Результаты поиска

Hyaluronan-based scaffolds (Hyalograft C) in the treatment of knee cartilage defects: preliminary clinical findings.

Hyalograft C is an innovative tissue-engineering approach for the treatment of knee cartilage defects involving the implantation of laboratory expanded autologous chondrocytes grown on a three-dimensional hyaluronan-based scaffold. This technique has recently been introduced into clinical practice, with more than 600 patients treated so far. Because no periosteal coverage is required to keep the graft in place, surgical time and morbidity are reduced, and handling of the graft is much simpler than currently available autologous chondrocyte implantation techniques. The safety profile of the tre

Patellar instability: assessment on MR images by measuring the lateral trochlear inclination-initial experience.

Lateral trochlear inclination (LTI) of the knee was compared on magnetic resonance (MR) images obtained in 30 patients with patellar instability (PI) and 30 patients with nonspecific internal knee derangement. Differences in LTI values between the two populations were significant (P <.001). Reproducibility of the measurement was judged excellent with an intraclass correlation superior to 0.98. Below a threshold value fixed at 11 degrees, LTI appears to be an excellent diagnostic test of PI with a sensitivity of 0.93 (28/30), a specificity of 0.87 (26/30), and an accuracy of 0.90 (54/60).

[Clinical research of arthroscopy with minimally invasive percutaneous plate osteossynesis for low energy tibial plateau fracture with ligament injury].

OBJECTIVE: To compare clinical effects of minimally invasive percutaneous plate osteosynthesis(MIPPO) and open reduction and internal fixati … f less trauma, good recovery of joint function, less complications and could deal with ligament and meniscus injury.

[Impact of tibial tunnel position in artificial posterior cruciate ligament reconstruction on postoperative knee function and stability].

OBJECTIVE: To investigate the impact of tibial tunnel position on postoperative knee function and stability in patients undergoing artificia … core, International Knee Documentation Committee (IKDC) score, or the composition ratio of combined meniscus and cartilage injuries. The tibial tunnel positions were compared. Postoperative recovery of knee function was evaluated using the IKDC score, Lysholm score, Tegner score, and knee ROM. The differences between pre- and post-operative values (change …

Spontaneous Healing of Meniscal Tears With ACL Injuries and Its Impact on Timing of ACL Surgery.

BACKGROUND: Acute anterior cruciate ligament (ACL) tears with meniscal injuries elevate posttraumatic osteoarthritis risk. While early ACL r … erior horn; morphology: longitudinal, compound, horizontal, and radial). Spontaneous healing of the meniscus was defined as a complete fibrous union observed during arthroscopic evaluation. RESULTS: A total of 2723 patients (3562 menisci) were included, including 2493 with lateral meniscal tears and 2001 with medial meniscal (MM) tears. The overall sponta …

Gel@CAT-L hydrogel mediates mitochondrial unfolded protein response to regulate reactive oxygen species and mitochondrial homeostasis in osteoarthritis.

OBJECTIVE: This study investigates the role of Gelatin-Catalase (Gel@CAT)-L hydrogel in mediating reactive oxygen species (ROS) production a … ell staining and CCK8 assays. An OA mouse model was established using destabilization of the medial meniscus (DMM) surgery. X-ray and micro-CT imaging were employed to evaluate the structural integrity of the mouse knee joints, while histological staining was used to assess cartilage degeneration. Immunohistochemistry was performed to analyze the expressio …

Relationships Between Tibiofemoral Contact Forces and Cartilage Morphology at 2 to 3 Years After Single-Bundle Hamstring Anterior Cruciate Ligament Reconstruction and in Healthy Knees.

BACKGROUND: Prevention of knee osteoarthritis (OA) following anterior cruciate ligament (ACL) rupture and reconstruction is vital. Risk of p … ined: (1) 62 patients who received single-bundle hamstring reconstruction with an intact, uninjured meniscus (mean age, 29.8 ± 6.4 years; mean weight, 74.9 ± 13.3 kg); (2) 38 patients with similar reconstruction with additional meniscal injury (ie, tear, repair) or partial resection (mean age, 30.6 ± 6.6 years; mean weight, 83.3 ± 14.3 kg); and (3) 30 liga …

Arthroscopic reconstruction of the anterior cruciate ligament with patellar-tendon autograft and interference screw fixation. The results at seven years.

Deficiency of the anterior cruciate ligament (ACL) is a common disorder which can lead to changes in lifestyle. We followed 59 patients who had had arthroscopic reconstruction of the ACL using a central-third patellar-tendon autograft for seven years to assess the long-term effectiveness of recent advances in reconstruction of the ACL. The standard criteria for evaluation of the International Knee Documentation Committee, the Lysholm knee score and measurements using the KT 1000 arthrometer all showed satisfactory results. Deterioration in the clinical performance after seven years was associa

Work, sport activities and factors associated with medial meniscal tears in nonathletic subjects.

BACKGROUND: It is known that late surgical reconstruction of the anterior cruciate ligament (ACL) is associated with a medial meniscal (MM) tears. However, the association between factors relating to sports and work activities and joint instability, has not been examined in non-athletic subjects. OBJECTIVE: To compare sports and work activities and other factors associated with MM tears, in subjects with ACL rupture. METHOD: A case-control design study, of patients with ACL injury, 140 cases and 140 controls with and without a rupture of MM respectively, were included. Sociodemographic facto

Computed tomography-based Three-Column Classification in tibial plateau fractures: introduction of its utility and assessment of its reproducibility.

BACKGROUND: The purpose of our study is to introduce a new Three-Column Classification for tibial plateau fractures and evaluate its reproducibility and reliability. METHODS: From December 2004 to December 2006, 278 consecutive patients with tibial plateau fractures were treated operatively at the Department of Orthopedics and Trauma III in Shanghai Sixth People's Hospital. Computed tomography (CT) and three-dimensional reconstruction were preformed for each patient before open reduction and internal fixation. The approaches were instructed by the Three-Column Classification. To test the repr

Tibial plateau fracture after primary anatomic double-bundle anterior cruciate ligament reconstruction: a case report.

Tibial plateau fracture after primary anatomic double-bundle anterior cruciate ligament (ACL) reconstruction is rare. To our knowledge, this is the first case report of a tibial plateau fracture after primary anatomic double-bundle ACL reconstruction. In our patient the tibial plateau fracture occurred after a torsional injury to the involved extremity. The fracture occurred 4.5 years after the ACL reconstruction. The fracture was intra-articular Schatzker type IV and had a significant displacement. The patient was treated operatively by open reduction-internal fixation. He recovered well.

The posterior shearing tibial plateau fracture: treatment and results via a posterior approach.

OBJECTIVES: This study was designed to describe the fracture patterns and early results of treatment of posterior shearing tibial plateau fractures. DESIGN: Retrospective case series. SETTING: Tertiary care hospital. PATIENTS: Thirteen patients identified from prospective trauma database with posterior shearing tibial plateau fractures. INTERVENTION: Open reduction and internal fixation through a posterior approach to the knee. MAIN OUTCOME MEASUREMENTS: Functional outcome assessed by Musculoskeletal Functional Assessment score and Visual Analogue Scale pain scores. Clinical and radiograp

Case report: Immune-mediated meibomian gland dysfunction following pembrolizumab therapy for advanced urothelial carcinoma.

Ocular immune-related adverse events are a relatively rare complication of immune checkpoint inhibitors. Common ocular toxicities range from dry eyes to inflammatory uveitis and ocular myasthenia gravis. Here, we present the case of a 55-year-old woman with recurrent urothelial carcinoma of the ureter after initially being managed with neoadjuvant cisplatin-based chemotherapy and surgical resection. She was treated with pembrolizumab which was complicated by immune-mediated pneumonitis after the eighth cycle, which was managed with a prolonged steroid course. The patient also developed red eye

Совпадение в полном тексте источника
… The patient was also noted to have thin tear meniscus in both eyes. Digital expression of the meibomian glands revealed thick, turbid meibum. Infrared meibography revealed bilateral grade 2 meibomian gland atrophy ( Figure 2 ). … The diagnosis of MGD involves a series of examinations including tear meniscus height measurement, tear breakup time, Schirmer test, and additional tests such as corneal staining, meibomian gland expression, and meibography ( 11 , 24 ). …

Acupuncture with micro-needle for dry eye disease: A study protocol for a randomized, sham-controlled, clinical trial.

INTRODUCTION: Dry Eye Disease (DED) is a prevalent and significant condition that affects a large number of people. Artificial tears can all … ace Disease Index (OSDI), non-invasive tear film break-up time (NIBUT), Schirmer Test I (SIT), Tear Meniscus Height (TMH), and Corneal Fluorescein Staining (CFS). Questionnaires, including OSSS, CDEQ, and OSDI, will be administered at screening, at the end of week two, and at the conclusion of week four, when treatment is completed. They will also be condu …

Sargassum polysaccharide attenuates osteoarthritis in rats and is associated with the up-regulation of the ITGβ1-PI3K-AKT signaling pathway.

BACKGROUND: Osteoarthritis (OA) presents a formidable challenge, characterized by as-yet-unclear mechanical intricacies within cartilage and … the chondrogenesis of SP in vitro. To assess the efficacy of SP in vivo, surgically induced medial meniscus destabilization (DMM) OA rats underwent an 8-week SP treatment. The therapeutic effects of SP in OA rats were comprehensively evaluated using X-ray imaging, micro-computed tomography (μ-CT), histopathological analysis, as well as immunohistochemical …

Failure rate, return-to-sports and magnetic resonance imaging after meniscal repair: 119 patients with 7 years mean follow up.

BACKGROUND: One of the most important factors to consider in relation to meniscal repair is the high failure rate reported in the existing literature. AIM: To evaluate failure rates, return to sports (RTS) rate, clinical outcomes and magnetic resonance image (MRI) evaluation after meniscus suture repair for longitudinal tears at a minimum 2-year-follow-up. METHODS: We conducted a retrospective review of meniscal repairs between January 2004 and December 2018. All patients treated for longitudinal tears associated or not with an anterior cruciate ligament reconstruction (ACL-R) were included.…

3D Printed Chitosan Composite Scaffold for Chondrocytes Differentiation.

AIMS: Our aim is to develop 3D printed chitosan-gelatin-alginate scaffolds using a costeffective in house designed 3D printer followed by its characterization. To observe chondrocyte differentiation on 3D printed scaffolds as part of scaffold application. BACKGROUND: Cartilage is considered to be a significant tissue in humans. It is present in between the rib cage, the lobe of the ear, nasal septum in the form of hyaline cartilage, in between ribs costal cartilage, intervertebral discs in the form of fibrocartilage, meniscus, larynx, epiglottis and between various joints of bones. To replace…

[Closing-wedge valgus high tibial osteotomy].

PURPOSE OF THE STUDY: The aim of the study was to evaluate the group of patients treated for varus arthritic knee by the method of high tibi … y arthroscopy with treatment of the pathologies found; these most frequently included a torn medial meniscus, synovitis or medial compartment chondropathy. The outcomes were evaluated using a system of clinical and radiographic assessment (A) and the Lysholm score (B) before and after surgery. RESULTS: The A system evaluation showed excellent, good and po …

Plasma-derived exosomes from obese knee osteoarthritis aggravate synovitis by promoting cellular senescence of synovial fibroblasts.

OBJECTIVES: As the most important risk factor for knee osteoarthritis (OA), obesity is closely associated with the clinical symptoms of OA. … another animal study, synovitis and synovial fibroblast senescence of destabilization of the medial meniscus surgery (DMM)-induced OA mice were assessed after intra-articular injection of plasma-derived exosomes extracted from diet-induced-obese and non-obese mice. Plasma-derived exosomes were used to treat H2O2-induced senescent fibroblasts and the cellul …

Simultaneous anterior cruciate ligament reconstruction with valgus high tibial osteotomy improves mid- to long-term clinical outcomes without increasing the complication rates in young anterior cruciate ligament deficient patients with varus malalignment: a systematic review and meta-analysis.

PURPOSE: The purpose of this study is to systematically review and quantitatively analyze the mid- to long-term clinical outcomes of simulta … physically active ACL-D patients with knee varus resulting from medial compartment OA and/or medial meniscus insufficiency, rather than ACL injury with constitutional knee varus. Compared with HTO alone, the combined procedure improved knee function, but did not reduce the incidence of radiological OA progression or complication risk. LEVEL OF EVIDENCE: L …