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UEG Week 2015 Poster Presentations

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… Stanciu 2 1 Institute of Gastroenterology and Hepatology, University of Medicine and Pharmacy IASI, 2 Institute of Gastroenterology and Hepatology, Institute of Gastroenterology and Hepatology, Iasi, Romania Contact E-mail Address: cvsfarti@gmail.com Introduction: Carvedilol is a good alternative … Aims & Methods: We compared retrospectively the impact on mortality of carvedilol versus NSBB in patients with cirrhosis hospitalized in a tertiary referral center in Romania. We included patients with alcoholic and viral cirrhosis admitted in our center from 01 January 2010 to 31 December 2014. …

Amyloids and the Heart: An Update.

Amyloids consist of fibrils that can be formed by a large variety of different precursor proteins. In localized amyloidosis, amyloids accumulate at the production site with a single organ being affected, whereas in systemic amyloidosis several organs are affected, with the heart being the most common, followed by the kidneys, liver, and the nervous system. The two most frequent systemic amyloidosis types affecting the heart in the vast majority (>95%) of cases are immunoglobulin light chain (AL) amyloidosis and transthyretin (TTR) amyloidosis (ATTR amyloidosis). Patients with amyloid cardiopat

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… Role of Diphosphonates Bone Scintigraphy in Correlation with Biomarkers for a Personalized Approach to ATTR Cardiac Amyloidosis in North-Eastern Romania. Diagnostics. 2022;13:83. doi: 10.3390/diagnostics13010083. 107. …

ESMO expert consensus statements on the screening and management of financial toxicity in patients with cancer.

BackgroundFinancial toxicity, defined as both the objective financial burden and subjective financial distress from a cancer diagnosis and its treatment, is a topic of interest in the assessment of the quality of life of patients with cancer and their families. Current evidence implicates financial toxicity in psychosocial, economic and other harms, leading to suboptimal cancer outcomes along the entire trajectory of diagnosis, treatment, supportive care, survivorship and palliation. This paper presents the results of a virtual consensus, based on the evidence base to date, on the screening an

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… Jurisdiction-specific laws vary; in some countries (France, the Netherlands, Portugal, Romania, Spain), survivors need not disclose their cancer history after 5-10 years after treatment. In Belgium, disclosure is mandatory but cannot be used to deny services. …

UEG Week 2017 Oral Presentations

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Abstract

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… Penso Marco 1 , Fisicaro Samantha 1 , Caravita Sergio 1 , Baratto Claudia 1 , Delcea Caterina 1 , Gavazonni Mara 1 , Cascella Andrea 1 , Benzoni Giorgia 1 , Muraru Denisa 1 1 Istituto Auxologico Italiano, IRCCS, Ospedale San Luca - Milan Italy, 2 Clinical Emergency County Hospital of Craiova - Craiova Romania … Iliescu” - Bucharest Romania INTRODUCTION: In the presence of secondary tricuspid regurgitation (STR) the chronic volume overload determined by the regurgitant volume (RegVol) may lead to an overestimation of right ventricular (RV) systolic function assessed by conventional echocardiographic parameters …

37th International Symposium on Intensive Care and Emergency Medicine (part 2 of 3) : Brussels, Belgium. 21-24 March 2017

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Радиум - с момента открытия и до настоящего времени - обзор событий.

После его открытия радий первоначально пропагандировался в качестве терапевтического агента для широкого круга заболеваний, включая расстройства кожи, аллергию, проблемы зрения, боль в суставах и общее средство для укрепления здоровья. Однако последующие исследования продемонстрировали ее значительную радиологическую токсичность и вредное воздействие на здоровье человека. Несмотря на эти риски, более чем через сто лет после его открытия, некоторые радиевые изотопы по-прежнему имеют ограниченное применение в медицинских целях, особенно при лечении конкретных раковых заболеваний. После поглощени

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… The Radium Palace in Jáchymov, Czech Republic (opened in 1912) and other similar spas or radon-rich springs still exist in Austria, Germany, Romania, Bulgaria, Poland, Russia, Italy, France, Greece, Serbia, Chile, and Japan. …

The role of the PD-1/PD-L1 immune checkpoint pathway in myocardial infarction: a review from pathophysiological mechanisms to therapeutic strategies.

Programmed cell death protein 1 (PD-1) and its ligand, programmed death-ligand 1 (PD-L1), are vital molecules in immune checkpoints, significantly impacting cancer treatment. Recent studies have increasingly highlighted the complex roles of the PD-1/PD-L1 pathway in cardiovascular diseases, particularly in myocardial infarction (MI). In addition to being involved in immune modulation and the inflammatory response post-myocardial ischemia, this pathway is also crucial for myocardial repair and regeneration. Additionally, the clinical application of PD-1/PD-L1 immune checkpoint inhibitors has le

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… Footnotes Edited by: Antonio Rodríguez-Sinovas , Vall d'Hebron Research Institute (VHIR), Spain Reviewed by: Romeo Mihaila , Lucian Blaga University of Sibiu, Romania Ludmiła Grzybowska-Szatkowska , Medical University of Lublin, Poland Author contributions ZL: Writing – original draft, Writing – …

Mechanistic Insights into the Metabolic Pathways and Neuroprotective Potential of Pentacyclic Triterpenoids: In-Depth Analysis of Betulin, Betulinic, and Ursolic Acids.

Due to their complexity, both genotypic and phenotypic, neurodegenerative diseases are one of the main causes of death globally nowadays. Among phytochemicals of high scientific interest, based on experimental studies, pentacyclic triterpenoids (TTs), including mainly betulin, betulinic, and ursolic acid, became targets of scientific research in recent years, especially in terms of their biological activity and pharmacological potential. Due to their anti-inflammatory and antioxidant properties, as well as their involvement in cellular signal transductions, they have been observed to act as an

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… Biodiatech RTD, Cluj-Napoca, Romania, 2025 (manuscript in preparation) 30. Adepoju F.O. Duru K.C. Li E. Kovaleva E.G. Tsurkan M.V. Pharmacological Potential of Betulin as a Multitarget Compound Biomolecules 2023 13 1105 10.3390/biom13071105 37509141 PMC10377123 31. Šiman P. Bezrouk A. Tichá A. …

Abstracts of the 19th International Congress on Neuromuscular Diseases 7th – 11th July 2026

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:: 8th Европейский конгресс фармацевтики: выдержки из выступлений

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… Challenges in risk-benefit assessment Roxana Dondera National Agency for Medicine and Medical Devices of Romania, Pharmacovigilance and Risk Management Department This presentation presents challenges in risk-benefit assessment of the Periodic Safety Update Reports (PSURs) concerning Nationally Authorized …

Time toxicity in cancer care: A concept analysis using Walker and Avant's method.

ObjectiveThe purpose of this concept analysis was to explore and clarify the concept of time toxicity in the context of cancer care using Walker and Avant's method, identify its defining attributes, antecedents, and consequences, and explore its implications for cancer care.MethodsWalker and Avant's eight-step method was employed to analyze time toxicity. The literature was reviewed, focusing on peer-reviewed articles, grey literature, and cancer care policy documents to identify the defining attributes, antecedents, consequences, and empirical referents of time toxicity. Contextual factors, s

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… Analysis of the healthcare system in Romania: a brief review Healthcare 11 14 2023 2069 10.3390/healthcare11142069 37510510 PMC10379121 36 Lewandowska A. Rudzki G. Lewandowski T. …

ePoster.

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… Biomedicine and Movement Sciences, University of Verona, Verona, Italy; 11 Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana,” Neuroscience Section, University of Salerno, Salerno, Italy; 12 Department of Neurology, Faculty of Medicine, Transilvania University of Brașov, Brașov, Romania … Falup‐Pecurariu 1 1 Department of Neurology, County Clinic Hospital, Transilvania University Brasov, Romania; 2 Department of Neurology, County Clinic Hospital, Brasov, Romania Background and aims: Lower urinary tract symptoms (LUTS) are common autonomic manifestations of Parkinson's disease (PD), …

Paraneoplastic Endocrine Changes in Gastrointestinal Tumors: A Clinical and Mechanistic Review.

Paraneoplastic endocrine syndromes (PESs) are hormonal disturbances associated with malignancies that result from tumor-related production of hormone-like substances, immune-mediated mechanisms, or dysregulated signaling pathways. While they are well recognized in lung and neuroendocrine cancers, their relevance in gastrointestinal tumors remains less clearly defined. This narrative review synthesizes current knowledge on paraneoplastic endocrine manifestations in gastrointestinal malignancies, based on a structured search of the literature in major databases, including PubMed, Scopus, and Web

CAR-T cell therapy for cancer: current challenges and future directions.

Chimeric antigen receptor T (CAR-T) cell therapies have transformed the treatment of relapsed/refractory (R/R) B-cell malignancies and multiple myeloma by redirecting activated T cells to CD19- or BCMA-expressing tumor cells. However, this approach has yet to be approved for acute myeloid leukemia (AML), the most common acute leukemia in adults and the elderly. Simultaneously, CAR-T cell therapies continue to face significant challenges in the treatment of solid tumors. The primary challenge in developing CAR-T cell therapies for AML is the absence of an ideal target antigen that is both effec

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… Treatment with R2 or R-CHOP Australia, Canada, Czechia, Hungary, Republic of Korea, Poland, Romania, Singapore, Slovakia, Spain, Taiwan - - 477 NCT04094311 III To evaluate the safety of tisa-cel that is OOS for release as commercial product. … Treatment with R2 or R-CHOP | Australia, Canada, Czechia, Hungary, Republic of Korea, Poland, Romania, Singapore, Slovakia, Spain, Taiwan | - | - | 477 NCT04094311 | III | To evaluate the safety of tisa-cel that is OOS for release as commercial product. …

Acquired platelet disorders.

Platelets are essential to primary hemostasis, and defects in their number or function can lead to clinically significant bleeding or thrombosis. Acquired platelet disorders are far more common than the inherited forms and arise in a wide range of settings, including drug exposure, autoimmune, systemic, and critical illnesses. This review examines current understanding of the mechanisms driving acquired platelet dysfunction and outlines the diagnostic and therapeutic approaches that are shaping contemporary standards of care. Drug-related and immune-mediated platelet defects remain the most re

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… Lee , University of North Carolina at Chapel Hill, United States Ruxandra Irimia , Carol Davila University of Medicine and Pharmacy, Romania Author contributions RA: Writing – original draft, Writing – review & editing. …

40th Annual CAPO Conference-Responding to the Human Experience of Cancer and Caring for the Soul: Building on 40 Years of Global Leadership in Psychosocial Oncology.

On behalf of the Canadian Association of Psychosocial Oncology, we are pleased to present the Abstracts from the 2025 Annual Conference, titled "Responding to the Human Experience of Cancer and Caring for the Soul: Building on 40 years of global leadership in psychosocial oncology". The 40th Annual CAPO Conference was held in Toronto from 23 April 2025 to 25 April 2025. In an era marked by the rapid advancement of biologically focused precision medicine, it is imperative to redirect our attention towards the human experience of illness and the soul of medicine. Biomedicine has conceptualized i

MicroRNA Express Profiles как биомаркеры реакции на корректирующую болезнь терапию при множественном склерозе: системный обзор.

Хотя микроРНК (миРНК) являются активной областью исследований в области множественного склероза (МС) и были предложены в качестве потенциальных биомаркеров реакции на лечение, имеющиеся данные по-прежнему трудно интерпретировать. В рамках этого систематического обзора изучается взаимосвязь между выражением miRNA и реакцией на корректирующие заболевания методы лечения (DMT) у взрослых с MS. С момента создания базы данных PubMed/MedLINE и веб-страницы научных исследований проводились систематические обыски 11 Февраль 2026. Fifteen исследования, которые сравнивали выражение miRNA между респондент

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… Acknowledgments This work was conducted as a part of an Investigator-Sponsored Non-Interventional Study grant (Contract No. 1951/19.11.2025) from Merck Romania S.R.L. This systematic review did not receive direct financial support. …

Препятствия и факторы, способствующие реформированию системы здравоохранения.

ВВЕДЕНИЕ: Системы здравоохранения во всем мире сталкиваются с растущим давлением, обусловленным растущим бременем неинфекционных заболеваний и старением населения, а также хронической нехваткой рабочей силы, инфраструктурными ограничениями и структурными дисгармониями между моделями ухода, предназначенными для лечения острых заболеваний, и долгосрочными потребностями сложных пациентов. Многие страны предпринимают комплексные усилия по преобразованию, включая перенос ухода ближе к дому, улучшение раннего выявления заболеваний и решение проблем, связанных с рабочей силой. Цель этого исследования

Comprehensive view on chemotherapy-free management of acute myeloid leukemia by using venetoclax in combination with targeted and/or immune therapies.

A hallmark of cancer biology is resistance to apoptosis. BCL-2 is an anti-apoptotic molecule that is being overexpressed in several myeloid diseases, such as acute myeloid leukemia and myelodysplastic syndromes, but also in several lymphoid cancers, such as acute lymphoblastic leukemia, chronic lymphocytic leukemia, non-Hodgkin lymphomas and multiple myeloma. Venetoclax (VEN) is a BCL-2 small molecule inhibitor. Data about its structure, biochemical characteristics and in vitro efficacy against several blood cancer cell lines were first reported in 2013. Shortly after, the first clinical trial

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… new era of immunotherapy), by an international grant of the European Commission—Horizon Europe Framework Network, HORIZON-TMA-MSCA-DN, Proposal Number 101227725—"Advancing in the CHallenge of Improving Lymphoma and LEukemia Survival— ACHILLES”, as well as by a bilateral collaboration grant between Romania …