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Augmented reality based navigation for distal interlocking of intramedullary nails utilizing Microsoft HoloLens 2.

BACKGROUND AND OBJECTIVE: The distal interlocking of intramedullary nail remains a technically demanding procedure. Existing augmented reality based solutions still suffer from hand-eye coordination problem, prolonged operation time, and inadequate resolution. In this study, an augmented reality based navigation system for distal interlocking of intramedullary nail is developed using Microsoft HoloLens 2, the state-of-the-art optical see-through head-mounted display. METHODS: A customized registration cube is designed to assist surgeons with better depth perception when performing registratio

Psychotherapy and psychological time: a case study.

AIM: The present study is a comparative case study as part of research on the psychotherapeutic process. This research describes the perception of subjective time in two psychotherapeutic processes, one successful and one unsuccessful. METHODS: We studied two psychotherapeutic processes of cognitive orientation, which were video recorded and fully transcribed in each session. First a qualitative analysis was applied for quality coding (Top-down) was performed to identify category types of subjective time, depending on psychological well-being. These were categorized as past, present, and futu

Cytomegaloviral retinitis-related retinal detachment: outcomes following vitrectomy in the developing world.

The purpose of this study is to describe the functional and anatomical outcomes of cytomegaloviral retinitis (CMVR) patients undergoing vitrectomy for retinal detachment (RD) in South Africa. In this retrospective case series, CMVR diagnoses were based on clinical examination alone. All vitrectomies were performed by a single surgeon. Main outcome measures were visual acuity (VA) and retinal re-attachment success rate. Thirty-nine patients (43 eyes) were followed up from the time of RD diagnosis for a mean 19.3 months ± 13.8 (standard deviation). Successful anatomical re-attachment was achieve

The importance of spirituality in supportive care.

BACKGROUND: It has been shown that the pineal gland plays a fundamental role in mediating either the spiritual perception or the anticancer immunity by stimulating the endogenous production of anticancer cytokine interleukin (IL)-2. OBJECTIVE: The present study was performed to evaluate the impact of a spiritual approach consisting of Kriya Yoga program alone or in association with melatonin (MLT) or low-dose IL-2 plus MLT on the survival time in a group of metastatic cancer patients with life expectancy less than 1 year. MATERIALS AND METHODS: A case-control study was carried out in 240 pat

Changes in the quality of life of hemiplegic stroke patients with time: a preliminary report.

To evaluate the influence of time on the quality of life of hemiplegic stroke patients living at home, we analyzed a sample of 45 outpatients. The sample was divided into two groups, according to the delay between the discharge time from hospital and the assessment (Group 1, fewer than 6 mo; Group 2, more than 6 mo after discharge). We hypothesized that patients in Group 2 would have a lower level of quality of life than patients in Group 1. Disability was assessed with the Functional Independence Measure, and the quality of life was assessed with the Reintegration to Normal Living Index. Both

The contribution of ventricular tachyarrhythmias to the genesis of cardiac pain during transient myocardial ischaemia in patients with variant angina.

The 24-h ambulatory electrocardiograms of 15 patients with both variant angina and ischaemia-related arrhythmias were analyzed to correlate cardiac pain with the following variables: site, type, duration and magnitude of ECG changes, presence and type of arrhythmias and time of occurrence of ischaemic attacks during the 24-h. Apart from sublingual nitrate therapy, Holter monitoring was performed in the Coronary Care Unit (CCU), in the drug-free state in all patients. During a total of 79 days of monitoring, patients had 1385 ischaemic episodes, of which only 30% were painful. The site of ischa

Application of virtual reality haptic simulators in periodontics: insights from dental professionals.

INTRODUCTION: Virtual reality haptic simulator (VRHS)-training devices that integrate visual immersion with tactile feedback- are increasingly used in dental education, yet their application in periodontics remains limited. Sonic scaling requires high tactile precision and control, making it a suitable domain for evaluating VRHS efficacy. This study assessed faculty perceptions and performance using VRHS for preclinical periodontal training compared with conventional simulation. METHODS: A quasi-experimental, repeated-measures study was conducted with 30 calibrated faculty members (15 periodo

Factors associated with never treatment and acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana, 2021.

Guyana remains one of four countries in the Americas endemic for lymphatic filariasis (LF). Elimination of LF requires repeated annual mass drug administration (MDA) with sufficient levels of coverage for success. This study assesses the acceptability and never treatment of LF MDA using data from a routine assessment survey in 2021. A subset of individuals, over 20 years of age (n = 2498), were selected to receive an expanded questionnaire to examine factors associated with acceptability and never treatment. Assessed factors include respondent demographics, knowledge, risk perceptions of LF, a

"It is always better for a man to know his HIV status" - A qualitative study exploring the context, barriers and facilitators of HIV testing among men in Nairobi, Kenya.

HIV testing services are an important component of HIV program and provide an entry point for clinical care for persons newly diagnosed with HIV. Although uptake of HIV testing has increased in Kenya, men are still less likely than women to get tested and access services. There is, however, limited understanding of the context, barriers and facilitators of HIV testing among men in the country. Data are from in-depth interviews with 30 men living with HIV and 8 HIV testing counsellors that were conducted to gain insights on motivations and drivers for HIV testing among men in the city of Nairob

Correlation between operative time and crowd-sourced skills assessment for robotic bariatric surgery.

INTRODUCTION: Operative time has been traditionally used as a proxy for surgical skill and is commonly utilized to measure the learning curve, assuming that faster operations indicate a more skilled surgeon. The Global Evaluative Assessment of Robotic Skills (GEARS) rubric is a validated Likert scale for evaluating technical skill. We hypothesize that operative time will not correlate with the GEARS score. METHODS: Patients undergoing elective robotic sleeve gastrectomy at a single bariatric center of excellence hospital from January 2019 to March 2020 were captured in a prospectively maintai

Auditory Cues Guide Predictive Gaze Orienting during Navigation in Virtual Reality.

Natural vision is an active, predictive process guided by expectations about when and where information will appear. Yet how gaze is shaped in dynamic, multisensory environments remains poorly understood. Using immersive virtual reality with eye tracking, we examined gaze behavior during naturalistic navigation. Participants cycled through a virtual city while avatar cyclists, first heard overtaking them from behind via spatialized auditory cues, later became visible as they passed. Auditory cues triggered anticipatory gaze shifts to expected locations, indicating that gaze allocation was guid

The impact of health policies on immigrant women's experiences of maternal health services in the United Kingdom and Canada: A qualitative systematic review and meta-synthesis.

The perinatal period is a critical time for the health of women, during which delays or limited access to care can have serious consequences. For immigrant women, this period is marked by multiple barriers exacerbated by restrictive policies. With rising immigration to countries such as the UK and Canada, we examined immigrant women's experiences of maternal healthcare. We conducted a Boolean search across four databases (Medline, Embase, CINAHL, Global Health) from January 2000 to November 10, 2025. We identified thirty-three eligible studies, involving over 1000 migrant women of various immi

Превышение зависимости от предыдущих ожиданий при пересылке множественных склерозов.

Когнитивное расстройство является общей и недействующей особенностью множественного склероза (МС). Байезийские модели восприятия и действий обеспечивают мощную основу для понимания того, как познавательные процессы изменяются в НР. В этом исследовании по контролю мы использовали модель временнóго воспроизведения в байесовской системе для выявления когнитивной дисфункции у пациентов с релапсирующим MS, используя модифицированную байезскую модель наблюдателя, которая разделяет время на сенсорные измерения, оценки и моторные ступени. Как НР, так и контрольные группы переоценивали короткие промежу

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… Abnormal Activity in the Precuneus during Time Perception in Parkinson’s Disease: An fMRI Study PLoS One 7 2012 e29635 10.1371/journal.pone.0029635 PMC3253091 22238630 36 Akrami A. Kopec C.D. Diamond M.E. Brody C.D. … PerPsych: An iPadOS-based open-source neuropsychological software for time perception assessment MethodsX 12 2024 102504 10.1016/j.mex.2023.102504 PMC10765042 38179067 50 Toosi F. Rahimi C. Sajjadi S. …

Single-neuron encoding of rapidly learned visual information reshapes human perception.

Humans can swiftly learn to recognize visual objects after minimal exposure. Integrating new information with existing knowledge requires forming enduring neuronal representations to enable future recognition. Yet, the neuronal mechanisms in the human brain underlying such rapid perceptual changes remain unclear. We recorded single-neuron activity in occipital (OC) and medial temporal lobe (MTL) regions as participants rapidly learned to recognize degraded images. OC and MTL neurons modulated their activity to encode newly learned visual information and reshape perception. Population decoding

Association of real life postural transitions kinematics with fatigue in neurodegenerative and immune diseases.

Fatigue is prevalent in immune-mediated inflammatory and neurodegenerative diseases, yet its assessment relies largely on patient-reported outcomes, which capture perception but not fluctuations over time. Wearable sensors, like inertial measurement units (IMUs), offer a way to monitor daily activities and evaluate functional capacity. This study investigates the relationship between sit-to-stand and stand-to-sit transitions and self-reported physical and mental fatigue in participants with Parkinson's, Huntington's, rheumatoid arthritis, systemic lupus erythematosus, primary Sjögren's syndrom

Human-like Dexterous Grasping Through Reinforcement Learning and Multimodal Perception.

Dexterous robotic grasping with multifingered hands remains a critical challenge in non-visual environments, where diverse object geometries and material properties demand adaptive force modulation and tactile-aware manipulation. To address this, we propose the Reinforcement Learning-Based Multimodal Perception (RLMP) framework, which integrates human-like grasping intuition through operator-worn gloves with tactile-guided reinforcement learning. The framework's key innovation lies in its Tactile-Driven DCNN architecture-a lightweight convolutional network achieving 98.5% object recognition ac

Quality of life of people with human immunodeficiency virus and seroconcordant and serodiscordant partnerships.

OBJECTIVES: to assess quality of life of people with HIV with seroconcordant and serodiscordant partnerships. METHODS: a cross-sectional study, carried out in three outpatient clinics with 190 people with HIV (95 with seroconcordant and 95 serodiscordant partnerships), using characterization form and quality of life assessment instrument. Descriptive statistics and associations among variables were performed, considering p-value<0.05 as statistically significant. RESULTS: the majority had a higher perception of quality of life, with no difference between groups. Females had lower scores in a

A primate model animal revealed the inter-species differences and similarities in the subtype specifications of the spiral ganglion neurons.

Type I spiral ganglion neurons are peripheral neurons essential for hearing perception. While they can be subdivided in mice based on characteristic gene expression patterns, detailed examinations of these subtypes in primates and humans are lacking. In this study, we investigated the developmental subtypes of spiral ganglion neurons in the common marmoset (Callithrix jacchus). We confirmed that Type I spiral ganglion can be divided based on the characteristic gene expression patterns of several marker genes. However, some combinations of these genes differ from those in rodents, suggesting co

Parenting of mothers of children in early childhood during the COVID-19 pandemic: qualitative research.

OBJECTIVES: to understand practices of mothers of children in early childhood who live in contexts of poverty in the face of the COVID-19 pandemic. METHODS: an exploratory, descriptive and qualitative study. Participants were selected in the community context, composing an intentional sample to be collected through semi-structured online interviews. Data were analyzed inductively and anchored in the Bioecological Model of Human Development. RESULTS: eight mothers participated in the research. Mothers highlighted pleasure in taking care of their children, although they were overloaded with ac

An Investigation of temporomandibular pain, headache, and fatigue in relation with long-term mask use during the COVID-19 pandemic period.

OBJECTIVE: To investigate the effects of long-term mask use on temporomandibular pain, headache, and fatigue during the COVID-19 pandemic period via a survey. METHODS: The survey was sent online, and symptoms associated with mask use, perception of mask discomfort, temporomandibular dysfunction, fatigue, headache, and trigger points of temporomandibular joint were evaluated. RESULTS: For the study, 909 people were screened. Head, neck, face, throat, ear, and jaw pain, cheek tension, teeth clamping, acne, mask trace, palpitation, and voice and sleep disorders were different between groups (p