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Bilateral high-level percutaneous cervical cordotomy in cancer pain due to lung cancer: a case report.

BACKGROUND: Computed tomography-guided high-level percutaneous cordotomy has been used unilaterally or bilaterally for the treatment of localized intractable pain in malignancies. CASE DESCRIPTION: A 57-year-old man was admitted to the hospital with the complaint of intractable pain involving the left side of the chest, axillary region, and shoulder. He was operated for small cell lung cancer on the left side in December 2003 and received radiotherapy and chemotherapy. His neurological examination was normal. Magnetic resonance imaging of the thorax revealed contrast-enhancing lesions on the

Cordotomy for pain control and opioid reduction in cancer patients: A cancer center 11-year experience.

BACKGROUND: Percutaneous lateral cervical cordotomy (PLCC) is a treatment option for predominantly nociceptive pain of oncological origin th … nge: 0.0-396.0). CONCLUSION: PLCC is a valuable therapeutic intervention for patients experiencing cancer pain that is unresponsive to conservative treatments. The anticipated analgesic outcomes are generally favorable, particularly in cases where the pain is localized unilaterally in the abdomen or lower body segments.

Pain, cancer-related distress, and physical and functional well-being among men with advanced prostate cancer.

PURPOSE: Men with advanced prostate cancer (APC) experience high levels of pain, which contribute to poor psychosocial and functional outcomes. Cancer-related distress explains the relationship between pain severity and interference, yet specificity of distress characteristics (e.g., hyperarousal, intrusive, or avoidant symptoms) in explaining associations between pain experiences and well-being has not been explored within APC. This study examined men with APC entering a clinical trial and tested associations of baseline pain, cancer-related distress, and physical and functional well-being.

The role of fatigue and sleep quality in the link between pain severity, perceived injustice and pain catastrophizing in breast cancer survivors with pain: a network analysis.

PURPOSE: Breast cancer survivors frequently report persistent pain accompanied by fatigue, sleep disturbances, and psychological factors such as pain catastrophizing and perceived injustice. Although these symptoms often co-occur, their multivariate interrelations and potential directional dependencies remain insufficiently understood. This study investigates the relationship between pain severity, perceived injustice and pain catastrophizing, and their connection with fatigue and sleep quality in breast cancer survivors by examining the interconnections, strengths, and directional dependencie

Understanding how children and young people with chronic non-cancer pain and their families experience living with pain, pain management and services: a meta-ethnography.

BACKGROUND: Childhood chronic pain is a widespread public health issue. We need to understand how children with chronic pain and their famil … mber 2022, to identify qualitative studies with children aged 3 months to 18 years with chronic non-cancer pain and their families. We included studies with rich explanatory data; appraised methodological limitations using the Critical Appraisal Skills Programme tool; and extracted, analysed and synthesised studies' findings. We used Grading of Recommendation …

P2X2/3 receptors as a potential target for cancer pain treatment.

In the process of tumor growth and metastasis, which can invade nerve tissue, sensitize peripheral receptors, enhance sensory information transmission and induce pain. Bone cancer pain is the most common type of cancer pain, caused by primary bone tumors or other types of cancer metastasis, destruction and dissolution of bone tissue, leading to pain generation. The pathological mechanism of cancer pain is complex and its treatment is a thorny problem at present. P2X2/3 receptors are mainly expressed in nociceptive sensory neurons. ATP released by cells is involved in nociceptive and pain signa…

Регулирование причиняемой раком боли в хосписе и паллиативном уходе.

Раковая боль в костях (CIBP) one - наиболее распространенные симптомы инвалидности, встречающиеся в хосписе и паллиативном уходе. Метастазы костей особенно часто встречаются у пациентов с множественной миеломой, раком груди и раком простаты, и они могут вызывать непрерывную фоновую боль, боль, связанную с движением, патологический перелом, злокачественное сжатие спинного мозга и гиперкальцемию злокачественности. CIBP является результатом сложного взаимодействия ноцицептивных, подстрекательских и нейропатических механизмов, обусловленных взаимодействием опухолей со стромой и центральной сенсиби

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… In advanced cancer, pain related to bone metastasis is one of the most common and burdensome manifestations requiring palliative intervention [ 3 , 4 ]. From a clinical standpoint, cancer-induced bone pain (CIBP) is not simply a localized nociceptive complaint. … The 2023 ASCO guideline recommends offering opioids to adults with moderate-to-severe cancer pain unless contraindicated, starting with the lowest effective dose of an immediate-release opioid and reassessing promptly based on analgesia, adverse effects, organ function, and prior opioid exposure [ 16 …

Prevalence and characteristics of neuropathic pain in adolescent survivors of childhood cancer.

PURPOSE: Neuropathic pain (NP) in individuals with cancer can arise from the cancer itself or its treatments. The prevalence of NP has been estimated in children living with cancer; however, the prevalence in adolescent survivorship is unknown. The aims of this study were to estimate the prevalence of NP among adolescent survivors of childhood cancer and explore biopsychosocial factors associated with NP. METHODS: This was a cross-sectional study of cancer survivors (diagnosed > 18 months prior) aged 13-18 years in a pediatric cancer survivorship clinic. A survey was administered to participa

The impostor of chest pain: a case of lung cancer mimicking angina.

Chest pain is a common symptom with a complex etiology involving multiple organs and systems. Cardiovascular, digestive and respiratory diseases can cause chest pain. A single condition usually reformulates and can cause this symptom, but a combination of conditions can also cause it. This case reports a 69-year-old male suffered from recurrent chest pain. Coronary heart disease, gastroesophageal reflux disease and left lung adenocarcinoma were diagnosed successively for nearly 1 year. The patients focus on one disease, and the medical staff neglects to deal with multiple diseases simultaneous

Ketamine as an Adjunct Therapy for Refractory Cancer Pain: A Case Report.

Adequate analgesia in patients with advanced cancer can pose a significant clinical challenge, particularly when refractory to conventional opioid-based therapies. Refractory cancer pain, characterized by inadequate relief despite optimized opioid regimens or intolerable side effects, often prompts alternative treatments to improve patient's quality of life. Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, may represent a useful adjunctive therapy due to its unique analgesic properties and potential to mitigate opioid tolerance and hyperalgesia. While traditionally recognized for …

Nationwide Survey of Pharmacist Involvement in Managing Cancer Pain in Children.

BACKGROUND: Cancer pain distresses pediatric patients, affects quality of life, and is a psychological burden for families. The purpose of this study was to clarify the role of pharmacists in assisting children with cancer pain and their families. METHODS: Between February and May 2024, a nationwide questionnaire survey was conducted among hospital pharmacists from the Japanese Society for Pharmaceutical Palliative Care and Sciences. The survey examined pharmacist involvement with children <15 years of age with cancer pain and their families, particularly in pain assessment, explaining analge…

Mesencephalotomy for the treatment of facial cancer pain: a systematic review of the literature.

AIMS: This systematic review aims to analyze and explore the risks, benefits, and efficacy of performing Mesencephalotomy in patients with unilateral facial pain secondary to cancer. METHODS: This study followed PRISMA guidelines and used the PubMed and "Biblioteca Virtual em Saúde" (BVS) databases. The risk of bias for all included studies was assessed individually with the "Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I)" tool. RESULTS: Six articles were included in this review. The surgical outcomes were promising, supporting the safety and efficacy of mesencephalotomy

Repetitive Transcranial Magnetic Stimulation: Is it an Effective Treatment for Cancer Pain?

Cancer is a major public health issue, with an estimated 20 million new cases and 9.7 million cancer-related deaths worldwide in 2022. Approximately 44.5% of patients experience cancer pain, significantly impacting their quality of life and causing physical and psychological burdens. Repetitive transcranial magnetic stimulation (rTMS), a non-invasive neuromodulation technique, shows potential in managing cancer pain. This review summarizes current research on rTMS for cancer pain, focusing on pain directly caused by tumors, pain from cancer treatments, postoperative pain, and cancer-related sy…

The effect of oral methadone on the QTc interval in cancer pain patients.

INTRODUCTION: The QTc prolongation effect of methadone has been extensively studied at higher doses commonly used in opioid dependence maintenance therapy, but evidence remains limited regarding its impact at the lower doses typically prescribed for cancer pain. This study aims to evaluate the effect of oral methadone on QTc intervals in cancer pain patients. METHODS: A retrospective analysis was performed on adult patients initiated on oral methadone therapy for cancer. Pre- and post-methadone QTc intervals, obtained within six months before and between six to twelve months after methadone i…

Effects of Opioids on Immune and Endocrine Function in Patients with Cancer Pain.

Opioids are an important treatment in managing cancer pain. Uncontrolled pain can be detrimental to function and quality of life. Common adverse effects of opioids such as sedation, constipation and nausea are well recognised, but opioid effects on the endocrine and immune systems are less apparent. The evidence for the immunomodulatory effects of opioids suggest that some opioids might be immunosuppressive and that their use might be associated with reduced survival and increased rates of infection in patients with cancer. However, the quality of this evidence is limited. Opioid-induced endoc…

Pain Treatment and Cancer Patients: Are we Heeding Quality of Life?

The use of opioid analgesics remains the primary therapy for pain control in cancer patients. However, ample evidence persists showing that treatment is still inadequate. This cross-sectional study was carried out during one year in a Brazilian Cancer Hospital to evaluate the impact of opioid use on analgesia and patients' quality of life. The Pain Management Index (PMI), EORTC QLQ.C30 (Quality of Life of Cancer Patients), Karnofsky Performance Status (KPS), Douleur Neuropathique 4 (DN4), and Brief Pain Inventory-Short Form (BPI-SF) were used. A hundred patients with advanced solid tumors and

Early Interventional Treatments for Patients with Cancer Pain: A Narrative Review.

Between 10% and 20% of patients with cancer-related pain cannot achieve adequate control following the three-step ladder guidelines by the World Health Organization. Therefore, a "fourth step", including interventional approaches, has been suggested for those cases. Systematic reviews support the early use of interventional procedures to treat refractory cancer pain, control symptoms and prevent opioid dose escalation. There is strong evidence of the efficacy of celiac plexus or splanchnic neurolysis, vertebroplasty, kyphoplasty and intrathecal drug delivery. Those procedures have been found t…