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Revising cancer incidence in a Central European country: a Hungarian nationwide study between 2011-2019 based on a health insurance fund database.

BackgroundThe nationwide HUN-CANCER EPI study examined cancer incidence and mortality rates in Hungary from 2011 to 2019.MethodsUsing data from the National Health Insurance Fund (NHIF) and Hungarian Central Statistical Office (HCSO), our retrospective study analyzed newly diagnosed malignancies between Jan 1, 2011, and Dec 31, 2019. Age-standardized incidence and mortality rates were calculated for all and for different tumor types using both the 1976 and 2013 European Standard Populations (ESP).FindingsThe number of newly diagnosed cancer cases decreased from 60,554 to 56,675 between 2011-20

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… Hungary, the proportions of daily and weekly alcohol consumers were 6.3% and 19.1% in 2019, respectively, lower than the EU average (8% and 28.4%, respectively), Czech Republic (7.8% and 33.8%), and Bulgaria (10.2% and 23.8%), but similar to Slovakia (4.1% and 19.3%), Croatia (10.2% and 17.9%), and Romania …

Применение периферального магнитного стимула в процессе реабилитации: обзор.

Перпериферийная магнитная стимуляция все чаще используется для лечения дисфункций, связанных с различными расстройствами. Однако в настоящее время отсутствует консенсус в отношении его эффективности применительно к конкретным группам населения, болезням, условиям вмешательства, продолжительности лечения или результатам. Цель этого аналитического обзора заключалась в выявлении, обобщении и составлении карт соответствующей литературы по периферической магнитной стимуляции с уточнением ее применения в разбивке по типам заболеваний, участку лечения, функциональным дефектам, результатам и условиям

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… 91 ) and Poland 92 , 93 , 94 , 95 ) ; 2 in New Zealand, 96 , 97 ) Saudi Arabia, 98 , 99 ) Slovenia, 100 , 101 ) Spain, 15 , 16 ) the United Kingdom, 102 , 103 ) and Brazil 104 , 105 ) ; and 1 in Australia, 106 ) Austria, 107 ) Denmark, 108 ) Iran, 109 ) Israel, 110 ) Lithuania, 111 ) Nigeria, 112 ) Romania … Moldovan et al., 2012 | Romania | RCT | Knee osteoarthritis n=65 Female, 72.3% Age: PEMF: 57.7±8.67 years Placebo: 57.8±8.67 years | Pain and dysfunction | Knee | PEMF 1.5 Hz frequency Intensity: 30 mT 15 min/session 10 days | ∙ WOMAC | There was a significant improvement in WOMAC score in both groups …

Резюме докладов 51st Конференция Европейского общества генетики человека: плакаты

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Резюме ESPR 2013Европейское общество педиатрической радиологии 50th Ежегодное совещание и 36th Курсы для аспирантов. Июнь 3–7 2013. Будапешт, Венгрия.

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Emerging Role of GLP-1 Agonists in Obesity: A Comprehensive Review of Randomised Controlled Trials.

Obesity is a chronic disease with high prevalence and associated comorbidities, making it a growing global concern. These comorbidities include type 2 diabetes, hypertension, ventilatory dysfunction, arthrosis, venous and lymphatic circulation diseases, depression, and others, which have a negative impact on health and increase morbidity and mortality. GLP-1 agonists, used to treat type 2 diabetes, have been shown to be effective in promoting weight loss in preclinical and clinical studies. This review summarizes numerous studies conducted on the main drugs in the GLP-1 agonists class, outlini

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… The Obesity in Romania (ORO) study included a sample of 2103 participants with an average age of 41.5 years and an average BMI of 29.9 kg/m 2 (range: 15.2 to 57.8 kg/m 2 ). …

ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts

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… hemodialysis center PC-29 Action of a working group depending on our drug commission for the use of a computerized physician order entry (CPOE) PC-40 Analysis of the activity in a dispensing unit aimed to external patients PC-50 The patient–pharmacist communication in a community pharmacy chain in Romania … PC-51 Pharmaceutical care level in Romania community pharmacies PC-61 Medication administration in nursing homes: can pharmacists contribute to error prevention? …

American College of Rheumatology Guidance Statement for Diagnosis and Management of VEXAS Developed by the International VEXAS Working Group Expert Panel.

OBJECTIVE: Vacuoles E1 enzyme X-linked autoinflammatory somatic syndrome (VEXAS) is a recently identified rare genetic disorder associated with somatic mutations in the UBA1 gene. VEXAS presents with a combination of inflammatory and hematologic manifestations, leading to increased morbidity and mortality. METHODS: Given the variability in disease presentation and the limited number of studies to date, no clinical documents currently exist to provide guidance to health care providers about the management of VEXAS. To address this gap, we formed an international multidisciplinary panel of VEXA

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… of the panel and item generation Consensus guidance was developed by a multidisciplinary expert panel composed of 57 internationally recognized members from 18 countries including Armenia, Australia, Belgium, Canada, Czech Republic, France, Germany, Italy, Japan, The Netherlands, Poland, Portugal, Romania …

Preoperative Vitamin D as Predictor of MRONJ: A Retrospective Multivariate Analysis.

Background: Medication-related osteonecrosis of the jaw (MRONJ) is a grave complication in patients with cancer treated with antiresorptive agents, particularly after invasive dental procedures. Identifying reliable clinical factors to assess MRONJ risk remains a clinical challenge. Methods: The retrospective observational study comprised 61 oncologic patients undergoing dental extractions during antiresorptive therapy. Preoperative serum levels of 25-hydroxyvitamin D and β-C-terminal telopeptide cross-link (β-CTx), along with relevant clinical variables, were measured. The analyses included c

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… The Independent Ethics Committee of the University of Medicine and Pharmacy “Victor Babeș”, Timișoara, Romania, granted ethical approval (no. 51/2 October 2023). …

Elevated Macrophage Migration Inhibitory Factor 1 Is Associated with Left and Right Ventricular Systolic Dysfunction in Heart Failure with Reduced Ejection Fraction.

Background/Objectives: Low-grade systemic inflammation, characteristic of heart failure (HF), is a nonspecific inflammatory syndrome that affects the entire body. Macrophage migration inhibitory factor 1 (MIF-1) is a pro-inflammatory cytokine, a key mediator of the innate immune response, and may serve as a potential biomarker of monocyte homing and activation in HF with reduced and mildly reduced ejection fraction (HFrEF, HFmrEF). Methods: We evaluated 70 hemodynamically stable patients with left ventricular EF (LVEF) < 50% by means of echocardiography and blood sampling. Results: We report s

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… Research Design and Method Seventy patients with HF and left ventricular ejection fraction (LVEF) < 50% were enrolled from the Cardiology Department of the Mures County Clinical Hospital, Targu Mures, Romania. All participants were hemodynamically stable at the time of examination. …

Флюидные биомаркеры в демиелионирующих синдромах: прошлое, настоящее и перспективы.

По-прежнему продолжается работа над диагностическим алгоритмом демиелионирующих расстройств центральной нервной системы, а также поиск идеальных биомаркеров. Так называемый "идеальный" биомаркер должен обеспечивать точное различие между наиболее распространенными демиелионирующими патологиями ЦНС и подтипами одной и той же патологии (например, переход от релапсирующего многоразового склероза к вторичному прогрессивному фенотипу). Достижения в области технологии способствовали проведению этого исследования, и в нижеследующих разделах мы всесторонне проанализируем большинство из них, охарактериз

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… Funding Statement The APC was funded by the “Carol Davila” University of Medicine and Pharmacy Bucharest, Romania, Department of Research and Grants through funding by the Romanian Ministry of Research and Innovation (“Publish not Perish”). …

Позвоните посредникам в Множественной миеломе: увязка ожирения с болезнями костей с помощью воспаленных путей.

У пациентов, у которых диагностирован множественный миелома (ММ), основные жалобы на момент диагностики часто связаны с костями, что существенно влияет на качество жизни и повышает заболеваемость и смертность. Ожирение ассоциируется с хроническим воспалительным состоянием, которое приводит к производству различных цитокинов и адипокинов, что может способствовать разрушению костей. Адипониктин, адипокин, в основном скрытый адипоцитами, значительно сокращается в обращении среди лиц с ожирением, что также наблюдается в MM. Это сокращение может привести к нарушению и без того скомпрометированной а

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… Acknowledgments This study is part of the PhD thesis of Alexandra-Ştefania Stroe-Ionescu from the University of Medicine and Pharmacy of Craiova, Craiova, Romania. Alina Daniela Tǎnase and Alexandra-Ştefania Stroe-Ionescu share equal contributions and status as main/first authors. …

Proceedings of the International Cancer Imaging Society Meeting and 21st Annual Teaching Course : Boston, MA, USA. 12-14 September 2022

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… Gallagher 1,2 , K Brindle 2 , R Woitek 1,2,4 , E Sala 1,2 1 University of Cambridge, Cambridge, UK, 2 Cancer Research UK Cambridge Institute, Cambridge, UK, 3 County Clinical Emergency Hospital, Cluj-Napoca, Romania, 4 Medical University, Vienna, Austria Correspondence: V. …

45th International Symposium on Intensive Care & Emergency Medicine.

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… Nat Rev Rheumatol 2022;18:191–204 P042 Inhaled nitric oxide reduces mortality in severe ARDS with pulmonary hypertension: meta-analysis of 6 RCTs V Gherghina 1 , I Cîndea 1 , A Balcan 2 , D Costea 3 , R Popescu 3 1 SCJU Constanta, ATI, Constanta, Romania, 2 Facultatea de Medicin 259, ATI, Constanta … , Romania, 3 Facultatea de Medicin259, Chirurgie, Constanta, Romania Critical Care 2026, 30 (Suppl 1): P042 Introduction: Right ventricular failure from pulmonary hypertension (mPAP > 35 mmHg) complicates 25–35% of severe ARDS with 60–80% mortality. …

Obesity is associated with suppressed bone turnover: a systematic review and meta-analysis.

BackgroundObesity is an increasingly serious public health issue on a global scale. Although there is increasing research on the relationship between obesity and biochemical markers of bone turnover, this relationship is complex and unclear. We conducted a systematic review and meta-analysis aimed at comparing the concentrations of biochemical markers of bone turnover between individuals with obesity and those with normal-weight.MethodA systematic search was conducted using the PubMed, EMBASE, Web of Science, Cochrane Library, and EBSCO databases from database inception to December 15, 2025. T

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… Susan Darroudi , Azienda Ospedaliero Universitaria Policlinico di Modena, Italy Reviewed by: Suzan Kamel-ElSayed , Oakland University William Beaumont School of Medicine, United States Eniko Nemes-Nagy , George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureş, Romania …

Exploring the Vasculitis-Tumors Link: Epidemiological Patterns, Mechanistic Insights, and Clinical Implications.

This review systematically examines the association between vasculitis and malignancies by summarizing the risk of tumor-associated vasculitis, their clinical characteristics, and proposed pathogenic mechanisms across different vasculitic subtypes. Relevant case reports and mechanistic studies are integrated to provide a comprehensive overview of this entity. The findings offer practical value for rheumatologists in distinguishing primary vasculitis from malignancy-associated forms and optimizing patient surveillance, and for oncologists in improving recognition of tumor-associated vasculitis

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… | GCA | 73 M | Portugal | Night sweats, headache, thigh pain, low fever, mandibular claudication | / | Normocytic normochromic anemia; CRP↑; ESR↑ | Temporal artery Doppler ultrasound: edematous halo | Prednisolone | Rapid relief; bone metastasis at 3 months Barbu et al., 2024 [ 80 ] | LCV | 60 M | Romania …

Pro-inflammatory cytokine-mediated anemia: regarding molecular mechanisms of erythropoiesis.

Anemia of cancer and chronic inflammatory diseases is a frequent complication affecting quality of life. For cancer patients it represents a particularly bad prognostic. Low level of erythropoietin is considered as one of the causes of anemia in these pathologies. The deficiency in erythropoietin production results from pro-inflammatory cytokines effect. However, few data is available concerning molecular mechanisms involved in cytokine-mediated anemia. Some recent publications have demonstrated the direct effect of pro-inflammatory cytokines on cell differentiation towards erythroid pathway,

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… Fontana L Pelosi E MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation Proceedings of the National Academy of Sciences of the United States of America 2005 102 50 18081 18086 16330772 10.1073/pnas.0506216102 PMC1312381 130 Felli N Pedini F Romania …

Как готовить пациентов, получающих антирезортивную терапию, к извлечению зубов: обзор.

Бифосфонаты (БП) и Деносумаб (ДМБ) являются антирепрессивными агентами (АА), обычно используемыми для лечения остеопороза, множественной миеломы (8,0%), рака груди (3,3%), рака простаты (2,9 процента) и других магнелез (0,7 процента), метастаза кости и гиперкальцемии, вызванной раком. Однако эта терапия связана со значительным риском связанного с лекарствами остеонекроза челюсти (MRONJ), особенно после выведения зубов. Цель этого описательного обзора заключалась в обобщении текущих данных о мерах, направленных на снижение риска ДРОНЖ после извлечения зубов, и в критическом обсуждении достоверн

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… Effect of Nd:YAG laser light on post-extractive socket healing in rats treated with zoledronic acid and dexamethasone Proceedings of the Sixth International Conference on Lasers in Medicine, Bucharest, Romania, 7–9 May 2015 Todea D.C. Podoleanu A.G. Duma V.-F. …

Overview of dyslipidemia and metabolic syndrome in myeloproliferative neoplasms.

Myeloproliferative neoplasms (MPNs) occur due to the abnormal proliferation of one or more terminal myeloid cell lines in peripheral blood. Subjects suffering from MPNs display a high burden of cardiovascular risk factors, and thrombotic events are often the cause of death in this population of patients. Herein, we provide a brief overview of dyslipidemia and metabolic syndrome and their epidemiology in MPNs and examine the common molecular mechanisms between dyslipidemia, metabolic syndrome, and MPNs, with a special focus on cardiovascular risk, atherosclerosis, and thrombotic events. Further

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… Specialty type: Oncology Country of origin: Romania Peer-review report’s classification Scientific Quality: Grade C Novelty: Grade B Creativity or Innovation: Grade C Scientific Significance: Grade B P-Reviewer: Cigrovski Berkovic M, Croatia S-Editor: Li L L-Editor: Filipodia P-Editor: Zhao YQ …

Availability and Access to Orphan Drugs for Rare Cancers in Bulgaria: Analysis of Delays and Public Expenditures.

Rare cancers are defined by an annual incidence of fewer than 6 per 100,000. Bearing similarities to rare diseases, they are associated with substantial health inequalities due to diagnostic complexity and delayed access to innovative therapies. This situation is further aggravated in Southeastern European countries like Bulgaria, where limited public resources and expertise underscore the need for additional policy and translational research on rare cancers. This study aimed to explore the availability and access to orphan drugs for rare cancers in Bulgaria for the period of 2020-2023. We cro

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… PDG61 Cancer drugs shortages in Romania: Magnitude, causes and solutions. Value Health. 2019;22:S607. doi: 10.1016/j.jval.2019.09.1074. 81. Cherny N., Sullivan R., Torode J., Saar M., Eniu A. …

European guidance for the diagnosis and management of osteoporosis in postmenopausal women.

Guidance is provided in a European setting on the assessment and treatment of postmenopausal women at risk from fractures due to osteoporosis.IntroductionThe International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis published guidance for the diagnosis and management of osteoporosis in 2013. This manuscript updates these in a European setting.MethodsSystematic reviews were updated.ResultsThe following areas are reviewed: the role of bone mineral density measurement for the diagnosis of osteoporosis and assessment of fracture

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… This is the approach to intervention thresholds proposed or used in Belgium, Finland, France, Italy, Ireland, Poland, Romania, Russia, Spain, Switzerland and by the National Osteoporosis Guideline Group (NOGG) in the UK [ 89 , 122 ] and European guidelines for glucocorticoid-induced osteoporosis [ 123 … In several countries (Finland, Lebanon, Romania, UK), there is a link between the FRAX web site to an independent site that plots the FRAX output against the intervention thresholds for that country and facilitates treatment decisions. …