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COVID-19 in Adult Patients with Hematological Malignancies-Lessons Learned after Three Years of Pandemic.

The COVID-19 pandemic is undoubtedly the most difficult health challenge of the 21st century with more than 600 million laboratory-confirmed SARS-CoV-2 infections and over 6.5 million deaths worldwide. The coronavirus pandemic contributed to rapid development of mRNA vaccines, which, along with new antiviral drugs, have been the subject of extensive research for many decades. Nevertheless, elderly, multi-morbid and immunocompromised patients continue to face a more severe clinical course and a higher risk of death from COVID-19, even now that the risk of COVID-19 in the general population is s

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… Morales M.D. Benzo G. Gómez-Catalan I. Coll R. De La Fuente I. Luna A. Risk Factors and Outcome of COVID-19 in Patients with Hematological Malignancies Exp. Hematol. Oncol. 2020 9 21 10.1186/s40164-020-00177-z 32864192 PMC7445734 124. Passamonti F. Cattaneo C. Arcaini L. Bruna R. Cavo M. Merli F. … Morales M.-D. Frequency, Clinical Characteristics and Outcome of Adults with Acute Lymphoblastic Leukemia and COVID 19 Infection in the First vs. Second Pandemic Wave in Spain Clin. Lymphoma Myeloma Leuk. 2021 21 e801 e809 10.1016/j.clml.2021.06.024 34376375 PMC8286547 138. Palanques-Pastor T. …

Disease-Modifying Therapies for Multiple System Atrophy: Where Are We in 2022?

Multiple system atrophy is a rapidly progressive and fatal neurodegenerative disorder. While numerous preclinical studies suggested efficacy of potentially disease modifying agents, none of those were proven to be effective in large-scale clinical trials. Three major strategies are currently pursued in preclinical and clinical studies attempting to slow down disease progression. These target α-synuclein, neuroinflammation, and restoration of neurotrophic support. This review provides a comprehensive overview on ongoing preclinical and clinical developments of disease modifying therapies. Furth

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… [62] Wrasidlo W, Tsigelny IF, Price DL, Dutta G, Rockenstein E, Schwarz TC, Ledolter K, Bonhaus D, Paulino A, Eleuteri S, Skjevik Å, Kouznetsova VL, Spencer B, Desplats P, Gonzalez-Ruelas T, Trejo-Morales M, Overk CR, Winter S, Zhu C, Chesselet MF, Meier D, Moessler H, Konrat R, Masliah E (2016) A … [102] Spencer B, Valera E, Rockenstein E, Trejo-Morales M, Adame A, Masliah E (2015) A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy. Mol Neurodegener 10, 48. …

The Extent of Engagement With Telehealth Approaches by Patients With Advanced Cancer: Systematic Review.

BackgroundTelehealth approaches are increasingly being used to support patients with advanced diseases, including cancer. Evidence suggests that telehealth is acceptable to most patients; however, the extent of and factors influencing patient engagement remain unclear.ObjectiveThe aim of this review is to characterize the extent of engagement with telehealth interventions in patients with advanced, incurable cancer reported in the international literature.MethodsThis systematic review was registered with PROSPERO (International Prospective Register of Systematic Reviews) and is reported in lin

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… Chávarri-Guerra Y, Ramos-López WA, Covarrubias-Gómez A, Sánchez-Román S, Quiroz-Friedman P, Alcocer-Castillejos N, Milke-García MD, Carrillo-Soto M, Morales-Alfaro A, Medina-Palma M, Aguilar-Velazco JC, Morales-Barba K, Razcon-Echegaray A, Maldonado J, Soto-Perez-de-Celis E. …

Personal Medicine and Bone Metastases: Biomarkers, Micro-RNAs and Bone Metastases.

Bone metastasis is a major cause of morbidity within solid tumours of the breast, prostate, lung and kidney. Metastasis to the skeleton is associated with a wide range of complications including bone fractures, spinal cord compression, hypercalcaemia and increased bone pain. Improved treatments for bone metastasis, such as the use of anti-bone resorptive bisphosphonate agents, within post-menopausal women have improved disease-free survival; however, these treatments are not without side effects. There is thus a need for biomarkers, which will predict the risk of developing the spread to bone

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… Morales M. Urosevic J. Enhanced MAF Oncogene Expression and Breast Cancer Bone Metastasis J. Natl. Cancer Inst. 2015 107 djv256 10.1093/jnci/djv256 26376684 PMC4681582 20. Brown J.E. Westbrook J.A. Wood S.L. … Flores-Morales A. Stattin P. Egevad L. Widmark A. Gene expression profiles define molecular subtypes of prostate cancer bone metastases with different outcomes and morphology traceable back to the primary tumor Mol. Oncol. 2019 13 1763 1777 10.1002/1878-0261.12526 31162796 PMC6670017 38. Zhang K. …

α2-3-sialylated Гликосфинголипиды при нейроинфламмации, иммунитете и запрограммированной смерти клеток: механистические доказательства и регулирование в зависимости от контекста: всеобъемлющий обзор.

α2-3-sialylated glycosphingolids (α2)3-GSLs) являются основными составляющими нейронных мембран и липидных плотов, где они формируют сепарацию рецепторов, комплекс сигналов и связь с клетками. Однако их биологическое воздействие варьируется в зависимости от молекулярного подтипа, типа клеток, стадии заболевания, концентрации и местной микроокружающей среды. В настоящем обзоре обобщены данные о перепончатых изменениях в α2-3-GSL профили и их связи с нейроинфламмацией, иммунной реакцией, протеостазом и запрограммированной клеточной смертностью через болезнь Паркинсона, болезнь Альцгеймера, болез

Impact of the COVID-19 pandemic on the diagnosis and treatment of onco-hematologic patients: a discussion paper.

We do not know the precise figure for solid organ tumors diagnosed each year in Spain and it is therefore difficult to calculate whether there has been a decrease in cancer diagnoses as a consequence of the pandemic. Some indirect data suggest that the pandemic has worsened the stage at which some non-hematological neoplasms are diagnosed. Despite the lack of robust evidence, oncology patients seem more likely to have a poor outcome when they contract COVID-19. The antibody response to infection in cancer patients will be fundamentally conditioned by the type of neoplasia present, the treatmen

Direct Endoplasmic Reticulum Targeting by the Selective Alkylphospholipid Analog and Antitumor Ether Lipid Edelfosine as a Therapeutic Approach in Pancreatic Cancer.

Pancreatic ductal adenocarcinoma (PDAC), the most common malignancy of the pancreas, shows a dismal and grim overall prognosis and survival rate, which have remained virtually unchanged for over half a century. PDAC is the most lethal of all cancers, with the highest mortality-to-incidence ratio. PDAC responds poorly to current therapies and remains an incurable malignancy. Therefore, novel therapeutic targets and drugs are urgently needed for pancreatic cancer treatment. Selective induction of apoptosis in cancer cells is an appealing approach in cancer therapy. Apoptotic cell death is highly

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… Cabeza-Morales M. Martinez-Useros J. Garcia-Foncillas J. New Hope for Pancreatic Ductal Adenocarcinoma Treatment Targeting Endoplasmic Reticulum Stress Response: A Systematic Review Int. J. Mol. Sci. 2018 19 2468 10.3390/ijms19092468 30134550 PMC6165247 117. Nawrocki S.T. Carew J.S. Dunner K. Jr. … Morales R. Moda F. Moreno-Gonzalez I. Concha-Marambio L. Lee A.S. Hetz C. Soto C. The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo Sci. Rep. 2017 7 44723 10.1038/srep44723 28333162 PMC5363067 139. Liu Z. Lv Y. Zhao N. Guan G. Wang J. …

Естественные и синтетические АМП из Латинской Америки по всему спектру технологий и приложений в области разнообразия.

Биоразнообразие в Латинской Америке примерно 60% в целом по миру, подпитывая научные исследования в области природных продуктов, весьма значимой области открытия наркотиков по сей день. Это сопровождается увеличением числа антимикробных пептидов (АМП), полученных из натуральных продуктов в регионе, которые за последнее десятилетие были переработаны путем модификации, усовершенствования и уточнения их физико-химических свойств и антимикробной эффективности с использованием подходов, которые варьируются от изучения рациональной конструкции и соотношения структуры-активности (САР) до методов иску

Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures.

The aging population worldwide is facing a significant increase in age-related non-communicable diseases, including cardiovascular and brain pathologies. This comprehensive review paper delves into the impact of the exposome, which encompasses the totality of environmental exposures, on unhealthy aging. It explores how environmental factors contribute to the acceleration of aging processes, increase biological age, and facilitate the development and progression of a wide range of age-associated diseases. The impact of environmental factors on cognitive health and the development of chronic age

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… Rojas GA Saavedra N Saavedra K Hevia M Morales C Lanas F Salazar LA Polycyclic aromatic hydrocarbons (PAHs) exposure triggers inflammation and endothelial dysfunction in BALB/c mice: a pilot study Toxics. 2022 10 497 10.3390/toxics10090497 36136462 PMC9504903 138. … Persiani E Cecchettini A Ceccherini E Gisone I Morales MA Vozzi F Microplastics: a matter of the heart (and vascular system) Biomedicines. 2023 11 264 10.3390/biomedicines11020264 36830801 PMC9953450 144. …

Intestinal Coccidian Infections in Cancer Patients: A Case Series.

Introduction Coccidian protozoa and microsporidian fungi are opportunistic pathogens increasingly implicated in infections in immunosuppressed individuals. These parasites typically infect the intestinal epithelium, resulting in secretory diarrhea and malabsorption. The disease burden and timeline are both greater and longer among immunosuppressed patients. Therapeutic options for immunocompromised individuals are limited. As a result, we wanted to better characterize the disease course and treatment efficacy of these parasitic gastrointestinal infections. Methods We performed a single-center,

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… Sifuentes-Osornio J, Porras-Cortés G, Bendall RP, Morales-Villarreal F, Reyes-Terán G, Ruiz-Palacios GM. Clin Infect Dis. 1995;21:1092–1097. doi: 10.1093/clinids/21.5.1092. 10. …

Dutch Physician's Perspectives on Diagnosis and Treatment of Waldenström's Macroglobulinemia Before and After the Implementation of a National Guideline.

Waldenström's macroglobulinemia (WM), a rare low-grade B-cell non-Hodgkin lymphoma (NHL), has a distinct clinical presentation and different treatment-related side effects compared with other NHL. Currently, a wide variety of therapeutic agents are available for the treatment of WM but there is no consensus on optimal treatment in first line and/or at relapse. The aim of this survey was to evaluate the current knowledge and perspectives of hematologists on diagnosis and treatment of WM. Also, we compare these results to a similar survey done before the publication of the first Dutch national g

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… Santos-Lozano A Morales-Gonzalez A Sanchis-Gomar F . Response rate to the treatment of Waldenström macroglobulinemia: a meta-analysis of the results of clinical trials. Crit Rev Oncol Hematol . 2016 ; 105 : 118 – 126 . 27423974 10.1016/j.critrevonc.2016.06.004 12. …

Busulfan plus melphalan versus melphalan alone conditioning regimen after bortezomib based triplet induction chemotherapy for patients with newly diagnosed multiple myeloma.

BackgroundHigh dose melphalan (HDMEL) is considered the standard conditioning regimen for autologous stem cell transplantation (ASCT) in multiple myeloma (MM) patients. Recent studies showed superiority of busulfan plus melphalan (BUMEL) compared to HDMEL as a conditioning regimen. We compared the efficacy of HDMEL and BUMEL in newly diagnosed Asian MM patients, who are often underrepresented.MethodsThis is a single-center, retrospective study including MM patients who underwent ASCT after bortezomib-thalidomide-dexamethasone (VTD) triplet induction chemotherapy between January 2015 and August

Added value of post-mortem computed tomography (PMCT) to clinical findings for cause of death determination in adult "natural deaths".

PurposeThe aim of this study was to investigate whether post-mortem computed tomography (PMCT) provides additional information regarding the cause of death and underlying diseases in a general practitioners' (GP), out-of-hospital population.Methods and materialsBodies donated to our anatomy department between January 2014 and January 2018, who consecutively underwent a total body PMCT and had given permission for retrieval of their medical records during life, were included. PMCT scans were assessed by a radiologist and compared with the cause of death as stated in the medical records. Discrep

Anticancer and cardio-protective effects of liposomal doxorubicin in the treatment of breast cancer.

Breast cancer (BC) is a highly prevalent disease, accounting for the second highest number of cancer-related mortalities worldwide. The anthracycline doxorubicin (DOX), isolated from Streptomyces peucetius var. caesius, is a potent chemotherapeutic drug that is successfully used to treat various forms of liquid and solid tumors and is currently approved to treat BC. DOX exerts its effects by intercalation into DNA and inhibition of topoisomerases I and II, causing damage to DNA and the formation of reactive oxygen species (ROS), resulting in the activation of caspases, which ultimately leads t

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… Lipo-Dox®) combined with cyclophosphamide and 5-fluorouracil is effective and safe as salvage chemotherapy in taxane-treated metastatic breast cancer: an open-label, multi-center, non-comparative phase II study BMC Cancer 2015 15 423 25994543 10.1186/s12885-015-1433-4 PMC4440506 43 Gil-Gil MJ Bellet M Morales …

Disability-Adjusted Life Years for Cancer in 2010⁻2014: A Regional Approach in Mexico.

The disability-adjusted life years (DALYs) were used to estimate the regional (state of Colima, Mexico) cancer burden in 2010⁻2014. The years of life lost (YLL) were estimated with mortality data and years lived with disability (YLD) using incidence data. The DALYs were calculated as the arithmetic addition of YLL and YLD. Sex and cancer site-specific estimations were made and DALY rates were used to identify the leading causes of disease burden. Data from 2532 deaths were analyzed and, for all malignant tumors combined, 18,712.9 DALYs and 20,243.3 DALYs were estimated in males and females res

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… Morales-Rodriguez I.B. Garza-Guajardo R. Ponce-Camacho M.A. Rojas-Martinez A. Population based prostate cancer screening in north Mexico reveals a high prevalence of aggressive tumors in detected cases BMC Cancer 2009 9 91 10.1186/1471-2407-9-91 19317909 PMC2666762 26. Liang Y. Messer J.C. …

Adapting Yoga Therapy to Meet the Needs of Inpatients Undergoing Hematopoietic Stem Cell Transplantation: Insights From an International, Multisite, Qualitative Study.

PurposeYoga therapy (YT) is a growing mind-body approach in oncology. However, its integration into hematopoietic stem cell transplantation (HSCT) remains limited, particularly in non-Western and resource-constrained settings. This formative qualitative study aimed to explore the lived experiences of HSCT patients in the United States, India, and Tanzania to inform the development of a culturally adapted YT protocol.MethodsFifteen post-HSCT adult participants were recruited from three international cancer centers using purposive sampling. Semistructured interviews were conducted in participant

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… engagement (exercise, walking, gardening) Recreational engagement (TV, music, reading, chess) Cognitive engagement (positive thinking, mental stimulation) | Wide range of physical and recreational activities Quotes: “Every small step forward is a step toward healing” (MDA03) “It's helpful, especially for my morale …

Determining the Relationship Between Perceptions of Nursing Care Quality and Satisfaction Status in Multicultural Patients with Hematological Malignancies.

AIM: This study aims to investigate the correlation between multicultural patients with hematologic malignancies' perceptions of nursing care and their level of satisfaction, with the objective of providing recommendations for enhancing the quality of nursing care based on the findings. METHODS: This descriptive and cross-sectional study was conducted with 140 patients aged 18 years and over who were hospitalized in the hematology and bone marrow transplantation unit between January and October 2024, who agreed to participate in the study and were able to communicate. Data were collected usin

Azathioprine for remission maintenance in anti-interferon-γ autoantibody-associated immunodeficiency syndrome- a retrospective single-center cohort study.

BACKGROUND: Anti-interferon-γ autoantibody (Anti-IFN-γ Aab) disease is associated with frequent recurrent infections. Adjunctive immunosuppressive treatment, including rituximab, can achieve disease remission. However, disease relapses and recurrent infections occur after immunosuppressive drugs are discontinued. Azathioprine (AZA) is used for maintenance therapy in many autoimmune diseases with few adverse effects. This study aimed to assess the effectiveness of AZA in maintaining clinical remission in patients with Anti-IFN-γ Aab disease. METHODS: This retrospective observational study was

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… Doffinger R, Helbert MR, Barcenas-Morales G, et al. Autoantibodies to interferon-gamma in a patient with selective susceptibility to mycobacterial infection and organ-specific autoimmunity. Clin Infect Dis. 2004;38:e10–4. 20. Masaki Y, Nakase H, Tsuji Y, et al. …

Impact of payment source, referral site, and place of residence on outcomes after allogeneic transplantation in Mexico.

BackgroundThe impact of social determinants of health in allogeneic transplant recipients in low- and middle-income countries is poorly described. This observational study analyzes the impact of place of residence, referring institution, and transplant cost coverage (out-of-pocket vs government-funded vs private insurance) on outcomes after allogeneic hematopoietic stem cell transplantation (alloHSCT) in two of Mexico's largest public and private institutions.AimTo evaluate the impact of social determinants of health and their relationship with outcomes among allogeneic transplant recipients i

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… González Block MÁ, Reyes Morales H, Hurtado LC, Balandrán A, Méndez E. Mexico: Health System Review. Health Syst Transit. 2020;22:1–222. 6. Rivera-Franco MM, Leon-Rodriguez E, Castro-Saldaña HL. Costs of hematopoietic stem cell transplantation in a developing country. …

Uncovering the knowledge about systemic amyloidosis relevant to the rheumatologists.

Amyloidosis is a localized or systemic disease caused by deposition of proteins in the extracellular space of various organs and tissues. As part of the disease, proteins that were originally soluble misfold and acquire a fibrillar conformation that renders them insoluble and resistant to proteolysis. Systemic amyloidosis is a rare, often underdiagnosed condition. In recent years, the incidence of newly diagnosed cases of amyloidosis has been increasing in association with the aging of the population and greater access to diagnostic tests. From a clinical perspective, systemic amyloidosis is f

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… Almenara-Tejederas M, Alonso-García F, Aguillera-Morales WA, de la Prada-Álvares F, Salgueira-Lazo M. Blockade of interleukin-6 as a possible therapeutic target for AA amyloidosis. Nefrologia (Engl Ed). 2022;42(1):28–32. 46. Jung JY, Kim YB, Kim JW, Suh CH, Kim HA. …