Результаты поиска

Body mass index and colorectal cancer screening among cancer survivors: the role of sociodemographic characteristics.

We examined the association between body mass index (BMI) and guideline-concordant colorectal cancer (CRC) screening utilization among cance … lysis to examine the mentioned associations. Among 44,244 eligible cancer survivors, those who were overweight (84%) had the greatest CRC screening use, followed by those who were obese (81.3%), and underweight/normal weight (79.2%; p values < 0.001). Multivariable logistic regression analysis revealed those who were overweight or obese compared to underweig …

Body mass index and prognosis of infective endocarditis.

BACKGROUND AND OBJECTIVES: Malnutrition is associated with prognosis in several heart diseases, but there is little information in patients with infective endocarditis (IE). Our objective was to assess the influence of body mass index (BMI) on the prognosis of IE. METHODS: National registry of patients with definite or probable IE from 2008 to 2021, comparing in-hospital and 1-year mortality according to BMI. RESULTS: From 3645 patients, 91 (2.5%) were underweight, 1432 (39.3%) had normal weight, 1503 (41.2%) were overweight, and 619 (17.0%) had obesity. The median age was lowest in the unde…

Extreme Heat Exposure Enhanced the Associations Between Prepregnancy Weight and the Hypertensive Disorders of Pregnancy and Endothelial Dysfunction.

BACKGROUND: Prepregnancy overweight or obesity may increase cardiovascular risk, but whether extreme heat intensifies its association with hypertensive disorders of pregnancy (HDPs) or endothelial dysfunction (ED) is unclear. METHODS: In this population-based cohort of 7820 pregnant women, prepregnancy body mass index and HDPs were obtained from hospital records. Ambient temperature data were sourced from the National Centers for Environmental Information. Plasma endothelial biomarkers (VCAM-1 [vascular cell adhesion molecule-1], ICAM-1 [intercellular adhesion molecule-1], E-selectin) were me…

Association of obesity subphenotypes with indices of cardiac remodeling in the Framingham heart study.

BACKGROUND: Previous studies have reported that obesity-related metabolic abnormalities (eg, diabetes and hypertension) lead to myocardial dysfunction and adverse cardiac remodeling. However, it is unclear whether such cardiac remodeling is from obesity or obesity-related metabolic abnormalities. We hypothesize that overweight and obesity are associated with adverse cardiac remodeling independent of associated metabolic abnormalities. METHODS: We evaluated 6,639 participants from the Framingham Heart Study who underwent echocardiography and had no prevalent cardiovascular disease. Individuals…

The Impact of Maternal Nutrition Status on Maternal and Fetal Outcomes: A Prospective Observational Study.

BACKGROUND: Maternal body mass index (BMI) significantly influences both maternal and fetal outcomes. Changing socioeconomic factors in India have led to a rise in both obesity due to lifestyle factors and malnutrition due to poverty. Each extreme of BMI-underweight and overweight-has distinct risks. Overweight and obese women face complications, such as gestational diabetes, gestational hypertension, and macrosomia, while underweight women are at higher risk of conditions, like intrauterine growth restriction (IUGR), low birth weight, and anemia. MATERIALS AND METHODS: This observational stu…

Body mass index as a predictive factor for efficacy of adjuvant taxane-based chemotherapy in early-stage breast cancer patients: A pooled analysis from adjuvant GEICAM Spanish Breast Cancer Group and TRIO Translational Research in Oncology Group studies.

Adjuvant anthracyclines and taxanes reduce recurrence and death in early-stage breast cancer (EBC) patients, but toxicity is a concern. Stud … IO trials (1996-2008) conducted. Patients were classified into four BMI categories: normal (<25.0), overweight (25.0-29.9), obese (30.0-34.9), and severely obese (≥35.0). BMI was evaluated as a predictive factor for the efficacy and toxicity of taxane-based chemotherapy. Our results show the following findings: patients' distribution by BMI was 44% normal, 3 …

Relationship between body mass index and pain, peripheral muscle strength, disability and quality of life in patients with cervical radiculopathy.

BACKGROUND: The aim of this study was to compare pain, cervical range of motion (ROM), peripheral muscle strength, disability, and quality of life according to body mass index (BMI) in individuals with cervical radiculopathy (CR) and to examine the relationship with BMI. METHODS: This cross-sectional study was conducted with 86 patients (mean age: 44.20 ± 8.31) diagnosed with CR. Patients were divided into two groups according to BMI: normal and overweight/obese. Pain (visual analog scale (VAS)), cervical joint range of motion, shoulder and grip muscle strength, disability, and quality of lif…

Premodulator microbiome alterations associated with postmodulator growth outcomes in pediatric cystic fibrosis: Can we predict outcomes?

OBJECTIVES: The gut microbiota plays an important role in childhood growth. Our longitudinal cohort includes children with cystic fibrosis ( … rd deviation of the mean (SD) were considered normal weight, those >1 SD were classified as risk of overweight while children <1 SD were considered undernourished, although no CwCF met this latter criterion here. Multivariate regression models were applied to identify significant associations between metadata and microbial taxonomic relative abundances. RES …

Trajectories of body mass index before the diagnosis of type 2 diabetes in a cohort of Taiwanese adults.

BACKGROUND: Although the prevalence of overweight/obesity is lower in Asian countries, the risk of type 2 diabetes (T2DM) is disproportionally higher. We identified and characterized the trajectory patterns of body mass index (BMI) before the onset of T2DM in a Taiwanese population. METHODS: Using the Taiwan MJ cohort study, we sampled the health examination data of 22,934 participants, including 7618 cases of T2DM and 15,316 controls. We used latent class trajectory analysis to identify distinct groups of pre-disease BMI trajectory. To compare the trajectories of cardiometabolic risk factors…

Poor Sleep Quality in Jamaican Adults With Sickle Cell Disease: Prevalence, Risk Factors, and Association With Quality of Life.

Poor sleep and chronic illnesses have a bidirectional relationship where presence of one can worsen the other. Sickle cell disease (SCD) is … efficiency (p 0.005), sleep latency (p 0.03) and higher use of sleeping medications (p 0.02). Those overweight/obese had significantly worse subjective sleep quality (p 0.001) and sleep efficiency (p 0.05). In multivariate regression analysis, overweight individuals had poorer sleep quality (OR: 2.9; 95% C.I.: 1.07, 7.88) than those with normal weight wherea …

Likelihood of obesity in early and late childhood based on growth trajectory during infancy.

BACKGROUND: Childhood obesity rates have reached epidemic levels with Mediterranean countries reporting among the highest numbers globally. Evidence suggests early life factors, including infant growth rate, increase the likelihood of obesity later in childhood. However, optimal rates of infant growth associated with lower odds of future obesity still remain undetermined. The study aim was to determine the optimal infant growth rate associated with a lower likelihood of childhood overweight and obesity. METHODS: Perinatal and anthropometric data collected from 1778 Greek preschool (2-5 years …

Electronic phenotypes to distinguish clinician attention to high body mass index, hypertension, lipid disorders, fatty liver and diabetes in pediatric primary care: Diagnostic accuracy of electronic phenotypes compared to masked comprehensive chart review.

BACKGROUND/OBJECTIVES: Electronic phenotyping is a method of using electronic-health-record (EHR) data to automate identifying a patient/population with a characteristic of interest. This study determines validity of using EHR data of children with overweight/obesity to electronically phenotype evidence of clinician 'attention' to high body mass index (BMI) and each of four distinct comorbidities. METHODS: We built five electronic phenotypes classifying 2-18-year-old children with overweight/obesity (n = 17,397) by electronic/health-record evidence of distinct attention to high body mass inde…

Dual-energy X-ray absorptiometry and adiposity index are sensitive methods to evaluate central fat accumulation in women with polycystic ovary syndrome and normal body mass index.

OBJECTIVE: This study aimed to determine the differences in body fat distribution and central obesity indicators using dual-energy X-ray abs … COS (non-PCOS group). The volunteers were grouped by body mass index (BMI): normal (18-24.9 kg/m2), overweight (25-29.9 kg/m2), or obese (>30 kg/m2). The visceral adiposity index (VAI) and lipid accumulation product (LAP) were calculated, regions of interest (ROIs) were determined, and the fat mass index (FMI) was calculated using DXA. RESULTS: VAI, LAP, RO …

The association between pre-pregnancy body mass index and perinatal death and the role of gestational age at delivery.

INTRODUCTION: The pathophysiology behind the association between obesity and perinatal death is not fully understood but may be in part due to higher rates of pregnancy complications at earlier gestation amongst obese women. We aimed to quantify the proportion of perinatal deaths amongst obese and overweight women mediated by gestational age at stillbirth or live birth. METHODS: The study included all singleton births at ≥20 weeks' gestation in British Columbia, 2004-2017, and excluded pregnancy terminations. The proportion of the association between BMI and perinatal death mediated by gestat…

Связь между питанием и остротой денге у тайских детей и подростков.

Большинство случаев заражения вирусом денге незначительны, но тяжелые случаи могут быть смертельными. Поэтому определение факторов, связанных с жесткостью денге, имеет важнейшее значение для улучшения состояния здоровья пациентов и сокращения смертности. Цель этого исследования состояла в том, чтобы оценить взаимосвязь между состоянием питания и остротой денге среди тайских детей и подростков. Это ретроспективное перекрестное исследование было основано на медицинских записях 355 пациентов с денге в больнице по тропическим заболеваниям (Бангкок, Таиланд) в период с 2017 по 2019 год. Темами были

Совпадение в аннотации оригинала
Most cases of dengue virus infection are mild, but severe cases can be fatal. Therefore, identification of factors associated with dengue se … onal status. The proportions of patients with dengue fever who were underweight, normal weight, and overweight were 8.8%, 61.5%, and 29.7%, respectively. The proportions of patients with dengue haemorrhagic fever (DHF) who were underweight, normal weight, and overweight were 10.2%, 66.1%, and 23.7%, respectively. The proportions of patients with non-severe d …

Evaluation of endometrial immune status of polycystic ovary syndrome.

Polycystic ovary syndrome (PCOS) is described as a low-grade chronic inflammatory state. However, there are limited studies on the specific endometrial immune status of PCOS patients. Whether this endometrial immune cell pattern is intrinsic to PCOS or the consequence of PCOS-associated obesity is a subject of debate. This study retrospectively included one hundred women diagnosed with PCOS and ninety-five normal fertile controls, which further divided into four groups (normoweight PCOS; overweight PCOS; normoweight control; overweight control) based on body mass index. The percentages of endo…

A Comparison of Length of Hospitalization and Costs in Obese and Non-Obese Pediatric Patients at a Single Hospital in Honolulu.

The association of obesity with increased hospital costs and length of stay among hospitalized pediatric patients identified by ICD-9 coding … on diagnosis ICD-9 codes. Length of hospital stay and total hospital costs were compared for obese, overweight, and normal-weight patients based on body mass index (BMI), controlling for age, sex, ethnicity, insurance type, diagnosis, and calendar year using logistic regression. Analysis of 730 patients showed 1% of overweight patients and 35% of obese patie …

Impact of early-life weight status on urinary tract infections in children: a nationwide population-based study in Korea.

OBJECTIVES: We aimed to evaluate the association between early-life weight status and urinary tract infection (UTI) risk in children. METHODS: A nationwide study was conducted using Korean National Health Screening (NHS) data and National Health Insurance Service data. A sample cohort was selected using data from the 2014 and 2015 NHS for infants and children (4-71 months) and followed up until the end of 2017. Participants were divided into 4 groups (underweight, normal weight, overweight, and obese) based on the weight-for-age (< 2 years) or body mass index (≥ 2 years). Hazard ratios (HRs) …

Neonatal overnutrition programming impairs cholecystokinin effects in adultmale rats.

Overfeeding and rapid weight gain during early life are risk factors for the development of obesity in adulthood. This metabolic malprogramm … feeding on the central and peripheral CCK systems in adulthood. Rats raised in small litters became overweight during lactation and remained overweight as adults, with increased adiposity and plasma levels of lipids, glucose, insulin, and leptin. Neonatally over-nourished rats showed attenuation of gastric emptying and anorexigenic response to CCK, suggestin …

Association of body mass index on disease activity in axial spondyloarthritis: systematic review and meta-analysis.

OBJECTIVES: In axial spondyloarthritis (axSpA), higher body mass index (BMI) is associated with worse outcomes including response to biologi … ndardised mean differences (SMDs) and 95% CIs of BASDAI or ASDAS, comparing obese (BMI>30 kg/m2) or overweight/obese (BMI>25 kg/m2) individuals to those with normal BMI (18.5-24.9 kg/m2). RESULTS: Twelve studies were included in the meta-analysis. Among all studies reporting the BASDAI at baseline, the pooled SMD of the BASDAI for those with an obese or ove …