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Multi-omics and experimental evidence in human chondrocytes identify caspase-8 as a non-apoptotic regulator of inflammatory, senescent, and fibrotic signaling in osteoarthritis.

BACKGROUND: Osteoarthritis (OA) is characterized by chronic inflammation, cellular senescence, and progressive cartilage remodeling, yet eff … and senescence-related programs. Additional analyses of aging, murine destabilization of the medial meniscus (DMM), and spatial transcriptomic datasets (GSE287861, GSE26475, and GSE254844) highlighted context-dependent CASP8 patterns, including senescence- but not inflammation-associated CASP8 elevation in naturally aged cartilage, no consistent CASP8 expr …

Promising functional outcomes following anterior cruciate ligament repair with suture augmentation.

PURPOSE: There has been a renewed interest in the repair of the torn anterior cruciate ligament (ACL). Purpose of this study was to evaluate … failure rate of 10% cannot be neglected and warrants further attention. Concomitant injuries to the meniscus and/or collateral ligaments do not seem to be associated with inferior PROMs. LEVEL OF EVIDENCE: Level IV.

Longitudinal Evaluation Using the Forgotten Joint Score-12 for Double-Bundle Primary Anterior Cruciate Ligament Reconstruction: A Retrospective Observational Study.

Introduction There are several postoperative evaluation methods for anterior cruciate ligament reconstruction (ACLR), and patient-reported o … f 28.5 ± 11.8 years at the time of surgery and a BMI of 23.2 ± 3.7 kg/m2. Fifty-eight patients with meniscus injuries requiring treatment were observed. A total of 54 patients were used to compare the results at one and two years, while 87 patients were included in the multivariate analysis for FJS at one year. The median of FJS at one and two years post-s …

The Effect of Conjunctival Flap Transplantation, Pterygium Excision, and Scleral Fixation Surgery in Treating Pterygium Combined with Conjunctival Laxity and Its Impact on Postoperative Complications.

OBJECTIVE: Pterygium and conjunctival laxity are common ocular conditions that can significantly affect visual comfort and quality of life. … ere trending downward after surgery, while the breakup time of the tear film and height of the tear meniscus was increasing but there was no significant difference in the above indicators (P > .05). However, there was no significant difference in the above indicators between the two groups before surgery, at 1, 3, and 6 months, and at 1 year after surgery …

WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of exposure to occupational ergonomic risk factors and of the effect of exposure to occupational ergonomic risk factors on osteoarthritis of hip or knee and selected other musculoskeletal diseases.

BACKGROUND: The World Health Organization (WHO) and the International Labour Organization (ILO) are developing a joint methodology for estim … ondylitis medialis; epicondylitis lateralis; bursitis elbow; bursitis hip; chondromalacia patellae; meniscus disorders; and/or bursitis knee). For Systematic Review 1, we will include quantitative prevalence studies of any exposure to occupational ergonomic risk factors stratified by country, gender, age and industrial sector or occupation. For Systematic …

Is Preferred Language Other Than English Associated With Delayed Surgery After ACL Injury in Children and Adolescents?

BACKGROUND: Previous studies have investigated the impact of social determinants of health, such as the type of healthcare insurance and hou … yses were used to determine whether PLOE was associated with increased time to surgery, concomitant meniscus injury, or performance of meniscectomy while adjusting for confounding variables. Variables were included in multivariable models if they met the threshold for statistical significance in univariate testing (p < 0.05). RESULTS: The median time betw …

Teriparatide ameliorates articular cartilage degradation and aberrant subchondral bone remodeling in DMM mice.

OBJECTIVE: Knee osteoarthritis (KOA) is a highly prevalent musculoskeletal disorder characterized by degeneration of cartilage and abnormal … ) were investigated and compared. Post-traumatic KOA model was created by destabilization of medial meniscus (DMM). WT mice were randomly assigned into three groups: the sham group (WT-sham; n ​= ​18), the DMM group (WT-DMM; n ​= ​18), and the PTH (1-34)-treated group (WT-DMM ​+ ​PTH (1-34); n ​= ​18). Similarly, the OPG-/- mice were randomly allocated int …

Advances in the mechanism and therapies of achondroplasia.

Achondroplasia (ACH), is the prevailing type of genetic dwarfism in humans, caused by mutations in fibroblast growth factor receptor 3 (FGFR3) that are inherited in an autosomal dominant manner. FGFR3 is mainly expressed in condensed mesenchyme, chondrocytes, and mature osteoblasts and osteoclasts, in which it regulates the formation, development, growth, and remodeling of the skeletal system. Mutations in FGFR3 causing ACH result in enhanced FGFR3 signaling through combined mechanisms including enhancing FGF dimerization and tyrosine kinase activity and stabilizing FGF receptors. In ACH, supp

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… Synovial joints consist of multiple tissue elements, such as articular cartilage that envelops the bone surface, meniscus, synovium that protects the joint from the external environment, and intra-joint and peri-joint ligaments that provide mechanical stability. … and ligaments. 27 Recent research has discovered that cells expressing Gdf5 and FGFR2 play pivotal roles in the formation of various tissues, such as the meniscus, cruciate ligaments, and articular cartilage, within synovial joints. 28 The axial skeleton and its relevant skeletal muscles originate …

MSC-EV therapy for bone/cartilage diseases.

Mesenchymal stromal cells (MSCs) have been utilized in cell therapy for various diseases. Recent studies have demonstrated that extracellular vesicles (EVs) released by MSCs play an important role in their therapeutic activities. EVs contain a variety of bioactive molecules such as proteins, messenger RNAs (mRNAs), and micro RNAs (miRNAs) and modify the function of the recipient cells by transferring these molecules. Despite the promising potential of EV therapy as a substitute for MSC therapy, there are challenges that need to be addressed for the clinical success of EV therapy. EV quality ha

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… Wang et al., 2018a Commercial rat MSC DMEM +10%FBS, 100 U/ml of penicillin and 100 μg/ml of streptomycin Exosome extraction kit 12w-male SD rats transecting the medial collateral ligament and the medial meniscus Intra-articular injections 100 μl MSC-exosome, 1 × 10 11 MSC-exosome particles Lower OARSI … Wang et al., 2018a | Commercial rat MSC | DMEM +10%FBS, 100 U/ml of penicillin and 100 μg/ml of streptomycin | Exosome extraction kit | 12w-male SD rats transecting the medial collateral ligament and the medial meniscus | Intra-articular injections 100 μl MSC-exosome, 1 × 10 11 MSC-exosome particles …

Electroacupuncture Inhibits Cartilage Degeneration in a Rat Knee Osteoarthritis (KOA) Model by Suppressing ADAMTS5 Expression.

Background Knee osteoarthritis (KOA) is characterized by cartilage degradation, osteophyte formation, and synovitis. Cartilage degradation i … +LR8), and KOA treated at ST36-Ex-LE2 (Heding) (KOA+Ex-LE2). The DMM (destabilization of the medial meniscus) procedure induced KOA, and EA was applied thrice weekly for four weeks. The rotarod test was used to assess motor coordination, and samples were collected for immunofluorescence, Western blot, and histological analysis. Pain was assessed via c-fos …

Lateral Opening-wedge Distal Femoral Osteotomy: Pain Relief, Functional Improvement, and Survivorship at 5 Years.

BACKGROUND: Distal femoral varus osteotomy may be used to treat valgus knee malalignment or to protect a knee compartment in which cartilage restoration surgery (such as osteochondral or meniscus allografting) has been performed. Medial closing-wedge osteotomy has demonstrated good success in treatment of osteoarthritis in published series, but few studies have evaluated distal femoral lateral opening-wedge osteotomy in terms of correction of deformity, pain and function, and survivorship. QUESTIONS/PURPOSES: (1) Does lateral opening-wedge osteotomy lead to accurate correction? (2) What pain …

[The medial closed-wedge osteotomy of the distal femur for the treatment of unicompartmental lateral osteoarthritis of the knee].

OBJECTIVE: Shifting of the mechanical axis from the lateral to the medial compartment in patients with lateral osteoarthritis in combination with valgus deformity. INDICATIONS: Osteoarthritis of the lateral compartment in combination with valgus deformity of the (distal) femur. Posttraumatic and congenital valgus deformities of the (distal) femur. CONTRAINDICATIONS: Osteoarthritis of the medial compartment (>or=grade 3 on Outerbridge Scale). Total loss of the medial meniscus. Acute or chronic infections. Rheumatoid arthritis. Heavy smoking. Extension or flexion deficit>20 degrees. Poor soft-…

[Treatment of intra-articular proximal tibial evaluation of two- to seven-year follow-up].

PURPOSE OF THE STUDY: Intra-articular fractures of the proximal tibia always present a complicated therapeutic problem. In this retrospectiv … , with the exception of AO type 41A-1 fracture, an Y-ray image intensifier system is necessary. The meniscus above the injured bone should be preserved in order to maintain good function of the joint. CONCLUSIONS: In intra-articular fractures of the proximal tibia, treatment outcomes depend on the type of fracture as well as correct reduction and use of a …

Identification of HBEGF+ fibroblasts in the remission of rheumatoid arthritis by integrating single-cell RNA sequencing datasets and bulk RNA sequencing datasets.

BACKGROUND: Fibroblasts are important structural cells in synovium and play key roles in maintaining the synovial homeostasis. By single-cel … d macrophages, and EGFR, receptor to EGF signaling pathway, was highly expressed by fibroblasts and meniscus cells. Moreover, HBEGF was downregulated under RA state and it had an increase after classical treatment. We then defined fibroblasts with high expression of HBEGF as HBEGF+ fibroblasts. In addition, we also found that HBEGF+ fibroblasts highly expr …

Problems With Large Joints: Knee Conditions.

As a large joint dependent on ligaments for stability and muscles and tendons for function, the knee is susceptible to a spectrum of acute and overuse injuries. Acute injuries involve the ligaments, menisci, and weight-bearing surfaces. Overuse injuries commonly affect the patellar tendon, iliotibial band, and patellofemoral complex. Acute and overuse knee injuries can be debilitating but most can be diagnosed and managed by family physicians. An appropriate history and physical examination are essential to guide diagnosis and management decisions. X-ray imaging often is required. Magnetic res

[Biomechanical mechanism of acupotomy on cartilage degeneration in KOA rabbits based on three-dimensional finite element model].

OBJECTIVE: To observe the effect of acupotomy on cartilage degeneration in rabbits with knee osteoarthritis (KOA) from the perspectives of f … oup, in the model group, the ratios and the contact areas of the medial and lateral condyles of the meniscus, femoral cartilage and tibial cartilage were significantly deviated. Those in the EA group and the acupotomy group tended to be more similar to the normal group, and those in the acupotomy group were superior to the EA group. CONCLUSION: Acupotomy …

Concurrent Chylothorax, Chylopericardium, and Superior Vena Cava Syndrome in a Young Male With Primary Mediastinal Large B-cell Lymphoma: A Report of a Rare Case.

Primary mediastinal large B-cell lymphoma (PMBCL) is an uncommon and aggressive subtype of non-Hodgkin lymphoma (NHL) that predominantly affects young adults and typically presents with a bulky anterior mediastinal mass. We report the case of a 23-year-old male who presented with progressive dyspnea, orthopnea, and facial swelling, subsequently found to have superior vena cava (SVC) syndrome, chylothorax, and chylopericardium, an exceedingly rare triad of complications. Diagnostic evaluation required integration of advanced imaging, fluid analysis, and histopathological confirmation, ultimatel

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… The right costophrenic angle is obliterated, with a meniscus noted. Findings are suggestive of a right-sided pleural effusion. …

[Anterior cruciate ligament reconstruction with double-bundle artificial ligament based on four-dimensional impingement free mechanism: a comparative study with single-bundle reconstruction].

OBJECTIVE: To investigate the surgical method of anterior cruciate ligament (ACL) reconstruction with double-bundle artificial ligaments bas … ow posterolateral bundle)]. Baseline data-including age, injured side, cause of injury, concomitant meniscus injury, and preoperative Lysholm score, International Knee Documentation Committee (IKDC) score, and Tegner score-showed no significant difference between the two groups ( P>0.05); however, the difference in gender distribution between the two group …

[Diagnosis, Treatment and Complications of Knee Dislocation: a Retrospective Study].

PURPOSE OF THE STUDY Acute knee dislocation is a less common injury of the knee joint. It is, however, a serious injury with a high rate of … he aim of the final treatment is to perform anatomic suture or reconstruction of knee ligaments and meniscus to achieve a stable, pain-free, functional knee and to prevent any complications. CONCLUSIONS Knee joint dislocation ranks among less common injuries that can be accompanied by a vascular injury in 20% on average and a nerve lesion in 10-40% (around …