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Subtype shift, relapse rate and risk factors of frequent relapse in cluster headache: A multicenter, prospective, longitudinal observation.

AimTo prospectively determine subtype shift, relapse rate and risk factors of frequent relapse in cluster headache (CH).MethodsThis multicen … cluding known chronic CHs at baseline, the incidence of chronic CH newly found during a prospective observation was 3.8% in patients with first-onset CH and 1.4% in those with a history of episodic CH. In 244 patients with episodic CH in an active bout at the time of recruitment, the relapse rate was 0.29 (95% confidence interval (CI) = 0.27-0.32; p < 0.001) …

Observation of the efficacy of hemocoagulase atrox combined with Mayinglong hemorrhoid Cream on postoperative treatment of perianal abscess.

To observe and study the efficacy of combined therapy of Hemocoagulase Atrox for Injection and Mayinglong Hemorrhoid cream on wound healing and complications after perianal abscess resection. The data of 162 patients who underwent perianal abscess resection were retrospectively analyzed. The data were divided into an observation group and a control group. The control group applied Mayinglong hemorrhoid cream on the wound surface on the basis of normal saline flushing and the observation group injected atrocoagulase on this basis. The medication cycle was 4 weeks and the clinical effect, wound …

Porto-sinusoidal vascular disease-like alterations in transplant liver biopsies: A clinicopathologic observation of transplant-associated portal vasculopathy.

OBJECTIVE: Non-cirrhotic portal hypertension (NCPH) encompasses hepatic vascular disorders without cirrhosis, now grouped under porto-sinusoidal vascular disease (PSVD). While PSVD features are well described in native livers, their significance in the liver transplant setting remains unclear and may present diagnostic challenges. This study aimed to investigate PSVD-like histologic alterations in liver allografts and their clinical relevance. DESIGN: We retrospectively analyzed 95 liver biopsies from 43 transplant recipients (2020-2022). Biopsies were reviewed for PSVD-specific features (obl

Sulfur Dioxide- and Fluoride-Associated Declines in Lung Function Over an 11-Year Observation Among Aluminum Smelter Workers.

BACKGROUND: Work exposure-related declines in lung function among aluminum smelter workers are well documented, yet task-varying exposures are likely to contribute differently to respiratory outcomes. This study aimed to assess the association between potroom exposure and lung function changes over time among aluminum smelter workers. METHODS: A retrospective review of spirometric assessments of 265 potroom workers and their exposure to sulfur dioxide (SO2) and fluoride was conducted. Cumulative exposure was described through job exposure matrices by job titles and exposure across the lifetim

Mortality and risk factors in Japanese patients with rheumatoid arthritis: a 14-year observation of the IORRA cohort.

OBJECTIVES: To investigate the standardized mortality ratio (SMR), causes of death, and mortality risk factors in Japanese patients with rheumatoid arthritis (RA) between 2007 and 2021, representing the biological disease-modifying antirheumatic drug (bDMARD) era. METHODS: We analysed Japanese patients in the Institute of Rheumatology, Rheumatoid Arthritis cohort. The SMR was calculated using the Japanese General Population Life Table. Multiple imputation methods were used for sensitivity analysis of lost-to-follow-up cases. Risk factors were analysed using a time-dependent Cox proportional h

Clinical observation of percutaneous transforaminal endoscopic discectomy for lumbar disc herniation and analysis of influencing factors for recurrence.

OBJECTIVE: To investigate the clinical effects of percutaneous transforaminal endoscopic discectomy (PELD) in treating lumbar disc herniation (LDH) and analyze the related factors for postoperative recurrence. METHODS: A retrospective analysis was conducted on 168 patients with lumbar disc herniation who underwent percutaneous transforaminal endoscopy at the Second Hospital of Tangshan from January 2017 to January 2021. The patients were followed up for 1 year. The Oswestry disability index (ODI) and visual analog scale (VAS) for low back pain/radicular pain were recorded before the operation

Principles of Endoscopic Surveillance of Extrapapillary Duodenal Lesions in Familial Adenomatous Polyposis: A 14-Year Single-Center Observation.

Background: In patients with familial adenomatous polyposis (FAP), the duodenum is another high-risk region for malignancy after the large bowel. However, endoscopic and surgical management differs for papillary lesions and adenomas located in other parts of the duodenum. The aim of the study was to present the principles of the endoscopic surveillance of extrapapillary polyps based on a single-center 14-year observational study. Methods: The retrospective analysis was carried out in 2010-24 on a group of 45 people enrolled in endoscopic surveillance of the upper gastrointestinal tract due to …

Associations between Progression of Retinal Pigment Epithelial and Outer Retinal Atrophy and Choroidal Thickness: A 2-Year observation.

PURPOSE: To evaluate the clinical course of retinal pigment epithelial and outer retinal atrophy (RORA) with best-corrected visual acuity (BCVA) and risk factors for rapid progression to explore the pathogenesis. DESIGN: Retrospective observational study. SUBJECTS: Data on eyes with fovea-involved RORA associated with age-related macular degeneration were collected over time from 10 hospitals in Japan. METHODS: Data on ophthalmic examination, BCVA, and OCT images were analyzed. MAIN OUTCOME MEASURES: Relationships between changes in BCVA and extents of RORA and outer plexiform layer (OPL) …

Observation on the therapeutic effect of a modified Devine procedure with subcutaneous sliding fixation method for concealed penis.

To evaluate the therapeutic effect of a modified Devine procedure with a subcutaneous sliding fixation method for the treatment of congenital concealed penis, we retrospectively selected 45 patients with congenital concealed penises who were admitted to General Hospital of Ningxia Medical University (Yinchuan, China) between September 2020 and November 2023. In all cases, the penis was observed to be short, and retracting the skin at the base revealed a normal penile body, which immediately returned to its original position upon release. All patients underwent the modified Devine procedure wit

[Clinical observation of Jin's three-needle therapy combined with game therapy in the treatment of autism spectrum disorder].

OBJECTIVE: To observe the clinical effect of Jin's three-needle therapy combined with game therapy on children with autism spectrum disorder (ASD). METHODS: Sixty children with ASD were randomly divided into an observation group and a control group, with 30 cases in each. The children in the observation group received Jin's three-needle therapy combined with game therapy. The acupoints used in Jin's three-needle therapy included Zhisanzhen, Niesanzhen, Sishenzhen and Naosanzhen, and matches acupoints with syndromes. The acupoints included Shenting (GV24), Naohu (GV17) and bilateral Benshen (G…

A novel histopathological subclassification of oral submucous fibrosis based on epithelial keratinization: A proof-of-concept pilot observation.

Oral submucous fibrosis (OSMF) is a chronic, progressive oral potentially malignant disorder strongly associated with areca nut consumption. Despite extensive research, a reliable and clinically applicable biomarker for predicting malignant transformation remains unavailable. The present pilot investigation introduces a novel concept by classifying OSMF into two histopathological variants-hyperkeratinized and non-hyperkeratinized-based on epithelial keratinization patterns, a distinction not previously described in the literature. Archival biopsy samples of 51 histologically confirmed OSMF cas

Воздействие обучения методам наблюдения за действиями на функционирование, прочность верхней конечности и усталость у лиц с множественным склерозом.

Множественный склероз (MS) — хроническое аутоиммунное заболевание, которое влияет на центральную нервную систему и часто приводит к нарушению конечностей, что оказывает значительное воздействие на повседневную жизнь и качество жизни. Программа подготовки по наблюдению за действиями (AOT) представляет собой новый метод нейрореабилитационной работы, который использует зеркальную нейронную систему для улучшения характеристик двигателя. Цель этого исследования состояла в том, чтобы оценить эффективность АОТ в деле совершенствования функции рук, укрепления сцепления и сокращения усталости у людей с

Совпадение в аннотации оригинала
BACKGROUND: Multiple sclerosis (MS) is a chronic autoimmune condition that affects the central nervous system, frequently resulting in upper limb impairment, which considerably affects activities of daily living and quality of life. Action Observation Training (AOT) is a novel neurorehabilitation method that utilizes the mirror neuron system to improve motor…

Proportion of Patients With Ductal Carcinoma In Situ That Qualify for Observation Criteria Set Forth by Clinical Trials.

BACKGROUND: The COMET, LORD, and LORIS clinical trials are investigating the role of active surveillance in low-risk ductal carcinoma in situ (DCIS). The objective of this study was to identify the proportion of patients eligible for these trials amongst a cohort of patients treated at our institution. METHODS: Retrospective chart review was performed of patients diagnosed with DCIS who were treated from 2013 to 2022. Clinical, tumor, and imaging inclusion and exclusion criteria of the aforementioned observation trials were applied to determine the proportion of patients eligible for each tri…

Observation on the therapeutic effect of probiotics on early oral feeding in the treatment of severe acute pancreatitis.

OBJECTIVES: To evaluate the clinical efficacy of probiotics and early oral feeding in patients with severe acute pancreatitis. METHODS: A prospective, randomized, controlled trial was conducted involving 66 patients, who were randomly divided into a control group (n = 32) receiving standard enteral nutrition and an observation group (n = 34) receiving additional Bifidobacterium quadruplex live bacterial tablets. Serum inflammatory markers, including white blood cells (WBC), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP), were measured on days 1, 3, and 7 p…

Combined action observation and mental imagery versus neuromuscular electrical stimulation as novel therapeutics during short-term knee immobilization.

Limb immobilization causes rapid declines in muscle strength and mass. Given the role of the nervous system in immobilization-induced weakne … ales) were randomized into one of four groups: immobilization only (n = 9), immobilization + action observation/mental imagery (AOMI) (n = 10), immobilization + neuromuscular electrical stimulation (NMES) (n = 12), or control group (n = 8). The AOMI group performed daily video observation and mental imagery of knee extensions. The NMES group performed twice d …

A Multimodal Ultrasound Observation Study on the Effect of Vitamin D on Uterine Fibroids in Non-menopausal Women.

INTRODUCTION: It has been reported in the literature that Vitamin D can inhibit the growth of uterine fibroids, but the evaluation index is only the size of the uterine fibroids. The purpose of this study was to evaluate the effect of vitamin D on the size, hardness, and blood flow of uterine fibroids in premenopausal women by multimodal ultrasound. METHODS: A total of 64 pre-menopausal women with uterine fibroids complicated vitamin D deficiency were enrolled in this study and randomly divided into two groups: the vitamin D group (n=32) which received oral vitamin D (1600 IU/ day) and the co

[Preliminary clinical observation and analysis of structural changes of optic nerve head in glaucoma patients after visual training].

Objective: To investigate the effect of virtual reality visual training on remodeling optic nerve structures of glaucoma patients and analyze the influencing factors of visual training effect. Methods: A prospective non-randomized controlled trial was conducted. Glaucoma patients who presented to the Department of Ophthalmology, Beijing Shijitan Hospital between October 2021 and October 2022 were collected and divided into the training group or the control group according to their intentions. The training group accepted 3 months of visual training, while the control group did not. Optical cohe

An observation of two NHS trusts' use of organisational wellbeing interventions during the COVID-19 pandemic: lessons learnt.

BACKGROUND: Healthcare workers' (HW') mental health during pandemics may be challenged due to the demands of their professional work. There is a need for effective organisational wellbeing strategies so that HW' mental health is safeguarded. In this article, we sought to examine approaches to implementing wellbeing strategies in hospital trusts, which we hope will improve future workplace planning. METHODS: A pilot study comprising semi-structured interviews with five management staff in two NHS trusts (which employ approximately 5,000 staff each) in north-west England (NWE) were conducted to

Sequence-specific delayed gains in motor fluency evolve after movement observation training in the absence of early sleep.

Following physical practice, delayed, consolidation-phase, gains in the performance of the trained finger-to-thumb opposition sequence (FOS) can be expressed, in young adults, only after a sleep interval is afforded. These delayed gains are order-of-movements specific. However, in several perceptual learning tasks, time post-learning, rather than an interval of sleep, may suffice for the expression of delayed performance gains. Here we tested whether the affordance of a sleep interval is necessary for the expression of delayed performance gains after FOS training by repeated observation. Parti…

Minimally Invasive Assessment of Peripheral Residual Disease During Maintenance or Observation in Transplant-Eligible Patients With Multiple Myeloma.

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary en … ic value for PFS. This study supports the use of less invasive PRD monitoring during maintenance or observation in transplant-eligible patients with MM.