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Measuring the Unseen Burden: Immunotherapy and Targeted Therapy Reduce Treatment-Related Time Toxicity in Incurable Malignancies.

BackgroundTreatment-related time toxicity (TrTT) poses a cumulative burden on quality of life. We aimed to analyze and quantify the impact of the TrTT on patients with incurable malignancies in our ambulatory oncology clinic.MethodsWe performed a retrospective observational analysis of the TrTT for individuals with incurable solid cancers at a regional safety-net oncology office that focuses on underserved communities. Time toxicity is calculated as the number of days a patient spent with any healthcare-related encounters during the initial 12-week period of the most recent line of therapy fro

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… intelligence Centers for Disease Control and Prevention Eastern Cooperative Oncology Group US Food and Drug Administration National Comprehensive Cancer Network progression-free survival treatment-related time toxicity References 1 Baltussen JC Cardenas-Reyes P Chavarri-Guerra Y Ramirez-Fontes A Morales-Alfaro …

Stem cell therapy as a potential treatment option for psoriasis.

Psoriasis is a chronic inflammatory dermatological disorder characterized by white scales and clearly demarcated erythematous plaques. The prevalence of psoriasis varies from country to country and can occur at any age, implying that ethnicity, environmental factors, and genetic background all play a role in its onset. According to the World Psoriasis Day Consortium, 125 million people globally and 2%-3% of the overall community have psoriasis. The introduction of biological treatments has revolutionized the treatment of moderate to severe psoriasis. These novel drugs, particularly those targe

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… Castro-Manrreza M.E., Bonifaz L., Castro-Escamilla O., Monroy-García A., Cortés-Morales A., Hernández-Estévez E., et al. Mesenchymal Stromal Cells from the Epidermis and Dermis of Psoriasis Patients: Morphology, Immunophenotype, Differentiation Patterns, and Regulation of T Cell Proliferation. …

Breakthrough COVID-19 in Vaccinated Patients with Haematologic Malignancies-The First Single-Centre Experience from the Czech Republic.

Vaccination is an important tool in the fight against the COVID-19 pandemic in patients with haematologic malignancies. The paper provides an analysis of the course of breakthrough SARS-CoV-2 infection in a group of vaccinated patients with haematological malignancy and a comparison with a historical cohort of 96 non-vaccinated patients with haematologic malignancies and bone marrow failure syndromes (two patients) in the treatment of COVID-19. A severe or critical course of COVID-19 was significantly less frequent in the group of vaccinated patients (10.2% vs. 31.4%, p = 0.003). The need for

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… Morales M. Ziv-Baran T. Arbel Y.S. Scarfò L. Efficacy of the BNT162b2 mRNA COVID-19 vaccine in patients with chronic lymphocytic leukemia Blood 2021 137 3165 3173 10.1182/blood.2021011568 33861303 PMC8061088 19. Greenberger L.M. Saltzman L.A. Senefeld J.W. Johnson P.W. DeGennaro L.J. Nichols G.L. …

The EPICURE study: a pilot prospective cohort study of heterogeneous and massive data integration in metastatic breast cancer patients.

BackgroundBreast cancer is the most common cancer in women and the first cancer concerning mortality. Metastatic breast cancer remains a disease with a poor prognosis and about 30% of women diagnosed with an early stage will have a secondary progression. Metastatic breast cancer is an incurable disease despite significant therapeutic advances in both supportive cares and targeted specific therapies. In the management of a metastatic patient, each clinician follows a highly complex and strictly personal decision making process. It is based on a number of objective and subjective parameters whic

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… Krop IE Mayer IA Ganju V Dickler M Johnston S Morales S Yardley DA Melichar B Forero-Torres A Lee SC de Boer R Petrakova K Vallentin S Perez EA Piccart M Ellis M Winer E Gendreau S Derynck M Lackner M Levy G Qiu J He J Schmid P Pictilisib for oestrogen receptor-positive, aromatase inhibitor-resistant …

Evolving treatment strategies for myeloma.

In this article, we will discuss how treatment strategies for myeloma have evolved and outline the challenges now faced following the introduction of a number of novel active agents. In particular, we will focus on how achieving a maximum response and maintaining such responses is becoming a key therapeutic strategy and how novel agents can be used to achieve this in the context of current strategies such as autologous transplantation.

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… Cancer Res 61 : 3071 –3076 11306489 Lahuerta JJ, Martinez-Lopez J, Serna JD, Blade J, Grande C, Alegre A, Vazquez L, Garcia-Larana J, Sureda A, Rubia JD, Conde E, Martinez R, Perez-Equiza K, Moraleda JM, Leon A, Besalduch J, Cabrera R, Miguel JD, Morales A, Garcia-Ruiz JC, Diaz-Mediavilla J, San-Miguel …

Bioengineered Mesenchymal Stem/Stromal Cells in Anti-Cancer Therapy: Current Trends and Future Prospects.

Mesenchymal stem/stromal cells (MSCs) are one of the most widely used cell types in advanced therapies due to their therapeutic potential in the regulation of tissue repair and homeostasis, and immune modulation. However, their use in cancer therapy is controversial: they can inhibit cancer cell proliferation, but also potentially promote tumour growth by supporting angiogenesis, modulation of the immune milieu and increasing cancer stem cell invasiveness. This opposite behaviour highlights the need for careful and nuanced use of MSCs in cancer treatment. To optimize their anti-cancer effects,

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… Morales-Molina A. Gambera S. Cejalvo T. Moreno R. Rodriguez-Milla M.A. Perise-Barrios A.J. Garcia-Castro J. Antitumor virotherapy using syngeneic or allogeneic mesenchymal stem cell carriers induces systemic immune response and intratumoral leukocyte infiltration in mice Cancer Immunol. Immunother. … Morales-Molina A. Gambera S. Leo A. Garcia-Castro J. Combination immunotherapy using G-CSF and oncolytic virotherapy reduces tumor growth in osteosarcoma J. Immunother. Cancer 2021 9 e001703 10.1136/jitc-2020-001703 33737338 PMC7978281 159. Rincon E. Cejalvo T. Kanojia D. Alfranca A. …

The Impact and Molecular Mechanisms of Exercise in Cancer Therapy.

Cancer is a major global health issue, and exercise has become a key supportive treatment. It contributes to reducing cancer risk, enhancing prognosis, and aiding recovery, especially for survivors. However, the exact mechanisms, such as how exercise reduces cancer risk or enhances treatment, are still unclear. Current research often focuses on specific cancer types, ignoring the diverse needs of patients. This limits the development of personalized exercise plans. Additionally, there is insufficient comparison of exercise types-like aerobic, resistance, and high-intensity interval training-re

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… Arroyo-Morales M. Effectiveness of Lumbopelvic Exercise in Colon Cancer Survivors: A Randomized Controlled Clinical Trial Med. Sci. Sports Exerc. 2016 48 1438 1446 10.1249/MSS.0000000000000917 27015381 118. Wendler A. Wehling M. …

If treating obesity with GLP-1-based therapies protects the heart, could it also prevent cancer or improve cancer outcomes? The case for randomized trials.

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… Morales DR, Bu F, Viernes B, et al. Risk of thyroid tumors with GLP‐1 receptor agonists: a retrospective cohort study. Diabetes Care. 2025;48(8):1386‐1394. doi: 10.2337/dc25-0154 11. Abdelmalek MF, Harrison SA, Sanyal AJ. …

Налтрексон для острого управления навязчивыми сексуальными и одержимыми симптомами у пациента с неевроразвитым расстройством.

Навязчивое сексуальное расстройство (CSBD) характеризуется постоянной сложностью контроля за сексуальными желаниями и поведением, связанным с явными расстройствами или расстройствами. Данные, основанные на населении, свидетельствуют о том, что ~8.6% , взрослых американцев испытывают трудности, связанные с борьбой с сексуальными желаниями, чувствами и поведением, в то время как крупные международные исследования в области скрининга показывают, что ~5% ОСББ может подвергаться высокому риску, однако лишь меньшинство обращается за лечением. Диагностическая классификация по-прежнему сопряжена с тру

Воздействие общей стигматизации населения на вступление в брак у пациентов, у которых диагностирован множественный склероз: перекрестное исследование.

Множественный склероз (MS) представляет собой долгосрочное состояние, затрагивающее центральную нервную систему, которое обычно проявляется у молодых людей. Стигма создает серьезные психосоциальные проблемы для пациентов с НР, что негативно сказывается на их личной и общественной жизни. Вместе с тем в ограниченных исследованиях рассматривается вопрос о том, каким образом стигматизация, связанная с НР, влияет на брак. Это исследование было посвящено не состоящим в браке лицам в возрасте 20-40 лет в Иране, с тем чтобы определить распространенность общественного осуждения и их готовность выйти за

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… Similarly, Morales-Gonzalez’s study of 371 Spanish patients reported a 31% incidence of divorce and separation after 10 years [ 34 ]. …

К крупномасштабным квантовым оптимистам с небольшим количеством кубиков.

Квантовые компьютеры обещают более эффективные комбинаторные оптимизирующие решения, которые могут изменить игру для широкого круга приложений. Однако одним из узких мест для материализации таких преимуществ является то, что для того, чтобы бросить вызов классическим алгоритмам на практике, основные подходы требуют ряда кубитов непомерно больших размеров для краткосрочного оборудования. Здесь мы введем вариационное решение проблем MaxCut на m=O(nk) бинарные переменные, используя только n квиты, с тунцом k > 1. Количество параметров и глубина цепи демонстрируют мягкие линейные и подлинейные диа

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… Akshay V Philathong H Morales M Biamonte J Reachability deficits in quantum approximate optimization Phys. Rev. Lett. 2020 124 090504 10.1103/PhysRevLett.124.090504 32202873 Akshay, V., Philathong, H., Morales, M. & Biamonte, J. Reachability deficits in quantum approximate optimization. Phys. Rev. …

Autoimmune Rheumatic Diseases and Vascular Function: The Concept of Autoimmune Atherosclerosis.

Autoimmune rheumatic diseases (AIRDs) with unknown etiology are increasing in incidence and prevalence. Up to 5% of the population is affected. AIRDs include rheumatoid arthritis, system lupus erythematosus, systemic sclerosis, and Sjögren's syndrome. In patients with autoimmune diseases, the immune system attacks structures of its own body, leading to widespread tissue and organ damage, which, in turn, is associated with increased morbidity and mortality. One third of the mortality associated with autoimmune diseases is due to cardiovascular diseases. Atherosclerosis is considered the main un

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… Etchegaray-Morales I. Morales-Sánchez H. Berra-Romani R. Cervera R. Endothelial dysfunction and arterial stiffness in patients with systemic lupus erythematosus: A systematic review and meta-analysis Atherosclerosis 2020 297 55 63 10.1016/j.atherosclerosis.2020.01.028 32078830 130. Thompson T. …

Cannabis, One Health, and Veterinary Medicine: Cannabinoids' Role in Public Health, Food Safety, and Translational Medicine.

Public health is connected to cannabis with regard to food, animal feed (feed), and pharmaceuticals. Therefore, the use of phytocannabinoids should be examined from a One Health perspective. Current knowledge on medical cannabis treatment (MCT) does not address sufficiently diseases which are of epidemiological and of zoonotic concern. The use of cannabinoids in veterinary medicine is illegal in most countries, mostly due to lack of evidence-based medicine. To answer the growing need of scientific evidence-based applicable medicine in both human and veterinary medicine, a new approach for the

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… Hernández-Cervantes R, Méndez-Díaz M, Prospéro-García Ó, Morales-Montor J. Immunoregulatory role of cannabinoids during infectious disease. Neuroimmunomodulation. 2017;24:183–99. doi: 10.1159/000481824. 100. Croxford JL, Wang K, Miller SD, Engman DM, Tyler KM. … In: Rodriguez-Morales AJ, editor. Current Topics in Neglected Tropical Diseases. London, UK: IntechOpen Limited; 2019. 119. Cortes S, Afonso MO, Alves-Pires C, Campino L. Stray dogs and leishmaniasis in urban areas, Portugal. Emerg Infect Dis. 2007;13:1431–2. doi: 10.3201/eid1309.070101. 120. …

Pathogenic Mechanisms of Myeloma Bone Disease and Possible Roles for NRF2.

Osteolytic bone lesions are one of the central features of multiple myeloma (MM) and lead to bone pain, fractures, decreased quality of life, and decreased survival. Dysfunction of the osteoclast (OC)/osteoblast (OB) axis plays a key role in the development of myeloma-associated osteolytic lesions. Many signaling pathways and factors are associated with myeloma bone diseases (MBDs), including the RANKL/OPG and NF-κB pathways. NRF2, a master regulator of inflammatory signaling, might play a role in the regulation of bone metabolism via anti-inflammatory signaling and decreased reactive oxygen s

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… Pellegrini G.G., Cregor M., McAndrews K., Morales C.C., McCabe L.D., McCabe G.P., Peacock M., Burr D., Weaver C., Bellido T. Nrf2 regulates mass accrual and the antioxidant endogenous response in bone differently depending on the sex and age. … Ortiz-Ruiz A., Ruiz-Heredia Y., Samur M., Aguilar-Garrido P., Morales M.L., Valeri A., Garcia-Ortiz A., Barrio S., Bárcena C., Garcia-Martin R.M. Increase of Mitochondrial Activity Contributes to the Bortezomib-Relapsed in Multiple Myeloma, a Novel Therapeutic Opportunity. …

Storage diseases with hypertrophic cardiomyopathy phenotype.

Never judge a book by its cover, nor assume hypertrophic cardiomyopathy (HCM) as sarcomeric, as appearances can deceive. HCM phenocopies account for a 5-10% of the cases, mainly represented by storage diseases, flagged by the increasing prevalence of senile cardiac amyloid in developing countries. Multisystemic and heterogeneous presentation of these entities is a challenge for clinicians, and time delay in diagnosis is a major concern. Promising drugs and gene-specific tailored therapies are under development, therefore, more than ever, appropriate understanding of these conditions is mandato

Porphyromonas gingivalis поощряет передачу Т-клеток через канал сигнала NF-_B/CXCR3 в экспериментальном аутоиммунном энцефаломиелите.

Множественный склероз (MS) является хроническим аутоиммунным заболеванием центральной нервной системы (CNS); его моделью является экспериментальный аутоиммунный энцефаломиелит (EAE). Периодонтит с участием Porphyromonas gingivalis (P. gingivalis) был связан с MS и продемонстрировал, что он усугубляет EAE, однако механизмы остаются неясными. МЕТОДЫ: Мыши были случайны four группы (n = 8): контроль, только периодонтит, только EAE и EAE с периодонитом. Ежедневно проводилась оценка неврологического дефицита. Спинальный CD4+ и CD4+CXCR3+ T-фильтрация и активация NF-_B были оценены иммунофлюоресценц

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… J Clin Periodontol. 2020;47:268–288. doi: 10.1111/jcpe.13189 [26] Baeza M, Morales A, Cisterna C, et al. Effect of periodontal treatment in patients with periodontitis and diabetes: systematic review and meta-analysis. … Sci Rep. 2024;14:6222. doi: 10.1038/s41598-024-56849-x [34] Nuñez-Belmar J, Morales-Olavarria M, Vicencio E, et al. Contribution of -Omics technologies in the study of Porphyromonas gingivalis during periodontitis pathogenesis: a minireview. …

Oxidative Stress in Multiple Myeloma: Pathogenic Mechanisms, Biomarkers, and Redox-Targeted Therapeutic Strategies.

Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by high metabolic activity, chronic endoplasmic reticulum stress, and persistent redox imbalance. Excessive immunoglobulin synthesis and adaptation to the hypoxic bone marrow microenvironment lead to sustained production of reactive oxygen species (ROS). Their excessive accumulation promotes genomic instability, disease progression, osteolytic bone disease, and resistance to therapy. Paradoxically, MM cells adapt to oxidative stress by activating antioxidant and metabolic defense mechanisms, including Nuclear factor ery

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… Morales M.L. Gómez-Gordo R. Justo P. Cuéllar C. Sánchez-Pina J. López N. Alonso R. Short-Chain Fatty Acid Production by Gut Microbiota Predicts Treatment Response in Multiple Myeloma Clin. Cancer Res. 2023 30 904 917 10.1158/1078-0432.CCR-23-0195 PMC10870002 38109212 98. Wang Y. Yang Q. Zhu Y. … Morales M.L. Guevara-Ramirez P. Justo P. López-Muñoz N. Microbiota-Derived Urolithin A in Monoclonal Gammopathies and Multiple Myeloma Therapy Microbiome 2025 13 56 10.1186/s40168-025-02045-6 40022244 PMC11869585 116. Iglesias-Aguirre C.E. Romo-Vaquero M. Selma M.V. Espín J.C. …

Enhanced sialylation of bone marrow mesenchymal stromal cells contributes to immune remodeling through macrophage polarization in multiple myeloma patients.

INTRODUCTION: In multiple myeloma (MM), the immune system is disrupted, partly due to tumor-modified bone marrow mesenchymal stromal cells (BM-MSCs). These MSCs show altered glycosylation, including increased sialylation, which may promote immune evasion through Siglec interactions. METHODS: We quantified sialic acids and Siglec ligands on healthy donors-, MM-, T-MM-(treated multiple myeloma) and MGUS (monoclonal gammopathy of undetermined significance)-MSCs, and examined how different culture conditions (myeloma coculture, conditioned medium, hypoxia, inflammation, 3D culture) affect MSC gly

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… Cortés-Morales VA, Vázquez-González WG, Montesinos JJ, Moreno-Ruíz L, Salgado-Pastor S, Salinas-Arreola PM, et al. Human bone marrow mesenchymal stem cells promote the M2 phenotype in macrophages derived from STEMI patients. Int J Mol Sci. (2023) 24:16257. doi: 10.3390/ijms242216257 50. … Bautista-Sebastián E, Cortés-Morales VA, Fajardo-Orduña GR, Monroy-García A, Castro-Manrreza ME, Saucedo-Campos AD, et al. Interaction between mesenchymal stromal cells and tumor cells present in cervical cancer influences macrophage polarization. …

What Cardiologists Should Know About Amyloidosis.

Background: Cardiac amyloidosis (CA) is an increasingly recognized but historically underdiagnosed cause of restrictive cardiomyopathy and heart failure with preserved ejection fraction (HFpEF). It results from the extracellular deposition of misfolded protein fibrils, most commonly transthyretin (ATTR) or immunoglobulin light chains (AL), leading to progressive myocardial dysfunction and multi-organ involvement. Objective: This review provides a comprehensive, cardiology-centered overview of cardiac amyloidosis, with an emphasis on early recognition, diagnostic strategies, subtype differentia

Understanding In-Person and Online Exercise Oncology Programme Delivery: A Mixed-Methods Approach to Participant Perspectives.

Alberta Cancer Exercise (ACE) is an exercise oncology programme that transitioned from in-person to online delivery during COVID-19. The purpose of this work was to understand participants' experiences in both delivery modes. Specifically, survivors' exercise facilitators and barriers, delivery mode preference, and experience with programme elements targeting behaviour change were gathered. A retrospective cohort design using explanatory sequential mixed methods was used. Briefly, 57 participants completed a survey, and 19 subsequent, optional interviews were conducted. Most participants indic

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… Galiano-Castillo N., Cantarero-Villanueva I., Fernández-Lao A., Ariza-García L., Díaz-Rodríguez R., Del-Moral-Ávila R. … Sagarra-Romero L., Butragueño J., Gomez-Bruton A., Lozano-Berges G., Vincente-Rodríguez G., Morales J.S. Effects of an online home-based exercise intervention on breast cancer survivors during COVID-19 lockdown: A feasibility study. Support. …