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Enhanced Antimicrobial Activity of Green-Synthesized Artemisia-ZnO Nanoparticles: A Comparative Study with Pure ZnO Nanoparticles and Plant Extract.

The green synthesis of zinc oxide nanoparticles (ZnO NPs) using Artemisia absinthium L. extract has gained considerable attention due to its … hrough a co-precipitation method, resulting in an average particle size of 36.6 nm. The presence of polyphenols and flavonoids in A. absinthium L. extract acted as both a reducing agent and stabilizer for the nanoparticles. The physicochemical characterization revealed strong absorption peaks indicative of ZnO, confirming successful nanoparticle formation. In …

BiombalanceTM: A Specific Oligomeric Procyanidin-Rich Grape Seed Extract as Multifunctional Ingredient Integrating Antibacterial, Antioxidant, and Anti-Inflammatory Activities with Beneficial Gut-Brain Axis Modulation.

Polyphenols, as natural compounds abundant in plant-derived foods, have been recognised for their human health benefits. This study evaluates the multifunctional properties of BiombalanceTM (BB), a grape seed extract rich in oligomeric procyanidins, in various in vitro and in vivo models. BB was studied to assess (i) its antimicrobial effects in different bacterial species; (ii) its protective effects against oxidative and inflammatory stress in Caco-2 cells; and (iii) its effects in mice, which were fed a standard diet with or without BB at two different doses (BB1X and BB2X) to understand th…

In Vitro Influence of a Chemically Characterized Hippophae rhamnoides L. Fruit Extract on Healthy and Constipated Human Gut Microbiota Functionality and Aquaporin-3 Expression.

To identify the underlying mechanisms by which H. rhamnoides fruit extract exerts regulatory effects on intestinal function, we investigated … ID of the fermented samples. In the extract, 23 compounds belonging to a variety of classes (mainly polyphenols) were tentatively identified. The extract significantly upregulated AQP-3 expression in the absence of cytotoxicity. After in vitro fermentation with gut microbiota isolated from constipated subjects, ABTS and FRAP values significantly decreased, as …

Phloridzin's Diabetic Wound Healing Potential through DPP-4 Enzyme Inhibition: A Review Article.

Diabetic wound healing is a dynamic medical process that takes place in an environment within the body that is complex and contains elevated sugar levels, oxygen deprivation, and cellular oxidative stress. Phloridzin (Phlorizin) is one of the most well-known polyphenols found in apples because of its anti-inflammatory, antioxidant, antibacterial, antidiabetic, and antiseptic properties; it can also play a significant part in the healing of diabetic wounds. The study aimed to investigate the role of phloridzin as an efficient DPP-4 inhibitor with additional therapeutic effects in diabetic wound…

An updated systematic review and meta-analysis of pomegranate consumption on lipid profile.

Pomegranate, rich in bioactive compounds such as polyphenols and flavonoids, has been studied for its potential lipid-modulating effects, yet evidence remains inconsistent. This systematic review and meta-analysis aimed to evaluate the impact of pomegranate consumption on plasma lipid profiles by synthesizing data from randomized controlled trials (RCTs). Following PRISMA guidelines, 37 RCTs (n = 2695 participants) were included after searching Scopus and MEDLINE databases. Studies assessed pomegranate products (juice, extract, seed oil) administered orally for ≥ 7 days, with lipid parameters,…

The Preventive Power of the Mediterranean Diet Against Blue-Light-Induced Retinal Degeneration: Is the Secret in the Herbs and Spices?

The Mediterranean diet, rich in plant-based foods, healthy fats, and herbs, has long been associated with a range of health benefits, includ … nt in the Mediterranean diet to mitigate blue-light-induced retinal damage. These herbs are rich in polyphenols, flavonoids, essential oils, and terpenes, which offer antioxidant, anti-inflammatory, and antimicrobial properties, contributing to retinal health and reducing oxidative damage. By focusing on bioactive compounds such as eucalyptol (1,8-cineole), r …

Anti-Hair Loss Potential of Perilla Seed Extracts: In Vitro Molecular Insights from Supercritical Fluid Extraction.

Perilla seed has long been recognized in traditional diets for its health-promoting properties, but its potential role in hair loss prevention remains underexplored. This study compared three extraction methods-maceration (MAC), screw pressing (SC), and supercritical fluid extraction (SFE)-to determine their efficiency in recovering bioactive compounds and their effects on androgenetic alopecia (AGA)-related pathways. The SFE extract contained the highest levels of polyunsaturated fatty acids and tocopherols, while MAC uniquely recovered a broader range of polyphenols. Among all extracts, SFE-…

Unveiling the Potential of Three Endemic Gypsophila L. (Caryophyllaceae) Taxa as Promising Carbonic Anhydrase Inhibitors-Bio-Metabolic Profiles and In Vitro Evaluation of Enzyme Inhibition and Antioxidant Capacity.

The Caryophyllaceae family, commonly utilized in traditional medicine, exhibits various effects revealed by ethnopharmacological studies. Th … bition. The results show that the G. simonii leaf exhibited the highest quantity of rutin and total polyphenols content (TPC). On the other hand, the G. germanicopolitana leaf showed the highest quantity of rosmarinic acid, and the G. eriocalyx leaf contained the maximum total flavonoids content (TFC). The antioxidant results indicated that G. eriocalyx has t …

Antiproliferative Evaluation of Dextran Polymer-Based Pomegranate Ethanolic Extract.

The pomegranate peel represents an important source of secondary metabolites such as hydrolysable ellagitannins, which are recognized for th … conferred by polymer conjugation. Overall, these findings highlight dextran-conjugated pomegranate polyphenols as promising candidates for next-generation nutraceuticals and phytopharmaceuticals in cancer chemoprevention and adjunctive therapy, with potential applications extending to other biomedical fields and functional foods.

Modulation of human neutrophil functions by hydroethanolic cladode extract of Opuntia ficus-indica: an in vitro experimental study.

BACKGROUND: Opuntia ficus-indica is recognised for its anti-inflammatory effects and potential health benefits. Its different parts are rich … ochrome C reduction assay. RESULTS: HPLC analysis revealed that the extract contains flavonoids and polyphenols involved in oxidative stress inhibition. HECEs significantly inhibited neutrophil chemotaxis, reduced MPO degranulation, and strongly reduced ROS production in phorbol 12-myristate 13-acetate (PMA)- or N-formyl-methionyl-leucyl-phenylalanine (FMLP)- …

Influence of Gamma Irradiation and Antioxidants on the Quality of Spicy Chicken Meat During Refrigerated Storage.

The effects of antioxidants on microbial quality, color, lipid oxidation, fatty acids, odor, and volatile compounds in irradiated spicy chicken were investigated. Chicken meat was treated with antioxidants (α-tocopherol, phytic acid, tea polyphenols, and tertiary butydroquinone) and 4 kGy gamma irradiation. The results showed that the total viable bacteria (TVB) and total coliform count (TCC) were significantly decreased after irradiation, and the combination of four kinds of antioxidants had no direct antibacterial effect. However, the antioxidants significantly inhibited the color fading of …

Unveiling the mystery of the genus Tiliacora: A holistic view on the ethnomedicinal uses, phytochemical richness and pharmacological potentials.

The genus Tiliacora is a flowering plant of the family Menispermaceae, and they are indigenous to Asia and Africa. The species in this genus … ochemicals isolated from Tiliacora species, while other classes of compounds including fatty acids, polyphenols, hydrocarbons and ethyl esters have also been reported. The rich diversity of secondary metabolites from the genus have accounted for the significant pharmacological activities reported from plants in the genus such as antidiabetic, anticancer, anti …

Oxidative Stress Biomarkers in Hypertension.

Arterial hypertension is a silent and progressive disease with deleterious vascular implications on all target organs, including the heart, … itors, offers the potential to mitigate oxidative stress and its detrimental effects. Additionally, polyphenols, found in plant-based foods, show promise in managing oxidative stress in hypertensive patients although this data has not been confirmed in randomized clinical trials. Understanding the intricate relationship between oxidative stress and hypertensi …

Macrophyte Restoration Promotes Lake Microbial Carbon Pump to Enhance Aquatic Carbon Sequestration.

Macrophyte-based lake restoration has successfully transitioned lakes from turbid conditions dominated by phytoplankton to a more natural, c … ed compounds, 8.68% in carboxyl-rich alicyclic molecules, 37.54% polycyclic condensed aromatics and polyphenols, and 20.21% in SUVA254. Additionallly, key microbial taxa with potent carbon pump functions-primarily Gammaproteobacteria, Alphaproteobacteria, and Actinobacteria-are enriched in restored areas. Structural equation modeling (SEM) further elucidated …

Ashitaba Chalcone 4-Hydroxydericcin Promotes Glucagon-Like Peptide-1 Secretion and Prevents Postprandial Hyperglycemia in Mice.

Certain polyphenols improve glucose tolerance by stimulating glucagon-like peptide-1 (GLP-1) secretion from intestinal L-cells. Ashitaba chalcones, 4-hydroxyderricin (4-HD), and xanthoangelol (XAG) have antihyperglycemic effects, but their molecular mechanism, including whether they promote GLP-1 secretion is unknown. This study investigates the 4-HD-induced GLP-1 secretory mechanisms and its anti-hyperglycemic effects. The secretory mechanisms were examined in STC-1 cells and antihyperglycemic effects in male ICR mice. In STC-1 cells, 4-HD, but not XAG, stimulated GLP-1 secretion through memb…

Improved genomic DNA extraction from citrus species using a modified CTAB method.

BACKGROUND: Citrus species are recalcitrant to DNA extraction due to high levels of polysaccharides, polyphenols, and secondary metabolites that interfere with DNA yield and purity. This study presents an optimized cetyltrimethylammonium bromide (CTAB)-based protocol for efficient genomic DNA isolation from citrus leaves. METHODS: Leaf tissues were ground in liquid nitrogen and extracted using a CTAB buffer supplemented with 2% β-mercaptoethanol and 2% polyvinylpyrrolidone. Contaminants were removed by two rounds of phenol: chloroform: isoamyl alcohol (25:24:1) extraction. RNase A treatment w…

Cardiovascular Effects, Antioxidant Activity, and Phytochemical Analysis of Rubus ulmifolius Schott Leaves.

Wild blackberry (Rubus ulmifolius Schott) is a culinary and medicinal plant traditionally used to treat various ailments, including hyperten … 1.58%, and 45.19%, respectively. MERu also demonstrated potent antioxidant activity and was rich in polyphenols, particularly tannins. Sixteen compounds were identified, notably rubanthrone A, a galloyl-bis-HHDP glucose derivative, ellagic acid, and quercetin-3-O-β-D-glucuronide. These results suggest that R. ulmifolius may have therapeutic potential for hype …

Reducing acrylamide in bread with plant additives: a systematic review.

Reducing acrylamide (AA) formation in thermally processed foods, particularly bread, is a major food safety concern. Plant-based additives, including powders and extracts, offer a promising natural strategy for AA mitigation due to their bioactive compounds, such as polyphenols and flavonoids, which can scavenge reactive intermediates, modulate Maillard reactions, and inhibit lipid oxidation. This study systematically evaluated the effects of various plant powders and extracts, including green tea, rosemary, turmeric, buckwheat, and traditional spices, on AA formation in bread. Based on report…

Cyanidin-3-glucoside: targeting atherosclerosis through gut microbiota and anti-inflammation.

With the shifting global disease spectrum, atherosclerosis (AS) has emerged as a leading contributor to mortality worldwide, with associated cardiovascular diseases (CVDs) representing the predominant cause of death. AS, a chronic inflammatory pathology, is mechanistically linked to oxidative stress and gut microbiota dysbiosis, which drive excessive reactive oxygen species (ROS) production and elevated levels of pro-inflammatory cytokines. Dietary polyphenols, particularly anthocyanins, are well-characterized for their dual role in modulating gut microbial communities and ameliorating chronic…

От ожирения до митохондриальной дисфункции в периферальных тканях и в центральной нервной системе.

Ожирение - это состояние хронического низкосортного воспаления, затрагивающего периферийные органы тела, а также центральную нервную систему. Дефункция жировой ткани, возникающая в условиях ожирения, является ключевым фактором возникновения и развития различных заболеваний, включая нейродегенеративные расстройства. Митохондрия, ключевые органеллы в производстве клеточной энергии, играет важную роль в этой дисфункции тканей. В многочисленных исследованиях подчеркивается тесная связь между ожирением и дисфункцией митохондриалов адипоцита, что приводит к чрезмерному производству ROS и воспалению

Совпадение в аннотации оригинала
Obesity is a condition of chronic low-grade inflammation affecting peripheral organs of the body, as well as the central nervous system. The … on mitochondrial functions. Among these, some molecules present in the Mediterranean diet, such as polyphenols, carotenoids, and omega-3 PUFAs, exert a protective action due to their antioxidant and anti-inflammatory ability. The aim of this review is to provide an overview of the involvement of adipose tissue dysfunction in the development of neurodegenerat …