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Effects of Taraxacum mongolicum Hand.-Mazz. (dandelion) on growth performance, expression of genes coding for tight junction protein and mucin, microbiota composition and short chain fatty acids in ileum of broiler chickens.

BACKGROUND: Dandelion is becoming an exploitable alternative to the widely prohibited antibiotics in the poultry production. This research a … ative abundance of Lactobacillus in LD and CTC group were increased (P < 0.05), while Bacteroidete, Bacteroides, and Alistipes relative abundance in dandelion and CTC groups were decreased (P < 0.05). On day 42, the Actinobacteriota relative abundance in CTC group tended to be higher (P = 0.05), and Lysinibacillus relative abundance of CTC group was higher (P …

Effects of vaginal seeding on gut microbiota, body mass index, and allergy risks in infants born through cesarean delivery: a randomized clinical trial.

BACKGROUND: Vaginal seeding-exposure of neonates to maternal vaginal fluids-has been proposed to improve the microbiota of infants born thro … 48). For infants from the vaginal seeding group, the relative abundance of genera Lactobacillus and Bacteroides in the gut microbiota was slightly yet nonsignificantly elevated at birth and 6 months, and the risk of overweight/obesity was lower at 6 months (0/57 vs 6/59; relative risk, 0.03 [95% confidence interval, 0.00-0.57]; P=.03) though not at subsequent …

Wilson's disease-associated gut dysbiosis: novel insights into microbial functional alterations, virulence changes, and resistance markers.

BACKGROUND: Although the gut microbiota is associated with a variety of metabolic, inflammatory, and neurological disorders through microbia … in the microbial community structure, including Prevotella stercorea, Firmicutes bacterium CAG 110, Bacteroides salyersiae, Lactococcus petauri, Streptococcus cristatus, Actinomyces sp. HMSC035G02, and Streptococcus viridans. Widespread functional dysbiosis was detected across multiple biological levels in patients with WD, with significant correlations ident …

Multiomics reveal human umbilical cord mesenchymal stem cells improving acute lung injury via the lung-gut axis.

BACKGROUND: Acute lung injury (ALI) and its final severe stage, acute respiratory distress syndrome, are associated with high morbidity and … in the feces of HUS-MSC-treated ALI mice were significantly increased. In addition, Lactobacillus, Bacteroides, and unidentified_Rikenellaceae genera appeared in both feces and BALF. Moreover, this study performed metabolomic analysis on the lung tissue and identified five upregulated metabolites and 11 downregulated metabolites in the LPS + MSC group compar …

Fecal metabonomics combined with 16S rRNA gene sequencing to analyze the changes of gut microbiota in rats with kidney-yang deficiency syndrome and the intervention effect of You-gui pill.

ETHNOPHARMACOLOGICAL RELEVANCE: A myriad of evidence have shown that kidney-yang deficiency syndrome (KYDS) is associated with metabolic dis … ncing analysis, we further discovered that KYDS was primarily linked to three gut microbiotas (i.e. Bacteroides, Desulfovibrio and [Eubacterium]_coprostanoligenes_group) and eleven related metabolites (i.e. deoxycholate, n-butyrate, valine, isoleucine, acetate, taurine, glycine, α-gluconse, β-glucose, glycerol and tryptophan) mediated various metabolic disord …

Clinical and bacteriological aspects on the use of oxytetracycline and flunixin in primiparous cows with induced retained placenta and post-partal endometritis.

Retention of the fetal membranes and post-partal endometritis (RFM) are common problems in dairy cows. Treatment often includes manual remov … i alpha-haemolytic streptococci, Fusobacterium necrophorum, Arcanobacterium (Actinomyces) pyogenes, Bacteroides spp., Pasteurella spp. and Proteus spp. Fusobacterium necrophorum and A. pyogenes could be isolated for 3-5 weeks post-partum and E. coli Pasteurella and Proteus could be isolated for 2-3 weeks post-partum. Animals treated with tetracycline after pl …

Мультиомика Менделиан Рандомилизация Возрождение Иммунометаболические Подделки Гут Микробиота в оптовом нерете и потенциальная терапевтическая роль витамина В6.

Оптический неврит (ON) является воспалительным заболеванием, часто связанным с аутоиммунными расстройствами, такими, как множественный склероз (MS) и оптовый спектр нейромиелита (NMOSD). Несмотря на низкий уровень заболеваемости, ОН может привести к серьезному необратимому нарушению зрения. Появляющиеся данные свидетельствуют о том, что кишечная микробиота (ГМ) может влиять на организм через сложные иммунные и метаболические пути, однако эти механизмы по-прежнему недостаточно изучены. Для оценки причинно-следственных связей между ГМ такса и ОН в этом исследовании использовался подход, основанн

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… We discovered that Bacteroides faecis could affect ON by acting on 1-linoleoyl-gpc and 1-linoleoyl-GPE. The researchers observed that Bacteroides faecis (beta = 0.331) was associated with an increased total risk of ON. … We discovered a significant negative causal relationship between vitamin B6 and Bacteroides faecis (OR = 0.85, 95% CI 0.78–0.92, P  = 7.02E − 5), while Bacteroides faecis may increase the risk of ON (OR = 1.39, 95% CI 1.08–1.79, P  = 9.11E − 5) (Fig.  5 ). …

Application of IgA-Seq in schizophrenia to identify key gut bacteria that promote abnormal behavior in mice.

Schizophrenia (SCZ) has a complex etiology, and growing evidence implicates the microbiota-gut-brain axis. Because abundance-based profiling … nts specified for each experiment. Candidate IgA+ taxa included Streptococcus, Pseudomonas, and Parabacteroides, whereas IgA- candidates included Collinsella, Eggerthella, Bifidobacterium, Bacteroides, Enterococcus, and Clostridium. In experiment 1, the GF IgA+ and GF IgA- groups differed in open-field center-zone time (P = 0.032). Marble-burying behavior sho …

Systematic pharmacology-guided analysis of the therapeutic mechanism of Sedum sarmentosum against chronic liver injury.

OBJECTIVE: To study the molecular mechanism of active compounds in Sedum sarmentosum Bunge. (SS) for treating chronic liver injury (CLI) ind … es between model group and other groups were found. Compared to model group, Phascolarctobacterium, Bacteroides, Lactobacillus were significantly reduced, while Aeromonas, Helicobacter pylori, Clostridium were significantly increased in other groups. Western blot results showed that different concentrations of quercetin and isorhamnetin could reduce the prote …

Integrated gut microbiota and metabolomic profiling reveals key associations between amino acid levels and gut microbial composition in patients with obesity.

INTRODUCTION: Obesity is an increasingly serious global health concern and is closely associated with gut dysbiosis and metabolic imbalance. … a (AUC = 0.71, 95% CI: 0.565-0.855; p = 0.028) was enriched in obesity, while at the species level, Bacteroides fragilis (AUC = 0.733, 95% CI: 0.593-0.873; p = 0.016) and Parabacteroides distasonis (AUC = 0.61, 95% CI: 0.466-0.754; p = 0.033) were noted to be enriched. Metabolomic analysis revealed that in patients with obesity, the abundance of carnosine (lo …

Exploring the mechanism of Xingpi Capsule in diarrhea predominant-irritable bowel syndrome treatment based on multiomics technology.

BACKGROUND: Xingpi Capsule (XP), a commercially available over-the-counter herbal medicine in China, plays a prominent role in treating diar … ce of Desulfurium and Prevotella 9 at the phylum and genus levels while increasing the abundance of Bacteroides at the genus level. RNA-Seq combined with WB validation showed that XP exerted antidiarrheal effects by inhibiting the ASK1/P38 MAPK signaling pathway. Additionally, XP also increased the relative expression level of the metabolite HPX, as revealed …

[Detection and analysis of intestinal flora diversity in patients with complex anal fistula].

Objective: To explore the possibility that the intestinal flora profile in complex anal fistula patients is different to that of healthy con … acteria spp. (0.02%±4.2% vs. 9.3%±14.4%, P<0.01), Enterococcus (0.02%±2.3% vs. 9.3%±19.6%, P<0.05), Bacteroides (24.7%±9.9% vs. 29.8%±9.1%, P<0.05) and Klebsiella (0.4%±4.2% vs. 3.9%±7.3%, P<0.05) compared with healthy controls. Intestinal flora diversity in the complex anal fistula group was richer than in controls, as indicated by a higher ACE index (293.30 …

[Clinical characteristics and risk factors of early septic patients complicated with bloodstream infection].

OBJECTIVE: To analyze the clinical characteristics, risk factors and prognosis of early septic patients with bloodstream infection (BSI) in … oli (26 strains, 34.2%), Klebsiella pneumoniae (11 strains, 14.4%), Enterococcus (7 strains, 9.2%), Bacteroides fragilis (6 strains, 7.9%) and Staphylococcus aureus (6 strains, 7.9%). There were no significant differences in mechanical ventilation time, the length of ICU stay and 28-day mortality between the BSI group and the non-BSI group. The difference of …

[Characteristics of war wound infection].

War wounds are the most complex type of non-targeted injuries due to uncontrolled tissue damage of varied and multifold localizations, expos … d dust; anaerobic gram-positive sporogeneous rods Clostridium spp, gram-negative asporogeneous rods Bacteroides spp and gram-positive anaerobic cocci; Peptostreptococcus spp and Peptococcus spp. The latter usually colonize the intestine, primarily the colon, and the skin, while clostridium spores are also found in the environment. Early empirical antibiotic t …

Differential expression of mitogen activating protein kinases in periodontitis.

AIM: Following toll-like receptor (TLR) engagement, lipopolysaccharide (LPS) can stimulate the expression of pro-inflammatory cytokines thus activating the innate immune response. The production of inflammatory cytokines results, in part, from the activation of kinase-induced signalling cascades and transcriptional factors. Of the four distinct classes of mitogen-activated protein kinases (MAPK) described in mammals, p38, c-Jun N-terminal activated kinases (JNK1-3) and extracellular activated kinases (ERK1,2) are the best studied. Previous data have established that p38 MAPK signalling is requ

[Clinical study on efficacy and mechanism of separated moxibustion in the treatment of rheumatoid arthritis and related negative emotions based on gut microbiota].

OBJECTIVES: To investigate the clinical efficacy of separated moxibustion in the treatment of rheumatoid arthritis (RA) and related negative … , Sobs, Shannon indices) and the abundances of beneficial bacteria (Bacteroidota, Faecalibacterium, Bacteroides, Bifidobacterium) in the observation and control groups were significantly lower (P<0.01), while the Firmicutes/Bacteroidota (F/B) ratio and the abundances of opportunistic pathogenic bacteria (Firmicutes, Prevotella, Proteobacteria, Actinobacteriot …

Efficacy and safety of herbal formulas with the function of gut microbiota regulation for gastric and colorectal cancer: A systematic review and meta-analysis.

BACKGROUND: Currently, gastric cancer (GC) and colorectal cancer (CRC) are the most common causes of cancer-related mortality worldwide. Gut … ormulas that could regulate the gut microbiota of Bifidobacterium, Lactobacillus, Escherichia coli, Bacteroides, and Enterococcus faecalis. The meta-analysis results were subgrouped to three different stages in GC and CRC. 1) For the perioperative stage, HFGMR combined with conventional therapy could shorten the time to bowel sound recovery by 1.63 h [mean di …

Микробиота человека в области здравоохранения и отдельные раковые заболевания.

Большинство эпителиальных поверхностей нашего тела, пищеварительный тракт, дыхательные и врожденные системы, колонизируются большим количеством бактерий, археи, грибов, протозоанов и вирусов. Эти микробиота, особенно кишки, играют важную и полезную роль в пищеварении, метаболизме и синтезе витаминов. Их метаболиты стимулируют производство цитокина человеком, которое используется против потенциальных патогенов. На состав микробиоты влияет ряд внутренних и внешних факторов, включая питание, возраст, болезни и образ жизни. Такие изменения, называемые дисбиозом, могут быть связаны с развитием разл

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… A vegetarian or vegan diet increases the proportion of Bacteroides thetaiotaomicron , Clostridium clostridioforme , Faecalibacterium prausnitzii , Bifidobacterium , and Lactobacillus , but decreases that of Acteroides spp., Enterobacteriaceae , Escherichia coli , Bacteroides fragilis , Clostridium … Antibiotic therapy mainly reduces the diversity and/or abundance of Bacteroides, and decreases the evenness of the community [ 118 ]. …

Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi.

Little is known about the inter-individual variation of cytokine responses to different pathogens in healthy individuals. To systematically describe cytokine responses elicited by distinct pathogens and to determine the effect of genetic variation on cytokine production, we profiled cytokines produced by peripheral blood mononuclear cells from 197 individuals of European origin from the 200 Functional Genomics (200FG) cohort in the Human Functional Genomics Project (http://www.humanfunctionalgenomics.org), obtained over three different years. We compared bacteria- and fungi-induced cytokine pr