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Диметилфумарат смягчает прогрессию остеоартрита путем активации Nrf2 с помощью средств подавления окислительного стресса и субхондрального остеоластогенеза.

Osteoarthritis (OA) — дегенеративное соеденительное заболевание, связанное с несбалансированной субхондральной реконструкцией костей, и в настоящее время лечебное лечение отсутствует. В ОА чрезмерная остеокластная активность приводит к потере костей и подстрекательским реакциям. Диметилфумарат (ДМФ) - активатор Nrf2, уже используемый при лечении псориаза и множественного склероза, - может облегчить ОА путем подавления окислительного стресса и остеокластогенеза. В этом исследовании изучается воздействие ДМФ на остеокласты, субхондральную кость, артикулярный хрящ и механизмы, лежащие в основе ра

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Osteoarthritis (OA) is a degenerative joint disease associated with imbalanced subchondral bone remodeling, and there is currently no curati … e Nrf2 signaling pathway. For in vivo experiments, OA was induced via destabilization of the medial meniscus (DMM) surgery, with mice divided into sham, DMM, and DMF-treated (50 mg/kg/day) groups. Evaluations at 2, 4, and 8 weeks included Micro-CT, gait analysis, TRAP/H&E/Safranin-O staining, and immunohistochemistry (Nrf2, CTSK, Netrin-1) to examine subch …

The influence of the weight-bearing state on three-dimensional (3D) planning in lower extremity realignment - analysis of novel vs. state-of-the-art planning approaches.

BACKGROUND: The use of 3D planning to guide corrective osteotomies of the lower extremity is increasing in clinical practice. The use of com … reported. The relationship between the reported differences and BMI, preoperative HKA (LLR), medial meniscus extrusion, Outerbridge osteoarthritis grade and joint line convergence angle (JLCA) was analyzed. RESULTS: The mean (std) planned opening angle of 3D hybrid did not differ between 3D hybrid and 3D WB (0.4 ± 2.1°) (n.s.) but was higher in 3D hybrid …

[Combination of acupuncture and medication for dry eye complicated with computer vision syndrome: a randomized controlled trial].

OBJECTIVE: To compare the clinical efficacy of acupuncture, Chinese medication and combination of acupuncture and medication in the treatmen … st tear film break-up time (NIBUT f), non-invasive average tear film break-up time (NIBUT av), tear meniscus height (TMH), ocular surface disease index (OSDI) score, and CVS symptom score were compared between the patients of each group before and after treatment. RESULTS: After treatment, the NIBUT f, NIBUT av, and TMH were increased compared with those …

Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain.

INTRODUCTION: Knee pain, a common complaint in primary care, has many causes, the most common of which is osteoarthritis (OA). Other common causes are meniscus tears, tendinosis, ligament tears or sprains, rheumatoid arthritis, lupus and septic arthritis. Also, referred pain from hip joint pathology like slipped capital femoral epiphysis can result in knee pain.1 The use of peptides BPC157 and thymosin-beta-4 (TB4) has not been studied in the treatment of knee pain. METHODS: A retrospective study was done at the Institute for Hormonal Balance in Orlando, Florida, USA to see whether intra-arti…

The effect of punctal occlusion on tear production, tear clearance, and ocular surface sensation in normal subjects.

PURPOSE: To evaluate the effect of temporary punctal occlusion on tear production, tear clearance, and ocular surface sensation in normal su … the fluorescein concentration in minimally stimulated tear samples collected from the inferior tear meniscus 15 minutes after instillation of fluorescein. Schirmer test was performed without anesthesia. The tests were performed at days 0, 1, 3, 7, and 14 to 17 after punctal occlusion. Relationships were analyzed with linear regressions, and a quadratic ter …

Primary repair plus intra-articular iliotibial band augmentation in the treatment of an acute anterior cruciate ligament rupture. A follow-up study of 70 patients.

Between September 1987 and November 1989, we treated 90 consecutive patients with an acute anterior cruciate ligament (ACL) rupture with the … ated ACL ruptures and 31, ACL ruptures combined with a medial CL rupture. In 9 cases, an additional meniscus injury and in one case an additional posterior CL - lateral CL rupture was found. At the follow-up, 55 patients (79%) were satisfied with the end result, and according to our objective functional criteria 55 (79%) had an excellent or good outcome. A …

MR diagnosis of complete tears of the anterior cruciate ligament of the knee: importance of anterior subluxation of the tibia.

OBJECTIVE: The primary role of the anterior cruciate ligament is to resist anterior subluxation of the tibia. When the ligament is torn, the … ars of the anterior cruciate ligament (n = 2) or when a displaced bucket-handle tear of the lateral meniscus blocks anterior subluxation of the tibia (n = 1). CONCLUSION: An anterior tibial subluxation greater than 5 mm (grade 2 or greater) is a simple objective measurement that serves as a helpful adjunctive sign in the diagnosis of complete tears of the …

Multiple myeloma presenting with amyloid arthropathy as the first manifestation: Two case reports.

BACKGROUND: Multiple myeloma (MM) can be accompanied by amyloidosis, which occurs in a small number of patients and is characterized by deposition of light chains in the joints, leading to multiple myeloma-associated amyloid arthropathy (MAA). As a rare complication of MM, clinical manifestations of MAA are often similar to those of rheumatoid arthritis, and the two are easily confused. CASE SUMMARY: In recent years, our center treated two patients of MM with amyloid arthropathy as the first manifestation, both of whom presented with polyarthritis. After treatment for MM, both patients achiev

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… The MRI scans also revealed a right knee medial meniscus posterior angle injury grade III, double hip joint capsule slip membrane hyperplasia (obvious on the left side and invading the femoral head and adjacent soft tissue masses), secondary osteoarthritis of both hips, and effusion of the right hip … A: Shoulder synovial hyperplasia; B: Knee meniscus injury; C and D: Femoral neck erosion with hyperplasia of the surrounding synovial tissue. …

Neuropeptide Y1 receptor antagonist alleviated osteoarthritis by restoring chondrocyte autophagy through PI3K/AKT/mTOR signaling pathway.

BACKGROUND: Osteoarthritis (OA) is a debilitating joint disorder affecting millions worldwide, characterized by progressive cartilage degrad … pathways. In vivo, OA was induced in 8-week-old male C57BL/6 mice via destabilization of the medial meniscus (DMM) or intra-articular injections of NPY (5 μM, every 4 weeks). Mice were treated with the Y1R antagonist (0.1 μM, weekly) or vehicle control. Pain behavior was assessed using von Frey filaments and CatWalk gait analysis. Cartilage degeneration wa …

Efficacy of electromyographic biofeedback and electrical stimulation following arthroscopic partial meniscectomy: a randomized controlled trial.

OBJECTIVE: To compare the effectiveness of electromyographic biofeedback training and electrical stimulation therapy for rehabilitation following arthroscopic partial meniscectomy. DESIGN: Randomized, prospective, controlled single-blind trial. SETTING: Department of physical medicine and rehabilitation, university hospital. SUBJECTS: Forty-five patients who had undergone surgery for arthroscopic partial meniscectomy were randomly divided into three groups with 15 patients in each group. INTERVENTIONS: The control group had home exercise, the second and third groups received electromyograp

Development of a novel protocol to evaluate contact-lens related ocular surface health on marmosets (Callithrix jacchus).

Contact lens wear affects the ocular surface and can cause contact lens-induced dry eye (CLIDE). The purpose of this study was bifold: (1) to develop a novel protocol to assess the ocular surface in a non-human primate (NHP) model, the common marmoset (Callithrix jacchus), and (2) to characterize central corneal thickness (CCT), tear osmolarity, blink rate and tear meniscus height (TMH) longitudinally, in untreated marmosets (controls) compared to animals treated with contact lenses (CL). Longitudinal changes in CCT (N = 10 control; N = 10 treated with contact lenses, CL-treated), osmolarity (…

Extrusion of tibial tunnel bioabsorbable screw 15 months after anterior cruciate ligament reconstruction.

The use of bioabsorbable implants in orthopaedic surgery has become a common practice. Despite their many theoretical advantages, recent reports have proposed certain concerns and complications associated with their use. We report the case of a bioabsorbable screw that extruded from the tibial insertion site 15 months after anterior cruciate ligament reconstruction.

Tubercular infection after arthroscopic anterior cruciate ligament reconstruction.

PURPOSE: Tubercular infection has not been described, to our knowledge, in the literature after anterior cruciate ligament (ACL) reconstruction, and, hence, the purpose of our case series was to describe our experience, evaluate the clinical and laboratory findings, and assess the treatment outcome. METHODS: We performed a retrospective analysis of 1,152 cases of arthroscopic ACL reconstruction with autografts performed at our institution between January 1998 and May 2007. Tubercular infection was considered to be present in the setting of recurrent negative bacterial cultures but a positive

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… Sarthak Chopra, Pradyumna Raval, Harbeer Ahedi, Alexander Nicholls Sydney Orthopaedic Research Institute, Sydney, NSW, Australia OP-201 5:06 PM–5:10 PM Features of discoid lateral meniscus in pediatric patients with achondroplasia Jennifer Sheasley, Maya Gopalan, Emily Niu, Apeksha Gupta, Zachary … Stinson, Marie-Lyne Nault , Sasha Carsen, Craig Finlayson, R Jay Lee, Brian Michael Haus, Daniel W Green, John A Schlechter, Benton E Heyworth, Jennifer J Beck, Jie C Nguyen, Gregory A Schmale, PRiSM Meniscus Research Interest Group Seattle Children’s Hospital, Seattle, WA, USA OP-202 5:11 PM–5:15 …

Soft tissue knee injury with concomitant osteochondral fracture is associated with higher degree of acute joint inflammation.

BACKGROUND: Osteochondral fractures are often seen on magnetic resonance imaging (MRI) of acutely injured knees, but their existence has gained little interest because of a lack of knowledge of their relation to treatment options and outcome. It is not clear whether acute phase synovial fluid (SF) concentrations of cartilage and bone markers and proinflammatory cytokines are different between traumatically injured knees with or without osteochondral fracture. HYPOTHESIS: Acutely injured knees with an osteochondral fracture, particularly fractures with disrupted cortical bone, have higher conc

Arthroscopic lavage and debridement for osteoarthritis of the knee: an evidence-based analysis.

OBJECTIVE: The purpose of this review was to determine the effectiveness and adverse effects of arthroscopic lavage and debridement, with or … n patients with pain due to a meniscal tear, of the medial compartment in particular, repair of the meniscus results in better pain control at 2 years following surgery than if the pain is attributable to other causes. There is insufficient evidence to comment on the effectiveness of lateral meniscus repair on pain control. CONCLUSIONS: Arthroscopic debri …

Clinical Outcomes After Medial Meniscal Ramp Lesion Repair and Anterior Cruciate Ligament Reconstruction in Pediatric and Adolescent Patients: A Multicenter Study With a Mean Follow-up of 5 Years.

BACKGROUND: Medial meniscal ramp lesions (MMRLs) can occur in up to 28% of pediatric patients at the time of anterior cruciate ligament (ACL … nosed partial or complete peripheral vertical/longitudinal tear of the posterior horn of the medial meniscus at/or within 3 mm of the meniscocapsular junction that underwent repair at the time of ACLR. Postoperative outcome measures included subjective International Knee Documentation Committee (IKDC) scores, return to sport (RTS), patient satisfaction, co …

Integrative network pharmacology and in vitro/in vivo validation reveal the protective effects of sotetsuflavone against osteoarthritis associated with PI3K/Akt/NF-κB signaling.

Osteoarthritis (OA) is a prevalent whole-joint disease characterized by progressive cartilage degeneration, extracellular matrix (ECM) break … xperiment was performed using 740Y-P, a PI3K/Akt pathway activator. A destabilization of the medial meniscus (DMM)-induced mouse model was established to evaluate the protective effects of SF against OA-related structural and inflammatory changes in vivo. Network pharmacology analysis identified 68 overlapping targets between SF and OA-associated genes, wi …

[Blink patterns in mild thyroid-associated ophthalmopathy-related dry eye and their association with tear film stability].

Objective: To analyze the differences in blink patterns among patients with mild thyroid-associated ophthalmopathy (TAO, with eyelid retract … oup and the primary DED group, no significant differences were found in Schirmer test results, tear meniscus height, ocular redness score, meibomian margin morphology score, lipid layer saturation, or lipid spread speed (all P>0.05). However, non-invasive tear film breakup time (NIBUT) was significantly shorter in the mild TAO group than in the primary DED …

Adjuvant denosumab in postmenopausal patients with hormone receptor-positive breast cancer (ABCSG-18): disease-free survival results from a randomised, double-blind, placebo-controlled, phase 3 trial.

BACKGROUND: In postmenopausal women with hormone receptor-positive, early-stage breast cancer, treatment with adjuvant aromatase inhibitors … steoarthritis (62 [3·6%] of 1709 in the denosumab group vs 58 [3·4%] of 1690 in the placebo group), meniscus injury (23 [1·3%] vs 24 [1·4%]), and cataract (16 [0·9%] vs 28 [1·7%]). One (<0·1%) treatment-related death (due to pneumonia, septic kidney failure, and cardiac decompensation) occurred in the denosumab group. INTERPRETATION: Denosumab constitutes …