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Myxedema Coma as the Initial Presentation of Undiagnosed Hypothyroidism: A Rare but Reversible Emergency.

Myxedema coma is a rare, life-threatening endocrine emergency representing the extreme manifestation of untreated hypothyroidism. It usually presents with nonspecific symptoms such as confusion, hypothermia, and bradycardia, which can lead to delayed recognition, particularly in elderly patients with multiple comorbidities. We report the case of a 77-year-old man with hypertension, stage 4 chronic kidney disease, anemia of chronic disease, myeloma, and prostate cancer who presented with reduced consciousness following a period of increasing lethargy and confusion. On arrival, he was hypotensiv

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… A computed tomography (CT) scan of the head showed incidental opacification of the right mastoid air cells and middle ear cavity, suggesting otomastoiditis with bony erosion anteriorly into the temporomandibular joint (TMJ). …

A clinical nomogram for predicting recurrence after percutaneous radiofrequency ablation in the management of primary hemifacial spasm.

PURPOSE: To identify independent predictors of recurrence following CT-guided partial radiofrequency ablation (RFA) via the stylomastoid foramen for refractory primary hemifacial spasm (HFS). METHODS: We retrospectively analyzed data from 195 primary HFS patients who underwent the procedure between August 2019 and August 2024. Predictive factors were screened using LASSO regression and further assessed by multivariate Cox regression to build a nomogram. The model's performance was evaluated using ROC curves, calibration curves, and decision curve analysis (DCA). RESULTS: The median follow-up…

Health of singletons born after frozen embryo transfer until early adulthood: a Finnish register study.

STUDY QUESTION: Is the health of singletons born after frozen embryo transfer (FET) comparable to that of singletons born after fresh embryo … CI 1.11, 1.38), neoplasms (aHR 1.68; 95% CI 1.48, 1.91), diseases of the eye and adnexa, the ear or mastoid process (aHR 1.11; 95% CI 1.01, 1.21), the respiratory system (aHR 1.15; 95% CI 1.06, 1.23), the digestive system (aHR 1.17; 95% CI 1.05, 1.32), the skin or subcutaneous tissue (aHR 1.28; 95% CI 1.14, 1.43) and the genitourinary system (aHR 1.27; 95 …

Временная плазмоцитома костей: исключительная локализация плазматомы одиночных костей, подчеркивающая роль мультимодальной съемки и многодисциплинарного управления.

Одинокая плазмоцитома (SP), редкая форма неоплазмы плазменных клеток, характеризуется моноклонным распространением плазменных клеток в локальном повреждении костей или мягких тканей. Временная плазмоцитома - это редкое проявление этого состояния, которое часто сопровождается такими неспециальными симптомами, как потеря слуха, утенок и краниальный нервный дефицит. Диагноз часто является сложным, учитывая совпадение с другими патологиями, такими, как холеститома и параганлиома. Гистопатологический анализ обычно показывает наличие листов плазменных клеток, которые подтверждаются иммунохимией для

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… The temporal bone, particularly its petrous and mastoid portions, contains marrow spaces that may harbor precursor B-cells prone to neoplastic transformation. … High-resolution temporal bone CT typically demonstrates a well-circumscribed, osteolytic, and expansile lesion involving the mastoid or petrous bone, often extending into adjacent structures such as the middle ear, jugular bulb, or sigmoid sinus. …

Diseases prevalent before major depressive disorder diagnosis: an exploratory nested case-control study using health insurance-based claims data.

ObjectivesMajor depressive disorder (MDD) is often comorbid with other chronic and/or serious diseases. However, little is known about the prevalence of various diseases that are present before MDD onset. We examined the prevalence of all pre-existing diseases in the 12 months before an MDD diagnosis.DesignExploratory nested case-control study.SettingData, including diagnoses based on International Statistical Classification of Diseases and Related Health Problems, 10th revision codes, were from a Japanese health insurance database (JMDC).ParticipantsAdults newly diagnosed with MDD during 2015

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… The OR for diseases of the eye and adnexa (H00–H59) was low (1.1), whereas the OR for diseases of the ear and mastoid process (H60–H95) was relatively high (1.8). … Interestingly, we observed that the OR for diseases of the ear and mastoid process was higher than for diseases of the eye and adnexa (1.8 vs 1.1). …

Topical antiseptics for chronic suppurative otitis media.

BACKGROUND: Chronic suppurative otitis media (CSOM), sometimes referred to as chronic otitis media (COM), is a chronic inflammation and infection of the middle ear and mastoid cavity, characterised by ear discharge (otorrhoea) through a perforated tympanic membrane. The predominant symptoms of CSOM are ear discharge and hearing loss. Topical antiseptics, one of the possible treatments for CSOM, inhibit the micro-organisms that may be responsible for the infection. Antiseptics can be used alone or in addition to other treatments for CSOM, such as antibiotics or ear cleaning (aural toileting). A…

Abstracts

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Intrathecal 2-hydroxypropyl-β-cyclodextrin decreases neurological disease progression in Niemann-Pick disease, type C1: a non-randomised, open-label, phase 1-2 trial.

BACKGROUND: Niemann-Pick disease, type C1 (NPC1) is a lysosomal storage disorder characterised by progressive neurodegeneration. In preclini … on for 2 doses based on caregiver hardship and one patient had treatment interrupted for 1 dose for mastoiditis. 11 patients were assessed at 18 months. Between Dec 11, 2013, and June 25, 2014, three participants were assessed for eligibility and enrolled at RUMC, and were assigned to receive intrathecal HPβCD at a starting dose of 200 mg every 2 weeks (t …

Саркоидоз и повышенный риск сопутствующих заболеваний и смертности в Швеции.

ВВЕДЕНИЕ: Саркоидоз — это системное воспалительное заболевание с неясной этиологией, включающее образование гранулом. В большинстве случаев оно затрагивает легкие и лимфоузлы в грудной полости. Саркоидоз может протекать в острой или хронической форме, каждая из которых имеет различные клинические проявления и прогноз. МЕТОДЫ: Кейс-контрольное исследование коморбидности и морбидности у лиц, диагностированных с саркоидозом (код ICD10 D86) в Швеции с 2007 по 2016 год. Контроли были сопоставлены с случаями в соотношении 2:1 по возрасту, полу и району диагностики. Данные собрали из Шведского нацио

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… | 2.31 (1.75 – 3.04)* | | Male | 66 | 52 | 2.55 (1.77 – 3.67)* | | Female | 42 | 42 | 2.01 (1.31 – 3.08)* Diseases of the eye and adnexa | VII | Total | 47 | 32 | 2.95 (1.88 – 4.62)* | | Male | 25 | 18 | 2.78 (1.52 – 5.10)* | | Female | 22 | 14 | 3.15 (1.61 – 6.16)* Diseases of the ear and mastoid … | 1 Otitis externa | H60 | 0 | 1 Other disorders of external ear | H61 | 2 | 0 Nonsuppurative otitis media | H65 | 0 | 1 Suppurative and unspecified otitis media | H66 | 4 | 3 Cholesteatoma of middle ear | H71 | 1 | 2 Perforation of tympanic membrane | H72 | 1 | 1 Other disorders of middle ear and mastoid …

Анализ траекторий заболеваний, ведущих к множественным склерозам: общенациональное когортное исследование.

ОКРУЖАЮЩАЯ СРЕДА: Продромальная фаза множественного склероза (MS) получает все большее признание, однако в большинстве исследований основное внимание уделяется изолированным симптомам или статичной коморбиде, в результате чего меняющаяся структура преднамеренного бремени болезней недооценивается. ЦЕЛЬ: Охарактеризовать динамические траектории заболеваний, предшествующие НР, путем моделирования продольной сети. МЕТОДЫ: ЗДРАВООХРАНЕНИЯ 10,273 Психиатрические заболевания и 47,167 Были проанализированы соответствующие меры контроля в Швеции. Были построены сети совместного лечения заболеваний thre

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… ICD-10 chapter ranges shown in the figure correspond to the following categories: A00–B99 (infectious/parasitic), C00–D48 (neoplasms), D50–D89 (blood/immune), E00–E90 (endocrine/metabolic), F00–F99 (mental/behavioral), G00–G99 (nervous system), H00–H59 (eye), H60–H95 (ear/mastoid), I00–I99 (circulatory …

Metastatic lung adenocarcinoma causes extensive destruction of the hip and pelvis.

BackgroundLung cancer is the most prevalent tumor and frequently present with distant metastases, with the bone being one of the most common affected sites. However, bone metastases leading to complete resorption of the hip joint and pelvis are extremely rare. This case aimed to report an extensive destruction of the hip and pelvis in metastatic lung adenocarcinoma, and conduct a literature review to explore the factors influencing the diagnosis and treatment decisions of bone metastasis.Case presentationA 56-year-old woman presented with progressive pain in her left hip joint and pelvis accom

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… . | 2012 | 59 | F | Non-small cell lung cancer | Headache, hearing loss, and facial pain | Sphenoid bone, mastoid, frontal bone | Chemotherapy | High-dose steroids, radiation treatments | Passed away three weeks later Bing et al. | 2013 | 71 | M | Lung squamous cell carcinoma | Right knee pain | Right …

A new taxonomy was developed for overlap across 'overviews of systematic reviews': A meta-research study of research waste.

Multiple 'overviews of reviews' conducted on the same topic ("overlapping overviews") represent a waste of research resources and can confuse clinicians making decisions amongst competing treatments. We aimed to assess the frequency and characteristics of overlapping overviews. MEDLINE, Epistemonikos and Cochrane Database of Systematic Reviews were searched for overviews that: synthesized reviews of health interventions and conducted systematic searches. Overlap was defined as: duplication of PICO eligibility criteria, and not reported as an update nor a replication. We categorized overview to

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… period | 7 | 1.3 Certain infectious and parasitic diseases | 22 | 4.1 Codes for special purposes | 12 | 2.2 Congenital malformations, deformations, and chromosomal abnormalities | 0 | 0.0 Diseases of the circulatory system | 42 | 7.8 Diseases of the digestive system | 24 | 4.4 Diseases of the ear and mastoid … No overviews were found for two WHO ICD‐10 medical classifications, namely ‘congenital malformations, deformations and chromosomal abnormalities’ and ‘diseases of the ear and mastoid process’ (Table 1 ). …

Topical versus systemic antibiotics for chronic suppurative otitis media.

BACKGROUND: Chronic suppurative otitis media (CSOM), sometimes referred to as chronic otitis media (COM), is a chronic inflammation and often polymicrobial infection (involving more than one micro-organism) of the middle ear and mastoid cavity, characterised by ear discharge (otorrhoea) through a perforated tympanic membrane. The predominant symptoms of CSOM are ear discharge and hearing loss. Antibiotics are the most common treatment for CSOM, which act to kill or inhibit the growth of micro-organisms that may be responsible for the infection. Antibiotics can be administered both topically an…

Systemic antibiotics for chronic suppurative otitis media.

BACKGROUND: Chronic suppurative otitis media (CSOM), sometimes referred to as chronic otitis media (COM), is a chronic inflammation and often polymicrobial infection of the middle ear and mastoid cavity, characterised by ear discharge (otorrhoea) through a perforated tympanic membrane. The predominant symptoms of CSOM are ear discharge and hearing loss. Systemic antibiotics are commonly used to treat people with CSOM. This is the first update to the review published in 2021, and is one of a suite of seven Cochrane reviews evaluating the effects of non-surgical interventions for CSOM. OBJECTIV…

Evaluating the Impact of Insurer-Sponsored Health Coaching on Hospitalization and Costs in India: A Retrospective Cohort Study.

Health coaching programs are emerging as a promising intervention to improve disease management and reduce healthcare costs, particularly in the context of insurer-sponsored wellness initiatives. While such programs have shown positive outcomes in Western healthcare settings, their effectiveness in India remains underexplored. This study examines the impact of a health coaching program implemented by a prominent Indian health insurer (Aditya Birla Health Insurance), focusing on hospitalization rates and claims paid among high-risk policyholders. To assess the intervention's effectiveness, a re

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… postprocedural complications and disorders of eye and adnexa, not elsewhere classified | Non-preventable H60 - Otitis externa | Non-preventable H6090 - Unspecified otitis externa, unspecified ear | Non-preventable H65 - Nonsuppurative otitis media | Non-preventable H65-H75 - Diseases of middle ear and mastoid … | Non-preventable H66 - Suppurative and unspecified otitis media | Non-preventable H72 - Perforation of tympanic membrane | Non-preventable H74 - Other disorders of middle ear mastoid | Non-preventable H80 - Otosclerosis | Non-preventable H81 - Disorders of vestibular function | Non-preventable H83 …

Пациенты, которые потенциально нуждаются в паллиативном уходе в Германии - региональная оценка малых районов на основе данных регистрации смерти.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Демографические изменения и растущая распространенность хронических заболеваний приводят к повышению спроса на паллиативный уход. В настоящее время мало что известно о потенциальной необходимости паллиативного ухода на уровне малых районов в Германии. Однако это имеет решающее значение для планирования услуг. Мы стремились рассчитать долю населения, потенциально нуждающегося в паллиативном уходе, на уровне малых районов и проиллюстрировать различия в масштабах всей страны. МЕТОДЫ: Ретроспективное межсекторальное исследование на основе статистических данных о причинах сме

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… 100.0 | 0 | 0.0 F00-F99 | Mental and behavioral disorders | 68,767 | 6.5 | 9,509 | 13.8 | 59,258 | 86.2 G00-G99 | Diseases of the nervous system | 38,985 | 3.7 | 10,891 | 27.9 | 28,094 | 72.1 H00-H59 | Diseases of the eye and adnexa | 35 | 0 | 35 | 100.0 | 0 | 0.0 H60-H95 | Diseases of the ear and mastoid …

Rare Extraoral Plasmablastic Lymphoma in the Context of HIV and Toxoplasmosis: A Detailed Case Analysis With Therapeutic Insights.

Plasmablastic lymphoma (PBL), a rare aggressive B-cell malignancy linked to HIV, is increasingly noted in extraoral sites beyond its traditional oral cavity presentation. This case report details a 48-year-old HIV-positive woman with prior cerebral toxoplasmosis, presenting with facial swelling, pain, proptosis, and dysphagia despite antiretroviral therapy and cotrimoxazole prophylaxis (CD4 120 cells/μL, suboptimal viral suppression). Imaging identified a sinonasal mass with nasopharyngeal involvement and lymphadenopathy, with immunohistochemistry confirming PBL (MUM1+, weakly CD79a+, CD20-, C

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… Mucosal thickening in the paranasal sinuses and bilateral mastoid air cell effusion were noted. Laboratory results showed hemoglobin of 10.5 g/dL, white blood cell count of 4.2 × 10 9 /L, platelet count of 180 × 10 9 /L, and normal liver and renal function. …

Sinusitis and oroantral fistula in patients with bisphosphonate-associated necrosis of the maxilla.

BACKGROUND: The management of bisphosphonate related necrosis of the jaw has become clinical routine. While approximately two thirds of the lesions are in the mandible, one third is located in the maxilla. In 40-50 % of maxillary necrosis the maxillary sinus is involved, leading to maxillary sinusitis and oro-antral communications. METHODS: This retrospective single center study includes all patients with diagnosis of BP-ONJ of the maxilla and concomitant maxillary sinusitis. The information collected includes age, gender, primary disease, bisphosphonate intake, involving type of bisphosphona

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… Also secondary osteomyelitis can arise after otitis, mastoiditis or sinusitis and may lead to osteonecrosis. Remarkably, the sinus mucosa in all patients of the present study was altered. …

Antibiotics versus topical antiseptics for chronic suppurative otitis media.

BACKGROUND: Chronic suppurative otitis media (CSOM), sometimes referred to as chronic otitis media (COM), is a chronic inflammation and infection of the middle ear and mastoid cavity, characterised by ear discharge (otorrhoea) through a perforated tympanic membrane. The predominant symptoms of CSOM are ear discharge and hearing loss. Antibiotics and antiseptics kill or inhibit the micro-organisms that may be responsible for the infection. Antibiotics can be applied topically or administered systemically via the oral or injection route. Antiseptics are always directly applied to the ear (topica…

Aural toilet (ear cleaning) for chronic suppurative otitis media.

BACKGROUND: Chronic suppurative otitis media (CSOM), sometimes referred to as chronic otitis media, is a chronic inflammation and often polymicrobial infection of the middle ear and mastoid cavity, characterised by ear discharge (otorrhoea) through a perforated tympanic membrane. The predominant symptoms of CSOM are ear discharge and hearing loss. Aural toileting describes processes for manually cleaning the ear, including dry mopping (with cotton wool or tissue paper), suction clearance (typically under a microscope), or irrigation (using manual or automated syringing). Aural toileting can be…