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Nuances in the treatment of malignant tumors of the clival and petroclival region.

Introduction Malignancies of the clivus and petroclival region are mainly chordomas and chondrosarcomas. Although a spectrum of malignancies may present in this area, a finite group of commonly encountered malignant pathologies will be the focus of this review, as they are recognized to be formidable pathologies due to adjacent critical neurovascular structures and challenging surgical approaches. Objectives The objective is to review the literature regarding medical and surgical management of malignant tumors of the clival and petroclival region with a focus on clinical presentation, diagnost

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… The facial nerve canal is identified inside the mastoid in the most anterior compartment and should be left inside the cortical bone in cases there is no need for facial nerve transposition. …

Каталоги оценок показателей качества жизни, связанных с здоровьем, по шкале EQ-5D-3L для 199 хронических заболеваний и рисков здоровья для использования в Великобритании и США.

СВОДНАЯ ИНФОРМАЦИЯ: В экономической оценке важное значение имеют связанные со здоровьем показатели качества жизни (HRQOL), однако в некоторых случаях отсутствуют первичные источники и требуется информация из вторичных источников. Существующие каталоги HRQOL Соединенного Королевства/США основаны, в частности, на предыдущих системах классификации диагнозов. Недавно опубликованный датский каталог объединился EQ-5D-3L Данные национальных обследований в области здравоохранения с использованием национальных регистров, содержащих информацию о пациентах ICD-10 - диагностика, медицинское обслуживание и

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… 0.788 0.757 0.674 0.807 0.821 0.795 0.839 0.818 0.759 G—Diseases of the nervous system G00–G14; G20–G32; G35–G37; G40–47; G50–64; G70–73; G80–G83; G90–G99 6698 55.1 4.8 0.697 0.708 0.690 0.752 0.694 0.586 0.775 0.783 0.771 0.813 0.774 0.697 H—diseases of the eye and adnexa and diseases of the ear and mastoid … 0.839 | 0.818 | 0.759 G—Diseases of the nervous system | G00–G14; G20–G32; G35–G37; G40–47; G50–64; G70–73; G80–G83; G90–G99 | 6698 | 55.1 | 4.8 | 0.697 | 0.708 | 0.690 | 0.752 | 0.694 | 0.586 | 0.775 | 0.783 | 0.771 | 0.813 | 0.774 | 0.697 H—diseases of the eye and adnexa and diseases of the ear and mastoid …

Imaging for Plasma Cell Dyscrasias: What, When, and How?

Imaging plays a vital role in the diagnosis, response assessment, and follow-up of patients with plasma cell bone disease. The radiologic diagnostic paradigm has thus far evolved with developing technology and availability of better imaging platforms; however, the skewed availability of these imaging modalities in developed vis-à-vis the developing countries along with the lack of uniformity in reporting has led to a consensus on the imaging criteria for diagnosing and response assessment in plasma cell dyscrasia. Therefore, it is imperative for not only the radiologists but also the treating

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… Image (E) a large lytic lesion with associated soft tissue component is seen involving the mastoid temporal bone on the right side (arrow). …

Global Panoramic analysis of clinical research in cell therapy: clinical trial landscape, marketed products, and regulatory trends.

IntroductionCell therapy is a vital field in modern medicine. This review assesses its global clinical development landscape, approved products, and regional regulatory characteristics.MethodsA comprehensive search and analysis of global clinical trial databases (e.g., https://clinicaltrials.gov/ClinicalTrials.gov), regulatory agency announcements, and relevant literature up to October 2025 was conducted. Key data points regarding trial numbers, phases, therapy types, and approved products were extracted and analyzed descriptively by region.ResultsA cumulative total of 10,373 cell therapy clin

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… Visual system diseases | 143 | 1.4% | 34 | 1.0% | 39 | 1.2% | 20 | 1.3% Injury | 58 | 0.6% | 15 | 0.4% | 26 | 0.8% | 4 | 0.3% Mental, behavioral, neurodevelopmental disorders | 31 | 0.3% | 8 | 0.2% | 6 | 0.2% | 3 | 0.2% General symptoms and signs | 18 | 0.2% | 6 | 0.2% | 3 | 0.1% | 2 | 0.1% Ear or mastoid …

Proceedings of ICIS SGCR-WIRES 2024, held jointly with the 23rd International Cancer Imaging Society Annual Conference, collaborating with the Singapore Radiological Society and College of Radiologists Singapore.

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… Tumour spread can compress the eustachian tube, leading to middle ear and mastoid effusion. Involvement of adjacent soft tissues, including medial and lateral pterygoid muscles, and prevertebral muscles. Further spread may involve the carotid space, encasing the carotid artery. …

Kabuki Syndrome-Clinical Review with Molecular Aspects.

Kabuki syndrome (KS) is a rare developmental disorder principally comprised of developmental delay, hypotonia and a clearly defined dysmorphism: elongation of the structures surrounding the eyes, a shortened and depressed nose, thinning of the upper lip and thickening of the lower lip, large and prominent ears, hypertrichosis and scoliosis. Other characteristics include poor physical growth, cardiac, gastrointestinal and renal anomalies as well as variable behavioral issues, including autistic features. De novo or inherited pathogenic/likely pathogenic variants in the KMT2D gene are the most c

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… Recurrent AOM puts children at increased risk for chronic complications—namely open mastoid cavity, antro-atticotomy and tympanosclerosis [ 96 ]. KS children and healthy children are treated identically for recurrent AOM [ 100 ]. These infections generally cause conductive hearing loss. …

Application of Next Generation Sequencing in Laboratory Medicine.

The rapid development of next-generation sequencing (NGS) technology, including advances in sequencing chemistry, sequencing technologies, bioinformatics, and data interpretation, has facilitated its wide clinical application in precision medicine. This review describes current sequencing technologies, including short- and long-read sequencing technologies, and highlights the clinical application of NGS in inherited diseases, oncology, and infectious diseases. We review NGS approaches and clinical diagnosis for constitutional disorders; summarize the application of U.S. Food and Drug Administr

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Резюме ESPR 2013Европейское общество педиатрической радиологии 50th Ежегодное совещание и 36th Курсы для аспирантов. Июнь 3–7 2013. Будапешт, Венгрия.

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Infectious Diseases

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… — S. aureus, S. epidermidis , aerobic Gram negative bacilli*, diphtheroids basilar skull fracture — S. pneumoniae , H. influenzae , group A Streptococci *aerobic Gram-negative bacilli include Klebsiella, E. coli, Serratia, and Pseudomonas RISK FACTORS FOR S. pneumoniae —pneumonia, otitis media, mastoiditis …

Infectious Diseases

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… PNEUMONIAE —pneumonia, otitis media, mastoiditis, sinusitis, endocarditis, head trauma with CSF leak, alcoholism, splenectomy RISK FACTORS FOR L . …

A Comprehensive Review of the Role of the Latest Minimally Invasive Neurosurgery Techniques and Outcomes for Brain and Spinal Surgeries.

Minimally invasive neurosurgical techniques offer reduced surgical trauma, lower complication rates, and faster recovery compared to traditional open procedures. Approaches such as keyhole craniotomy, endoscopic skull base surgery, endovascular neurosurgery, and percutaneous spinal techniques have advanced the management of cranial and spinal pathologies. These methods aim to minimize tissue disruption, blood loss, and hospital stay while maintaining surgical efficacy. This narrative review explores their evolution, applications, and advantages in modern neurosurgery.

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… The CT scan showed focal dehiscence in the left tegmen tympani and fluid in the mastoid cells, and the MRI confirmed the presence of the fluid in the left temporal bone. …

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians.

The current literature provides a body of evidence on C-Reactive Protein (CRP) and its potential role in inflammation. However, most pieces of evidence are sparse and controversial. This critical state-of-the-art monography provides all the crucial data on the potential biochemical properties of the protein, along with further evidence on its potential pathobiology, both for its pentameric and monomeric forms, including information for its ligands as well as the possible function of autoantibodies against the protein. Furthermore, the current evidence on its potential utility as a biomarker of

Rare Diseases of the Nose, the Paranasal Sinuses, and the Anterior Skull Base.

Due to their low incidence and thus resulting limited diagnostic criteria as well as therapeutic options, rare diseases of the nose, the paranasal sinuses, and the anterior skull base are a significant challenge. The value as of which a disease has to be considered as rare amounts to a maximum of 5 patients per 10 000 people. Within these diseases, however, there are extreme differences. Some rare or orphan diseases like for example the inverted papilloma belong to regularly diagnosed and treated diseases of larger departments of oto-rhino-laryngology whereas other rare diseases and malformati

Rare Diseases of the Orbit.

This article provides an overview of rare orbital diseases. Congenital malformations, inflammatory diseases, benign and malignant neoplasias are described. Although it represents a relatively small area of the body the orbit contains multiple different tissues. Therefore, a great variety of diseases can be found within the orbital space. That is the reason, why both the completeness and the level of detail in the description of particular diseases must be somewhat limited. Nevertheless, clinical manifestations, important aspects of diagnosis, treatment strategies, and, when specific data are a

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… some of the bony-cartilaginous structures facial asymmetry highly variable disease activity over 2 to 20 years until self-limiting stagnation malformation of the external auricle (misplaced ear, auditory canal atresia, adnexae, reduced ossicles, small tympanum) unilateral micrognathia hypoplastic mastoid …

Esid 2014 oral presentations.

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The leptomeninges as a critical organ for normal CNS development and function: First patient and public involved systematic review of arachnoiditis (chronic meningitis).

BACKGROUND & IMPORTANCE: This patient and public-involved systematic review originally focused on arachnoiditis, a supposedly rare "iatrogenic chronic meningitis" causing permanent neurologic damage and intractable pain. We sought to prove disease existence, causation, symptoms, and inform future directions. After 63 terms for the same pathology were found, the study was renamed Diseases of the Leptomeninges (DLMs). We present results that nullify traditional clinical thinking about DLMs, answer study questions, and create a unified path forward. METHODS: The prospective PRISMA protocol is pu

2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference.

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… Infections prior to diagnosis were: Pneumoniae (45.5%, mean 1.5 episodes), meningitis (36%), AOM (36%, mean 1), bacteremia (36%), cellulitis (27%), mastoiditis (18%), septic arthritis (18%).The microorganisms isolated were: S. pneumoniae (70%), N. meningitidis (10%), H. influenzae (10%) and N. fowleri …

17th Конгресс ЕВНОС: Милан, Италия, 4–6 Июнь, 2026 года

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Proceedings of the RAMI Intern Section Meeting.

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… Procedure: A longitudinal neck incision along the anterior border of the right sterno-mastoid muscle was used to reach a large retropharyngeal and mediastinal haematoma. The patient’s symptoms were successfully relieved via drainage within 48 hours. …