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Natural bioactive molecules and chemotherapeutics synergism for enhanced cancer therapy.

BACKGROUND: Chemotherapy remains a foundation of cancer care but is limited by multidrug resistance, systemic toxicities, and suboptimal selectivity, prompting interest in adjunctive strategies that improve efficacy and tolerability without adding significant burden to patients or healthcare systems. AIMS/OBJECTIVES: This review highlights evidence on natural bioactive compounds, including polyphenols, alkaloids, terpenoids, and fungal metabolites, as adjuvants to standard chemotherapeutics, with objectives to: first, delineate mechanisms by which these agents enhance cytotoxic efficacy and o

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… Misgiati et al. extracted ergosterol from Agaricus blazei Murill using n -hexane and found it exhibited significant anticancer activity against MCF-7 cells, with an IC50 of 43.10 µg/mL, working through cell cycle inhibition and apoptosis induction [ 77 ]. … Matrine, the primary active component from Sophora flavescens (matrine plant), reduces MCF-7 cell drug resistance through dual mechanism: PI3K/AKT upregulation and AKT phosphorylation reduction via PTEN [ 246 ]. …

Anti-Cancer Research Progress of Triptolide: Mechanisms of Action, Structural Modifications, Nanodelivery Systems and Clinical Challenges.

Triptolide is a bioactive diterpenoid lactone from traditional Chinese medicine with notable anti-tumor, immunosuppressive, and anti-inflammatory properties. However, its clinical utility is hampered by poor solubility, a narrow therapeutic index, and multi-organ toxicity. In response, extensive efforts have been made to improve its efficacy and safety profile. This review critically examines recent progress in Triptolide research, covering its mechanisms of action, derivative design, drug delivery systems, and cancer-specific applications. It also evaluates its clinical potential against panc

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… Triptolide induces autophagy and apoptosis through ERK activation in human breast cancer MCF-7 cells. Exp Ther Med. 2018;15:3413–3419. doi:10.3892/etm.2018.5830 38. Wang Y , Guo S-H, Shang X-J, et al. …

Bisphosphonate-Based Conjugates and Derivatives as Potential Therapeutic Agents in Osteoporosis, Bone Cancer and Metastatic Bone Cancer.

Metastatic bone cancer occurs in every type of cancer but is prevalent in lung, breast, and prostate cancers. These metastases can cause extensive morbidity, including a range of skeletal-related events, often painful and linked with substantial hospital resource usage. The treatment used is a combination of chemotherapy and surgery. However, anticancer drugs are still limited due to severe side effects, drug resistance, poor blood supply, and non-specific drug uptake, necessitating high toxic doses. Bisphosphonates are the main class of drugs utilized to inhibit metastatic bone cancer. It is

Exploration of the Use of Natural Compounds in Combination with Chemotherapy Drugs for Tumor Treatment.

Currently, chemotherapy is the main treatment for tumors, but there are still problems such as unsatisfactory chemotherapy results, susceptibility to drug resistance, and serious adverse effects. Natural compounds have numerous pharmacological activities which are important sources of drug discovery for tumor treatment. The combination of chemotherapeutic drugs and natural compounds is gradually becoming an important strategy and development direction for tumor treatment. In this paper, we described the role of natural compounds in combination with chemotherapeutic drugs in synergizing, reduci

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… Toosendanin combined with doxorubicin significantly promoted the apoptosis of drug-resistant MCF-7 cells and inhibited the phosphorylation of AKT at the non-cytotoxic concentration of toosendanin. … Matrine, the main active substance extracted from Matrine, can also decrease the drug resistance of MCF-7 cells by up-regulating PI3K/AKT and down-regulating the phosphorylation level of AKT through the negative regulatory factor PTEN [ 86 ]. …

Экспериментальные и клинические исследования фармакологических действий рода ахиллия: всеобъемлющий и обновленный обзор.

ЦЕЛЬ: Виды рода Ахиллеа (от семейства Compositae или Asteraceae) широко используются для их многочисленных фармакологических свойств. В настоящем документе рассматриваются фармакологические действия и их возможные основополагающие молекулярные механизмы, о которых сообщается в отношении различных видов ахиллы. МАТЕРИАЛЫ И МЕТОДЫ: использовались различные базы данных, включая PubMed, Science Direct и Scopus. Результаты: Для этих растений были продемонстрированы эффекты иммуноспрепрессии, против воспламенения и против окислителей. Кроме того, было продемонстрировано, что эти растения оказывают н

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… The anti-proliferative effects of various extracts from A. millefolium on three human tumor cell lines (HeLa, MCF-7 and A431) showed that the chloroform extract has a strong inhibitory activity on HeLa and MCF-7 cells and casticin and paulitin were highly effective against all three tumor cell lines … The chloroform-soluble extract of A. millefolium showed high inhibitory activities on HeLa and MCF-7 cells (Csupor‐Löffler et al., 2009a). …

Clinically proven natural products against breast cancer, with mechanistic insights.

BackgroundBreast cancer still stands to be the foremost contributor to cancer-related incidence and mortality in women globally accounting for about 14% of all female cancer-related deaths worldwide. This research seeks to illustrate the mechanisms and clinical findings of natural products against breast cancer treatment.MethodologyRequired data for this review article was retrieved employing several readily obtainable search databases, including Web of Science® (Thomson Reuters, USA), PubMed® (U.S. National Library of Medicine, USA), and SciVerse Scopus® (Elsevier Properties S.A., USA), takin

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… Mechanistic view Sulforaphane (isothiocyanate), obtained from cruciferous vegetables, has promising capability in fighting breast cancer by inhibiting cancer cell expansion through a G2-M cell cycle arrest in MCF-7 cells [ 47 ]. … Mammalian lignans and genistein decrease the activities of aromatase and 17beta-hydroxysteroid dehydrogenase in MCF-7 cells. J Steroid Biochem Mol Biol. 2005;94(5):461–7. doi: 10.1016/j.jsbmb.2005.02.002; 25. Khan MI, Bouyahya A, Hachlafi NEL, Menyiy NE, Akram M, Sultana S, et al. …

Targeting Cancer Through Thymoquinone: From Molecular Mechanisms to Clinical Prospects.

Thymoquinone (TQ), the active compound in Nigella sativa (black seed), has shown promising effects against cancer in many laboratory studies. In this review, we explore how TQ works on different aspects of cancer, from stopping cancer cell growth and spread, to triggering cancer cell death, reducing inflammation, and helping the immune system fight back. We also highlight how TQ may overcome one of the biggest problems in cancer treatment-chemoresistance. When used together with common treatments like chemotherapy, radiation, or immunotherapy, TQ has been shown to improve their effects and red

Parasites' immunomodulators: a breakthrough in immunotherapeutics displaying antineoplastic activity against human colorectal and hepatocellular carcinoma cells.

The complex interplay between parasites and cancer is yielding promising advances in the field of cancer therapeutics. This study explored the in vitro anti-cancer potential of parasite immunomodulators (antigens and antibodies) of Schistosoma mansoni, Trichinella spiralis, and Toxoplasma gondii on human HT-29 colorectal and HepG2 hepatocellular carcinoma cells using the MTT assay. Results revealed that those parasites' immunomodulators exhibited antineoplastic activity and demonstrated a statistically significant inhibition of both cancer cell lines' proliferation (P ˂0.05). Notably, Trichine

Proceedings of the CIMAGO Congress - Environment, Genetics and Oncobiology in the 21st Century - Challenges and Opportunities.

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… PET functional scans are important to control tumours’ development and/or the need to reinject the animals with MCF-7 cells. Conclusions: An in vitro adjuvant effect of GTEpo was observed for the tested protocol. … Methods: Tumours were induced, using WiDr and MCF-7 cell lines, in Balb/c(-) male or female mice, respectively (slight scarification of the skull, followed by injection of the cell suspension). …

Advancing cancer therapy: Nanomaterial-based encapsulation strategies for enhanced delivery and efficacy of curcumin.

Curcumin, a polyphenolic compound derived from Curcuma longa, has gained significant attention as a potential anticancer agent due to its anti-inflammatory, antioxidant, and antitumor properties. Despite its therapeutic potential, the clinical application of curcumin is limited by its poor aqueous solubility, rapid metabolism, and limited bioavailability. To address these limitations, various nanomaterial-based encapsulation strategies have been developed, including polymeric nanoparticles, liposomes, solid lipid nanoparticles, micelles, dendrimers, and hybrid nanomaterials. These formulations

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… Moreover, combining curcumin with PI3K inhibitors synergistically induces apoptotic effects in MCF-7 cells, offering a novel strategy for breast cancer treatment [ [55] , [56] , [57] ]. …

Drug-Drug Interactions of Cannabidiol with Standard-of-Care Chemotherapeutics.

Cannabidiol (CBD) is an easily accessible and affordable Marijuana (Cannabis sativa L.) plant derivative with an extensive history of medical use spanning thousands of years. Interest in the therapeutic potential of CBD has increased in recent years, including its anti-tumour properties in various cancer models. In addition to the direct anticancer effects of CBD, preclinical research on numerous cannabinoids, including CBD, has highlighted their potential use in: (i) attenuating chemotherapy-induced adverse effects and (ii) enhancing the efficacy of some anticancer drugs. Therefore, CBD is ga

Redefining Breast Cancer Care by Harnessing Computational Drug Repositioning.

Breast cancer faces significant therapeutic challenges, particularly for triple-negative breast cancer (TNBC), due to limited targeted therapies and drug resistance. Drug repositioning leverages existing safety and pharmacokinetic data to expedite the identification of new indications with cost-effective benefits compared to de novo drug discovery. In this critical narrative review, we examine recent advances in computational repositioning strategies for breast cancer, focusing on network-based methods, computer-aided drug design, artificial intelligence and machine learning, transcriptomic si

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… Quinacrine and irinotecan exhibited higher antiproliferative activity than lapatinib and gefitinib in MCF-7 cells; quinacrine outperformed both standard drugs in MCF-7 and MDA-MB-231 cell lines. Wnt pathway antagonists remain an unmet need in oncology. …

Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation.

Cancer is one of the main causes of death globally and considered as a major challenge for the public health system. The high toxicity and the lack of selectivity of conventional anticancer therapies make the search for alternative treatments a priority. In this review, we describe the main plant-derived natural products used as anticancer agents. Natural sources, extraction methods, anticancer mechanisms, clinical studies, and pharmaceutical formulation are discussed in this review. Studies covered by this review should provide a solid foundation for researchers and physicians to enhance basi

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… Moreover, it has a pivotal role in the inhibition of breast cancer cell proliferation and induction of apoptosis via activation of the P53 pathway in MCF-7 cell line, the finding revealed that a time-dependent increase of PTEN occurs in cells treated with TQ as compared with the untreated cells [ 173 … Commercially available bromelain exerted strong effects towards MCF-7 breast cancer cells; it showed an inhibitory effect against proliferation of MCF-7 with IC 50 values of 5.13 µg/mL, compared to taxol with IC 50 value of 0.063 µg/mL, and the microscopic observation of bromelain-treated MCF-7 cells …

Pectin: A Bioactive Food Polysaccharide with Cancer Preventive Potential.

Pectin is an acidic heteropolysaccharide found in the cell walls and the primary and middle lamella of land plants. To be authorized as a food additive, industrial pectins must meet strict guidelines set forth by the Food and Agricultural Organization and must contain at least 65% polygalacturonic acid to achieve the E440 level. Fruit pectin derived from oranges or apples is commonly used in the food industry to gel or thicken foods and to stabilize acid-based milk beverages. It is a naturally occurring component and can be ingested by dietary consumption of fruit and vegetables. Preventing lo

Unlocking the potential of tumor-targeting peptides in precision oncology.

Targeted cancer therapy has emerged as a promising alternative to conventional chemotherapy, which is often plagued by poor selectivity, off-target effects, and drug resistance. Among the various targeting agents in development, peptides stand out for their unique advantages, including minimal immunogenicity, high tissue penetration, and ease of modification. Their small size, specificity, and flexibility allow them to target cancer cells while minimizing damage to healthy tissue selectively. Peptide-based therapies have shown great potential in enhancing the efficacy of drug delivery, improvi

Next-Generation HDAC Inhibitors: Advancing Zinc-Binding Group Design for Enhanced Cancer Therapy.

Histone deacetylases (HDACs) are pivotal epigenetic regulators that control gene expression, cell proliferation, and differentiation, and their dysregulation is closely associated with the onset and progression of multiple cancers. The therapeutic importance of these enzymes is reflected by FDA approval of HDAC inhibitors for oncology indications. Despite this clinical success, most FDA-approved agents employ conventional zinc-binding groups (ZBGs) such as hydroxamic acid and 2-aminoanilide, which are frequently linked to metabolic instability, genotoxicity, and poor pharmacokinetic behavior.

Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer.

Cancer is one of the most dreadful diseases in the world with a mortality of 9.6 million annually. Despite the advances in diagnosis and treatment during the last couple of decades, it still remains a serious concern due to the limitations associated with currently available cancer management strategies. Therefore, alternative strategies are highly required to overcome these glitches. The importance of medicinal plants as primary healthcare has been well-known from time immemorial against various human diseases, including cancer. Commiphora wightii that belongs to Burseraceae family is one suc

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… Moreover, the combination of these isomers exhibited an additive effect on the inhibition of invasion of MCF-7 cells [ 117 ]. Besides, the treatment of monocytes with GS reduced RANKL-activated NF-κB activation, which correlated with inhibition of IKK and phosphorylation and degradation of IκBα. … Reversal of multidrug resistance by guggulsterone in drug-resistant MCF-7 cell lines . Chemotherapy. 2011 ; 57 : 62 – 70 . 10.1159/000321484 21282948 175. Buhrmann C Yazdi M Popper B Kunnumakkara AB Aggarwal BB Shakibaei M. …

An Insight into Anticancer Effect of Propolis and Its Constituents: A Review of Molecular Mechanisms.

Propolis is a natural compound collected by honeybees from different parts of plants. Honeybees produce a sticky component besides honey by mixing the tree resin and other botanical sources with saliva called propolis or bee glue. Propolis was traditionally used as a wound healing substance, cosmetic, medicine, and many other conditions. Till now, there is no definite curable treatment for most cancers and chemotherapeutic drugs and drugs used for targeted therapies have serious side effects. According to a recent research, natural products are becoming increasingly essential in cancer prevent

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… Anti-tumor activity evaluation of novel chrysin-organotin compound in MCF-7 cells Bioorganic & Medicinal Chemistry Letters 2016 26 2 570 574 10.1016/j.bmcl.2015.11.072 2-s2.0-84952988014 26670842 98 Acikelli A. H. Gustmann S. Bardenheuer W. … Ethanol extract of Brazilian red propolis induces apoptosis in human breast cancer MCF-7 cells through endoplasmic reticulum stress Journal of Agricultural and Food Chemistry 2012 60 44 11065 11070 10.1021/jf303004n 2-s2.0-84868545796 23066995 102 Sulaiman G. M. Ad’hiah A. H. Al-Sammarrae K. W. …

Triple‑negative breast cancer cell‑derived piR‑31115 promotes the proliferation and migration of endothelial cells via METTL3‑mediated m6A modification of YAP1.

Triple‑negative breast cancer (TNBC), a highly malignant breast cancer subtype with a pronounced metastatic propensity, forms the focus of the present investigation. MDA‑MB‑231, a prevalently utilized TNBC cell line in cancer research, was employed. In accordance with the tumour angiogenesis theory, cancer cells are capable of instigating angiogenesis and the formation of a novel vascular system within the tumour microenvironment, which subsequently sustains malignant proliferation and metastasis. Consequently, impeding the growth of tumour blood vessels holds substantial significance in suppr

Глубинные пространственные омики MLADI-MS, управляемые квантовой каскадной лазерной микроскопией среднего инфракрасного изображения.

В пространственной "omics " высокоуверенные молекулярные идентификации необходимы для исследования сложной биологии и для пространственной биомаркировки. Однако нынешняя масс-спектрометрическая съемка (MSI) на основе пространственной "омики" должна скомпрометировать скорость получения данных и глубину биохимического профилирования. Здесь мы введём быструю, без этикеток квантовую каскадную лазерную микроскопию среднего инфракрасного изображения (QCL-MIR), чтобы направить MSI в высокоинтересные области тканей, такие маленькие, как гломерули почки, культурные многоклеточные сфероидные я