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Cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infections caused by Gram-negative uropathogens: a phase 2, randomised, double-blind, non-inferiority trial.

BACKGROUND: Carbapenem-resistant Gram-negative bacteria represent the highest priority for addressing global antibiotic resistance. Cefiderocol (S-649266), a new siderophore cephalosporin, has broad activity against Enterobacteriaceae and non-fermenting bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii, including carbapenem-resistant strains. We assessed the efficacy and safety of cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infection in patients at risk of multidrug-resistant Gram-negative infections. METHODS: We did a phase 2, mult…

[Clinical characteristics of burn patients infected with Stenotrophomonas maltophilia and antibiotic resistance of the strains].

Objective: To investigate the clinical characteristics of burn patients infected with Stenotrophomonas maltophilia (SM) and antibiotic resis … ) The proportion of patients detected with pathogens before detection of SM was 66.4% (79/119), and Acinetobacter baumannii and Staphylococcus aureus occupied high proportion among the strains. (5) The proportion of patients using antibiotics before detection of SM was 91.6% (109/119), and 44.0% (48/109) patients used 3 kinds of antibiotics or more. The antibiotics were …

Clinical outcomes of antimicrobial resistance in cancer patients: a systematic review of multivariable models.

BackgroundInfections are major causes of disease in cancer patients and pose a major obstacle to the success of cancer care. The global rise of antimicrobial resistance threatens to make these obstacles even greater and hinder continuing progress in cancer care. To prevent and handle such infections, better models of clinical outcomes building on current knowledge are needed. This internally funded systematic review (PROSPERO registration: CRD42021282769) aimed to review multivariable models of resistant infections/colonisations and corresponding mortality, what risk factors have been investig

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… Fan L Wang Z Wang Q Xiong Z Xu Y Li D Increasing rates of Acinetobacter baumannii infection and resistance in an oncology department J Cancer Res Ther 2018 14 68 71 10.4103/jcrt.JCRT_737_17 29516962 141. … Ñamendys-Silva SA Correa-García P García-Guillén FJ González-Herrera MO Pérez-Alonso A Texcocano-Becerra J Outcomes of critically ill cancer patients with Acinetobacter baumannii infection World J Crit Care Med 2015 4 258 264 10.5492/wjccm.v4.i3.258 26261778 PMC4524823 144. …

Epidemiology and source of infection in cancer patients with febrile neutropenia: an experience from a developing country.

BackgroundFebrile neutropenia (FN) is a life-threatening complication that predisposes cancer patients to serious infections. This study aims to describe the epidemiology and source of infection in cancer patients with FN in a tertiary care hospital.MethodsA hospital-based retrospective study was conducted in a large tertiary care hospital from January 2020 to December 2021. Data on cancer patients with FN were collected from the hospital information system.Results150 cancer patients with FN were identified during the study period. Most patients were males (98; 65.3%), and the mean age of part

Safety and tolerability of the antimicrobial peptide human lactoferrin 1-11 (hLF1-11).

BackgroundThe treatment of patients with haematological malignancies by means of haematopoietic stem cell transplantation (HSCT) is often accompanied by life threatening infections. With emerging antimicrobial resistance there is an increased need for new agents, with a beneficial safety profile. Therefore we evaluated the safety of the promising new antimicrobial peptide human lactoferrrin 1-11 (hLF1-11) in healthy volunteers and patients.MethodsWe undertook a sequential, randomised, double-blind, placebo-controlled study using ascending single (0.005, 0.05, 0.5, 5 mg) and multiple intravenou

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… In vivo animal experiments indicated that hLF1-11 is highly effective against Staphylococcus aureus , Listeria monocytogenes and antibiotic resistant Acinetobacter baumannii , reducing bacterial loads in infected organs by 2 to 3 log [ 20 , 23 , 24 , 37 ]. … The synthetic N-terminal peptide of human lactoferrin, hLF(1-11), is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2004;48:4919–4921. doi: 10.1128/AAC.48.12.4919-4921.2004. …

Global burden associated with 85 pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019.

BACKGROUND: Despite a global epidemiological transition towards increased burden of non-communicable diseases, communicable diseases continu … am-negative bacterial species (ie, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, and Helicobacter pylori). Conversely, some pathogens had a burden that was smaller than anticipated. INTERPRETATION: Our detailed breakdown of DALYs associated with a comprehensive list of pathogens on a global, regional, and country level has rev …

Analysis of the microbial species, antimicrobial sensitivity and drug resistance in 2652 patients of nursing hospital.

OBJECTIVE: To understand the microbial species, antimicrobial sensitivity and drug resistance of patients in the nursing hospital, to bring … in sputum and urine. Proteus mirabilis is easily detected in the urine. Pseudomonas aeruginosa and Acinetobacter baumannii are easily detected in sputum. Among the fungi, Candida albicans, Candida bulgaricus, and Candida glabrata are easily detected in sputum. There is a significant statistically difference in the distribution of P. aeruginosa in all age groups. The res …

Effect of guideline-concordant, appropriate, and effective antimicrobial treatment on patient outcome in multidrug-resistant (MDR) infections.

Recently, to achieve cure, physicians have been resorting to overuse or misuse of antimicrobials to treat resistant infections, leading to t … amples that grew ESKAPE pathogens (Enterococcus spp., Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) between October 2020 to September 2022 were collected and evaluated consecutively for MDR. Charts of all identified MDR isolates who had received empiric therapy were evaluated for concordance with hos …

Смерть, вызванная распространением Герпеса Зостера в пациенте с множественной миеломой: Case Report and Licture Review.

Мы сообщаем о смертельном случае распространения герпеса-зостера в пациенте с множественной миеломой, иллюстрируя серьёзный риск иммунокомпромированных людей от вирусных инфекций. Путем объединения подробного доклада по делу с обширным анализом литературы в документе делается попытка пролить свет на факторы, лежащие в основе подверженности вирусной инфекции варицелла-зостр у нескольких пациентов, страдающих миэломой. Мы дополнительно оцениваем эффективные профилактические протоколы для герпеса-зостра, направленные на оснащение врачей улучшенными терапевтическими стратегиями. В данном случае по

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… The primary cause of death was identified as septic shock due to carbapenem-resistant Klebsiella pneumoniae septicaemia, compounded by multi-organ infections, including carbapenem-resistant Klebsiella pneumoniae, Acinetobacter baumannii pneumonia, fungal infections (Aspergillus fumigatus, Candida albicans … Sputum culture | Infection of multidrug-resistant strains of Acinetobacter baumannii, sensitive only to tigecycline. NGS of alveolar lavage fluid | Klebsiella pneumoniae and Acinetobacter baumannii; Aspergillus fumigatus and Candida albicans. …

Profile and Antibiotic Pattern of Blood Stream Infections of Patients Receiving Hematopoietic Stem Cell Transplants in Southwest China.

BackgroundBloodstream infection (BSI) is a serious medical issue causing non-relapsed mortality in patients receiving hematopoietic stem cell transplantations (HSCT).MethodsThe characteristics of all patients receiving HSCT (autologous and allogeneic HSCT) in our hospital from 2013 to 2019 were studied. Ratios, medians, and ranges were calculated to describe categorical variables. Chi-square tests were performed to compare the difference between ratios.ResultsA total of 741 patients receiving 746 HSCT procedures-including 376 allogeneic, 370 autologous, and four of both types-were included in

A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period.

For better management of patients with febrile neutropenia, our study investigated the epidemiologic, microbiologic, and clinical characteristics of adult inpatients with febrile neutropenia and their mortality-associated factors. To this end, we carried out a prospective, observational, multicenter study in 28 Argentinian hospitals between 2007 and 2012. We included 515 episodes of febrile neutropenia from 346 patients, median age 49 years. Neutropenia followed chemotherapy in 77% of cases, half of the cases due to hematological malignancies. Most episodes were classified as high-risk accordi

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… Microorganisms were indicated according to decreasing order of presentation Blood cultures | Isolated microbe (n) | n Blood cultures at the onset (n = 515) | Gram-negative bacilli | 38 Escherichia coli (18); Klebsiella pneumonia (7); Pseudomonas sp (7); Acinetobacter baumannii (1); Other Gram-negative … Staphylococcus aureus (1) Total | 33 Urine culture | Isolated microbe (n) Urine cultures at the onset (n = 515) | Gram-negative bacilli | 40 Escherichia coli (31) , Klebsiella pneumonia (4) , Enterobacter cloacae(2) , Acinetobacter baumannii (1) , Proteus mirabilis (1) , Pseudomonas sp (1) Gram-positive …

Nanovesicular Drug Delivery Systems for Overcoming Antibiotic Resistance.

Despite the early success of treating bacterial infections with antibiotics, resistance development has become a global problem. Treatment of organisms that have become resistant to common antibacterial agents is challenging and can cause severe and extended illness, longer hospital stays, and increased medical costs. Bacteria may develop antibiotic resistance by multiple biochemical pathways, including target-site gene mutations, decreased permeability, drug uptake or efflux mechanisms that remove the drug from the host cells, and alterations in metabolic pathways. Several strategies to overc

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… Particularly problematic are the major human pathogens, such as Pseudomonas aeruginosa , Klebsiella pneumoniae , Acinetobacter baumannii , Enterococcus faecium , Staphylococcus aureus ,and Enterobacter spp . … Synergistic antibacterial effect of ultrasound microbubbles combined with chitosan-modified polymyxin B-loaded liposomes on biofilm-producing Acinetobacter baumannii. Fu YY, Zhang L, Yang Y, Liu CW, He YN, Li P, Yu X. Int J Nanomedicine. 2019;14:1805–1815. doi: 10.2147/IJN.S186571. 30. …

The burden of bacterial antimicrobial resistance in the WHO Eastern Mediterranean Region 1990-2021: a cross-country systematic analysis with forecasts to 2050.

BACKGROUND: Antimicrobial resistance (AMR) is an urgent global crisis and one of the world's most complex challenges. Although there is incr … f burden: Streptococcus pneumoniae, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, Acinetobacter baumannii, and Pseudomonas aeruginosa. A substantial increase in the AMR burden due to S aureus was observed between 1990 (28 200 deaths [21 600-34 000]) and 2021 (49 500 deaths [43 100-56 200]); consequently, in 2021, methicillin-resistant S aureus was a lea …

Opportunistic Pathogens in Drinking Water Distribution Systems-A Review.

In contrast to "frank" pathogens, like Salmonella entrocolitica, Shigella dysenteriae, and Vibrio cholerae, that always have a probability o … luding Aeromonas hydrophila, Klebsiella pneumoniae, Serratia marcescens, Burkholderia pseudomallei, Acinetobacter baumannii, Stenotrophomonas maltophilia, Arcobacter butzleri, and several free-living amoebae including Naegleria fowleri and species of Acanthamoeba. The public health risk for these microbes in drinking water is still unclear, but in most cases, efforts to …

Prevalence and characteristics of concomitant septic and crystal-induced arthritis: A hospital database and literature review.

BACKGROUND AND OBJECTIVES: Concomitant septic and crystal-induced arthritis is a rare condition. Failure to diagnose this condition can result in significant harm to the patient. This study aims to investigate the prevalence and characteristics of concomitant septic and crystal-induced arthritis. METHODS: A retrospective study included patients diagnosed with concomitant septic and crystal-induced arthritis confirmed by positive bacterial culture and intracellular crystals in synovial fluid of the same joint, from January 1, 2015, to July 31 ,2024. RESULTS: A total of 45 cases were defined a

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… (97) | Salmonella group D | MSU | No | 82.2 42 | M | 66 | Yes | 1 | Knee | ESRD, HT, DM | 17,363 (89) | Sphingomonas paucimobilis | MSU | No | N/A 43 | M | 62 | Yes | 7 | Ankle | Gout, HT | 355,740 (80) | Burkholderia pseudomallei | MSU | Yes | N/A 44 | F | 55 | Yes | 1 | Knee | - | 193,280 (90) | Acinetobacter … baumannii | MSU | Yes | N/A 45* | F | 82 | Yes | 3 | Knee, Wrist | CKD4, HT, Cirrhosis | 51,000 (71) | Acinetobacter baumannii | MSU | Yes | N/A Clinical Presentations Fever was observed in 95.6% of patients. …

Смертность, связанная с инфекцией, после трансплантации стволовых клеток в условиях высокой антимикробной устойчивости.

: Инфекционные осложнения остаются одной из основных причин смертности после трансплантации стволовых клеток (ГХЦТ). Мы поставили перед собой цель описать инфекцию после ХСБТ и ее воздействие на выживание в центре региона с высоким антимикробным сопротивлением. МЕТОДЫ: В том числе 522 больные гематологическими расстройствами, проходящими через СХТ в университетском госпитале Коч, между 2016 и 2024. Кровоток и оппортунистические инфекции внутри 100 были проанализированы дни. Смертность, связанная с инфекцией, была определена как смерть, обусловленная главным образом инфекционными осложнениями.

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… Nosocomial infection agents like Acinetobacter baumannii or methicillin-resistant Staphylococcus aureus (MRSA) were not isolated during the study period. Fungal agents were detected in %5 ( n = 6) of the BSI episodes. … A notable strength of our center is the absence of highly resistant pathogens such as Acinetobacter baumannii and MRSA in our patient population, reflecting sustained infection control efforts. Limitations This study has several limitations. …

The Role of Drug Repurposing in the Development of Novel Antimicrobial Drugs: Non-Antibiotic Pharmacological Agents as Quorum Sensing-Inhibitors.

Background: The emergence of multidrug-resistant organisms (MDROs) is a global public health issue, severely hindering clinicians in administering appropriate antimicrobial therapy. Drug repurposing is a drug development strategy, during which new pharmacological applications are identified for already approved drugs. From the viewpoint of the development of virulence inhibitors, inhibition of quorum sensing (QS) is a promising route because various important features in bacterial physiology and virulence are mediated by QS-dependent gene expression. Methods: Forty-five pharmacological agents,

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… Rice in 2008), namely E: Enterococcus faecium , S: Staphylococcus aureus or recently Stenotrophomonas maltophilia , K : Klebsiella pneumoniae or recently C : Clostridioides difficile , A : Acinetobacter baumannii , P : Pseudomonas aeruginosa , E : Enterobacter spp., or recently Enterobacteriaceae ) present … baumannii , Stenotrophomonas maltophilia ); induction of bacterial competence (e.g., Streptococcus pneumoniae ), motility (e.g., P. aeruginosa ), adhesion (e.g., E. coli, Klebsiella pneumoniae ) and pigment-production (e.g., Chromobacterium violaceum , Serratia marcescens , P. aeruginosa )) are mediated …

Increasing Gram-Negative Catheter-Related Bloodstream Infection in Cancer Patients.

Background: We aimed to assess the incidence, etiology and outcomes of catheter-related bloodstream infection (CRBSI) in onco-hematological patients, to assess the differences between patients with hematological malignancies (HMs) and solid tumors (STs) and to identify the risk factors for Gram-negative (GN) CRBSI. Methods: All consecutive episodes of BSI in adult cancer patients were prospectively collected (2006-2020). The etiology of CRBSI was analyzed in three different 5-year periods. Risk factors for GN CRBSI were assessed in the whole cohort and separately in patients with HMs and STs.

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… baumannii as defined by Magiorakos et al. [ 13 ]. 2.3. … Table 3 Etiology of all 467 episodes of catheter-related bloodstream infection. 1 Other: Acinetobacter baumannii (1), Citrobacter freundi (1), Serratia marcescens (1), Providencia rettgeri (1), Ochrobactrum anthropi (1), Ralstonia picketti (1), Delfia acidovorans (1). 2 MDRGN: multidrug-resistant Gram-negative …

Anti-Infective-Associated AKI: A Narrative Review of the Epidemiology, Mechanisms, Risk Factors, Biomarkers, Clinical Course, Monitoring, Prevention, and Therapeutic Strategies.

Acute kidney injury (AKI) occurs commonly in hospitalized patients, especially patients in intensive care units (ICUs). Medications are among the major causative factors of AKI. This narrative review addressed and updated different aspects of anti-infective-associated AKI, including amphotericin B, cidofovir, foscarnet, polymyxins, vancomycin, and aminoglycosides. There is no standard definition or operational criteria to describe anti-infective-associated AKI. Characteristically, it usually occurs during the first two weeks of treatment and is typically dose dependent. Functional resolution o

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… These include carbapenem-resistant Enterobacteriaceae ( Escherichia coli , Klebsiella pneumoniae , and some Enterobacter spp.), Pseudomonas aeruginosa , and Acinetobacter baumannii [ 110 , 111 ]. 5.2. Epidemiology Polymyxins have a narrow therapeutic window [ 112 ]. … According to the results of a few retrospective and prospective studies in favor of comparable clinical and microbiological response rates between colistin and ampicillin–sulbactam in the treatment of carbapenem-resistant Acinetobacter baumannii infections [ 169 , 170 ], using alternative regimens or …

Causes of Death Among Stillbirths and Children Aged <5 Years in Africa and South Asia - Child Health and Mortality Prevention Surveillance, Seven Countries, 2016-2024.

PROBLEM/CONDITION: Sub-Saharan Africa and South Asia have the highest rates of stillbirths and rates of death among children aged <5 years, … rapartum care; and sepsis (36.5%), commonly resulting from infection with Klebsiella pneumoniae and Acinetobacter baumannii. Among infants and children, leading causes of death included lower respiratory infections (37.4%), sepsis (36.9%), malnutrition (27.3%), malaria (22.1%), and diarrheal disease (17.3%). Multiple conditions in the causal chain were common among neona …