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Redefining Breast Cancer Care by Harnessing Computational Drug Repositioning.

Breast cancer faces significant therapeutic challenges, particularly for triple-negative breast cancer (TNBC), due to limited targeted therapies and drug resistance. Drug repositioning leverages existing safety and pharmacokinetic data to expedite the identification of new indications with cost-effective benefits compared to de novo drug discovery. In this critical narrative review, we examine recent advances in computational repositioning strategies for breast cancer, focusing on network-based methods, computer-aided drug design, artificial intelligence and machine learning, transcriptomic si

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… The New Tale of Some Old Drugs Proceedings of the 17th Romanian National Congress oh Pharmacy—21st Century Pharmacy—Between Intelligent Specialization and Social Responsibility, Bucharest, Romania, 26–29 September 2018, Proceedings Filodiritto Bologna, Italy 2020 234 240 32. Sharma P.P. Bansal M. …

Targeting degradation of IKZF1 and IKZF3 through modulation of the E3 ligase substrates in the context of cellular therapies for multiple myeloma.

Multiple myeloma (MM) is a blood cancer characterized by the clonal evolution of plasma cells. In 2022, there were an estimated 118 000 MM cases and 121 000 deaths worldwide. The treatment landscape of MM has undergone a dramatic transformation in recent decades, shifting from conventional chemotherapy to more targeted approaches. In order to overcome intrinsic and acquired resistance mechanisms that frequently restrict the efficacy of single-agent therapies, drug combination strategies have been developed to simultaneously target multiple pathogenetic pathways. Building on the success of immu

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… C.T. is supported by by an international grant of the European Commission – Horizon Europe Framework Network, HORIZON-TMA-MSCA-DN (Proposal Number 101227725 – „Advancing in the CHallenge of Improving Lymphoma and LEukemia Survival – ACHILLES”) and by a bilateral collaboration grant between Romania and …

Изучение цереброваскулярных проявлений нейроборлиоза: обзор.

Заболевание Lyme - это зоонотическая инфекция, передающаяся Боррелией Бурдорфери, и, если ее не диагностировать, она может появиться на более поздних этапах с неврологическими проявлениями. Цель этого обзора заключается в обобщении данных о инсультовом или аналогичном цереброваскулярном исходе нейроборрелиоза Лайма (НБ) для содействия раннему распознаванию и лечению. 90 - пациенты, отвечающие критериям Европейской федерации неврологических обществ/Американской академии неврологических заболеваний/Американской школы ревматологии (EFNS/IDSA/AAN/ACR) для ЛНБ с радиологически или серологически под

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… ) | 4/90 (4.4%) Finland, n/N (%) | 4/90 (4.4%) Poland, n/N (%) | 4/90 (4.4%) Belgium, n/N (%) | 3/90 (3.3%) Croatia, n/N (%) | 2/90 (2.2%) Sweden, n/N (%) | 2/90 (2.2%) Norway, n/N (%) | 2/90 (2.2%) Portugal, n/N (%) | 2/90 (2.2%) Denmark, n/N (%) | 1/90 (1.1%) Czech Republic, n/N (%) | 1/90 (1.1%) Romania …

Терапия сотовой связи для руматоидного артрита.

Химерическая антигенная рецепторная (CAR) клеточная терапия Т произвела революцию в лечении лейкемии, лимфомы и множественных миеломы, реанимировав на поверхности этих клеток антигены CD19 и BCMA. В последнее время появляется все больше свидетельств того, что эти клеточные методы лечения могут также быть направлены против аутоиммунных заболеваний, включая системный волчаньий эритематос, системный склероз, расстройство спектрального спектра нейромиелита, миастения гравис, идиопатический воспалительный миосит, множественный склероз и ревматоидный артрит. На сегодняшний день ten Пациенты с ревмат

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… Unknown) | Preliminary study | Preliminary Clinical Study of UTAA09 Injection in the Treatment of Relapsed/​Refractory Autoimmune Diseases (including RA) | UTAA09 (Allogeneic CD19-targeting γδ CAR T cells) | Not yet recruiting NCT07115745 (US, Australia, Brazil, Czechia, France, Germany, Israel, Poland, Romania …

Natural Products/Bioactive Compounds as a Source of Anticancer Drugs.

Cancer is one of the major deadly diseases globally. The alarming rise in the mortality rate due to this disease attracks attention towards discovering potent anticancer agents to overcome its mortality rate. The discovery of novel and effective anticancer agents from natural sources has been the main point of interest in pharmaceutical research because of attractive natural therapeutic agents with an immense chemical diversity in species of animals, plants, and microorganisms. More than 60% of contemporary anticancer drugs, in one form or another, have originated from natural sources. Plants

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… Comparison of different extraction solvents for characterization of antioxidant potential and polyphenolic composition in Boletus edulis and Cantharellus cibarius mushrooms from Romania Molecules 2021 26 7508 10.3390/molecules26247508 34946590 PMC8704948 153. Nowakowski P. Markiewicz-Żukowska R. …

Assessment of kidney transplant suitability for patients with prior cancers: is it time for a rethink?

Kidney transplant recipients have up to a 100-fold greater risk of incident cancer compared with the age/sex-matched general population, attributed largely to chronic immunosuppression. In patients with a prior history of treated cancers, the type, stage and the potential for cancer recurrence post-transplant of prior cancers are important factors when determining transplant suitability. Consequently, one of the predicaments facing transplant clinicians is to determine whether patients with prior cancers are eligible for transplantation, balancing between the accelerated risk of death on dialy

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… Am J Transplant 2014 ; 14 : 1368 . 24730453 10.1111/ajt.12716 111 Suteu O , Blaga ML , Nicula F , et al Incidence trends and survival of skin melanoma and squamous cell carcinoma in Cluj County, Romania . …

A Review of New Findings in Adult T-cell Leukemia-Lymphoma: A Focus on Current and Emerging Treatment Strategies.

Adult T-cell leukemia-lymphoma (ATL), a rare and aggressive T-cell malignancy caused by human T-cell lymphotropic virus type 1 (HTLV-1), is associated with a poor prognosis. Evidence-based standard treatment options are lacking and outcomes are generally unsatisfactory, particularly for patients with relapsed or refractory disease. Continued research is contributing to changing treatment landscape as a number of existing and investigational agents are evaluated. We describe the epidemiology of HTLV-1 and ATL, discuss the biology behind the disease, review current treatment practices and guidel

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… Infection with the HTLV-1 virus is endemic in several regions, including southwestern Japan, some parts of the Caribbean, South America, some areas of intertropical Africa (such as South Gabon) and of the middle East (such as the Mashad region in Iran), isolated clusters in Australo–Melanesia, and Romania …

Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.

BACKGROUND: Timely and comprehensive analyses of causes of death stratified by age, sex, and location are essential for shaping effective health policies aimed at reducing global mortality. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023 provides cause-specific mortality estimates measured in counts, rates, and years of life lost (YLLs). GBD 2023 aimed to enhance our understanding of the relationship between age and cause of death by quantifying the probability of dying before age 70 years (70q0) and the mean age at death by cause and sex. This study enables comparis

Estimation of Future Patient Populations Eligible for Radioligand Therapies in the EU and the UK: A Modelling Study.

BackgroundThe eligible patient population for radioligand therapies (RLTs) has the potential to grow rapidly in the coming years. European healthcare systems may be ill-prepared to provide the additional treatment capacity required on top of current workload. To address this challenge, data on the size of the eligible patient pool and the potential utilisation of RLTs are needed.MethodsThe maximum pool of patients theoretically eligible for RLTs over the next decade was estimated for the 27 EU member states (EU-27) using incidence data, and additionally for France, Germany, Italy, Spain (EU-4)

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… 645,397 | 420 | <100 | 100 | 200–300 Malta | No | 520,971 | Not available | <100 | 100 | 100–200 Netherlands | Yes | 17,590,672 | 320 | 400–500 | 2300–3800 | 4700–6800 Poland | Yes | 37,654,247 | 830 | 900–1100 | 4300–7100 | 8700–12,600 Portugal | Yes | 10,352,042 | 800 | 200–300 | 1400–2300 | 2900–4200 Romania …

Oncolytic Viruses as Reliable Adjuvants in CAR-T Cell Therapy for Solid Tumors.

Although impactful scientific advancements have recently been made in cancer therapy, there remains an opportunity for future improvements. Immunotherapy is perhaps one of the most cutting-edge categories of therapies demonstrating potential in the clinical setting. Genetically engineered T cells express chimeric antigen receptors (CARs), which can detect signals expressed by the molecules present on the surface of cancer cells, also called tumor-associated antigens (TAAs). Their effectiveness has been extensively demonstrated in hematological cancers; therefore, these results can establish th

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… The authors would like to acknowledge the funding provided by the Ministry of Research, Innovation, and Digitization in Romania under Program 1—The Improvement of the National System of Research and Development, and Subprogram 1.2—Institutional Excellence—Projects of Excellence Funding in RDI, Contract …

Plasma exchange and COVID 19.

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… Hyperviscosity | Completed | No available | COVID-19 | Biological: TPE Other:standard of care | USA Therapeutic Plasma Exchange followed by Convalescent plasma transfusion in severe and critically ill COVID-19 patients | Completed | No available | COVID-19 pneumonia, respiratory infection, ARDS | Other: TPE | Romania …

Biotechnological Innovations from Ocean: Transpiring Role of Marine Drugs in Management of Chronic Disorders.

Marine drugs are abundant in number, comprise of a diverse range of structures with corresponding mechanisms of action, and hold promise for the discovery of new and better treatment approaches for the management of several chronic diseases. There are huge reserves of natural marine biological compounds, as 70 percent of the Earth is covered with oceans, indicating a diversity of chemical entities on the planet. The marine ecosystems are a rich source of bioactive products and have been explored for lead drug molecules that have proven to be novel therapeutic targets. Over the last 70 years, m

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… Funding Funding for publication of this paper was provided by the University of Oradea, Oradea, Romania, by an Internal Project. Institutional Review Board Statement Not applicable. Informed Consent Statement Not applicable. Data Availability Statement Not applicable. …

Characterizing the Patient Journey in Multiple Myeloma: Qualitative Review.

BACKGROUND: The patient experience of multiple myeloma (MM) is multifaceted and varies substantially between individuals. Current published information on the patient perspective and treatment of MM is limited, making it difficult to gain insights into patient needs regarding the condition. OBJECTIVE: In this review, a combined research method approach (ie, the review of published literature and social media posts) was undertaken to provide insight into patients' perspectives on the burden and treatment of MM, the impact of the COVID-19 pandemic, and the impact of MM on caregivers of patients

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… For example, patients in Belgium stated that hospital services continued as normal, but patients in Romania, Poland, and Scotland reported challenges associated with scheduling appointments and travel restrictions as well as limited hospital access. …

A multicountry ecological study of cancer incidence rates in 2008 with respect to various risk-modifying factors.

Observational and ecological studies are generally used to determine the presence of effect of cancer risk-modifying factors. Researchers generally agree that environmental factors such as smoking, alcohol consumption, poor diet, lack of physical activity, and low serum 25-hdyroxyvitamin D levels are important cancer risk factors. This ecological study used age-adjusted incidence rates for 21 cancers for 157 countries (87 with high-quality data) in 2008 with respect to dietary supply and other factors, including per capita gross domestic product, life expectancy, lung cancer incidence rate (an

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… Guyana, Hungary, Iceland, Iran, Ireland, Israel, Italy, Jamaica, Japan, Kazakhstan, Korea (Republic), Kuwait, Kyrgyzstan, Latvia, Lithuania, Luxembourg, Macedonia, Malaysia, Mauritius, Mexico, Mongolia, Netherlands, New Zealand, Nicaragua, Norway, Panama, Paraguay, Peru, Philippines, Poland, Portugal, Romania …

P941 – P1197

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17th Конгресс ЕВНОС: Милан, Италия, 4–6 Июнь, 2026 года

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Специальный выпуск: резюме 11th Конгресс Европейской академии неврологии, Хельсинки, Финляндия.

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… Panea 2 1 Neurology, Elias Emergency University Hospital, Bucharest, Romania; 2 Neurology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania Background and aims: Human Herpes Virus 6 (HHV‐6) is an omnipresent virus in the pediatric population, often associated with an exanthematic … Carol Davila”, Bucharest, Romania; 2 Clinical Neuroscience Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania Background and aims: Epstein‐Barr virus (EBV) is a rare cause of encephalitis in immunocompetent adults, with diagnosis often complicated by nonspecific clinical …

Burden of cancer in the Eastern Mediterranean Region, 2005-2015: findings from the Global Burden of Disease 2015 Study.

ObjectivesTo estimate incidence, mortality, and disability-adjusted life years (DALYs) caused by cancer in the Eastern Mediterranean Region (EMR) between 2005 and 2015.MethodsVital registration system and cancer registry data from the EMR region were analyzed for 29 cancer groups in 22 EMR countries using the Global Burden of Disease Study 2015 methodology.ResultsIn 2015, cancer was responsible for 9.4% of all deaths and 5.1% of all DALYs. It accounted for 722,646 new cases, 379,093 deaths, and 11.7 million DALYs. Between 2005 and 2015, incident cases increased by 46%, deaths by 33%, and DALYs

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… Davitoiu, PhD, University of Medicine and Pharmacy Bucharest, Bucharest, Romania. Subhojit Dey, PhD, Indian Institute of Public Health-Delhi, Public Health Foundation of India, Gurgaon, India. Samath D. …

36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016.

P001 - Sepsis impairs the capillary response within hypoxic capillaries and decreases erythrocyte oxygen-dependent ATP efflux R. M. Bateman, M. D. Sharpe, J. E. Jagger, C. G. Ellis P002 - Lower serum immunoglobulin G2 level does not predispose to severe flu. J. Solé-Violán, M. López-Rodríguez, E. Herrera-Ramos, J. Ruíz-Hernández, L. Borderías, J. Horcajada, N. González-Quevedo, O. Rajas, M. Briones, F. Rodríguez de Castro, C. Rodríguez Gallego P003 - Brain protective effects of intravenous immunoglobulin through inhibition of complement activation and apoptosis in a rat model of sepsis F. Esen

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… Tomescu Carol Davila University of Medicine and Pharmacy, Bucharest, Romania Introduction: sCD14 represents a key receptor for Lipopolysaccharide - Lipopolysaccharide binding protein complexes and activation of TLR-4 cascade. … Macovei 1 1 Bucharest Clinical Emergency Hospital, Bucharest, Romania; 2 Fundeni Clinical Institute, Bucharest, Romania Introduction: Fever is a sign that is commonly associated with syndromes in intensive care. …

Sternum Metastases: From Case-Identifying Strategy to Multidisciplinary Management.

We aimed to overview the most recent data on sternal metastases from a multidisciplinary approach (diagnosis strategies, outcome, and histological reports). This narrative review based on a PubMed search (between January 2020 and 22 July 2023) using key words such as "sternal", "manubrium", and "metastasis" within the title and/or abstract only included original papers that specifically addressed secondary sternal spreading of cancer in adults, for a total of 48 original articles (14 studies and 34 single case reports). A prior unpublished case in point is also introduced (percutaneous incisio

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… Carol Davila Central Military Emergency University Hospital, Bucharest, Romania (protocol code 607/06/28/2023). Informed Consent Statement Informed consent was obtained from the patient at the time of admission; the presented data were retrospectively collected. …