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The potential of the Medical Digital Twin in diabetes management: a review.

Diabetes is a chronic prevalent disease that must be managed to improve the patient's quality of life. However, the limited healthcare management resources compared to the large diabetes mellitus (DM) population are an obstacle that needs modern information technology to improve. Digital twin (DT) is a relatively new approach that has emerged as a viable tool in several sectors of healthcare, and there have been some publications on DT in disease management. The systematic summary of the use of DTs and its potential applications in DM is less reported. In this review, we summarized the key tec

Genetically predicted testosterone and cancers risk in men: a two-sample Mendelian randomization study.

ObjectiveIn observational studies, testosterone has been reported to be associated with some types of cancers. However, the direction and magnitude of the causal association between testosterone and different types of cancer remain unclear. This Mendelian randomization study assessed the causal associations of total testosterone (TT) and bioavailable testosterone (BT) with cancer risk in men.MethodsWe performed two-sample Mendelian randomization using publicly available GWAS summary statistics to investigate the genetically causal association between testosterone and the risk of 22 kinds of ca

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… Khera M, Crawford D, Morales A, Salonia A, Morgentaler A. A new era of testosterone and prostate cancer: from physiology to clinical implications. Eur Urol. 2014;65(1):115–123. doi: 10.1016/j.eururo.2013.08.015. 25. Morgentaler A, Traish AM. …

Comparing Perceptions, Determinants, and Needs of Patients, Family Members, Nurses, and Physicians When Making Life-Sustaining Treatment Decisions for Patients with Hematologic Malignancies.

PurposeThis descriptive study compared the perceptions, determinants, and needs of patients, family members, nurses, and physicians regarding life-sustaining treatment decisions for patients with hematologic malignancies in the hematology-oncology department of a tertiary hospital in Seoul, Korea.MethodsIn total, 147 subjects were recruited, gave written consent, and provided data by completing a structured questionnaire. Data were analyzed using analysis of variance, the chi-square test, and the Fisher exact test.ResultsNurses (F=3.35) and physicians (F=3.57) showed significantly greater fami

Multidisciplinary Approach to Patients With Metastatic Spinal Cord Compression: A Diagnostic Therapeutic Algorithm to Improve the Neurological Outcome.

INTRODUCTION: The morbidity associated with metastatic spinal disease is significant because of spinal cord and/or nerve root compression. The purpose of this paper is to define a diagnostic-therapeutic path for patients with vertebral metastases and from this path to build an algorithm to reduce the devastating consequences of spinal cord compression. MATERIALS AND METHODS: The algorithm is born from the experience of a primary care center. A spine surgeon, an emergency room (ER) physician, a neuroradiologist, a radiation oncologist, and an oncologist form the multidisciplinary team. The ER

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… La Chirurgia Degli Organi di Movimento ( 1998 ) 83 ( 1-2 ): 167–76 . 9718825 47 Greco C Pares O Pimentel N Moser E Louro V Morales X . Spinal Metastases: From Conventional Fractionated Radiotherapy to Single-Dose SBRT . …

Smartphone measurements of physical activity and fitness are associated with early trial discontinuation of patients in (hemato)oncology phase I/II clinical trials.

BackgroundPatients, who discontinue early, do not benefit from phase I/II clinical trials (early-phase clinical trials (EPCT)). In this study, associations between objective smartphone measurements of physical activity and fitness and early trial discontinuation in patients with cancer participating in EPCT were investigated.MethodsBefore start of treatment, physical activity (steps/day) and physical fitness (meters walked in 6 min) were measured with a smartphone, and patient-reported physical function (PRO-PF) was assessed (EORTC QLQ-C30-PF). Early trial discontinuation was defined as discon

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… Olmos D, A’Hern RP, Marsoni S, Morales R, Gomez-Roca C, Verweij J, Voest EE, Schoffski P, Ang JE, Penel N, Schellens JH, Del Conte G, Brunetto AT, Evans TR, Wilson R, Gallerani E, Plummer R, Tabernero J, Soria JC, Kaye SB. …

Longitudinal patterns of cancer patient reported outcomes in end of life care predict survival.

PurposePatients with advanced cancer typically demonstrate sharp deterioration in physical function and psychological status during the last months of life. This study evaluates the relationship between survival in patients with advanced cancer and longitudinal assessment of anxiety, depression, fatigue, pain interference, and/or physical function using the US National Institute of Health Patient Reported Outcomes Information System.MethodsMixed-effects models were used to evaluate patient-reported outcome trajectories over time among patients with advanced loco-regional or metastatic cancer r

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… Liu H Cella D Gershon R Shen J Morales LS Riley W Hays RD Representativeness of the Patient-Reported Outcomes Measurement Information System Internet panel J Clin Epidemiol 2010 63 1169 1178 10.1016/j.jclinepi.2009.11.021 20688473 PMC2943555 25. …

The "Palliative Care Quality of Life Instrument (PQLI)" in terminal cancer patients.

BackgroundThis paper describes the development of a new quality of life instrument in advanced cancer patients receiving palliative care.MethodsThe Palliative Care Quality of Life Instrument incorporates six multi-item and one single-item scale. The questionnaire was completed at baseline and one-week after. The final sample consisted of 120 patients.ResultsThe average time required to complete the questionnaire, in both time points, was approximately 8 minutes. All multi-item scales met the minimal standards for reliability (Cronbach's alpha coefficient > or =.70) either before or during pall

COVID-19 and haematology services in a cancer centre from a middle-income country: adapting service delivery, balancing the known and unknown during the pandemic.

The COVID-19 pandemic has caused major disruptions in multiple spheres of healthcare delivery in the world. Developing nations have had to tackle this unanticipated crisis in the midst of various other healthcare delivery issues and resource constraints. As a tertiary level cancer care provider located in an eastern Indian city, a COVID-19 hotspot, we share our experience from the perspective of haematology and haematopoietic stem cell transplantation (HSCT) services. The primary challenges related to infection control included infection screening and decreasing exposure among patients and hea

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… Protecting healthcare workers (median age at our institution: 27 years (18.8–70.4 years)) anxious by the fear of a yet unknown virus, maintaining staff morale, facilitating employee attendance and ensuring adequate coverage of services, were among many challenges the administration had to grapple with …

Influence of oral health on mucositis in patients undergoing hematopoietic progenitor cell transplantation (HPCT).

AimsTo establish whether or not the state of patient oral health can influence the occurrence and/or severity of oral mucositis during hematopoietic progenitor cell transplantation (HPCT).Materials and methodsThe study included 72 patients awaiting HPCT. Prior to transplantation, clinical exploration and radiology were carried out and oral photographs were taken. This evaluated the extent of caries present, the number of missing teeth and the number of dental fillings in each patient; CAO (Caries and Obturations Index) DMFS (Decayed, Missing, and Filled Surfaces) and Restoration Indices were c

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… They were referred to the Special Patients Teaching Unit at the University Dental Clinic by Morales Meseguer Hospital Oncohematology Service. …

Patients and healthcare professionals' perspectives on the implementation of shared decision making in multiple myeloma: a multinational qualitative study.

BACKGROUND: Shared decision making (SDM) is highly relevant in oncology and cancer care, yet its application within multiple myeloma (MM) remains underexplored. This study aims to (1) investigate SDM implementation in MM clinical practice, (2) assess the role of various stakeholders next to haematologists in the SDM process, and (3) identify barriers and potential solutions to SDM implementation in MM care. METHODS: This qualitative study consisted of semi-structured interviews with patients (n = 39), haematologists (n = 15), and haematology nurses (n = 5) from nine countries in Europe and Is

Оценка MS MoveSmart - онлайновая структурированная тренировка, основанная на социальной когнитивной теории поведенческих тренировок и программе поддержки сверстников - по проблемам тревоги при множественном склерозе.

У людей с множественным склерозом (PwMS) вызывает беспокойство. Хотя известно, что участие в практической деятельности имеет ряд преимуществ, в этом контексте меньше внимания уделяется той роли, которую играет эта деятельность в снижении уровня тревоги. Понимание воздействия упражнений на состояние тревоги, предвидетелей этого изменения и опыта участников будет способствовать дальнейшей разработке программ, которые могут оказать поддержку PwMS.AIM: В этом исследовании использовалась схема оценки до/после проведения оценки (AIM):1) для оценки эффективности структурированной онлайновой программы

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… Responses indicated that participants experienced benefit from this peer support in a number of ways including a sense of comradery and understanding: ‘I would value the programme for the contact with other people who are experiencing this stuff and it’s for good morale I think, and it certainly would … Additionally, the structure and regularity provided by the MoveSmart programme received considerable praise and seemed to help participants work towards their individual goals, as well as generally providing something for participants to ‘look forward to’ which was reported as positively impacting morale …

A Review of Approaches to Potentiate the Activity of Temozolomide against Glioblastoma to Overcome Resistance.

A glioblastoma (GBM) is one of the most aggressive, infiltrative, and treatment-resistant malignancies of the central nervous system (CNS). The current standard of care for GBMs include maximally safe tumor resection, followed by concurrent adjuvant radiation treatment and chemotherapy with the DNA alkylating agent temozolomide (TMZ), which was approved by the FDA in 2005 based on a marginal increase (~2 months) in overall survival (OS) levels. This treatment approach, while initially successful in containing and treating GBM, almost invariably fails to prevent tumor recurrence. In addition to

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… Hernández-Vega A.M., Del Moral-Morales A., Zamora-Sánchez C.J., Piña-Medina A.G., González-Arenas A., Camacho-Arroyo I. Estradiol Induces Epithelial to Mesenchymal Transition of Human Glioblastoma Cells. Cells. 2020;9:1930. doi: 10.3390/cells9091930. 59. …

What is new in the pathogenesis and treatment of IgA glomerulonephritis.

Recently, new findings have been clarified concerning both pathogenesis and treatment of IgA nephritis. The four hits theory has been confirmed but several genetic wide association studies have allowed finding several genes connected with the pathogenesis of the disease. All these new genes apply to each of the four hits. Additionally, new discoveries concerning the microbiota and its connection with immune system and IgA generation have allowed finding out the role of the mucosa in IgA nephropathy pathogenesis. The IgA treatment is also changed included the future possibilities. The treatment

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… Praga M, Gutiérrez E, González E, Morales E, Hernández E. Treatment of IgA nephropathy with ACE inhibitors: a randomized and controlled trial. J Am Soc Nephrol. 2003;14:1578–1583. doi: 10.1097/01.asn.0000068460.37369.dc. 46. … Broseta JJ, Albines ZS, Escamilla Cabrera B, Rivero Viera Y, Rodriguez Santarelli D, Salanova Villanueva L, Lopez Rodriguez F, Cancho Castellano B, Ibáñez Cerezon M, Gutierrez Rivas CP, Aresté N, Campos Gutiérrez B, Ródenas Gálvez A, Glucksmann Pizá MC, Balda Manzanos S, Soldevila A, Rodríguez Gayo L, Moral …

Effects of Dietary Oleacein Treatment on Endothelial Dysfunction and Lupus Nephritis in Balb/C Pristane-Induced Mice.

Systemic lupus erythematosus (SLE) is a chronic immune-inflammatory disease characterized by multiorgan affectation and lowered self-tolerance. Additionally, epigenetic changes have been described as playing a pivotal role in SLE. This work aims to assess the effects of oleacein (OLA), one of the main extra virgin olive oil secoiridoids, when used to supplement the diet of a murine pristane-induced SLE model. In the study, 12-week-old female BALB/c mice were injected with pristane and fed with an OLA-enriched diet (0.01 % (w/w)) for 24 weeks. The presence of immune complexes was evaluated by i

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… Morales L.D. Jang I.S. Cho Y.Y. Kim D.J. Protein Tyrosine Phosphatases as Potential Regulators of STAT3 Signaling Int. J. Mol. Sci. 2018 19 2708 10.3390/ijms19092708 30208623 PMC6164089 55. Jamilloux Y. El Jammal T. Vuitton L. Gerfaud-Valentin M. Kerever S. Sève P. … Gómez-Morales M. O’Valle F. López-Farré A.J. Algieri F. Gálvez J. Chronic Hydroxychloroquine Improves Endothelial Dysfunction and Protects Kidney in a Mouse Model of Systemic Lupus Erythematosus Hypertension 2014 64 330 337 10.1161/HYPERTENSIONAHA.114.03587 24842914 69. Romero M. Toral M. …

Efficacy and safety profile of COVID-19 mRNA vaccine in patients with hematological malignancies: Systematic review and meta-analysis.

Patient populations, including those with hematological malignancies, have different responses to COVID-19 vaccines. This study aimed to quantitatively analyze the efficacy and safety of COVID-19 mRNA vaccines in patients with hematological malignancies. Studies reporting on the efficacy and safety of COVID-19 mRNA vaccines in cohorts with hematological malignancies compared to healthy controls were systematically searched in four databases. Meta-analysis and subgroup analyses were performed to generate quantitative synthesis. Fifteen studies with 2,055 cohorts with hematological malignancies

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… Perry C, Luttwak E, Balaban R, Shefer G, Morales MM, Aharon A, et al. Efficacy of the BNT162b2 mRNA COVID-19 vaccine in patients with b-cell non-Hodgkin lymphoma. Blood Adv (2021) 5(16):3053–61. doi: 10.1182/bloodadvances.2021005094 27. … Avivi I, Balaban R, Shragai T, Sheffer G, Morales M, Aharon A, et al. Humoral response rate and predictors of response to BNT162b2 mRNA COVID19 vaccine in patients with multiple myeloma. Br J Haematol (2021) 195(2):186–93. doi: 10.1111/bjh.17608 30. …

Role of Cannabidiol for Improvement of the Quality of Life in Cancer Patients: Potential and Challenges.

There is currently a growing interest in the use of cannabidiol (CBD) to alleviate the symptoms caused by cancer, including pain, sleep disruption, and anxiety. CBD is often self-administered as an over-the-counter supplement, and patients have reported benefits from its use. However, despite the progress made, the mechanisms underlying CBD's anti-cancer activity remain divergent and unclear. Herein, we provide a comprehensive review of molecular mechanisms to determine convergent anti-cancer actions of CBD from pre-clinical and clinical studies. In vitro studies have begun to elucidate the mo

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… Morales P., Reggio P.H. An Update on Non-CB1, Non-CB2 Cannabinoid Related G-Protein-Coupled Receptors. Cannabis Cannabinoid Res. 2017;2:265–273. doi: 10.1089/can.2017.0036. 29. Holland M.L., Allen J.D., Arnold J.C. Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1) Eur. … Muller C., Morales P., Reggio P.H. Cannabinoid Ligands Targeting TRP Channels. Front. Mol. Neurosci. 2019;11:487. doi: 10.3389/fnmol.2018.00487. 34. Bakas T., van Nieuwenhuijzen P., Devenish S., McGregor I., Arnold J., Chebib M. …

Imaging for Plasma Cell Dyscrasias: What, When, and How?

Imaging plays a vital role in the diagnosis, response assessment, and follow-up of patients with plasma cell bone disease. The radiologic diagnostic paradigm has thus far evolved with developing technology and availability of better imaging platforms; however, the skewed availability of these imaging modalities in developed vis-à-vis the developing countries along with the lack of uniformity in reporting has led to a consensus on the imaging criteria for diagnosing and response assessment in plasma cell dyscrasia. Therefore, it is imperative for not only the radiologists but also the treating

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… Morales KA, Arevalo-Perez J, Peck KK, Holodny AI, Lis E, Karimi S. Differentiating Atypical Hemangiomas and Metastatic Vertebral Lesions: The Role of T1-Weighted Dynamic Contrast-Enhanced MRI. Am J Neuroradiol (2018) 39(5):968–73. doi: 10.3174/ajnr.A5630 53. Rahme R, Moussa R. … Morales MI, Lapa C, Buck AK. CXCR4 Imaging in Multiple Myeloma. Mol Imaging Mult Myeloma (2019), 87–92. doi: 10.1007/978-3-030-19019-4_6 74. Huang W, Dong H, Ji X, Xia S. Advanced Imaging in Evaluation of Bone Disease of Multiple Myeloma. …

The Arrhythmic Burden of Cardiac Amyloidosis: A Comprehensive Review.

Cardiac amyloidosis (CA) represents a growing etiology of heart failure (HF) and arrhythmogenesis, driven by the intramyocardial deposition of aberrantly folded proteins, notably immunoglobulin light chains (AL) and transthyretin (ATTR). This infiltrative process compromises myocardial compliance and disrupts the cardiac conduction system, leading to a diverse spectrum of dysrhythmias. The escalating prevalence of CA, particularly within geriatric demographics and individuals with plasma cell dyscrasias, underscores the imperative for refined diagnostic and therapeutic paradigms. The considera

Therapeutic Vaccines for Hematological Cancers: A Scoping Review of This Immunotherapeutic Approach as Alternative to the Treatment of These Malignancies.

Background/Objectives: The need for innovative cancer treatments has brought immunotherapies to the forefront as a promising approach, with therapeutic vaccines demonstrating the potential to mobilize immune cells to eliminate tumor cells. However, challenges such as genetic variability among patients, immune evasion mechanisms, and disease relapse contribute to the complexity of achieving an ideal therapy, especially for hematological cancers. This review systematically identifies and analyzes recent studies focused on the development of therapeutic immunotherapy vaccines, examining critical

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… Gómez-Morales L. Mendoza-Reveles R. Caballero-Hernández D. Karoyan P. Rodríguez-Padilla C. PKHB1 Tumor Cell Lysate Induces Antitumor Immune System Stimulation and Tumor Regression in Syngeneic Mice with Tumoral T Lymphoblasts J. Oncol. 2019 2019 9852361 10.1155/2019/9852361 31275386 PMC6582786 53. … Morales-Gonzalez S. Schuelke M. Nikolaus M. Hodgkin Lymphoma Cell Lines and Tissues Express MGluR5: A Potential Link to Ophelia Syndrome and Paraneoplastic Neurological Disease Cells 2023 12 606 10.3390/cells12040606 36831273 PMC9953995 92. Moubadder L. McCullough L.E. Flowers C.R. Koff J.L. …

Cardiac amyloidosis: evolving pathogenesis, multimodal diagnostics, and principles of treatment.

Amyloidosis is a protein deposition disorder in which insoluble fibril structures accumulate in the bodily tissues damaging the organ function. Cardiac amyloidosis is a severe but under-reported medical condition characterized by the accumulation of amyloid in the extracellular area of the myocardium, which results in thickening and stiffening of ventricular walls. Cardiac amyloidosis has recently gained much attention with its slowly surging incidence. With this study, we seek to comprehensively compile the pathophysiology and clinical picture of cardiac amyloidosis subtypes, extending a clin