Blood Culture Identification Panel to the Antimicrobial Stewardship Program of Patients with Febrile Neutropenia in a Peruvian Referral Hospital.

The addition of Biofire® FilmArray® Blood Culture Identification panel 2 (BCID2) to the antimicrobial stewardship program (ASP) could improve outcomes in bloodstream infections (BSI) of patients with febrile neutropenia (FN). A pre- and post-quasi-experimental single-center study was conducted at a reference hospital in Peru. Three groups were considered: patients with BSI before ASP intervention (control group), patients with BSI after ASP intervention (group 1), and patients with BSI after ASP intervention plus BCID2 PCR Panel implementation (group 2). Overall, 93 patients were identified (3

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… Chumbita M., Puerta-Alcalde P., Yáñez L., Cuesta M.A., Chinea A., Morales I.E., Abellán P.F., Gudiol C., Guerreiro M., González-Sierra P., et al. … Pérez-Lazo G., Abarca-Salazar S., Lovón R., Rojas R., Ballena-López J., Morales-Moreno A., Flores-Paredes W., Arenas-Ramírez B., Illescas L.R. Antibiotic Consumption and Its Relationship with Bacterial Resistance Profiles in ESKAPE Pathogens in a Peruvian Hospital. …

IgA Nephropathy: Current Treatment and New Insights.

IgA Nephropathy (IgAN) is the most common cause of primary glomerulonephritis worldwide. Despite the histopathologic hallmark of mesangial IgA deposition, IgAN is a heterogenous autoimmune disease not only in terms of clinical presentation but also in long-term disease progression. The pathogenesis of the disease is complex and includes the generation of circulating IgA immune complexes with chemical and biological characteristics that favor mesangial deposition and reaction to mesangial under-glycosylated IgA1 accumulation, which leads to tissue injury with glomerulosclerosis and interstitial

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… Morales E. Martínez M.Á. Usera G. Jackson E. Woodford S.Y. Miller P.M. Kritchevsky S. Factors that determine an incomplete recovery of renal function in macrohematuria-induced acute renal failure of IgA nephropathy Clin. J. Am. Soc. Nephrol. 2007 2 51 57 10.2215/CJN.02670706 17699387 7. Suzuki H. … Morales E. Hernandez E. Treatment of IgA nephropathy with ACE inhibitors: A randomized and controlled trial J. Am. Soc. Nephrol. 2003 14 1578 1583 10.1097/01.ASN.0000068460.37369.DC 12761258 29. Li P.K.T. Leung C.B. Chow K.M. Cheng Y.L. Fung S.K.S. Mak S.K. Tang A.W.-C. Wong T.Y.-H. Yung C.Y. …

From Clinical Clues to Final Diagnosis: The Return of Detective Work to Clinical Medicine in Cardiac Amyloidosis.

Cardiac amyloidosis is frequently misdiagnosed, denying patients the opportunity for timely and appropriate management of the disease. The purpose of this review and case studies is to raise awareness of the diagnostic "red flags" associated with cardiac amyloidosis and the currently available non-invasive strategies for diagnosis. The review focuses on the identification of one of the two main types of cardiac amyloidosis, transthyretin amyloid cardiomyopathy, and non-invasive tools to distinguish this from light-chain amyloidosis. A diagnostic algorithm centered around the use of non-invasiv

Research in haematological cancers: What do patients in the Netherlands prioritise?

IntroductionThe experiential knowledge of patients can provide research communities with complementary perspectives on disease. The aim of this study was to identify and prioritise everyday problems and research needs of haematological cancer patients and people who have undergone a stem cell transplantation.MethodsA mixed-method participatory research approach (the Dialogue Model) was applied, including interviews (n = 19), four focus group discussions (n = 27), a questionnaire (n = 146) and a stakeholder dialogue meeting (n = 30) with patients in the Netherlands.ResultsPatients' physical dis

Wearable activity monitors in oncology trials: Current use of an emerging technology.

BackgroundPhysical activity is an important outcome in oncology trials. Physical activity is commonly assessed using self-reported questionnaires, which are limited by recall and response biases. Recent advancements in wearable technology have provided oncologists with new opportunities to obtain real-time, objective physical activity data. The purpose of this review was to describe current uses of wearable activity monitors in oncology trials.MethodsWe searched Pubmed, Embase, and the Cochrane Central Register of Controlled Trials for oncology trials involving wearable activity monitors publi

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… Med ( 2012 ). 10.1186/1472-6882-12-132 PMC3492211 22909076 [76] Galiano-Castillo N , Ariza-Garcia A , Cantarero-Villanueva I , Fernandez-Lao C , Diaz-Rodriguez L , Legeren-Alvarez M , Sanchez-Salado C , Del-Moral-Avila R , Arroyo-Morales M , Telehealth system (e-CUIDATE) to improve quality of life in …

Use of Herbal Medicine Is Associated With Late-Stage Presentation in Tanzanian Patients With Cancer: A Survey to Assess the Utilization of and Reasons for the Use of Herbal Medicine.

PurposeIn Tanzania, patients with cancer present late with advanced stages. Among other reasons, the use of herbal medicine (HM) might contribute to delay in diagnosis and treatment. This study aims to understand the utilization of HM and the reasons for its' use.MethodsA semistructured 30-item questionnaire with closed- and open-ended questions was applied to a cohort of patients with cancer at Kilimanjaro Christian Medical Centre. Content analysis was performed for answers to open-ended questions.ResultsThree hundred two patients were interviewed, 50.9% males and 49.1% females. The mean age

Predicting Pathologic Bone Lesions Using Scout Computed Tomography (CT) Imaging.

The purpose of this study is to evaluate the benefit of reviewing scout CT images, obtained for routine oncologic surveillance, for the early identification of pathologic bony lesions. A retrospective review was conducted on patients who previously underwent surgical treatment by two orthopedic oncology surgeons at a tertiary care institution from 2009-2019 for pathologic lesions or fractures of the humerus or femur. Radiographic records were reviewed to identify patients in this cohort who had available scout views from CT imaging prior to official diagnosis of the bony lesion or fracture. CT

Comparison of outcome of patients with CLL who are referred or nonreferred to a specialized CLL clinic: a Canadian population-based study.

Chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL) patients in Manitoba are either referred to the CLL Clinic at CancerCare Manitoba (CCMB) or are followed by other hematologists and general practitioners. However, it has been unclear whether referral to the CLL clinic influences patient outcome. Overall survival (OS) was assessed for all CLL/SLL patients diagnosed in Manitoba between 2007 and 2011. Of 555 patients, 281 (51%) were referred to the CLL clinic. Patients seen in this clinic had a twofold increased OS compared to patients who were managed by other hematologists a

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… B., Morales C., Musto G., et al. 2009. High incidence of chronic lymphocytic leukemia (CLL) diagnosed by immunophenotyping: a population‐based Canadian cohort. Leuk. Res. 33:1463–1468. 2. Johnston, J. B. , Seftel M., and Gibson S. B.. 2013. Chronic lymphocytic leukemia Pp. 1888–1928 in Greer J. …

Percutaneous vertebroplasty for painful spinal metastasis: a good option for better quality of life.

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… Gangi A, Sabharwal T, Irani FG, Buy X, Morales JP, Adam A. Quality assurance guidelines for percutaneous vertebroplasty. Cardiovasc Intervent Radiol. 2006;29:173–178. doi: 10.1007/s00270-005-0146-5. 3. Aaron AD. The management of cancer metastatic to bone. JAMA. 1994;272:1206–1209. 4. Coleman RE. …

Short-Chain Fatty Acid Production by Gut Microbiota Predicts Treatment Response in Multiple Myeloma.

PurposeThe gut microbiota plays important roles in health and disease. We questioned whether the gut microbiota and related metabolites are altered in monoclonal gammopathies and evaluated their potential role in multiple myeloma and its response to treatment.Experimental designWe used 16S rRNA sequencing to characterize and compare the gut microbiota of patients with monoclonal gammopathy of undetermined significance (n = 11), smoldering multiple myeloma (n = 9), newly diagnosed multiple myeloma (n = 11), relapsed/refractory multiple myeloma (n = 6), or with complete remission (n = 9). Short-

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… Morales: Methodology, writing–review and editing. R. Gómez-Gordo: Software, formal analysis. P. Justo: Patients samples. C. Cuéllar: Patients samples. J. Sánchez-Pina: Patients samples. N. López: Patients samples. R. Alonso: Resources. N. Puig: Resources. M.-V. Mateos: Resources. R. … Rodríguez-García A, Linares M, Morales ML, Allain-Maillet S, Mennesson N, Sanchez R, et al. Efficacy of antiviral treatment in hepatitis C virus (HCV)-driven monoclonal gammopathies including myeloma. Front Immunol 2022;12:797209. 7. Bull MJ, Plummer NT. …

P-Glycoprotein as a Therapeutic Target in Hematological Malignancies: A Challenge to Overcome.

P-glycoprotein (P-gp), a transmembrane efflux pump encoded by the ABCB1/MDR1 gene, is a major contributor to multidrug resistance in hematological malignancies. These malignancies, arising from hematopoietic precursors at various differentiation stages, can manifest in the bone marrow, circulate in the bloodstream, or infiltrate tissues. P-gp overexpression in malignant cells reduces the efficacy of chemotherapeutic agents by actively expelling them, decreasing intracellular drug concentrations, and promoting multidrug resistance, a significant obstacle to successful treatment. This review exa

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… Created in BioRender by Morales-Villamil, F. https://BioRender.com/n96f826 (accessed on 21 December 2024). In addition to these strategies, natural compounds have emerged as potential candidates for combating drug resistance in acute myeloid leukemia (AML) by inhibiting P-gp activity. …

Advances and Challenges in Cervical Cancer: From Molecular Mechanisms and Global Epidemiology to Innovative Therapies and Prevention Strategies.

BackgroundIn the global scenario of public health, cervical cancer poses a major threat with high mortality rates, especially in women. New incidence cases and prevalence vary across different regions, as recently shown by GLOBOCAN data. The development of cervical cancer is primarily due to persistent infection by high-risk genotypes of human papillomavirus (HPV), which is a multifaceted process that is influenced by genetic, environmental, and lifestyle factors.PurposeThe goal of this study is to thoroughly investigate cervical cancer, including its etiology, molecular mechanisms, progressio

Упущенные возможности для поощрения процветания в лечении рака: краткое исследование множественной миеломы.

Недавние теоретические и эмпирические достижения в области науки о благосостоянии могут иметь существенные последствия для медицинского обслуживания при рассмотрении экзистенциальных проблем, с которыми сталкиваются люди с неизлечимым или ограниченным сроком жизни диагнозом рака. Мы предлагаем, чтобы определенные элементы процветания, такие, как смысл и цель, глубокие личные отношения и воспитание добродетели, могли быть воплощены в жизнь, если они будут надлежащим образом ориентированы на конец жизни. Был проведен качественный тематический анализ полуструктурированных опросов для изучения опы

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… Communication challenges, including fear of undermining patient morale and prognostic uncertainty in multiple myeloma, as expressed by interview participants, compound these barriers, alongside systemic issues like limited access to palliative care specialists and lack of standardized referral criteria …

Сайентометрический анализ неврологических публикаций в Иране.

История вопроса: Несомненно, медицина родилась с самого начала сотворения человека. Одной из его важных ветвей является неврология. Нейрофизики в Иране с небольшой задержкой из первого мира, с усилиями исследователей, открыли путь к диагностике и лечению неврологических заболеваний, и мы достигли того места, где мы находимся. Методы: В этом библиометрическом и сайентометрическом исследовании мы провели оценку процесса неврологии в Иране. Сославшись на надежные индексы, мы проверили Web of Science (WOS), PubMed и Scopus начиная с 1963 года. Мы показали опубликованную деятельность иранцев в виде

Corneal and Epidermal Nerve Quantification in Chemotherapy Induced Peripheral Neuropathy.

Chemotherapy-induced neurotoxicity is an increasingly recognized clinical issue in oncology. in vivo confocal microscopy (IVCM) of corneal nerves has been successfully used to diagnose peripheral neuropathies, including diabetic neuropathy. The purpose of this study was to test if the combination of corneal nerve density and morphology assessed by IVCM is useful to monitor the neurotoxic effects of chemotherapy compared to epidermal nerve quantification. Overall, 95 adult patients with different cancer types were recruited from the oncology and hematology departments of the San Raffaele Hospit

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… Chan A Hertz DL Morales M Adams EJ Gordon S Tan CJ . Biological predictors of chemotherapy-induced peripheral neuropathy (CIPN): MASCC neurological complications working group overview . Support Care Cancer. ( 2019 ) 27 : 3729 – 37 . 10.1007/s00520-019-04987-8 31363906 PMC6728179 9. …

Human resources for cancer control in uttar pradesh, India: a case study for low and middle income countries.

For addressing the growing burden of cancer in low and middle income countries, an important first step is to estimate the human resources required for cancer control in a country, province, or city. However, few guidelines are available to decision makers in that regard. Here, we propose a methodology for estimating the human and other resources needed in the state of Uttar Pradesh (UP), India as a case study. Information about the population of UP and its cities was obtained from http://citypopulation.de/. The number of new cancer cases annually for the commonest cancers was estimated from G

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… This results in chronically understaffed and poorly maintained facilities, leading to poor patient outcomes and low staff morale. …

Biomarkers of Tumor Metastasis and Invasiveness.

The identification of proteins as new cancer diagnostic and prognostic biomarkers continues to attract considerable attention in the oncology literature, especially in the context of invasion and metastasis activation process [...].

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… Pintor-Romero V.G., Hurtado-Ortega E., Nicolás-Morales M.L., Gutiérrez-Torres M., Vences-Velázquez A., Ortuño-Pineda C., Espinoza-Rojo M., Navarro-Tito N., Cortés-Sarabia K. Biological role and aberrant overexpression of syntenin-1 in cancer: Potential role as a biomarker and therapeutic target. …

Нейропсихологические аспекты расстройств контроля импульсов в болезни Паркинсона.

Синдромы импульсного контроля (ИДД), такие, как чрезмерные азартные игры, навязчивое сексуальное поведение, поедание бингов, навязчивые покупки, а также синдром регулирования дофамина, могут возникать как изнурительное нервно-психическое осложнение болезни Паркинсона (PD). Хотя патофизиология не в полной мере понятна, она, вероятно, включает мезолимбичную допаминергическую чрезмерную оптимизацию в сочетании с факторами уязвимости, связанными с заболеваниями, в плане поощрения, мотивации и ингибиционных сетей контроля. В настоящем описательном обзоре резюмируются данные о нейропсихологических,

Exercise as a Therapeutic Strategy to Improve Cerebrovascular Function and Cognition in Breast Cancer Survivors: A Scoping Review.

Breast cancer is the most diagnosed cancer globally. While the breast cancer prevalence continues to rise, so too do patient survival rates, thus resulting in a large survivor population. Up to 75% of this population report experiencing cancer-related cognitive impairment during their cancer journey, thus reducing their quality of survivorship. This review systematically evaluates the effect of physical activity and exercise training on cerebrovascular function and cognition in breast cancer survivors. Cross-sectional, intervention or observational studies that examined the effect of acute or

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… Galiano-Castillo N., Arroyo-Morales M., Lozano-Lozano M., Fernandez-Lao C., Martin-Martin L., Del-Moral-Avila R., Cantarero-Villanueva I. …