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[Analysis of reasons for failure of Meek micro-skin grafting in children with severe burn and treatment measures].

Objective: To analyze the reasons for failure of Meek micro-skin grafting in children with severe burns and to observe the clinical effects … e use rate of imipenem of 9 (30.00%) was the highest. Only 4 kinds of sensitive antibiotics such as ceftazidime were used in 30 children in successful skin graft group. (5) The preoperative levels of albumin and prealbumin of children in successful skin graft group were (32±4) g/L and (133±41) mg/L respectively, significantly higher than (27±4) g/L and (93±35 …

PB2584: EXPLOSIVE GROWTH ANTIMICROBIAL RESISTANCE IN CENTRAL KAZAKHSTAN IN ONCOHEMATOLOGICAL PATIENTS IN POST COVID PERIOD

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… In the structure of line 1 antibacterial therapy in 2021, ceftazidime and piperacillin tazobactam occupied the same proportion - 44.4% each, in 2022 - the appointment of piperacillin tazobactam increased to 76.6%. …

Critically Ill Immunosuppressed Host

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… Ceftazidime is an option chosen by some, but its poor activity against gram-positive cocci has caused some clinicians to use other agents. 18 Intensivists must recognize, however, that these monotherapy regimens may not be appropriate in an ICU. …

Prophylactic antibiotics for preventing gram-positive infections associated with long-term central venous catheters in adults and children receiving treatment for cancer.

BACKGROUND: This is an updated version of a Cochrane Review last published in 2013. Long-term central venous catheters (CVCs), including tun … prior to insertion of the CVC Six trials compared the use of antibiotics (vancomycin, teicoplanin, ceftazidime or cefazolin) versus no antibiotics given before the insertion of a long-term CVC. One study did not observe any CVC-related infection events in either group was not included in the quantitative analysis as it was not possible to calculate a risk ra …

Safety and feasibility of outpatient autologous stem cell transplantation in pediatric patients with primary central nervous system tumors.

High-dose chemotherapy with autologous hematopoietic stem cell transplantation (autoHSCT) is a well-established treatment for pediatric central nervous system (CNS) tumors. Given the risks of toxicity and infection, pediatric autoHSCT has been historically performed on hospitalized children. As our practice evolved, some patients were transplanted as outpatients. We performed a retrospective cohort analysis of 37 patients who received 90 transplant procedures (49 outpatient and 41 inpatient) at Children's Hospital Colorado. The most common primary diagnosis was medulloblastoma (51.4%). Of the

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… Table 4 Infectious complications of outpatient and inpatient transplant episodes Outpatient transplant episodes ( n = 49) Inpatient transplant episodes ( n = 41) p Value Antibiotics initiated, n (%) Meropenem 21 (53.8) 35 (87.5) Cefepime 14 (35.9) 3 (7.5) 0.01 Ceftazidime 4 (10.3) 1 (2.5) Vancomycin … transplant episodes SD standard deviation, CLABSI central line-associated bloodstream infection | Outpatient transplant episodes ( n = 49) | Inpatient transplant episodes ( n = 41) | p Value Antibiotics initiated, n (%) | | | Meropenem | 21 (53.8) | 35 (87.5) | Cefepime | 14 (35.9) | 3 (7.5) | 0.01 Ceftazidime …

Infectious Diseases

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… prolonged >7 days duration and profound neutropenia [ANC ≤0.1 × 10 9 /mL] and/or significant medical comorbid conditions such as hypotension, pneumonia, new-onset abdominal pain, or neurologic changes)—admit for intravenous antibiotics first line —one of imipenem 500 mg IV q6h, meropenem 2 g IV q8h, ceftazidime … If neurosurgery/trauma, CSF shunt, or basilar skull fracture, give ceftazidime 2 g IV q8h plus vancomycin . …

Early detection of acute cisplatin nephrotoxicity: interest of urinary monitoring of proximal tubular biomarkers.

BackgroundRenal toxicity induced by cisplatin (CisPt) is a clinical issue in patients with or without chronic kidney disease (CKD). Proximal tubular injury can result in acute kidney injury (AKI), which may compromise the course of chemotherapy and the prognosis. The purpose of this study was to investigate the time course of urinary markers of acute tubulotoxicity and to assess the usefulness of such monitoring in a routine clinical setting.MethodsThis work is an open prospective pilot study carried out among 23 patients receiving a platinum-based chemotherapy. Individual comorbidities, plasm

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… third cycle postponed by 1 week #2 1 83 → 76 CisPt 70 mg/m 2 35 mg/m 2 /day—d1, d2—1x/3 week #3 2 >90 → 36 CisPt 80 mg/m 2 40 mg/m 2 /day—d1, d2—1x/3 week Infection: d8 of first cycle cancelled; AKI: d8 of first and second cycles cancelled Dehydration (insufficient fluid intake + diuretics) + NSAIDs + ceftazidime … #2 | 1 | 83 → 76 | CisPt | 70 mg/m 2 | 35 mg/m 2 /day—d1, d2—1x/3 week | | #3 | 2 | >90 → 36 | CisPt | 80 mg/m 2 | 40 mg/m 2 /day—d1, d2—1x/3 week | Infection: d8 of first cycle cancelled; AKI: d8 of first and second cycles cancelled | Dehydration (insufficient fluid intake + diuretics) + NSAIDs + ceftazidime …

Host impairments in patients with neoplastic diseases.

Healthy individuals possess an immune system comprising physical barriers, innate and acquired immunity as well as the indigenous microflora that populate the body surfaces. The immune system maintains constant vigilance over the body at the cellular level as well as at the interface between the host integument and the resident microflora. However, neoplastic diseases and their treatment often lead to impaired immunity resulting in an increased risk of infections due to viruses, bacteria, fungi, and protozoa. This chapter explores the various aspects of host impairment focusing on the componen

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… Individual antibiotics that appear to spare colonization resistance, such as ceftazidime and piperacillin, might have a marked impact when given in combination, leading to an increase in both Clostridium difficile as well as yeasts [ 47 ]. … Chomarat M Espinouse D Lactobacillus rhamnosus septicemia in patients with prolonged aplasia receiving ceftazidime-vancomycin Eur J Clin Microbiol Infect Dis 1991 10 1 44 10.1007/BF01967099 2009881 49. …

P941 – P1197

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Review of clinical profile and bacterial spectrum and sensitivity patterns of pathogens in febrile neutropenic patients in hematological malignancies: A retrospective analysis from a single center.

BackgroundThe aim of this study was to study clinical profile with bacterial spectrum and susceptibility patterns of pathogens in culture positive febrile neutropenic (FN) patients of hematological malignancies.Materials and methodsWe retrospectively reviewed the medical records of 23 hematological malignancy patients admitted with chemotherapy induced febrile neutropenia with culture positive results, at our institute between June 2011 and December 2011.ResultsA total of 23 patients were studied 12 males and 11 females, with a median age of 35 years. Most common diagnosis was acute leukemia (

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… Majority of E. coli strains were sensitive to amikacin, ciprofloxacin and tigecycline while the majority were resistant to piperacillin/tazobactum (P/T), ceftazidime and cefazolin. …

Clinical and Histopathological Aspects of MRONJ in Cancer Patients.

Medication-related osteonecrosis of the jaw (MRONJ) is a major complication of bisphosphonate treatment in cancer patients, and its etiology is not completely clarified. The study's goal is to find connections between the clinical and histopathological characteristics of osteonecrosis and bisphosphonates in a cohort of cancer patients who had osteonecrosis treated surgically. The retrospective study includes 51 patients of both sexes, aged 46 to 85 years, who underwent surgical treatment for MRONJ in two oral and maxillofacial surgery clinics (Craiova and Constanța). Demographic, clinical, and

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… The antibiogram showed susceptibility of Staphylococcus aureus and Pseudomonas mendocina to penicillin, ceftazidime, ceftriaxone, and ciprofloxacin and resistance to clindamycin. … Clindamycin should be a potential antibiotic for allergic patients [ 37 ], but Staphylococcus aureus and Pseudomonas mendocina may be resistant, so the available antibiotics should be ceftazidime, ceftriaxone, and ciprofloxacin, as our results revealed. …

Infections in Hospitalized Cancer Patients.

Cancer patients are at an increased risk of developing infections that are primarily treatment-driven but may also be malignancy-driven. While cancer treatments such as chemotherapy, radiotherapy, and surgery have been known to improve malignancy morbidity and mortality, they also have the potential to weaken immune defenses and induce periods of severe cytopenia. These adverse effects pave the way for opportunistic infections to complicate a hospitalized cancer patient's clinical course. Understanding the risk each patient inherently has for developing a bacterial, fungal, or viral infection

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… Clinical experience with prolonged ceftazidime-avibactam infusion to treat carbapenem-resistant K. pneumonia is limited, but studies show a carbapenem can be added if the isolate has an elevated minimum inhibitory concentration to ceftazidime-avibactam [ 53 ]. …

Multidrug-Resistant Bacteria in Immunocompromised Patients.

The increasing incidence of antibiotic resistance in bacteria is a major problem in terms of therapeutic options, especially in immunocompromised patients, such as patients from intensive care units (ICUs), HIV-positive patients, patients with malignancies or transplant patients. Commensal bacteria, especially anaerobes, serve to maintain microbial stability by preventing overpopulation with pathogenic bacteria. In immunocompromised patients, microbiota imbalance caused by antibiotic therapy and decreased host immunity favors intestinal overpopulation with pathogenic species, leading to increa

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… Additionally, 32.8% of the 210 P. aeruginosa strains were resistant to imipenem and/or ceftazidime, while 20.75% of the 106 S. aureus strains were methicillin-resistant [ 72 ]. In China, Zhu et al. showed that 21 out of 320 patients (6.56%) with acute leukemia had intestinal colonization with CRE. … All of these isolates exhibited phenotypical resistance to third/fourth-generation cephalosporins (ceftriaxone, Cefotaxime, ceftazidime and Cefepime). Additionally, most species were resistant to piperacillin, and more than half showed resistance to trimethoprim/sulfamethoxazole. …

Anakinra: efficacy in the management of fever during neutropenia and mucositis in autologous stem cell transplantation (AFFECT-2)-study protocol for a multicenter randomized double-blind placebo-controlled trial.

BACKGROUND: Since decades, fever and infections have been the most important complications of intensive chemotherapy and hematopoietic stem cell transplantation (HSCT) in the treatment of hematologic malignancies. Neutropenia has long been considered to be the most important risk factor for these complications. However, recent studies have shown that not neutropenia, but the development of mucositis is the most important cause of these complications. Currently, limited options for the prevention and treatment of mucositis are available, of which most are only supportive. The pro-inflammatory c

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… In case of fever, defined as a tympanic temperature ≥ 38.5 °C, empirical therapy with ceftazidime shall be initiated. Study treatment The intervention will be administration of a daily intravenous dose of 300 mg anakinra, starting on day − 2, until day + 12. … This will be halted after the occurrence of fever or start of empirical antibiotics (ceftazidime). Additionally, blood cultures will be drawn in the occurrence of fever. Surveillance cultures of mucosal barriers are performed at admission and twice-weekly during hospitalization. …

Проблемы с диагностикой и оказанием неотложной медицинской помощи в случае быстро прогрессирующего заболевания лёгких, вторичного и многократного заболевания миеломой.

Одновременное представление множественной миеломы (ММ) и межститиальной болезни легких (МЛ) остается исключительно редким, при этом ограниченная литература описывает оптимальные стратегии управления для этой двойной патологии. Мы сообщаем о сложном случае 62-year-old Мужчина с недавно поставленным диагнозом MM с цитогенетикой промежуточного риска (del13q, набирающий 1q), который одновременно представил быстро прогрессирующий ILD, демонстрирующий обычную интерститальную пневмонию (МСАГВ). Пациентка 6-month Клинический курс был отмечен участием многих организаций, периодическими инфекциями, тром

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… Tracheal culture developed difficult-to-treat Pseudomonas for which ceftazidime-avibactam with aztreonam was initiated. In view of recurrent clot-related blockage, tracheostomy was planned, and by the sixth day, the patient was weaned off mechanical ventilation. …

Best Practices in the Management of Infectious Complications for Patients With Cancer: Management of Febrile Neutropenia.

Managing infection in patients with neutropenia is a difficult challenge, as fever is often the only clinical symptom. At JADPRO Live 2022, Kyle C. Molina, PharmD, BCIDP, AAVHIP, of the University of Colorado Hospital, discussed the epidemiology and pathophysiology associated with febrile neutropenia in patients with cancer. He reviewed appropriate treatment settings and empiric antimicrobial regimens for a patient and how to formulate a plan to safely de-escalate and target therapy for patients with febrile neutropenia.

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… Molina also noted the use of newer beta-lactam and beta-lactamase inhibitors (e.g., ceftazidime-avibactam, cefiderocol), which have broad-spectrum activity against resistant bacteria and are safer than aminoglycosides. According to Dr. …

Применение искусственного интеллекта в перипостетической суставной инфекции.

Перипростетическая суставная инфекция (ПСО) представляет собой one Из наиболее разрушительных осложнений, вызванных общей совместной артропластикой, часто требующих дополнительных операций и антимикробной терапии, и потенциально ведущих к инвалидности. Это значительно увеличивает нагрузку как на пациентов, так и на систему здравоохранения. С учетом значительных страданий, причиняемых ПСО, его профилактика и лечение уже давно являются ключевыми факторами, вызывающими озабоченность. Вместе с тем сохраняются проблемы, связанные с точной оценкой индивидуального риска, предотвращением инфекции, сов

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… First author Algorithm Target microorganism Target antibiotic Strengths Limitations Isolated strains/ mass spectra Gerada [174] CNN Gram-negative Enterobacterales bacterial strains amikacin, chloramphenicol, ciprofloxacin, gentamicin, meropenem, amoxicillin, amoxicillin/clavulanic acid, cefepime, ceftazidime … Algorithm | Target microorganism | Target antibiotic | Strengths | Limitations | Isolated strains/ mass spectra Gerada [174] | CNN | Gram-negative Enterobacterales bacterial strains | amikacin, chloramphenicol, ciprofloxacin, gentamicin, meropenem, amoxicillin, amoxicillin/clavulanic acid, cefepime, ceftazidime …

Neutropenic Enterocolitis as a Complication of Autologous Stem Cell Transplant in Patients With Multiple Myeloma: A Case Series.

Neutropenic enterocolitis (NE) is a rare but severe complication occurring in neutropenic patients undergoing intensive chemotherapy. Mortality is high, so early diagnosis is required to start urgent medical or surgical treatment. Data analysis of the development of NE after hematopoietic stem cell transplantation remains scarce. The aim of this case series is to discuss five out of 100 patients receiving autologous stem cell transplants (ASCTs) for multiple myeloma complicated with NE between 2016 and 2020 in the hematology department of the Cheikh Khalifa International University Hospital, C

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… Contrast-enhanced CT image for Case 5 (coronal plane) showing thickening of left large bowel wall and infiltration of the pericolic fat (arrows) Treatment was based on bowel rest, intravenous rehydration and parenteral alimentation, granulocytic colony-stimulating factors (G-CSF), and broad-spectrum antibiotics (ceftazidime …

Pseudomonas bronchopulmonary infections in a palliative care setting.

Blood stream infections and pneumonia caused by Pseudomonas aeruginosa is associated with high mortality, especially in an immunocompromised host. A large section of the palliative care patient population has varied forms of compromised immunity due to advanced cancer or cancer treatment, organ failures, chronic autoimmune disorders, degenerative conditions, and acquired immunodeficiency syndrome. The lung is one of the most frequently involved organs in a variety of complications in an immunocompromised host and infection is the most common complication. P. aeruginosa is one of the most commo

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… sensitivity results are available. (4) The patient's condition should be re-evaluated on a regular basis, with appropriate measurements to decide whether antibiotics should be continued.[ 6 ] In an inpatient setting, the recommendations are to use an antipseudomonal β-lactam (Piperacillin–Tazobactam, Ceftazidime …

Регенеративная терапия на основе коллагена в критическом ишемическом диабиотическом ульце: доклад по делу о лимб-алкоголе.

58-летний мужчина с диабетом, конечной стадией почечных заболеваний и тяжелой периферической артерией страдал от хронической ишемической язвы ступни до одного года традиционной терапии. Инъекционная регенеративная терапия на основе коллагена привела к полной эпителиализации в течение трех месяцев и к долговременному спасению конечностей даже после техногенного рецидива, требующего реваскуляции.

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… Targeted antimicrobial regimens, tailored to culture‐and‐sensitivity results, comprised repeated courses of intravenous vancomycin, meropenem, ceftazidime, and amikacin, alongside oral agents according to susceptibility profiles. …