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Metabolic features of myeloma cells in the context of bone microenvironment: Implication for the pathophysiology and clinic of myeloma bone disease.

Multiple myeloma (MM) is a hematological malignancy characterized by the accumulation of malignant plasma cells (PCs) into the bone marrow (BM). The complex interaction between the BM microenvironment and MM PCs can lead to severe impairment of bone remodeling. Indeed, the BM microenvironment exerts a critical role in the survival of malignant PCs. Growing evidence indicates that MM cells have several metabolic features including enhanced glycolysis and an increase in lactate production through the upregulation of glucose transporters and enzymes. More recently, it has been reported that MM ce

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… The last study comparing PET with 11 C-methionine and 18 F-FDG PET/CT was recently published by Morales-Lozano et al. ( 113 ) in 52 patients (8 SMM, 18 newly diagnosed MM and 26 relapsed MM patients) reporting a higher sensitivity of PET with 11 C-methionine than 18 F-FDG ( 113 ). 11 C-methionine detected … Morales-Lozano MI, Rodriguez-Otero P, Sancho L, Nunez-Cordoba JM, Prieto E, Marcos-Jubilar M, et al. (11)C-methionine Pet/Ct in assessment of multiple myeloma patients: Comparison to (18)F-fdg Pet/Ct and prognostic value. Int J Mol Sci (2022) 23(17). doi: 10.3390/ijms23179895 114. …

Modulation of Oxidative Stress by Ozone Therapy in the Prevention and Treatment of Chemotherapy-Induced Toxicity: Review and Prospects.

(1) Background: Cancer is one of the leading causes of mortality worldwide. Radiotherapy and chemotherapy attempt to kill tumor cells by different mechanisms mediated by an intracellular increase of free radicals. However, free radicals can also increase in healthy cells and lead to oxidative stress, resulting in further damage to healthy tissues. Approaches to prevent or treat many of these side effects are limited. Ozone therapy can induce a controlled oxidative stress able to stimulate an adaptive antioxidant response in healthy tissue. This review describes the studies using ozone therapy

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… Re L., Martínez-Sánchez G., Bordicchia M., Malcangi G., Pocognoli A., Angel Morales-Segura M., Rothchild J., Rojas A. Is ozone pre-conditioning effect linked to Nrf2/EpRE activation pathway in vivo? A preliminary result. Eur. J. Pharmacol. 2014;742:158–162. doi: 10.1016/j.ejphar.2014.08.029. 38. … Clavo B., Ceballos D., Gutierrez D., Rovira G., Suarez G., Lopez L., Pinar B., Cabezon A., Morales V., Oliva E., et al. Long-term control of refractory hemorrhagic radiation proctitis with ozone therapy. J. Pain Symptom Manag. 2013;46:106–112. doi: 10.1016/j.jpainsymman.2012.06.017. 75. …

Cancer center leadership during large-scale crises: a practical evidence-informed framework with perspectives from the Gulf Cooperation Council.

Cancer centers are disproportionately vulnerable to large-scale crises-including pandemics, armed conflicts, cyberattacks, and supply chain failures-and while COVID-19 generated valuable crisis guidance for oncology, frameworks tailored to the specific structural vulnerabilities of GCC cancer systems have been limited. The Gulf Cooperation Council region illustrates this gap with immediate, real-time urgency. The ongoing 2026 regional military escalation has reportedly disrupted Strait of Hormuz shipping and Gulf air cargo routes-critical corridors for pharmaceutical cold-chain logistics acros

Targeted antineoplastic therapy in critically ill cancer patients: a multicenter analysis of the iCHOP registry.

Approximately 20% of intensive care unit (ICU) patients have cancer, and their prognosis has markedly improved in recent years. In addition to improved treatment in the ICU, this is a result of advancements in cancer therapies, including the use of targeted therapies (TTs), such as antibodies and small-molecule kinase inhibitors. Despite the increasing use of TT, there are currently no comprehensive studies examining critically ill cancer patients receiving TT in the ICU. We studied the clinical characteristics of a multicenter cohort of cancer patients who received TT in the ICU. To this end,

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… Marhuenda Y, Morales D, del Carmen Pardo M (2014) Information criteria for Fay–Herriot model selection. Comput Stat Data Anal 70:268–280 26. …

Cardiac Amyloidosis: A Rare TTR Mutation Found in an Asian Female.

BACKGROUND: Transthyretin cardiac amyloidosis (ATTR) is a life-threatening, debilitating disease caused by abnormal formation and deposit of transthyretin (TTR) protein in multiple tissues, including myocardial extracellular matrix. It can be challenging to diagnose due to the myriad of presenting signs and symptoms. Additionally, numerous TTR mutations exist in certain ethnicities. Interestingly, our patient was discovered to have a very rare Gly67Ala TTR mutation typically not found in individuals of Asian descent. Recent advances in cardiovascular imaging techniques have allowed for earlier

Clinical Characteristics and Outcomes of COVID-19 in Turkish Patients with Hematological Malignancies

ObjectivePatients with solid malignancies are more vulnerable to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection than the healthy population. The outcome of SARS-CoV-2 infection in highly immunosuppressed populations, such as in patients with hematological malignancies, is a point of interest. We aimed to analyze the symptoms, complications, intensive care unit admissions, and mortality rates of patients with hematological malignancies infected with SARS-CoV-2 in Turkey.Materials and methodsIn this multicenter study, we included 340 adult and pediatric patients diagnosed

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… Piñana JL, Martino R, García-García I, Parody R, Morales MD, Benzo G, Gómez-Catalan I, Coll R, De La Fuente I, Luna A, Merchán B, Chinea A, de Miguel D, Serrano A, Pérez C, Diaz C, Lopez JL, Saez AJ, Bailen R, Zudaire T, Martínez D, Jurado M, Calbacho M, Vázquez L, Garcia-Cadenas I, Fox L, Pimentel AI …

CAR-T-OPENIA: Chimeric antigen receptor T-cell therapy-associated cytopenias.

Chimeric antigen receptor (CAR) T-cell is the most recent version in the evolution of cellular therapy with promising responses, which has revolutionized the management of some hematological malignancies in the current times. As the clinical use has progressed rather rapidly since the first approval in 2017, toxicities beyond cytokine release syndrome and immune effector cell-associated neurological syndrome have surfaced. Cytopenias are common in 90 days ("prolonged"); and have clinical implications to patient care as well as resource utilization. We review the details of etiology, factors as

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… Morales‐Mantilla DE, King KY. The role of interferon‐gamma in hematopoietic stem cell development, homeostasis, and disease. Curr Stem Cell Rep. 2018;4(3):264–71. 36. Neelapu SS, Tummala S, Kebriaei P, Wierda W, Gutierrez C, Locke FL, et al. …

Important End-of-Life Topics among Latino Patients and Caregivers Coping with Advanced Cancer.

There is a known end-of-life related disparity among Latino individuals, and there is a need to develop culturally sensitive interventions to help patients and caregivers cope with advanced cancer. Latino patients and caregivers coping with advanced cancer were asked to list important end-of-life topics to culturally inform a psychosocial intervention adaptation process. A qualitative study was conducted, and semi-structured interviews were performed, audio-recorded, and transcribed. Recordings and transcriptions were reviewed and analyzed using thematic content coding. The semi-structured int

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… Toro-Morales Y. Shen M. Breitbart W. Castro-Figueroa E.M. Psychosocial Intervention Cultural Adaptation for Latinx Patients and Caregivers Coping with Advanced Cancer Healthcare 2022 10 1243 10.3390/healthcare10071243 35885770 PMC9318517 …

Pre-transplant Dementia is Associated with Poor Survival After Hematopoietic Stem Cell Transplantation: A Nationwide Cohort Study with Propensity Score Matched Control.

ObjectiveNo previous study examined impact of dementia in the outcome of allogeneic hematopoietic stem cell transplantation (HSCT). We aimed to investigate overall survival (OS) of patients with dementia after receiving HSCT.MethodsAmong 8,230 patients who underwent HSCT between 2002 and 2018, 5,533 patients younger than 50 years were first excluded. Remaining patients were divided into those who were and were not diagnosed with dementia before HSCT (dementia group: n = 31; no dementia: n = 2,666). Thereafter, among 2,666 participants without dementia, 93 patients were selected via propensity-

COPD patients in need of palliative care: Identification after hospitalization through the surprise question.

Currently, few patients suffering from chronic obstructive pulmonary disease (COPD) who might benefit from a palliative care approach are referred to a palliative care team. Tools to identify patients eligible for a palliative care approach have been found to be difficult to apply in daily practice. Therefore, there is need for a simple and easily applicable tool to identify those patients who would benefit from referral to a palliative care team. The aim of this study was to determine if the surprise question (SQ) "Would I be surprised if this patient dies within 12 months?" in a subset of re

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… BMJ Support Palliat Care 2017 ; 7 : 32 – 38 . 10.1136/bmjspcare-2014-000679 25168076 36 Bloom CI Slaich B Morales DR Low uptake of palliative care for COPD patients within primary care in the UK . …

Профиль и полезность серума Цитокина для прогнозирования прогноза в Mielin Oligodendrocyte Glycoprotein Antibody-Associated болезня.

ЦЕЛИ: Охарактеризовать профиль сыворотки цитокина в миелине олигодендроците гликопротеиновых болезней, связанных с антителами (МОГАД), на начальном этапе и в ходе последующих мероприятий и оценить их полезность для прогнозирования рецидивов и инвалидности. МЕТОДЫ: Это ретроспективное многоцентральное когортное исследование охватывало пациентов в возрасте 16 МУГАД 2023 критерии при отборе проб сыворотки на основе базового уровня (≤3 Количество месяцев, прошедших с момента возникновения болезни) и последующих мероприятий≥6 Месяцы от базового уровня), а также возрастные соотношения и время до спа

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… Piñar Morales: drafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data. G. Álvarez Bravo: drafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data. L. …

Навязчивое сексуальное поведение и изменения в одиночных сексуальных поступках во время пандемии COVID-19

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Acute respiratory failure requiring mechanical ventilation in severe chronic obstructive pulmonary disease (COPD).

There are limited data on the epidemiology of acute respiratory failure necessitating mechanical ventilation in patients with severe chronic obstructive pulmonary disease (COPD). The prognosis of acute respiratory failure requiring invasive mechanical ventilation is believed to be grim in this population. The purpose of this study was to illustrate the epidemiologic characteristics and outcomes of patients with underlying severe COPD requiring mechanical ventilation.A retrospective study of patients admitted to a quaternary referral medical intensive care unit (ICU) between January 2008 and De

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… [25] Afessa B, Morales IJ, Scanlon PD, et al. Prognostic factors, clinical course, and hospital outcome of patients with chronic obstructive pulmonary disease admitted to an intensive care unit for acute respiratory failure. Crit Care Med 2002;30:1610–5. [26] Nevins ML, Epstein SK. …

Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia.

OBJECTIVES: This study aims to investigate dynamic thiol/disulphide homeostasis in patients with fibromyalgia syndrome (FMS). PATIENTS AND METHODS: Fifty female patients with FMS (mean age 40.5±7.2 years; range 21 to 55 years) and 40 healthy female controls (mean age 39±9.4 years, range 22 to 55 years) were included in the study. Pain visual analog scale, tender points, Fibromyalgia Impact Questionnaire, and Beck Depression Inventory were evaluated. Age, body mass index (BMI), and symptom durations were also recorded. Native thiol, disulphide and total thiol levels were measured with a novel

The End-of-Life Experience of Patients With Rare Cancers and Their Caregivers.

Little is known about the end-of-life (EOL) experience of patients with rare cancers (PRC) or their caregivers. From September 2002 to August 2008, 618 stage IV cancer patients [195 PRC and 423 patients with common cancers (PCC)] and their caregivers participated in an interview-based cohort study. Patients were interviewed about EOL preferences, planning, medical care, and followed until death. Interviews with caregivers at baseline assessed caregiver mental and physical health; and postmortem, assessed EOL patient care. PRC were four times more likely than PCC to be receiving both radiation

Case report: Therapeutic use of bortezomib in a patient with Schnitzler syndrome.

Schnitzler syndrome (SchS) is a rare acquired systemic autoinflammatory disorder, characterized by chronic urticarial rash and immunoglobulin M (IgM) monoclonal gammopathy. Anti-interleukin-1 (IL-1) therapies have been shown to be more effective in managing the clinical symptoms of SchS compared to anti-IL-6 therapies. In this case report, we present a male patient with urticarial rash, fever, and arthralgia. Laboratory tests identified the presence of IgMκ monoclonal protein, and the absence of IL-1β in serum. Whole exome sequencing (WES) did not reveal any pathological variants associated wi

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… Ramirez-Sandoval JC, Varela-Jimenez R, Morales-Buenrostro LE. Capillary leak syndrome as a complication of antibody-mediated rejection treatment: a case report. CEN Case Rep. (2018) 7:110–3. doi: 10.1007/s13730-018-0306-5 56. Orlowski RZ, Kuhn DJ. …

Изучение воздействия программы ухода за больными на основе эффективности, интегрированной со стратегиями вмешательства в области питания, на результаты лечения нескольких больных миеломой с почечной неполноценностью.

ЦЕЛЬ: Изучение воздействия схемы ухода за больными на основе теории эффективности в сочетании с пищевым вмешательством на пациентов с множественной миеломой (ММ), связанной с почечной недостаточностью. МЕТОДЫ: Ninety-two Пациенты с MM были осложнены почечной недостаточностью в нашей больнице с апреля 2022 по апрель 2024 были произвольно разделены на контрольную группу (46 :: случаи с использованием традиционных медицинских сестер) и наблюдательной группы46 - случаи с использованием схемы ухода за больными, основанной на теории эффективности, в сочетании с мерами в области питания). Показатели

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… Monthly rehabilitation (exchange meetings) facilitated peer interaction, experience sharing, and emotional bonding to boost morale. Feedback and adjustment Complication rates and behavioral changes were assessed. …

Новое определение "Моноклональной гаммопатии световой цепи" неизвестного значения.

ПОСЛЕДНИЕ ИССЛЕДОВАТЕЛЬСКИЕ ИССЛЕДОВАНИЯ говорят о том, что стандартные интервалы отсчета для бесперебойных световых цепочек (СВП) являются неточными и что эту проблему можно решить лишь частично путем использования отдельных интервалов отсчета для лиц с нарушенной функцией почек. Это снижает полезность тестирования FLC для клинической оценки и отслеживания расстройств плазменных клеток, особенно в том, что касается диагностики моноклонной гаммопатии световой цепи (LC) неопределенного значения (MGUS). ЦЕЛЬ: Оценить распределение соотношений сыворотки FLC и FLC у лиц с сохраненной функцией поче

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… Am J Clin Pathol . 2016 ; 146 ( 2 ): 207 - 214 . doi: 10.1093/ajcp/aqw099 27473738 11 Morales-García LJ , Pacheco-Delgado MS . Serum free light chain reference intervals in an Optilite and their influence on clinical guidelines . …

Изучение связи между 91 циркуляцией воспламенительных протеинов и нейродегенеративными заболеваниями: двухнаправленный анализ менделей и биоинформатики.

Циркуляция подстрекательских белков играет важную роль в патогенезе нейродегенеративных заболеваний (НДД). Однако точная причинно-следственная связь и механизмы, лежащие в основе их взаимодействия, по-прежнему остаются неясными. МЕТОДЫ: В каталоге GWAS были получены данные по 91 циркуляционному подстрекательскому протеину в рамках исследования ассоциации геномов (GWAS). Кроме того, данные GWAS о болезни Паркинсона (PD), болезни Альцгеймера (AD), амиотропическом боковом склерозе (ALS), множественном склерозе (MS) и ишемическом инсульте (IS) были получены в рамках проекта IEU Open GWAS. Для анал

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… CD40 activation can directly inhibit HSV‐1 proliferation (Vlahava et al. 2015 ; Bello‐Morales et al. 2021 ). Both MS patients and mouse models exhibit changes in gut microbiota, disruption of intestinal barriers, and decreased levels of bile acid metabolites. …

Epidemiology, Risk Factors, and Prophylaxis Use for Pneumocystis jirovecii Pneumonia in the Non-HIV Population: A Retrospective Study in Québec, Canada.

BACKGROUND: Pneumocystis jirovecii pneumonia (PJP) remains a significant threat in immunocompromised cases. Recent data on epidemiology and risk factors for PJP in non-HIV cases are scarce, and guidelines on appropriate prophylaxis are lacking. METHODS: In this multicenter retrospective trial, all non-HIV adult cases admitted to hospitals in Québec City, Canada, between January 2011 and January 2021 with a diagnosis of PJP were assessed for eligibility. RESULTS: An overall 129 cases of PJP were included. More than two-thirds had an underlying hematologic disease or an autoimmune/inflammatory

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… Kansenshogaku Zasshi 2014 ; 88 : 21 – 5 . 25796922 11 Mundo W , Morales-Shnaider L , Tewahade S , et al Lower mortality associated with adjuvant corticosteroid therapy in non–HIV-infected patients with Pneumocystis jirovecii pneumonia: a single-institution retrospective US cohort study . …