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[Development of multiple sclerosis with ocular onset as compared with other onset forms].

This work is to verify if multiple sclerosis started with a retrobulbar optic neuritis has a more favourable course, compared with the cases started with any other neurological symptomatology according to a large part of AA. We considered 47 cases of M.S. started with R.O.N. hospitalized in our Clinic from 1940 to 1975, controlled with two groups of 47 patients of the Clinic with M.S. without any ocular symptomatology. Any satisfactory information result from this inquiry to prognosticate a more favourable prognosis for the cases started with R.O.N.

First autopsy report of a multiple sclerosis case in Hokuriku District of Japan.

The first autopsy of a case of multiple sclerosis from the District of Hokuriku was reported. The patient, a 50-year-old house-wife, born in Toyama Prefecture, had noticed a paresthesia of her face, fatigue, numbness and weakness in the right limbs, dimness of vision and gait disturbance at ave 44. Furthermore, in the course of the disease, she had suffered from visual disorder, tetraplegia, hyperreflexia, pyramidal signs and cerebellar syndroms such as dysarthria, nystagmus, intention tremor and ataxia. She also showed symptoms of euphoria and dementia. After a course of six years she died of…

[Evolution and prognosis of retrobulbar optic neuritis as the initial symptom of multiple sclerosis].

In 61 of 300 patients suffering from multiple sclerosis, disease onset was retrobulbar optical neuritis. Comparing the clinical data of these patients with those of the remaining 239 cases, the following typical features were observed: in patients with optical neuropathy, disease onset is more frequently acute and course, in the early years of the disease, is in fits and starts. Recurrence frequency is higher in these patients but not significantly so. Prognosis, deduced from the analysis of degrees of invalidity, does not differ substantially between the two groups. Current techniques of diag…

Отсутствие борьбы с лимфоцитами и интерферонами, вызываемыми вирусом, при множестве склерозов.

Было установлено, что лимфоциты обычных взрослых доноров, подвергшиеся воздействию неактивированного вируса кори (33,9%), оказывают значительное воздействие на конканавалин. В отличие от этого, лимфоциты, полученные от нескольких склерозов, продемонстрировали значительно более низкую степень подавления (1,5%), а в 80% случаев вообще не удалось подавить. Степень подавления несколько возросла с возрастом пациента, но не колебалась в зависимости от клинической стадии заболевания. Не было никаких видимых генетических ограничений на деятельность подавителя. Несмотря на то, что специфичность этого я

Совпадение в аннотации оригинала
Lymphocytes from normal adult donors exposed in vitro to inactivated measles virus were found to exert significant suppression (33.9%) of the concanavalin A responses of cryopreserved, autochthonous responder cells. In marked contrast, lymphocytes from multiple sclerosis patients exhibited significantly reduced suppression (1.5%), and in 80% of cases failed …

Factors influencing the risk of multiple sclerosis developing in patients with optic neuritis.

One-hundred and forty-six patients who had presented with optic neuritis but without evidence of demyelination elsewhere in the nervous system, and in whom no specific cause could be identified, were reassessed clinically between one month and twenty-three years after the onset. Fifty-eight patients (40 per cent) had developed MS. All 146 patients were HLA-typed. Three factors were identified which were significantly associated with the development of MS: positive typing for the HLA antigen BT 101, winter onset of the initial attack of optic neuritis in BT 101-positive patients only, and recur

Nationwide survey of multiple sclerosis in Japan. Clinical analysis of 1,084 cases.

Between October 1972 and October 1973, the first nationwide survey of the multiple sclerosis group of diseases in Japan was performed by the Multiple Sclerosis Research Committee of Japan, supported by the Japan Ministry of Health and Welfare. Reports on 1,084 patients with the multiple sclerosis group were collected: 509 patients with multiple sclerosis, 82 with Devic's disease, 357 with "multiple sclerosis possible," and 136 with "other or unclassified demyelinating diseases." The natural history in the present nationwide series of multiple sclerosis patients showed considerable similarity t…

Lymphocyte sensitization to carcinoembryonic antigen (Gold) with special reference to multiple sclerosis.

Lymphocytes from patients with multiple sclerosis are sensitized to carcinoembryonic antigen (C.E.A.) in almost the same degree as are those from subjects with cancer. During pregnancy and the early puerperium there is an even higher degree of cellular sensitization to C.E.A. Patients with neurological diseases other than multiple sclerosis also show significant sensitization to C.E.A. though of less degree than do those with multiple sclerosis. Sensitization to C.E.A. is thus not specifically characteristic of cancer. The unexpected sensitization in multiple sclerosis may be associated with t…

Risk of Inflammatory Bowel Disease After Anti-CD20 Treatment in Multiple Sclerosis.

IMPORTANCE: Anti-CD20 biologics are widely used as disease-modifying therapy (DMT) for relapsing-remitting multiple sclerosis (RRMS), but recent reports have raised concerns about an increased risk of inflammatory bowel disease (IBD) during treatment. This study aimed to assess treatment-associated IBD risk in individuals with RRMS. OBJECTIVE: To compare the risk of new-onset IBD across different therapies for RRMS and relative to the general population. DESIGN, SETTING, AND PARTICIPANTS: This was a population-based cohort study conducted in Sweden. Through the Swedish MS register, initiatio…

Lesion-specific circular RNA and mRNA signatures in secondary progressive multiple sclerosis.

Circular RNAs (circRNAs) are single-stranded RNAs with a covalently closed loop structure which have been increasingly recognised as stable and functionally relevant regulators of gene expression via sponging miRNAs. Recently, studies have revealed their roles in human diseases, subsequently emerging as potential biomarkers. Multiple sclerosis (MS) is an inflammatory, neurodegenerative, and immune-related disease of the central nervous system characterised by distinct lesion types that reflect different stages of brain tissue injury and repair. Our study conducted a comprehensive transcriptomi…

Capillary serum-based spectroscopic signature for multiple sclerosis: A novel diagnostic perspective.

OBJECTIVE: To analyze the biochemical characteristics of capillary blood-derived serum using Fourier-transform infrared (FTIR) spectroscopy, aiming to differentiate individuals diagnosed with Multiple Sclerosis (MS) from a matched control group (CG). METHODS: The study included 52 patients with confirmed MS and 52 healthy control participants, matched by sex and age. Serum samples were obtained via capillary blood collection and analyzed using mid-infrared ATR-FTIR spectroscopy. Chemometric analyses were performed on the full spectrum (3700-900 cm-1) and on the fingerprint (1800-900 cm-1) and…

Pearls & Oy-sters: Diagnosis of Pediatric Tumefactive Multiple Sclerosis With MRI Biomarkers.

Multiple sclerosis (MS) is a demyelinating disease of the CNS with an estimated incidence of 0.05-2.85 per 100,000 children. One subtype, tumefactive MS, is particularly rare and difficult to diagnose, especially in differentiating from tumor. We describe the case of a 16-year-old boy who presented with subacute onset of headaches, cognitive difficulties, dizziness, blurry vision, right arm weakness, numbness, and gait difficulty. MRI of the brain demonstrated a multilobulated, contrast-enhancing, T2 hyperintense area of diffusion restriction in the left frontal lobe, an extensive left periven…

Multiple External Invasive Root Resorption and Calcification in Systemic Sclerosis-Case Report.

AIM: There are few reports in the literature of multiple external invasive root resorption (EIRR) lesions in patients with systemic sclerosis (SSc), and an association between root resorption and SSc is not well established. We report the only case that comprehensively illustrates-with the combination of histopathology, cone beam computed tomography (CBCT), orthopantomograms and photography-pulpal and periodontal ligament calcifications, multiple EIRR lesions progressing over time and the sequelae of treatment. Sixteen affected teeth, documented over 14 years, are presented. SUMMARY: A 51-yea