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Outcomes and Prognostic Factors in Critical Patients with Hematologic Malignancies.

Patients with hematologic malignancies (HMs) have a significantly elevated risk of mortality compared to other cancer patients treated in the intensive care unit (ICU). The prognostic impact of numerous poor outcome indicators has changed, and research has yielded conflicting results. This study aims to determine the ICU and hospital outcomes and risk factors that predict the prognosis of critically ill patients with HMs. In this retrospective study, conducted at a referral hospital in Taiwan, 213 adult patients with HMs who were admitted to the medical ICU were evaluated. We collected clinica

Структура агрессивного сексуального поведения: сетевое аналитическое исследование

Обобщающее сексуальное поведение - это явление, характеризующееся постоянной неспособностью контролировать интенсивные, повторяющиеся сексуальные порывы или желания, что приводит к повторяющемуся сексуальному поведению, вызывающему серьезные страдания или расстройства в личной, семейной, социальной, образовательной или профессиональной сферах деятельности. Несмотря на его существенное воздействие на психическое здоровье и качество жизни, мало что известно о его внутренней структуре и о том, различается ли это явление между полами, возрастными группами и статусом риска. С помощью сетевого анали

Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume I-conceptual challenges.

The sharing of clinical trial data and biomarker data sets among the scientific community, whether the data originates from pharmaceutical companies or academic institutions, is of critical importance to enable the development of new and improved cancer immunotherapy modalities. Through data sharing, a better understanding of current therapies in terms of their efficacy, safety and biomarker data profiles can be achieved. However, the sharing of these data sets involves a number of stakeholder groups including patients, researchers, private industry, scientific journals and professional societ

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… N Engl J Med 2017 ; 377 : 1990 – 2 . 10.1056/NEJMsb1708278 29141170 45 Resnik DB , Morales M , Landrum R , et al Effect of impact factor and discipline on Journal data sharing policies . …

Annual decline in forced expiratory volume and airway inflammatory cells and mediators in a general population-based sample.

BackgroundFew studies have examined the relationships between sputum inflammatory markers and subsequent annual decline in forced expiratory volume in 1 s (dFEV1). This study investigated whether indices of airway inflammation are predictors of dFEV1 in a general population-based sample.MethodsThe study, conducted from 2003 to 2005, included 120 healthy Norwegian subjects aged 40 to 70 years old. At baseline, the participants completed a self-administered respiratory questionnaire and underwent a clinical examination that included spirometry, venous blood sampling, and induced sputum examinati

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… Morales E, Garcia-Esteban R, Asensio de la Cruz O, Basterrechea M, Lertxundi A, Martinez López de Dicastillo MD, Zabaleta C, Sunyer J. Intrauterine and early postnatal exposure to outdoor air pollution and lung function at preschool age. …

Living with relapsed myeloma: Symptoms and self-care strategies.

Aims and objectivesTo explore which symptoms relapsed myeloma patients experience and what self-care strategies are used.MethodsThis was a qualitative study utilising focus group interviews (n = 4) with relapsed myeloma patients (n = 15) and carers (n = 9). The focus groups were analysed and guided by thematic analysis.ResultsThree major themes with subthemes were identified following analysis of the interview data: "difficult symptoms; "self-care" and "feeling vulnerable." These findings indicate the challenges relapsed myeloma patients experience with ongoing symptoms and highlight the impor

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… Assuming autonomy over self‐care appears to be an integral aspect of the relapsed myeloma patients’ journey; however, it is important to note that each new relapse brings with it an amount of debilitation and diminished morale (Stephens et al., 2014 ). …

A thirteen-gene expression signature predicts survival of patients with pancreatic cancer and identifies new genes of interest.

BackgroundCurrently, prognostication for pancreatic ductal adenocarcinoma (PDAC) is based upon a coarse clinical staging system. Thus, more accurate prognostic tests are needed for PDAC patients to aid treatment decisions.Methods and findingsAffymetrix gene expression profiling was carried out on 15 human PDAC tumors and from the data we identified a 13-gene expression signature (risk score) that correlated with patient survival. The gene expression risk score was then independently validated using published gene expression data and survival data for an additional 101 patients with pancreatic

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… Valsangkar NP, Morales-Oyarvide V, Thayer SP, Ferrone CR, Wargo JA, et al. (2012) 851 resected cystic tumors of the pancreas: a 33-year experience at the Massachusetts General Hospital. Surgery 152: S4–12. 45. …

Cancer Patients' Perspectives and Requirements of Digital Health Technologies: A Scoping Literature Review.

Digital health technologies have the potential to alleviate the increasing cancer burden. Incorporating patients' perspectives on digital health tools has been identified as a critical determinant for their successful uptake in cancer care. The main objective of this scoping review was to provide an overview of the existing evidence on cancer patients' perspectives and requirements for patient-facing digital health technologies. Three databases (CINAHL, MEDLINE, Science Direct) were searched and 128 studies were identified as eligible for inclusion. Web-based software/platforms, mobile or smar

Polyphenols as Antitumor Agents Targeting Key Players in Cancer-Driving Signaling Pathways.

Polyphenols constitute an important group of natural products that are traditionally associated with a wide range of bioactivities. These are usually found in low concentrations in natural products and are now available in nutraceuticals or dietary supplements. A group of polyphenols that include apigenin, quercetin, curcumin, resveratrol, EGCG, and kaempferol have been shown to regulate signaling pathways that are central for cancer development, progression, and metastasis. Here, we describe novel mechanistic insights on the effect of this group of polyphenols on key elements of the signaling

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… Nrf2 induces the expression of the antioxidant enzyme NQO1 that, aside from its primary function, forms a complex with p53, leading to its stabilization in curcumin-treated cervical cancer cells ( Patiño-Morales et al., 2020 ). … Dietary polyphenols have important regulatory activities on p53 ( Figure 5 ), including protein stabilization by its interaction with proteins (NQO1) in cells treated with curcumin ( Patiño-Morales et al., 2020 ); EGCG evokes the regulation of mRNA and protein levels ( Chu et al., 2017 ) or the epigenetic …

Six-year experience with GM test in hematological patients in a public Brazilian tertiary hospital.

Invasive fungal infection (IFI) is frequent in patients with hematologic malignancies or submitted hematopoietic stem cell transplantation (HSCT).ObjectivesTo evaluate the role of the GM (galactomannan) test in prescribing therapeutic antifungals; to determine invasive aspergillosis (IA) frequency, the factors associated with positive GM test, and the in-hospital mortality.MethodsWe conducted a retrospective observational study including patients aged 18 or over with hematological malignancy or submitted to HSCT. GM test was measured twice weekly. The hypothesis of IFI was considered in patien

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… Souza L., Nouér S.A., Morales H., Simões B., Solza C., Queiroz-Telles F., et al. Epidemiology of invasive fungal disease in haematologic patients. Mycoses. 2021;64:252–256. doi: 10.1111/myc.13205. 20. Nucci M., Anaissie E. …

Resilience and Sub-optimal Social Determinants of Health: Fostering Organizational Resilience in the Medical Profession.

The relationship between social determinants of health (SDOH) and resilience has been investigated at the individual level and, to some extent, at the community level. The aftermath of the COVID-19 pandemic further highlighted the necessity for organizational resilience in the United States. The US public health and health care system began the lengthy process of identifying the resiliency needs of its workforce that expand beyond disaster preparedness. The purpose of this article is to describe the relationship between resilience and SDOH and how medical training can infuse resiliency within

Impact of COVID-19 on patients treated with autologous hematopoietic stem cell transplantation: A retrospective cohort study.

BACKGROUND: Juvenile dermatomyositis (JDM) is an immune-mediated disease characterized by chronic organ inflammation. The pathogenic mechanisms remain ill-defined. METHODS: Raw microarray data of JDM were obtained from the gene expression omnibus (GEO) database. Based on the GSE3307 dataset with 39 samples, weighted correlation network analysis (WGCNA) was performed to identify key modules associated with pathological state. Functional enrichment analyses were conducted to identify potential mechanisms. Based on the criteria of high connectivity and module membership, candidate hub genes were

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… Pinana JL, Martino R, Garcia-Garcia I, Parody R, Morales MD, Benzo G, et al. Risk factors and outcome of COVID-19 in patients with hematological malignancies. Exp Hematol Oncol. 2020;9:21. doi: 10.1186/s40164-020-00177-z 13. Vijenthira A, Gong IY, Fox TA, Booth S, Cook G, Fattizzo B, et al. …

Preoperative elevation of serum C--reactive protein is predictive for prognosis in myeloma bone disease after surgery.

We investigated whether preoperative levels of serum C-reactive protein (CRP) and its correlation with tumour clinicopathological findings adds prognostic information beyond the time of diagnosis in patients with myeloma bone disease (MM) to facilitate the surgical decision-making process. Six hundred and fifty-eight myeloma patients were evaluated retrospectively for surgery. Clinicopathological variables of patients who underwent surgery (n=71) were compared between patients with preoperative CRP>or=6 mg l-1 and those with CRP<6 mg l-1. Univariate and multivariate analyses were performed to

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… Eur J Clin Invest 28: 679–686 Durie BG, Kyle RA, Belch A, Bensinger W, Blade J, Boccadoror M, Child JA, Comenzo R, Djulbegovic B, Fantl D, Gaharton G, Harousseau JL, Hungria V, Joshua D, Ludwig H, Mehta J, Morales AR, Morgan G, Nouel A, Okel M, Powles R, Roodman D, San Miguel J, Shimizu K, Singhal S …

Мелатонин за пределами хронобиологии: интеграция фармакокинетики, прогнозирование дозы и клинические данные.

Мелатонин установлен в качестве регулятора времени и сна в циркадиане, в то время как более широкий спектр зависящих от рецептора и независимых от рецептора биологических эффектов вызвал интерес к дополнительным видам терапевтического применения. В этом обзоре критически рассматривается вопрос о том, можно ли интерпретировать эти предлагаемые последствия в фармакологических рамках, основанных на воздействии. Мы интегрируем недавние доклинические и клинические данные с фармакокинетиками перорального и внутривенного мелатонина и с обычным дифференциальном уравнением (ОДВ) - прогнозом воздействия

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… Sola E, Morales-García JA, López-Muñoz F, Ramos E, Romero A (2025) Vivo Evidence of Melatonin’s Protective Role in Alkylating-Agent-Induced Pulmonary Toxicity: A Systematic Review. Antioxid (Basel) 14(6):712. 10.3390/antiox14060712 55. … García-García I, Seco-Meseguer E, Ruiz-Seco P, Navarro-Jimenez G, Martínez-Porqueras R, Espinosa-Díaz M, Ortega-Albás JJ, Sagastagoitia I, García-Morales MT, Jiménez-González M, Martínez de Soto L, Bajo-Martínez AI, Del Palacio-Tamarit M, López-García R, Díaz-García L, Queiruga-Parada J, Giesen C, Pérez-Villena …

Progress and challenges in the treatment of cardiac amyloidosis: a review of the literature.

Cardiac amyloidosis is a restrictive cardiomyopathy determined by the accumulation of amyloid, which is represented by misfolded protein fragments in the cardiac extracellular space. The main classification of systemic amyloidosis is determined by the amyloid precursor proteins causing a very heterogeneous disease spectrum, but the main types of amyloidosis involving the heart are light chain (AL) and transthyretin amyloidosis (ATTR). AL, in which the amyloid precursor is represented by misfolded immunoglobulin light chains, can involve almost any system carrying the worst prognosis among amyl

Potential Novel Biomarkers in Chronic Graft-Versus-Host Disease.

Prognostic, diagnostic or predictive biomarkers are urgently needed for assessment of chronic graft-versus-host disease (cGvHD), a major risk for patients undergoing allogeneic hematopoietic stem cell transplantation. The main goal of this review generated within the COST Action EUROGRAFT "Integrated European Network on Chronic Graft Versus Host Disease" was to identify potential novel biomarkers for cGvHD besides the widely accepted molecular and cellular biomarkers. Thus, the focus was on cellular biomarkers, alloantibodies, glycomics, endothelial derived particles, extracellular vesicles, m

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… El-Awar N, Terasaki PI, Nguyen A, Sasaki N, Morales-Buenrostro LE, Saji H, et al. Epitopes of human leukocyte antigen class I antibodies found in sera of normal healthy males and cord blood. Hum Immunol (2009) 70:844–53. 10.1016/j.humimm.2009.06.020 41. … Morales-Buenrostro LE, Terasaki PI, Marino-Vázquez LA, Lee J-H, El-Awar N, Alberú J. “Natural” Human Leukocyte Antigen Antibodies Found in Nonalloimmunized Healthy Males. Transplantation (2008) 86:1111–5. 10.1097/TP.0b013e318186d87b 42. Ciurea SO, Thall PF, Wang X, Wang SA, Hu Y, Cano P, et al. …

Recommendations for the management of COVID-19 in patients with haematological malignancies or haematopoietic cell transplantation, from the 2021 European Conference on Infections in Leukaemia (ECIL 9).

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel virus that spread worldwide from 2019 causing the Coronavirus disease 19 (COVID-19) pandemic. SARS-CoV-2 infection is characterised by an initial viral phase followed in some patients by a severe inflammatory phase. Importantly, immunocompromised patients may have a prolonged viral phase, shedding infectious viral particles for months, and absent or dysfunctional inflammatory phase. Among haematological patients, COVID-19 has been associated with high mortality rate in acute leukaemia, high risk-myelodysplastic syndromes,

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… Piñana JL, Martino R, García-García I, Parody R, Morales MD, Benzo G, et al. Risk factors and outcome of COVID-19 in patients with hematological malignancies. Exp Hematol Oncol. 2020;9:21. doi: 10.1186/s40164-020-00177-z. 11. Yigenoglu TN, Ata N, Altuntas F, Bascı S, Dal MS, Korkmaz S, et al. … Perry C, Luttwak E, Balaban R, Shefer G, Morales MM, Aharon A, et al. Efficacy of the BNT162b2 mRNA COVID-19 vaccine in patients with B-cell non-Hodgkin lymphoma. Blood Adv. 2021;5:3053–61. doi: 10.1182/bloodadvances.2021005094. 68. …

Monocyte engraftment dynamics and flow cytometric analysis in allogeneic and autologous peripheral blood stem cell transplantation: a prospective study.

BACKGROUND: Hematopoietic stem cell transplantation (HSCT) success relies on timely engraftment and immune reconstitution. While neutrophil and platelet recovery are well-established clinical endpoints, the dynamics of monocyte engraftment and their relationship with hematopoietic recovery remain insufficiently characterized. METHODS: In this prospective observational study, 56 patients undergoing autologous (n = 32) or allogeneic (n = 24) peripheral blood stem cell transplantation were enrolled. Pre-engraftment monocyte peak day was defined based on serial complete blood counts. Flow cytomet

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… Hartwell MJ, Özbek U, Holler E, Renteria AS, Major-Monfried H, Reddy P, Aziz M, Hogan WJ, Ayuk F, Efebera YA, Hexner EO, Bunworasate U, Qayed M, Ordemann R, Wölfl M, Mielke S, Pawarode A, Chen YB, Devine S, Harris AC, Jagasia M, Kitko CL, Litzow MR, Kröger N, Locatelli F, Morales G, Nakamura R, Reshef …

Последствия осуществления программы реабилитации пациента с множественной миеломой до пересадки на спинарном коре: тематическое исследование.

Введение: Множественная миелома представляет собой приблизительно 12% Гематологическое обледенение и главным образом затрагивает пожилых людей, что существенно снижает качество их жизни. Несмотря на то, что практические занятия показали преимущества в онкологии, данные, характерные для ММ, по-прежнему являются ограниченными и маловероятными. Наличие сложных коморбидов у пациентов из числа ММ требует весьма индивидуализированных подходов. Предварительная абилитация стала перспективной стратегией укрепления функциональных возможностей до аналоговой трансплантации стволовых клеток. В этом тематич

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… Martínez-Guijarro C., López-Fernández M.D., Lopez-Garzon M., Lozano-Lozano M., Arroyo-Morales M., Galiano-Castillo N. Feasibility and efficacy of telerehabilitation in the management of patients with head and neck cancer during and after oncological treatment: A systematic review. Eur. J. Oncol. …

Half a century of healing: celebrating the 50th anniversary of EBMT.

EBMT is a non-profit organization with a clear mission: "to save the lives of patients with blood cancers and other life-threatening diseases by advancing the fields of blood and marrow transplantation and cell therapy worldwide through science, education and advocacy". In 1974, EBMT was established by European physicians in St. Moritz to share bone marrow transplantation (BMT) experiences and foster collaboration. Founding members included Jon Van Rood, Bruno Speck, and Eliane Gluckman. By 1989, the group expanded significantly, emphasizing mutual trust and collaboration. EBMT played a crucia

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… Gluckman E, Lotsberg J, Devergie A, Zhao XM, Melo R, Gomez-Morales M, et al. Prophylaxis of herpes infections after bone-marrow transplantation by oral acyclovir. Lancet. 1983;2:706–8. 20. Gragert L, Eapen M, Williams E, Freeman J, Spellman S, Baitty R, et al. …

Оценка спроса на паллиативный уход у пациентов, не имеющих онкологов, в Чили.

Доступ к паллиативному уходу представляет собой новую глобальную проблему в области здравоохранения. В Чили недавно был принят закон о паллиативном уходе, предусматривающий охват паллиативным уходом неонологического населения. Таким образом, для надлежащего планирования политики в области здравоохранения необходима надежная и законная оценка спроса на паллиативную помощь. Годовая смертность от выявленных заболеваний оценивалась за периоды 2018-2020. Оценка спроса соответствует определению доли умерших пациентов, нуждающихся в паллиативном уходе, исходя из тяжести тяжелых страданий, связанных с

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… Martínez-Sanguinetti MA, Leiva-Ordoñez AM, Petermann-Rocha F, Celis-Morales C. Cómo ha cambiado el perfil epidemiológico en Chile en los últimos 10 años? Revista Médica Chile. 2021;149(1):149–52. doi: 10.4067/S0034-98872021000100149. 25. Senado. …