Результаты поиска

Chinese Herbal Medicine Is Helpful for Survival Improvement in Patients With Multiple Myeloma in Taiwan: A Nationwide Retrospective Matched-Cohort Study.

Aim of the studyThe purpose of this study is to demonstrate that Chinese herbal medicine is beneficial for survival improvement in patients with multiple myeloma.Materials and methodsWe performed a 1:1 propensity score-matched cohort study to analyze patients with multiple myeloma diagnosed between January 1, 2002, and December 31, 2012, through the Taiwanese National Health Insurance Research Database. Patients who received Chinese herbal medicine therapy from the initial date of diagnosis of multiple myeloma to December 31, 2012, were included in the Chinese herbal medicine group. Patients w

Совпадение в полном тексте источника
… Wolff), Mu-Dan-Pi ( Paeonia × suffruticosa Andrews), Ze-Xie ( Alisma orientale (Sam.) … Wolff), Shan-Yao ( Dioscorea opposita Thunb.), Mu-Dan-Pi ( Paeonia × suffruticosa Andrews), Ze-Xie ( Alisma orientale (Sam.) …

Anhydroicaritin suppresses tumor progression via the PI3K/AKT signaling pathway in hepatocellular carcinoma.

BackgroundHepatocellular carcinoma (HCC) is one of the most malignant tumors. The in vitro experiments on the application of Anhydroicaritin (AHI), the active ingredient of Bushen Huayu Decoction, in HCC treatment remain limited, particularly regarding its molecular mechanism.MethodsThe TCMSP platform was used for drug ingredient screening. The GeneCards database and DisGeNET database are used to collect liver cancer targets. PPI network construction of active component-target intersection target was completed with string database. The GO and KEGG pathway analyses were performed via bioinforma

Совпадение в полном тексте источника
… The active ingredients of Bushen Yangxue Huayu Decoction included Radix Rehmanniae, Eucommia ulmoides, Radix Paeoniae Alba, Radix Achyranthis, Radix Astragali, Herba Epimedii, Radix Angelicae Sinensis, Radix Carthamus, Caulis spatholobi, Cistanche deserticola, Rhizoma dogleg, and Radix Aucklandiae. … The active components of Radix Rehmanniae, Eucommia ulmoides, Radix Paeoniae Alba, Achyranthes bidentata, Radix Astragali, Epimedium, Angelica sinensis, safflower, Caulis spatholobi, Cistanche deserticola, Rhizoma dogleg and Radix Aucklandiae were retrieved respectively. …

Traditional herbal medicine for the prevention of chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis with association rule analysis.

IntroductionThis systematic review and meta-analysis evaluated the preventive efficacy and safety of orally-administered traditional herbal medicine (THM) for the management of chemotherapy-induced peripheral neuropathy (CIPN) in patients with cancer.MethodsRandomized controlled trials (RCTs) evaluating the efficacy of orally-administered THM in the prevention of CIPN published up to 30 April 2024 were retrieved from nine databases. The primary outcome was the incidence of CIPN, and the secondary outcomes included changes in neuropathic pain intensity, nerve conduction study parameters, Karnof

Совпадение в полном тексте источника
… [Lauraceae ; Cinnamomi Ramulus] | 24 | 6.92 | 14.70 Paeonia lactiflora Pall. [Paeoniaceae ; Paeoniae Radix Alba] | 18 | 5.19 | 19.89 Ziziphus jujuba Mill. … Kosterm [ Lauraceae ; Cinnamomi Ramulus] , and P. lactiflora Pall. [ Paeoniaceae ; Paeoniae Radix Alba] , and A. mongholicus Bunge [ Fabaceae ; Astragali Radix] and P. lactiflora Pall [ Paeoniaceae ; Paeoniae Radix Alba] ( Figure 12 ). …

Clinical antitumor application and pharmacological mechanisms of Dahuang Zhechong Pill.

Cancer still has elevated morbidity and mortality, which undoubtedly impacts the life quality of affected individuals. Remarkable advances have been made in cancer therapy, although the toxicities of traditional therapies remain an obvious challenge. Dahuang Zhechong Pill (DHZCP), developed by Zhongjing Zhang in the Synopsis of the Golden Chamber, represents an effective anticancer traditional Chinese medicine (TCM). In this review, it was found that DHZCP is therapeutically utilized in liver, lung, gastric, pancreatic and other cancers in clinic. Pharmacological evidence showed that its anti-

Совпадение в полном тексте источника
… Fig. 5 Chemical structures of components 52–64 from Paeoniae Radix Alba. Fig. 6 Chemical structures of components 65–78 from Glycyrrhizae Radix et Rhizoma. Fig. 7 Chemical structures of components 79–129 from animal medicines. Fig. 8 Chemical structures of other components 130–140. … Fig. 5 Chemical structures of components 52–64 from Paeoniae Radix Alba. Fig. 6 Chemical structures of components 65–78 from Glycyrrhizae Radix et Rhizoma. Fig. 7 Chemical structures of components 79–129 from animal medicines. Fig. 8 Chemical structures of other components 130–140. …

A systems-pharmacology analysis of herbal medicines used in health improvement treatment: predicting potential new drugs and targets.

For thousands of years, tonic herbs have been successfully used all around the world to improve health, energy, and vitality. However, their underlying mechanisms of action in molecular/systems levels are still a mystery. In this work, two sets of tonic herbs, so called Qi-enriching herbs (QEH) and Blood-tonifying herbs (BTH) in TCM, were selected to elucidate why they can restore proper balance and harmony inside body, organ and energy system. Firstly, a pattern recognition model based on artificial neural network and discriminant analysis for assessing the molecular difference between QEH an

Совпадение в полном тексте источника
… Except for Angelica sinensis , other herbs which have effect of blood-tonifying are Radix paeoniae alba , Polygonum multiflorum , and Rehmannia glutinosa . … Disease | TCM | Molecular | Target | Reference* Regulate hemopoietic growth factor | Radix paeoniae alba | Albiflorin | PKC α | Radix paeoniae alba | Paeonioflorin | IL-6, LBP, PKC α , TNF | Angelica sinensis | Ferulic acid | ADRA2A, PTGER4, SHP-2, F2, TUBB1 | Angelica sinensis | ligustilide | SOD1 …

Paeoniflorin Modulates TREM-1/NF-κB/LXRα/ABCG1 Pathway to Improve Cholesterol Metabolism and Inflammation in Hyperlipidemic Rat.

This study aimed to systematically elucidate the antihyperlipidemic mechanism of paeoniflorin, and we adopted an integrated multi-omics strategy to screen the key molecular targets and regulatory pathways involved in its action, followed by experimental validation to verify the potential regulatory effects of paeoniflorin on the screened targets and metabolic processes. Rats with high-fat diet-induced hyperlipidemia received paeoniflorin treatment. Liver histopathology was evaluated using hematoxylin-eosin and Oil Red O staining. Serum levels of total cholesterol, triglycerides, low-density li

Effect of Guanxin No.2 decoction on gene expression in different areas of the myocardial infarcted heart of rats using microarray technology.

OBJECTIVES: We have used microarray technology to detect the effect of Guanxin No.2 decoction on gene expression in different areas of the myocardial infarcted heart of rats. METHODS: Male Sprague-Dawley rats (180-200 g) were randomly divided into three groups: sham-operated; coronary artery ligation; and coronary artery ligation plus administration of Guanxin No.2 decoction (10.0 g raw materials/kg per day by gavage). The experiment was carried out on day seven after ligation. KEY FINDINGS: We found that the gene expression using microarray technology showed many differences in the border i

[Depression Syndrome Typing and Medication Pattern Analysis Through Unsupervised Clustering Combined With Latent Structure Dual Analysis].

OBJECTIVE: Depression, a most common psychiatric disease, is defined in Traditional Chinese Medicine (TCM) as Yu Syndrome, i.e., depression … nia and a depressed mood. Medication frequency analysis showed that Radix Bupleuri (Chai Hu), Radix Paeoniae Alba (Bai Shao), Poria (Fu Ling), Rhizoma Chuanxiong (Chuan Xiong), and Radix Curcumae (Yu Jin) were the most commonly used TCM herbs. For the depression sub-types of Clusters 1, 2, and 6, blood-activating and stasis-dissolving herbs were used most …

[Effect of herbal cake-separated moxibustion on behavioral stress reactions and blood lactic acid level and muscular AMPK/PGC-1α signaling in rats with chronic fatigue syndrome].

OBJECTIVE: To observe the effect of herbal cake-separated moxibustion (HCSM) on serum lactic acid (BLA) level and AMPK/PGC-1α signaling path … Xiaoyao Powder (Mental Ease Powder, composed of [Danggui (Radix Angelicae Sinensis), Baishao (Radix Paeoniae Alba), Chaihu (Radix Bupleuri), Fuling (Poria), Baizhu (Rhizoma Atractylodis, Macrocephalae), etc.]. The HCSM was applied to "Shenque" (CV8), "Guanyuan "(CV4), bilateral "Zusanli" (ST36) and "Qimen" (LR14), 5 moxa-cones for each acupoint, once dail …

The therapeutic effect of modified Huangqi Guizhi Wuwu Tang for multiple myeloma: An 18-year follow-up case report.

RationaleMultiple myeloma (MM) is a hematologic malignancy characterized by proliferation of clonal plasma cells in the bone marrow. The median survival has increased to 6 years in recent years. But MM remains incurable. Some studies about the effects of Chinese herb medicine on MM have been carried out. Long survival in MM patients through Traditional Chinese Medicine (TCM) therapies has been reported rarely before.Patient concernsWe report a case of a female patient who was diagnosed with MM in 2000 at the age of 49. She received 9 cycles of multiple chemotherapeutic regimens mainly based on

Совпадение в полном тексте источника
… The basic prescription is composed of Radix Astragali, Ramulus cinnamomi, Radix Paeoniae Alba, Common Ginger Rhizome, Common Jujube Fruit, Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae, Poria Cocos, Rhizoma Alismatis, and Polyporus umbellatus. … When monkshood was added, the modified prescription included another classical Chinese prescription, Zhen Wu Tang (monkshood, Poria Cocos, Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba, Common Ginger Rhizome), also recorded in Shanghan Lun. …

Herbal Medicine Ninjin'yoeito in the Treatment of Sarcopenia and Frailty.

Frailty and sarcopenia have recently gained considerable attention in terms of preventive care in Japan, which has an ever-increasing aging population. Sarcopenia is defined as atrophy of skeletal muscles caused by the age-related decrease in growth hormone/insulin-like growth factor and sex hormones. The Japanese Ministry of Health, Labor and Welfare reports that frailty can lead to impairment of both mental and physical functioning. Chronic diseases such as diabetes and dementia may underlie frailty. It is important to prevent progression of frailty and extend the healthy lifespan. In herbal

Совпадение в полном тексте источника
… Anti-inflammatory and immunomodulatory effects of Paeonia lactiflora pall. A traditional Chinese herbal medicine . Front Pharmacol . ( 2011 ) 2 : 10 . 10.3389/fphar.2011.00010 21687505 PMC3108611 54. Bae J Kim C Kim H Park J Ahn M . … Differences in the chemical profiles and biological activities of Paeonia lactiflora and Paeonia obovata . J Med Food ( 2015 ) 18 : 224 – 32 . 10.1089/jmf.2014.3144 25299493 PMC4312797 55. Kitagawa I Nishimura T Furubayashi A Yoshioka I . …

[Modified Shaoyao Gancao decoction()alleviates post-spinal cord injury muscle spasticity by regulating the lncRNA H19/miR-185-5p/Tph1 axis].

OBJECTIVE: To investigate the biological mechanisms underlying the therapeutic effect of modified Shaoyao Gancao decoction () in alleviating … significant differences;however, in the modified Shaoyao Gancao decoction (), compounds related to Paeonia exhibited higher responses, while those related to Glycyrrhiza demonstrated reduced responses. ②At 2 weeks post-administration, the BBB score was 10.000±1.291 in the drug-treated group and 9.667±1.633 in the positive control group, both significantl …

New and Interesting Fungi. 8.

Eight new genera, 28 new species, four epitypes, two lectotypes, and 21 interesting new host and / or geographical records are introduced in … dulosetulata (on bark of woody host, Germany), Mjuua pseudoclavispora (in association with Fusarium paeoniae and a bacterium, on dead fruit of Alnus glutinosa, Germany), Monilinia yunnanensis (on fruit of Prunus persica, China), Niesslia goniomae (on leaf of Gonioma kamassi, South Africa), Nothoniesslia solidaginis (on dead stems of Solidago sp., Germany) …

[Effects of Li-Dan-He-Ji on regulating oxidative stress and antagonising infantile cholestatic hepatic fibrosis].

OBJECTIVE: To explore the clinical effect of Li-Dan-He-Ji in the treatment of infantile cholestatic hepatic fibrosis. METHODS: Patients who … ae, Fructus Forsythiae, Radix et Rhizoma Rhei preparata, Radix Polygoni Multiflori Preparata, Radix Paeoniae Rubra, Ramulus Cinnamomi, Fructus Aurantii, Rhizoma Atractylodis Macrocephalae, Fructus Schisandrae Chinensis, Carapax Trionycis, and Radix Glycyrrhizae) was given on the basis of the routine treatment, by oral, enema or nasal feeding, 60 mL each d …

SFRP5 inhibits melanin synthesis of melanocytes in vitiligo by suppressing the Wnt/β-catenin signaling.

Secreted frizzled-related protein 5 (SFRP5) plays a pivotal role in regulating the development of many tissues and organs, however, as an inhibitor of Wnt signaling, the role of SFRP5 in vitiligo remains unknown. Hence, we speculated that SFRP5 might be associated with melanogenesis in melanocytes by regulating Wnt signaling in vitiligo. In this study, we found that SFRP5 was overexpressed in the skin lesions of patients with vitiligo. Compared with that in normal epidermal melanocytes (PIG1), the expression of SFRP5 was increased in vitiligo melanocytes (PIG3V). To investigate the effect of S

Совпадение в полном тексте источника
… Flower extracts from Paeonia decomposita and Paeonia ostii inhibit melanin synthesis via cAMP-CREB-associated melanogenesis signaling pathways in murine B16 melanoma cells. J Food Biochem. 2019;43(4) doi: 10.1111/jfbc.12777. 41. Xie H., Zhou F., Liu L. …

Proteomics and transcriptomics explore the effect of mixture of herbal extract on diabetic wound healing process.

BACKGROUND: The annual incidence of diabetic foot ulcers (DFUs) has been reported to vary from 0.2% to 11% in diabetes-specific clinical set … an affordable, non-surgical method to treat diabetic ulcers. Extracts of bark of Bauhinia purpurea, Paeoniae rubrae, Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav. (Hoffm.) Benth. & Hook.f. ex Franch. & Sav., Acorus calamus L, and Radix Angelicae biseratae have been used as traditional remedies to treat inflammation-related diseases and cut …

Модуляторные эффекты традиционной китайской медицины и производные активных метаболитов на аутоиммунально-воспалительных путях сигнала при множестве склерозов: обзор повествования.

Множественный склероз (MS) — нервно-воспалительное заболевание с иммунной помощью, характеризующееся обезвоживанием, аксоновой травмой и обширным разрушением целостности центральной нервной системы. Экспериментальный аутоиммунный энцефаломиэлит (EAE) — наиболее часто применяемая модель для имитации патологических особенностей человека. В настоящее время еще многое предстоит сделать для совершенствования стратегии лечения MS. Все больше исследований показывают, что традиционная китайская медицина (TCM) и связанные с ней активные метаболиты полезны для лечения MS и умело регулируют уровни подстр

Совпадение в полном тексте источника
… Bhandari | Myrrha | Oleo-gum resin | ( Kumar et al., 2021 ) Monoterpene glycoside | Paeoniflorin | Paeonia lactiflora Pall. | Paeoniae radix rubra | Dry roots | ( Zhang et al., 2017 ) Chinese botanical drugs | Frankincense | Boswellia sacra Flück. | Olibanum | Aromatic oil-containing resin | ( Stürner … It is formulated with Astragali Radix , Cinnamomi Ramulus , Paeoniae Radix Alba , Zingiberis Rhizoma Recens and Jujubae Fructus to produce a synergistic effect. …

Paeoniflorin Ameliorates BiPN by Reducing IL6 Levels and Regulating PARKIN-Mediated Mitochondrial Autophagy.

BACKGROUND: Bortezomib-induced peripheral neuropathy (BiPN) is a common complication of multiple myeloma (MM) treatment that seriously affects the quality of life of patients. The purpose of the present study was to explore the therapeutic effect of paeoniflorin on BiPN and its possible mechanism. METHODS: ELISA was used to measure the level of interleukin-6 (IL6) in the plasma of MM patients, and bioinformatics analysis was used to predict the mechanism underlying the effect of paeoniflorin on peripheral neuropathy. Cell and animal models of BiPN were constructed to evaluate mitochondrial fu

Совпадение в полном тексте источника
… Regarding neurological effects, IL6 has been shown to cause neuroinflammation in Parkinson’s disease patients by interfering with PARKIN and PINK1-mediated mitophagy. 20 Paeoniflorin is a biologically active compound purified from the Chinese herbal medicine plant Paeonia lactiflora and has been proven … Paeoniflorin, a water-soluble monoterpene glycoside, is the main bioactive component of Paeonia lactiflora Pall. 42 Paeoniflorin has been shown to display a wide spectrum of pharmacological effects, including anti-inflammatory, immunoregulatory, 43 antitumor, 44 and neuroprotective 45 , 46 effects, which …

Predicting and Quantifying Antagonistic Effects of Natural Compounds Given with Chemotherapeutic Agents: Applications for High-Throughput Screening.

Natural products have been used for centuries to treat various human ailments. In recent decades, multi-drug combinations that utilize natural products to synergistically enhance the therapeutic effects of cancer drugs have been identified and have shown success in improving treatment outcomes. While drug synergy research is a burgeoning field, there are disagreements on the definitions and mathematical parameters that prevent the standardization and proper usage of the terms synergy, antagonism, and additivity. This contributes to the relatively small amount of data on the antagonistic effect

Совпадение в полном тексте источника
… fruits, vegetables, berries, herbs | Bortezomib | Multiple myeloma | Blocked the anticancer activity of bortezomib by direct chemical interaction with its boronic acid moiety | U266- 6.70/3.08/4.22 RPMI/8226-11.39/3.34/8.54 MC/CAR-27.24/6.94/4.97 (TA/GA/CA) | [ 36 ] Si-Wu-Tang | | Combination: Radix Paeoniae … Si-Wu-Tang (SWT) Si-Wu-Tang (SWT) is a form of traditional Chinese medicine comprised of the combined extracts from four herbs: Radix Paeoniae Alba (bai shao yao), Rhizoma Ligusticum Chuanxiong (chuan xiong), Radix Angelica Sinensis (dang gui), and Radix Rehmanniae Preparata (shu di huang). …

The clinical effectiveness and safety of traditional Chinese medicine uremic clearance granule combined with high-flux hemodialysis in the treatment of uremic pruritus: A protocol for systematic review and meta analysis.

BackgroundSkin pruritus is a common complication in patients with uremia. When the hemodialysis time of patients is extended, and the probability of skin pruritus is greater. Patients often have the symptoms of skin pruritus intolerable, affecting the normal sleep and normal life of patients. The patients with uremic pruritus often constant scratching and pruritus skin, resulting in broken skin, and further symptoms such as infection, and subsequent skin shedding, prurigo nodularis, and other adverse complications, aggravating the patient's condition. Some patients will experience symptoms suc

Совпадение в полном тексте источника
… The composition of the drug is as follows: plantain, mulberry white, ginger pinellia, rhubarb, atractylodes, polygonum multiflorum, astragalus, salvia miltiorrhiza, sophora flavescens, ligusticum wallichii, poria cocos, radix paeoniae alba. …