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[Cardio-renal syndrome: perspectives of Исследование in infectious diseases].

Clinical and prognostic significance of cardio-renal syndrome in various infectious diseases are discussed. Incidence and prognosis, as well as pathogenesis of cardio-renal syndrome in patients with infectious diseases, admitted to ICU of infectious hospitals, as well as hemorrhagic fever with renal syndrome and in COVID-19 are reviewed.

Artificial intelligence in HIV Исследование, policy, and clinical care.

A large and rapidly growing percentage of health-care organisations are implementing artificial intelligence (AI; including generative AI), for Исследование, care delivery, and policy. Despite concerns (eg, ethical considerations and data privacy) by HIV stakeholders (eg, providers, patients, government, and community-based organisations), AI-driven tools are already being used in HIV-related areas such as testing, risk prediction, clinical decision making, and HIV interventions. This Viewpoint outlines the use of AI in both HIV and broader public health settings; provides examples across patient,…

Mapping Nutrition and Tuberculosis Research: Insights From Bibliometric Perspective.

BACKGROUND: Malnutrition and tuberculosis form a mutually reinforcing vicious cycle. While nutritional interventions are crucial for TB management, the knowledge structure and Исследование frontiers remain insufficiently characterised. OBJECTIVE: To systematically analyse the structure, trajectory and frontiers of Исследование in the nutrition-tuberculosis field using bibliometric methods. METHODS: Relevant literature published since 2007 was retrieved from the Web of Science Core Collection database. CiteSpace was employed to perform multidimensional analyses, including co-occurrence, cluster timel…

Исследование нарушений сна, связанных с множественным склерозом.

Множественный склероз является распространенным демиелинизирующим заболеванием в неврологии, характеризующимся сложным и непредсказуемым патогенезом, а также различными клиническими проявлениями, которые создают значительное бремя для физического и психического здоровья пациентов. Повреждения сна, как широко распространенный, но зачастую игнорируемый симптом потери трудоспособности в этой болезни, имеют высокий уровень заболеваемости и значительно снижает качество жизни пациентов. В этой статье систематически анализируются недавние улучшения в расстройствах сна, связанных с множественным склер

На пути к глобальной программе исследований по предотвращению множественных склерозов.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Был достигнут значительный прогресс в понимании генетических и экологических факторов риска в связи с множественным склерозом (МС), однако мы все еще не можем предотвратить НР. ЦЕЛИ: Достичь прогресса в первичной и вторичной профилактике НР путем разработки всеобъемлющей программы исследований на основе имеющихся знаний. МЕТОДЫ: В ходе глобального семинара-практикума были созваны люди, имеющие живой опыт, врачи, исследователи и разработчики политики, имеющие опыт работы в области MS, других хронических заболеваний, эпидемиологии, клинических испытаний, геномики, иммуноло

Совпадение в аннотации оригинала
BACKGROUND: Considerable progress has been made in understanding genetic and environmental risk factors for multiple sclerosis (MS), yet we still cannot prevent MS. OBJECTIVES: To drive progress in primary and secondary prevention of MS by developing a comprehensive Исследование agenda based on current knowledge. METHODS: A global workshop convened people with…

[Ferroptosis in male reproductive system diseases: Progress in Исследование].

Ferroptosis is an iron-dependent form of programmed cell death triggered by the excessive accumulation of lipid peroxides on the cell membrane. Recent studies have found that ferroptosis can be induced by exposure of the testis tissue and germ cells to some high-risk factors, accompanied by various characteristic reproductive system injuries, including changes in cell morphology, ferroptosis-related physicochemical indicators and gene expressions. This review focuses on the association of ferroptosis with male reproductive system diseases from three key aspects: iron metabolism abnormalities,

Diet-microbiota associations in gastrointestinal Исследование: a systematic review.

Interactions between diet and gastrointestinal microbiota influence health status and outcomes. Evaluating these relationships requires accurate quantification of dietary variables relevant to microbial metabolism, however current dietary assessment methods focus on dietary components relevant to human digestion only. The aim of this study was to synthesize Исследование on foods and nutrients that influence human gut microbiota and thereby identify knowledge gaps to inform dietary assessment advancements toward better understanding of diet-microbiota interactions. Thirty-eight systematic reviews a…

Current status and Исследование directions in acute myeloid leukemia.

The understanding of the molecular pathobiology of acute myeloid leukemia (AML) has spurred the identification of therapeutic targets and th … update the standard-of-care and investigational therapies and outline promising current and future Исследование directions.

[Research progress in animal embryo implantation and endometrial organoids].

Embryo implantation involves a complex interaction between the embryo and the endometrium of the mother, the study of which faces a variety of problems. The modeling of endometrial epithelial organoids and endometrial assembloids provides a new way to study the process of embryo implantation in vitro. This paper summarized the latest Исследование progress in embryo implantation, the regulation mechanism of endometrial receptivity by estrogen- progesterone coordination and embryo-derived signals, the establishment of endometrial organoids, and the development and application of endometrial assemblo…

Challenges in IBD Research 2024: Preclinical Human IBD Mechanisms.

Preclinical human inflammatory bowel disease (IBD) mechanisms is one of 5 focus areas of the Challenges in IBD Research 2024 document, which also includes environmental triggers, novel technologies, precision medicine, and pragmatic clinical Исследование. Herein, we provide a comprehensive overview of current gaps in inflammatory bowel diseases Исследование that relate to preclinical Исследование and deliver actionable approaches to address them with a focus on how these gaps can lead to advancements in IBD interception, remission, and restoration. The document is the result of multidisciplinary input fro…

Shedding Light on Antisocial Behavior Through Genetically Informed Research.

Antisocial behavior (ASB) refers to a set of behaviors that violate social norms and disregard the well-being and rights of others. In this … We also highlight clinical and legal implications, including how insights from genetically informed Исследование can help inform prevention and intervention, and we discuss some challenges and opportunities within this field of Исследование.

Advanced Research in Age-Related Macular Degeneration: Special Issue.

Age-related macular degeneration (AMD) is an eye disease that is the leading cause of irreversible vision loss in people over 55 years of age [...].

Digital storytelling to promote disability-inclusive Исследование in Africa.

BACKGROUND: Digital stories have been shown to be effective in sharing information. The Partnerships for Inclusive Research and Learning (PIRL) was a 4-year international participatory Исследование project focussed on the digital divide in inclusive Исследование. OBJECTIVES: Members of PIRL share their experience of using digital storytelling to get key messages from the project to a wide range of people. METHOD: Members of PIRL were invited to develop digital stories and create project-specific guidelines for digital story development. Seven people participated in workshops given by experts, read l…

[Current Исследование status of Peutz-Jeghers syndrome in children].

Peutz-Jeghers syndrome (PJS) is an autosomal dominant genetic disorder characterized by mucocutaneous pigmentation and multiple hamartomatou … development, and quality of life of the children. This article provides an overview of the current Исследование status regarding the clinical characteristics, etiology, pathogenesis, diagnosis, and treatment of PJS in children.

Research progress on Helicobacter pylori infection related neurological diseases.

Helicobacter pylori, a type of gram-negative bacterium, infects roughly half of the global population. It is strongly associated with gastrointestinal disorders like gastric cancer, peptic ulcers, and chronic gastritis. Moreover, numerous studies have linked this bacterium to various extra-gastric conditions, including hematologic, cardiovascular, and neurological issues. Specifically, Исследование has shown that Helicobacter pylori interacts with the brain through the microbiota-gut-brain axis, thereby increasing the risk of neurological disorders. The inflammatory mediators released by Helicobac…

CROI 2024: Summary of Basic Science Research in HIV.

Scientists from around the world gathered in Denver for the Conference on Retroviruses and Opportunistic Infections (CROI). The conference maintained its existing format and used a combination of plenary lectures, workshops, oral abstract sessions, themed discussions, and interactive symposia to deliver the latest advances in HIV/AIDS Исследование to the almost 4000 delegates in attendance. As with previous CROI meetings, the conference provided a fertile environment for early-stage investigators who were interested in getting updates in areas of Исследование outside of their particular domain. This w…

INSPIRE, a publicly available Исследование dataset for perioperative medicine.

We present the INSPIRE dataset, a publicly available Исследование dataset in perioperative medicine, which includes approximately 130,000 surgical operations at an academic institution in South Korea over a ten-year period between 2011 and 2020. This comprehensive dataset includes patient characteristics such as age, sex, American Society of Anesthesiologists physical status classification, diagnosis, surgical procedure code, department, and type of anaesthesia. The dataset also includes vital signs in the operating theatre, general wards, and intensive care units (ICUs), laboratory results from s…