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Treatment of community-onset pneumonia in neutropenic cancer patients: β-lactam monotherapy versus combination antibiotic regimens.

BackgroundAlthough β-lactam monotherapy may be sufficient in non-critically ill patients with community-acquired pneumonia, the value of combination antibiotic regimens in community-onset neutropenic pneumonia remains unclear.MethodsA retrospective cohort study was conducted to compare the effects of combination antibiotic regimens to those of β-lactam monotherapy in cancer patients with community-onset neutropenic pneumonia. Electronic medical records of patients diagnosed with community-onset neutropenic pneumonia between March 1995 and February 2015 at a tertiary care center were reviewed.R

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… Ceftazidime was used more frequently in the β-lactam group, while piperacillin-tazobactam was used more in the combination group. … The preferred regimen for neutropenic pneumonia at our center was changed from ceftazidime combined with tobramycin to cefepime after 2002 due to increasing ceftazidime-resistance [ 27 ]. …

[Basic and clinical studies on tazobactam/piperacillin in pediatric field].

A drug susceptibility test of the combination drug TAZ/PIPC, which consists of a newly developed beta-lactamase inhibitor, tazobactam (TAZ), … , that is, TAZ/PIPC, PIPC, penicillin G (PCG), ampicillin (ABPC), cefotiam (CTM), cefotaxime (CTX), ceftazidime (CAZ), and sulbactam/cefoperazone (SBT/CPZ). Of three clinically isolated species from patients, Staphylococcus aureus (S. aureus) was treated with TAZ/PIPC, PIPC, methicillin (DMPPC), CTM, CTX, and SBT/CPZ, and the others were treated with the same …

Prophylactic antibiotics for preventing Gram positive infections associated with long-term central venous catheters in oncology patients.

BACKGROUND: This is an updated version of the review which was first published in the Cochrane Database of Systematic Reviews in 2006. Long- … ow or unclear risk of bias. Five trials compared the use of antibiotics (vancomycin, teicoplanin or ceftazidime) given before the insertion of the long-term CVC with no antibiotics, and six trials compared antibiotics (vancomycin, amikacin or taurolidine) and heparin with a heparin-only solution for flushing or locking the long-term CVC after use. Administeri …

Pseudomonas aeruginosa Infections in Cancer Patients.

Pseudomonas aeruginosa (P. aeruginosa) is one of the most frequent opportunistic microorganisms causing infections in oncological patients, especially those with neutropenia. Through its ability to adapt to difficult environmental conditions and high intrinsic resistance to antibiotics, it successfully adapts and survives in the hospital environment, causing sporadic infections and outbreaks. It produces a variety of virulence factors that damage host cells, evade host immune responses, and permit colonization and infections of hospitalized patients, who usually develop blood stream, respirato

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… In our last study [ 69 ], we assessed the activity of ceftolozane/tazobactam, ceftazidime/avibactam, meropenem/vaborbactam and colistin against 150 P. aeruginosa strains isolated from oncological patients. … Another potential option, especially for the treatment of infections caused by Gram-negative bacteria producing MBL and ESBL simultaneously, might be the combination of aztreonam with ceftazidime/avibactam [ 72 ]. …

Sphingobacterium multivorum cellulitis: case report and mini-review.

BACKGROUND: Sphingobacterium multivorum is a gram-negative, non-fermentative, oxidase-positive, catalase-positive bacillus. S multivorum has been identified in urinary tract infections, respiratory tract infections, spontaneous peritonitis, septic arthritis, meningitis, bacteraemia and septic shock. Ours is the second case of skin and soft tissue infection sustained by S. multivorum (a case of necrotizing fasciitis with septic shock has been previously reported). In this paper, we furnish a review of the literature on all the cases of S multivorum described in the medical literature (with the

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… | Bacteraemia | Blood | Perfloxacin then TMP/SMX | Full recovery Reina [ 21 ] 1992 | F/20 m | Spain | Cystic fibrosis | | Acute exacerbation of chronic bronchopathy | Bronchial aspirates | Ceftazidim and amikacin | Full recovery Aydogan [ 18 ] 1993 | M/2 m | Turkey | Healthy | Sub-optimal hygiene condition … Hydrolysis of imipenem, meropenem, ceftazidime, and cefepime by multiresistant nosocomial strains of Sphingobacterium multivorum. Eur J Clin Microbiol Infect Dis. 1997;16:178–181. doi: 10.1007/BF01709484. 8. Singer M., Deutschman C.S., Seymour C.W., et al. …

Drug dosage adjustment in hospitalized patients with renal impairment at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia.

BACKGROUND: Dose adjustment for certain drugs is required in patients with reduced renal function to avoid toxicity as many drugs are eliminated by the kidneys. The aim of this study was to assess whether appropriate dosage adjustments were made in hospitalized patients with renal impairment. METHODS: A prospective cross-sectional study was carried out in the internal medicine wards of Tikur Anbessa Specialized Hospital. All patients with creatinine clearance ≤ 59 ml/min admitted to hospital between April and July, 2013 were included in the analysis. Data regarding serum creatinine level, age

Pseudomonas otitidis Bacteremia in a Patient with Cancer during the Palliative-care Phase.

Pseudomonas otitidis bacteremia is rare. We herein report a case of bacteremia caused by P. otitidis in a patient with advanced appendiceal cancer. A 79-year-old Japanese man developed infection when he was admitted to our hospital for palliative care. Blood culture revealed the presence of Pseudomonas spp. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was used to identify the organism accurately. The patient was treated with a two-week course of piperacillin/tazobactam, and the bacteremia was successfully controlled. Clinicians should be aware that P. otitidis c

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… The P. otitidis strain exhibited susceptibility to piperacillin, piperacillin/tazobactam, ceftazidime, cefepime, gentamicin, amikacin, and levofloxacin but was resistant to meropenem ( Table ). The patient was successfully treated with a two-week course of piperacillin/tazobactam. … MIC: minimal inhibitory concentration Antimicrobial agent | MIC (µg/mL) Piperacillin | ≤8 Piperacillin/tazobactam | ≤8 Ceftazidime | ≤4 Cefepime | ≤2 Imipenem | 2 Meropenem | 8 Gentamicin | ≤2 Amikacin | ≤8 Levofloxacin | ≤0.5 Figure. Clinical course of treatment. …

Clinical Outcome of Febrile Neutropenia and Associated Factors Among Adult Patients with Cancer Treated at Ethiopian Oncology Centers: A Retrospective Observational Study.

IntroductionFebrile neutropenia (FN) is a major cause of dose-limiting complications in cancer treatment that predisposes patients to serious infections. Despite advancements in therapies, including empirical and definitive antibiotics, FN remains a major morbidity and mortality issue among patients with cancer undergoing cancer treatment. Little is known about the 30-day all-cause mortality rates from FN in Ethiopia, particularly in the Northwest Ethiopia oncology centers.MethodsThis retrospective cross-sectional study was conducted via chart review without direct patient contact at two North

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… Vancomycin + meropenem | 47 (11.6) Ceftazidime + gentamicin | 46 (11.4) Ceftazidime + ciprofloxacin | 43 (10.6) Cefepime | 31 (7.6%) Ceftazidime | 22 (5.4) Meropenem | 18 (4.4) Ceftriaxone | 9 (2.2) Anti-bacterial therapeutic regimen ( n = 405) | Combination therapy | 325 (80.3) Monotherapy | 80 (19.7 … Combination antibiotic therapy was the common empiric treatment approach for FN, with ceftazidime + vancomycin being the most frequently used therapy. The most common monotherapeutic regimen was cefepime. …

Смертность, связанная с инфекцией, после трансплантации стволовых клеток в условиях высокой антимикробной устойчивости.

: Инфекционные осложнения остаются одной из основных причин смертности после трансплантации стволовых клеток (ГХЦТ). Мы поставили перед собой цель описать инфекцию после ХСБТ и ее воздействие на выживание в центре региона с высоким антимикробным сопротивлением. МЕТОДЫ: В том числе 522 больные гематологическими расстройствами, проходящими через СХТ в университетском госпитале Коч, между 2016 и 2024. Кровоток и оппортунистические инфекции внутри 100 были проанализированы дни. Смертность, связанная с инфекцией, была определена как смерть, обусловленная главным образом инфекционными осложнениями.

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… The limited availability and reimbursement restrictions of ceftazidime–avibactam during much of the study period likely contributed to delayed access to optimal therapy in selected cases. … R, Gundes S, Zengin R et al (2024) Multicenter evaluation of ceftazidime-avibactam use in carbapenem-resistant Klebsiella pneumoniae bloodstream infections in OXA-48 endemic regions. …

Infectious Complications of Cancer Therapy

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… Meropenem versus ceftazidime as empirical monotherapy in febrile neutropenia of paediatric patients with cancer. J Antimicrob Chemother. 2001;47:841–853. doi: 10.1093/jac/47.6.841. 208. Giamarellou H., Bassaris H.P., Petrikkos G., et al. … Monotherapy with meropenem versus combination therapy with ceftazidime plus amikacin as empiric therapy for fever in granulocytopenic patients with cancer. Antimicrob Agents Chemother. 1996;40:1108–1115. doi: 10.1128/aac.40.5.1108. …

Histiocytoid giant cellulitis-like Sweet syndrome at the site of sternal aspiration: A case report and review of literature.

BackgroundGiant cellulitis-like Sweet syndrome (SS) is a rare subtype of SS, and reports of the combined histiocytoid type of pathology are scarce. Here, we report a case of SS with distinctive clinical presentations and which was difficult to distinguish from cellulitis. By sharing this case and a discussion of the related literature in detail, we aim to provide clinicians with new insights into the characteristics of histiocytoid giant cellulitis-like (HGC)-SS and the pathogenesis of SS.Case summaryA 52-year-old male was admitted after experiencing progressive fatigue for 1 mo and tongue swe

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… The patient was administered ceftazidime [2 g intravenous (IV) every 8 h]. However, the lesion continued to expand, with bulla formation. … In addition to treatment for the nosocomial infection, malignancy, and neutropenia, the patient received ceftazidime treatment. …

[Analysis of epidemiological characteristics and risk factors of catheter-associated urinary tract infections in patients with perineal and/or hip burns].

Objective: To explore the epidemiological characteristics and risk factors of catheter-associated urinary tract infections in patients with … acillin/tazobactam ranged from 56.3% to 68.8%, and the resistance rates of Klebsiella pneumoniae to ceftazidime and tigecycline were lower than 50.0%. The resistance rates of Enterococcus faecalis to ciprofloxacin and penicillin were both 85.7%, the resistance rates of Enterococcus faecalis to erythromycin, clindamycin, moxifloxacin, and tetracycline ranged f …

Pharmacokinetics of antibacterial agents in the CSF of children and adolescents.

The adequate management of central nervous system (CNS) infections requires that antimicrobial agents penetrate the blood-brain barrier (BBB … effects and slower sterilization of the CSF than third-generation agents. Ceftriaxone, cefotaxime, ceftazidime, cefixime and cefepime have been studied in children and are all able to adequately penetrate the CSF. As with penicillins, concentrations are greatest in the presence of meningeal inflammation. Meropenem and imipenem are the only carbapenems with p …

Клиническое представление лептоспироза: ретроспективное исследование 34 Пациенты поступили в одно учебное заведение во Франции.

Лептоспироз имеет весьма изменчивое клиническое представление, которое может быть связано с различными заражающими сероварами, факторами хост-компьютеров или их комбинацией. Это исследование проводилось ретроспективно 34 Число пациентов с серологическим подтвержденным лептоспирозом, принятых в течение отчетного периода 1992-2002. Наиболее частыми симптомами при поступлении в школу были лихорадка (см.100%), головная боль75%), миальгии55%), артхальгии45%) и рвотой (т.е.39%). Применяемые лабораторные исследования включали в себя лимфопенцию (см.85%), тромбоцитопенсия75%), повышенные ферменты пече

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… Treatment with subMICs of ceftazidime and ciprofloxacin resulted in the alteration of polysaccharide structure of typable strains. … Results: Five P. putida isolates showed resistance to betalactams, including ampicillin (>128 mg/L), ceftazidime (>128 mg/L) and carbapenems (8→128 mg/L) such as imipenem and meropenem. …

[Analysis of the resistance mechanism and homology of carbapenems-resistant Pseudomonas aeruginosa].

OBJECTIVE: To study the resistance mechanism and homology of carbapenems-resistant Pseudomonas aeruginosa (PA). METHODS: A total of 812 str … with imipenem-ethylene diamine tetraacetic acid (EDTA) and enhancement test with imipenem-EDTA and ceftazidime-EDTA were used to screen metallo-β-lactamase (MBL)-producing strains; modified Hodge test was used to screen strains producing Klebsiella pneumoniae carbapenemases (KPC); the carbapenemase gene, plasmid mediated quinolone resistant (PMQR) gene, and …

[Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (1996)].

The bacteria isolated from the patients with lower respiratory tract infections were collected by institutions located throughout Japan, sin … howed the most potent activity against P. aeruginosa (mucoid strains) with MIC80 of 1 microgram/ml. Ceftazidime (CAZ), cefsulodin (CFS), IPM, gentamicin (GM), ABK and ciprofloxacin (CPFX) showed the next potent activities, with MIC80s of 2 micrograms/ml. The MIC80s of the other drugs ranged from 4 micrograms/ml to 16 micrograms/ml. 5) P. aeruginosa (non-mucoi …

[Comparative studies on activities of antimicrobial agents against causative organisms isolated from patients with urinary tract infections (1995). I. Susceptibility distribution].

The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 704 bacterial strains isolated from patients … crograms/ml in 1995. 9. Proteus mirabilis P. mirabilis was susceptible to a majority of drugs. CMX, ceftazidime (CAZ), cefixime (CFIX), and CRMN showed the highest activities against P. mirabilis isolated from patients with UTIs. MICs of CRMN for all

Understanding and Managing Sepsis in Patients With Cancer in the Era of Antimicrobial Resistance.

Sepsis is a frequent complication in immunosuppressed cancer patients and hematopoietic stem cell transplant recipients that is associated with high morbidity and mortality rates. The worldwide emergence of antimicrobial resistance is of special concern in this population because any delay in starting adequate empirical antibiotic therapy can lead to poor outcomes. In this review, we aim to address: (1) the mechanisms involved in the development of sepsis and septic shock in these patients; (2) the risk factors associated with a worse prognosis; (3) the impact of adequate initial empirical ant

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… Table 3 Summary of the main clinical and microbiological characteristics of the published case series and case reports on the use of ceftazidime/avibactam and ceftolozane/tazobactam in high-risk hematologic cancer patients. … Studies should also continue to clarify the role of new antibiotics, such as ceftolozane/tazobactam and ceftazidime/avibactam, in cancer patients with sepsis, particularly when used empirically. …

Real-Life Use of Ceftolozane/Tazobactam for the Treatment of Bloodstream Infection Due to Pseudomonas aeruginosa in Neutropenic Hematologic Patients: a Matched Control Study (ZENITH Study).

We sought to assess the characteristics and outcomes of neutropenic hematologic patients with Pseudomonas aeruginosa (PA) bloodstream infection (BSI) treated with ceftolozane-tazobactam (C/T). We conducted a multicenter, international, matched-cohort study of PA BSI episodes in neutropenic hematologic patients who received C/T. Controls were patients with PA BSI treated with other antibiotics. Risk factors for overall 7-day and 30-day case fatality rates were analyzed. We compared 44 cases with 88 controls. Overall, 91% of episodes were caused by multidrug-resistant (MDR) strains. An endogenou

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… Antibiotic families | Total n /available isolates n (%) a | Cases n /available isolates n (%) a | Controls n /available isolates n (%) a | P value Cephalosporins | 95/129 (73.6) | 37/44 (84.1) | 58/85 (68.2) | 0.053 Cefepime | 70/103 (68) | 34/39 (87.2) | 36/64 (56.3) | 0.001 Ceftazidime | 78/128 (60.9 … Ceftazidime/avibactam and ceftolozane/tazobactam: second-generation β-lactam/β-lactamase inhibitor combinations . Clin Infect Dis 63 : 234 – 241 . doi: 10.1093/cid/ciw243 . 27098166 PMC4928383 13 Cluck D , Lewis P , Stayer B , Spivey J , Moorman J . 2015 . …

Epidemiology of Bacteremia in Patients with Hematological Malignancies and Hematopoietic Stem Cell Transplantation and the Impact of Antibiotic Resistance on Mortality: Data from a Multicenter Study in Argentina.

The epidemiology of bacteremia and the antibiotic resistance profile (ARP) of Gram-negative bacilli (GNB) in hematological malignancies (HM) and hematopoietic stem cell transplant (HSCT) patients may differ according to geographic region. In addition, multidrug-resistant organisms (MDROs) may impact mortality. This is a prospective, observational, and multicenter study. The first episodes of bacteremia in adult patients with HM or HSCT were included. The risk factors for 30-day mortality were identified. One thousand two hundred and seventy-seven episodes were included (HM: 920; HSCT: 357). GN

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… ESBL production was determined by disk diffusion method using both ceftazidime and cefotaxime, alone and combined with clavulanic acid. … Meanwhile, resistance to ceftolozane–tazobactam and ceftazidime–avibactam was low in the isolates tested against these antibiotics. …