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SCS 6th Annual Meeting-EEVFA-11th International Congress of Biochemistry and Physiology of Exercise, Athens, Greece, 2023.

On behalf of the Strength and Conditioning Society (SCS) and the Hellenic Society of Biochemistry and Exercise Physiology (EEVFA), we are pleased to present the abstracts of the SCS 6th Annual Meeting and EEVFA-11th International Congress of Biochemistry and Physiology of Exercise. The event was held at the Hellenic Olympic Committee headquarters in Athens, Greece, on 19-22 October 2023, and comprised several invited sessions from international and national speakers on a variety of topics related to biochemistry and exercise physiology, strength and conditioning practices and their application

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… While there is evidence to suggest that acute WBV can enhance isometric strength and electromyographic (EMG) activity in the quadriceps muscle in adults, the optimal protocol for its application in adolescents remains to be fully explored (2–4). …

Экспериментальный аутоиммунный энцефаломиэлит вызывает мышечную дисфункцию мышей.

Множественный склероз (MS) — нервно-воспалительное заболевание мозга и спинного мозга, характеризующееся обезвоживанием, нейродегенерацией и хроническим воспалением. Более 90% людей с MS имеют периферийные мышечные дисфункции и постепенное снижение мобильности. Текущее лечение смягчает подстрекательские процессы, но не предотвращает прогрессирование заболеваний. В связи с этим сохраняется неудовлетворенная потребность в новых и/или дополнительных терапевтических подходах, которые конкретно улучшают мышечно-функциональное функционирование этого пациента. Разработка новых методов лечения скелетн

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… Muscle weight of the gastrocnemius-soleus complex (GS) and quadriceps muscle (c) . Relative mRNA expression of OXPHOS subunits; Ndufb5 for complex I, SDHB for complex II, Uqcrc2 for complex III, Cox5b for complex IV and ATP5o for complex V (d) . … Muscle weight of larger muscle groups, such as the gastrocnemius-soleus complex and the quadriceps muscle were not statistically significantly different between groups, although the quadriceps showed a trend toward lower muscle weight in diseased mice (−14.3%, p  = 0.06) ( Figure 3c ). …

Abstracts of the 5(th) Cachexia Conference, Barcelona, Spain, December 5-8, 2009.

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Применение периферального магнитного стимула в процессе реабилитации: обзор.

Перпериферийная магнитная стимуляция все чаще используется для лечения дисфункций, связанных с различными расстройствами. Однако в настоящее время отсутствует консенсус в отношении его эффективности применительно к конкретным группам населения, болезням, условиям вмешательства, продолжительности лечения или результатам. Цель этого аналитического обзора заключалась в выявлении, обобщении и составлении карт соответствующей литературы по периферической магнитной стимуляции с уточнением ее применения в разбивке по типам заболеваний, участку лечения, функциональным дефектам, результатам и условиям

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… Bustamante et al., 2010 | Spain | RCT | COPD n=18 Female, 0% Age: rPMS: 61±6 years Control: 62±8 years | Muscle dysfunction | Quadriceps muscle | rPMS 15 Hz frequency Intensity: 40% of the maximum stimulation (2T) Intensity was increased by 2%–3% every two sessions, ending the protocol at an intensity … muscles, with exercise capacity serving as the main outcome measure. …

How long do endoprosthetic reconstructions for proximal femoral tumors last?

BackgroundAs the life expectancy of patients with musculoskeletal tumors improves, long-term studies of endoprosthetic reconstructions are necessary to establish realistic expectations for the implants and compare them to other reconstruction approaches.Questions/purposes(1) What is the long-term survival of cemented bipolar proximal femoral replacements? (2) How does prosthesis survival compare to patient survival among patients with Stage I, II, and III disease? (3) Do modular implants outperform custom-built prostheses? (4) Do some proximal femoral replacements require conversion to THA?Pat

CSA-90 Promotes Bone Formation and Mitigates Methicillin-resistant Staphylococcus aureus Infection in a Rat Open Fracture Model.

BACKGROUND: Infection of open fractures remains a significant cause of morbidity and mortality to patients worldwide. Early administration o … n assay, 0 to 10 µg BMP-2 and 0 to 500 µg CSA-90 were delivered on a collagen sponge into bilateral quadriceps muscle pouches of 8-week-old rats (n = 10 per group). Micro-CT quantification of bone volume and descriptive histologic analysis were performed for all in vivo studies. Modified Kirby-Bauer disc diffusion assays were used to quantify antimicrobial activity …

Proximal Femur Megaprostheses in Orthopedic Oncology: Evaluation of a Standardized Post-operative Rehabilitation Protocol.

BackgroundReconstructions of the proximal femur after massive resections represent one of the main challenges in orthopedic oncology. Among the possible treatments, megaprostheses represent one of the most used and reliable reconstructive approaches. Although literature about their outcomes has flourished through the last decades, a consensus rehabilitative treatment is still far from being established.Materials and methodsWe evaluated the functional results of all our oncologic cases treated between 2016 and 2022 that could follow our standardized post-operative rehabilitative approach, consi

Bisphosphonate Treatment Ameliorates Chemotherapy-Induced Bone and Muscle Abnormalities in Young Mice.

Chemotherapy is frequently accompanied by several side effects, including nausea, diarrhea, anorexia and fatigue. Evidence from ours and other groups suggests that chemotherapy can also play a major role in causing not only cachexia, but also bone loss. This complicates prognosis and survival among cancer patients, affects quality of life, and can increase morbidity and mortality rates. Recent findings suggest that soluble factors released from resorbing bone directly contribute to loss of muscle mass and function secondary to metastatic cancer. However, it remains unknown whether similar mech

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… Real-Time Quantitative PCR Total mRNA from quadriceps muscle was isolated using the miRNeasy Mini Kit (Qiagen, Germantown, MD, USA) and following the protocol provided by the manufacturer. RNA was quantified using a Synergy H1 Spectrophotometer (BioTek Instruments, Winooski, VT, USA). … Figure 11 Muscle protein hypercatabolism is counteracted by ZA administration in C-treated mice. mRNA expression for the ubiquitin ligases Atrogin-1 and MuRF-1 in the quadriceps muscle of mice treated with cisplatin and/or ZA ( n = 4–5). Data are shown as means ± SEM. …

Pharmacological inhibition of myostatin effectively ameliorates osteolytic lesions in syngeneic and xenograft breast cancer mouse models.

Breast cancer (BC)-derived bone metastases colonize bone and drive severe bone degradation through complex interactions with bone-resorbing osteoclasts (OCs). Subsequent bone resorption liberates matrix-stored factors, such as TGF-β and calcium, which further stimulate tumor proliferation and exacerbate bone destruction. Myostatin (Mstn), a member of the TGF-β superfamily, is known to enhance OC differentiation and bone resorption in models of musculoskeletal disease; however, its role in BC-associated bone lesions and metastases remains unknown. Here, we demonstrate that bone metastases from

Exercise for reducing falls in people living with and beyond cancer.

BACKGROUND: Current treatment modalities for cancer have been successful in achieving improved survivorship; however, they come with a number of long-term adverse effects. Accidental falls are a common and clinically significant adverse event in people living with and beyond cancer and rates are higher than in the rest of the population. OBJECTIVES: To assess the effects of prescribed or provided exercise for reducing accidental falls, and falls risk factors of strength, flexibility and balance, in people living with and beyond cancer. SEARCH METHODS: We searched the following electronic dat

Роль VibraPlus в утомлении пациентов с множественным склерозом: случайный контролируемый процесс.

Предыстория и цель: Усталость представляет собой отличительный симптом множественного склероза (MS), однако его диагностика и клиническая оценка сопряжены с трудностями, поскольку он описывается как субъективное чувство истощенного физического и психического ощущения. Исследования также показали, что подходы, основанные на терапии и робототехнике, а также использование вибрации, которые используются для улучшения сенсорной интеграции, уменьшают усталость. Основным результатом этого исследования является оценка воздействия применения вибрации с помощью фокуса на снижение усталости, мышечной сил

A Unique Mode of Failure in the Noncontact Bridging Periprosthetic Plating System.

Although lateral locking plates are often a preferred and successful fixation construct for the treatment of periprosthetic proximal and distal femur fractures, specific complications and modes of failure have been associated and well-described with their use. We present two cases of implant failure in the Non-Contact Bridge Periprosthetic Plating System (Zimmer Biomet) in which a nonlocked screw fretted through the annular seating of the plate. One case demonstrates failure in the setting of a proximal femur periprosthetic fracture, whereas the other demonstrates failure in the setting of a d

Musculoskeletal Chronic Graft versus Host Disease-A Rare Complication to Allogeneic Hematopoietic Stem Cell Transplant: A Case-Based Report and Review of the Literature.

Musculoskeletal graft versus host disease (GVHD) is a rare manifestation of chronic GVHD (cGVHD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Left untreated, the disease can cause extensive damage to muscle tissue and joints. We describe a 62-year-old male with musculoskeletal GVHD and generalized muscle pain and stiffness. In addition, we performed a systemic literature review based on published cases of musculoskeletal GVHD between 1983 and 2019. We identified 85 cases, 62% male and 38% female with an age of 4-69 years and median age of 39 years at diagnosis. The

Обзор влияния мышечной вибрации на восстановление спасти.

ВВЕДЕНИЕ: В настоящем обзоре анализируются выгоды, связанные с вибрацией мышечных мышц (ВЧ) при лечении спастисти, способствующей углублению понимания и устойчивому улучшению моторных функций. Выводы могли бы способствовать отбору оптимальных протоколов по ТТС, направлять будущие исследования и давать представление о механизмах, с помощью которых ФТС может улучшить моторные функции у лиц, имеющих сенсибилизацию. МЕТОДЫ: Систематический поиск проводился с использованием онлайновых баз данных PubMed, Web of Science и Библиотеки Кокрана. Включая критерии: а) наличие у участников хронической спаст

Удобство, последовательность и эффективность одежды с текстильными электродами по сравнению с гидрогелевыми электродами для нейромускульной электрической стимуляции в ходе случайного перекрестного испытания.

Эффективность и комфортность нейромускульной электрической стимуляции (NMES) в значительной степени зависят от типа используемых электродов. Традиционные самоклеющиеся гидрогельные электроды, хотя и являются эффективными, создают ограничения с точки зрения износа, совместимости кожи и воспроизводимости. В ходе этого случайного перекрестного испытания изучается эффективность конкретного текстильного электрода, встроенного в одежду NMES нижних конечностей, с уделением особого внимания их потенциальному применению для реабилитации пациентов с неврологическими расстройствами, такими, как инсульт,

Randomized controlled trial on the effects of a supervised high intensity exercise program in patients with a hematologic malignancy treated with autologous stem cell transplantation: Results from the EXIST study.

BackgroundThis single blind, multicenter randomized controlled trial aimed to evaluate the effectiveness of a supervised high intensity exercise program on physical fitness and fatigue in patients with multiple myeloma or lymphoma recently treated with autologous stem cell transplantation.Methods109 patients were randomly assigned to the 18-week exercise intervention or the usual care control group. The primary outcomes included physical fitness (VO2peak and Wpeak determined using a cardiopulmonary exercise test; grip strength and the 30s chair stand test) and fatigue (Multidimensional Fatigue

Morphofunctional parameters as predictors of autologous hematopoietic stem cell transplantation outcomes.

IntroductionThere is a lack of predictive factors for specific complications in patients who undergo autologous hematopoietic stem cell transplantation. A complete morphofunctional assessment is not usually performed before the procedure. Malnutrition is related to lower survival in cancer patients. Our aim is to identify both risk and protective factors for such complications to refine management and improve outcomes.MethodsWe have implemented the program 'RHeNutrir', which involves a systematic malnutrition and sarcopenia screening, as well as a complete nutritional and functional assessment

Factors affecting pretransplant muscle strength in allogeneic stem cell transplant candidates prior transplantation.

PurposePhysical performance is crucial for prognosis after allogeneic hematopoietic stem cell transplantation (allo-HCT). Cardiorespiratory fitness has already been shown to have prognostic value, and there is increasing evidence that muscle strength and associated parameters (e.g., sarcopenia) are also of clinical relevance. Therefore, there is a need for the quantification of muscle strength and defining risk factors for reduced performance values.MethodsMaximal voluntary isokinetic (MVIC) and isometric (MIPT) muscle strength was assessed 2.4 ± 7.1 days prior admission for allo-HCT with a st

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… We chose the muscle strength of the quadriceps muscle as a representative value for loads of activities of daily living. The values of MVIC and MIPT were defined as dependent variable: MVIC Knee and MIPT Knee . Significant level was set at p < 0.05. …

Effect of exercise training on functional capacity & quality of life in head & neck cancer patients receiving chemoradiotherapy.

Background & objectivesPatients with head and neck cancer (HNC) undergoing chemoradiotherapy (CRT) suffer from fatigue causing a decrease in functional capacity and quality of life (QoL). Limited research in the field of exercise training among these patients demanded the need for this study to assess the effects of exercise training on functional capacity and quality of life.MethodsA randomized controlled trial was conducted on 48 patients with HNC undergoing CRT. The exercise group received an individually tailored, supervised, exercise programme for six weeks, while the control group did no

Design of the EXercise Intervention after Stem cell Transplantation (EXIST) study: a randomized controlled trial to evaluate the effectiveness and cost-effectiveness of an individualized high intensity physical exercise program on fitness and fatigue in patients with multiple myeloma or (non-) Hodgkin's lymphoma treated with high dose chemotherapy and autologous stem cell transplantation.

BACKGROUND: The use of high-dose chemotherapy combined with autologous stem cell transplantation has improved the outcome of hematologic malignancies. Nevertheless, this treatment can cause persistent fatigue and a reduced global quality of life, role and physical function. Physical exercise interventions may be beneficial for physical fitness, fatigue and quality of life. However, the trials conducted so far to test the effects of physical exercise interventions in this group of patients were of poor to moderate methodological quality and economic evaluations are lacking. Hence there is need