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Dentists' Awareness of Medication-Related Osteonecrosis of the Jaw (Risk Factors, Drugs, and Prevention) in the Republic of Croatia.

INTRODUCTION: Antiresorptive drugs (AR) have been used for many years in the treatment of various bone conditions such as osteoporosis, osteopenia, Paget's disease, bone metastases, multiple myeloma and the associated malignant hypercalcemia. As a side effect of AR therapy, medication-related osteonecrosis of the jaw, which affects the mandible more commonly than the maxilla, (MRONJ) has become an increased risk regarding patients' health and quality of life. The incidence of osteonecrosis has increased significantly in the last few years. One of the main methods of the disease prevention is t

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… Oral Dis . 2005 ; 11 : 365 – 9 . 10.1111/j.1601-0825.2005.01130.x 16269027 23 de Lima PB Brasil VLM de Castro JFL de Morales Ramos-Perez FM dos Anjos Pontual DE Knowledge and attitudes of Brazilian dental students and dentists regarding bisphosphonate-related osteonecrosis of the jaw. …

Prevalence of bisphosphonate associated osteonecrosis of the jaws in multiple myeloma patients.

BACKGROUND: Bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) is an adverse effect of bisphosphonate treatment with varying reported incidence rates. METHODS: In two neighboring German cities, prevalence and additional factors of the development of BP-ONJ in multiple myeloma patients with bisphosphonates therapy were recorded using a retrospective (RS) and cross-sectional study (CSS) design. For the RS, all patients treated from Jan. 2000--Feb. 2006 were contacted by letter. In the CSS, all patients treated from Oct. 2006--Mar. 2008 had a physical and dental examination. Additional

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… Aguiar Bujanda D, Bohn Sarmiento U, Cabrera Suarez MA, Aguiar Morales J. Assessment of renal toxicity and osteonecrosis of the jaws in patients receiving zoledronic acid for bone metastasis. Ann Oncol. 2007;18:556–560. doi: 10.1093/annonc/mdl408. …

Pediatric Drug Development: Reviewing Challenges and Opportunities by Tracking Innovative Therapies.

The paradigm of pediatric drug development has been evolving in a "carrot-and-stick"-based tactic to address population-specific issues. However, the off-label prescription of adult medicines to pediatric patients remains a feature of clinical practice, which may compromise the age-appropriate evaluation of treatments. Therefore, the United States and the European Pediatric Formulation Initiative have recommended applying nanotechnology-based delivery systems to tackle some of these challenges, particularly applying inorganic, polymeric, and lipid-based nanoparticles. Connected with these, adv

Future perspectives in melanoma research: meeting report from the "Melanoma Bridge", Napoli, December 5th-8th 2013.

The fourth "Melanoma Bridge Meeting" took place in Naples, December 5 to 8th, 2013. The four topics discussed at this meeting were: Diagnosis and New Procedures, Molecular Advances and Combination Therapies, News in Immunotherapy, and Tumor Microenvironment and Biomarkers.

Adapted physical activity for hematology inpatients: focus on lean mass gain.

Adapted physical activity (APA) has become an essential asset in the care of patients with cancer. Although its positive impact has mainly been studied regarding quality of life, few studies have focused on changes in lean mass (LM) and its determinants. This study reports the results of an APA program for inpatients in the hematology department of Nice University Hospital (France). Body composition analyses and physical tests were performed at admission and discharge. A total of 123 patients were analyzed with relative LM gain as the primary outcome. Over a median hospitalization duration of

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… Morales JS, González Vicent M, Valenzuela PL, et al. Tailored exercise during hematopoietic stem cell transplantation hospitalization in children with cancer: a prospective cohort study. Cancers. 2020;12(10):3020. doi: 10.3390/cancers12103020. 36. Schauer T, Hojman P, Gehl J, Christensen JF. …

Qualitative and Quantitative Inter-Observer Agreement of Multiparametric Whole-Body MRI in Staging and Follow-Up of Myeloma Patients.

Background: Whole-body magnetic resonance imaging (WB-MRI) is incorporated into international guidelines and recommendations for imaging patients with multiple myeloma. The aim of this study was to investigate inter-observer agreement of radiologists with different levels of expertise in reporting whole-body MRI performed along MY-RADS criteria in myeloma at baseline and in evaluating response to therapy to better certify the use of these criteria. Methods: A total of 52 patients with symptomatic myeloma at first presentation (47) or relapse (5) and planned for a new line of therapy were inclu

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… Garcia-Ruiz A., Macarro C., Zacchi F., Morales-Barrera R., Grussu F., Casanova-Salas I., Sanguedolce F., Gonzalez M., Cresta-Morgado P., de Albert M., et al. …

The Future of Oncology in Psychiatric Medications.

Recent years have provided numerous reports on the mechanisms of action of psychiatric medications (antidepressants, antipsychotics, mood stabilizers, and antidementia drugs) that directly inhibit the growth of cancer cells, as well as on their indirect effects on the psyche and immune system, and their supportive effects on chemotherapeutic agents. The mechanisms of the anticancer activity of psychiatric drugs include inhibition of dopamine and N-methyl-D-aspartate receptors that work via signaling pathways (PI3K/AKT/mTOR/NF-κB, ERK, Wnt/ß-catenin, and bcl2), metabolic pathways (ornithine dec

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… Rodríguez-Morales M. Bustamante-Montes L.P. Silva-Adaya D. Pérez-Plasencia C. Jacobo-Herrera N. Lithium: A Promising Anticancer Agent Life 2023 13 537 10.3390/life13020537 36836894 PMC9966411 30. Aron L. Ngian Z.K. Qiu C. Choi J. Liang M. Drake D.M. Hamplova S.E. Lacey E.K. Roche P. Yuan M. …

Oral squamous cell carcinoma vs. medication-related osteonecrosis of the jaw in patients assuming bone-modifying agents: a diagnostic challenge in a multi-hospital case series.

BACKGROUND: Despite advances in the diagnosis of oral squamous cell carcinoma (OSCC), most cases are diagnosed in advanced stages, influencing negatively the patient's prognosis. The absence of specific signs and symptoms contributes to the diagnostic delay of OSCC, often leading to confusion with various oral conditions, including, in patients with a history of bone modifying agents (BMA) and/or anti-angiogenic (AA) molecules, the Medication-Related Osteonecrosis of the Jaw (MRONJ). This study aims to investigate the characteristics of OSCC and MRONJ, focusing on clinical and radiological fea

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… Hernandez-Morales A Gonzalez-Lopez BS Scougall-Vilchis RJ Bermeo-Escalona JR Velazquez-Enriquez U Islas-Zarazua R Lip and oral cavity cancer incidence and mortality rates associated with smoking and chewing tobacco use and the human development index in 172 countries worldwide: an ecological study 2019 …

Arrhythmias and Device Therapies in Cardiac Amyloidosis.

Cardiac amyloidosis is caused by amyloid fibrils that deposit in the myocardial interstitium, causing restrictive cardiomyopathy and eventually death. The electromechanical, inflammatory, and autonomic changes due to amyloid deposition result in arrhythmias. Atrial fibrillation is by far the most common arrhythmia. The rate control strategy is generally poorly tolerated due to restrictive filling physiology and heart rate dependance, favoring adoption of the rhythm control strategy. Anticoagulation for stroke prophylaxis is warranted, irrespective of CHA2DS2-VASc score in patients with a favor

Global disparities in drug-related adverse events of patients with multiple myeloma: a pharmacovigilance study.

Multiple myeloma (MM) is a complex hematological malignancy of clonal plasma cells driven by alterations to the chromosomal material leading to uncontrolled proliferation in the bone marrow. Ethnic and racial disparities persist in the prevalence, diagnosis, management, and outcomes of MM. These disparities are multifaceted and intersect with various factors, including demographics, geography, socioeconomic status, genetics, and access to healthcare. This study utilized the openFDA human drug adverse events (AEs) to analyze global data pertaining to MM patients and patterns of treatment-relate

Burden of noncommunicable diseases among children and adolescents aged 10-24 years in China, 1990-2019: A population-based study.

China has hundreds of millions of children and adolescents aged 10-24 years, accounting for one-sixth of their total counterparts worldwide. We perform this study to clarify the priority of noncommunicable disease (NCD) control among youth in China via the Global Burden of Diseases Study 2019. The highest disability-adjusted life years (DALYs) from NCDs among youth in China remain in mental disorders, while the most increasing incidence is from diabetes and kidney diseases during 1990-2019. Bullying victimization and high BMI are the top risk factors for DALYs from mental disorders and diabete

Can type 1 diabetes be an unexpected complication of obesity?

Type 1 diabetes (T1D) is one of the most common chronic autoimmune diseases, characterized by absolute insulin deficiency caused via inflammatory destruction of the pancreatic β-cell. Genetic, epigenetic, and environmental factors play a role in the development of diseases. Almost ⅕ of cases involve people under the age of 20. In recent years, the incidence of both T1D and obesity has been increasing, especially among children, adolescents, and young people. In addition, according to the latest study, the prevalence of overweight or obesity in people with T1D has increased significantly. The r

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… Richardson TG, Crouch DJM, Power GM, Morales-Berstein F, Hazelwood E, Fang S, et al. Childhood body size directly increases type 1 diabetes risk based on a lifecourse mendelian randomization approach. Nat Commun (2022) 13:2337. doi: 10.1038/s41467-022-29932-y 66. …

Нынешний подход к решению проблемы вторичного недоедания у пациентов с гематологическими отклонениями: рекомендации в отношении консенсуса экспертов Испании.

Для оценки мнений клинических гематологов было проведено обследование на базе Делфи (n = 17) и клинических иммунологов (n = 18) по всей Испании о вторичных иммунодефицитах (СИД) в области лечения онкогематологических пациентов. Там было 100% :: согласие с необходимостью наличия руководящих принципов в отношении лечения иммунодефицита у пациентов, страдающих гематологией; проведение базовой иммунологической оценки у пациентов с хронической лимфоцитной лейкемией (КЛЛ), множественной миеломой (ММ), лимфомой и гематопоиетической трансплантацией стволовых клеток (ХСБТ); и количественная оценка уров

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… Ochoa-Grullón J., Guevara-Hoyer K., López C.P., de Diego R.P., Cortijo A.P., Polo M., Morales M.M., Mandley E.A., García C.J., Bolaños E., et al. Combined Immune Defect in B-Cell Lymphoproliferative Disorders Is Associated with Severe Infection and Cancer Progression. …

Impact of COVID-19 on Outcomes of Patients with Hematologic Malignancies: A Multicenter, Retrospective Study.

ObjectivesPatients with hematological malignancies have a high risk of mortality from coronavirus disease 2019 (COVID-19). This study aimed to investigate the impact of COVID-19 on mortality rates in patients with various hematological malignancies and to determine risk factors associated with all-cause mortality.MethodsA multicenter, observational retrospective analysis of patients with hematological malignancies infected with COVID-19 between July 2020 and December 2021 was performed. Demographic data, clinical characteristics, and laboratory parameters were recorded. Patients were grouped a

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… Pinana JL, Martino R, Garcia-Garcia I, Parody R, Morales MD, Benzo G, Gomez-Catalan I, Coll R, De La Fuente I, Luna A, Merchan B, Chinea A, de Miguel D, Serrano A, Perez C, Diaz C, Lopez JL, Saez AJ, Bailen R, Zudaire T, Martinez D, Jurado M, Calbacho M, Vazquez L, Garcia-Cadenas I, Fox L, Pimentel AI …

Understanding the symptom experience and self-management strategies of adult hematopoietic stem cell transplantation patients during hospitalization: findings from a qualitative longitudinal study.

PurposeThe aim of this study was to explore the symptom experience and self-management strategies of adult hematopoietic stem cell transplantation patients during hospitalization.MethodsThis was a qualitative descriptive study. A heterogeneous sample of 19 patients who underwent hematopoietic stem cell transplantation from May to October 2021 were enrolled in the study. Semi-structured interviews were conducted at four time points during hospitalization, providing a total of 64 interview datasets.ResultsFour themes and 11 subthemes reflecting the symptom experience and self-management strategi

A Phase II Study of the Efficacy and Safety of Oral Selinexor in Recurrent Glioblastoma.

PURPOSE: Selinexor is an oral selective inhibitor of exportin-1 (XPO1) with efficacy in various solid and hematologic tumors. We assessed intratumoral penetration, safety, and efficacy of selinexor monotherapy for recurrent glioblastoma. PATIENTS AND METHODS: Seventy-six adults with Karnofsky Performance Status ≥ 60 were enrolled. Patients undergoing cytoreductive surgery received up to three selinexor doses (twice weekly) preoperatively (Arm A; n = 8 patients). Patients not undergoing surgery received 50 mg/m2 (Arm B, n = 24), or 60 mg (Arm C, n = 14) twice weekly, or 80 mg once weekly (Arm

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… Ventero MP, Fuentes-Baile M, Quereda C, Perez-Valeciano E, Alenda C, Garcia-Morales P, et al. Radiotherapy resistance acquisition in glioblastoma. Role of SOCS1 and SOCS3. PLoS One 2019;14:e0212581. 32. Martini M, Pallini R, Luongo G, Cenci T, Lucantoni C, Larocca LM. …

Are the Physical Environments of Treatment Centres Meeting Recommendations for Patient-Centred Care? Perceptions of Haematological Cancer Patients.

The physical environment of a treatment centre may impact the well-being of patients and their perceptions of care. Outpatients with haematological cancer may be in contact with the treatment centre over long periods and could be particularly affected. This study aimed to identify haematological cancer patients' perceptions of supportive design elements in the hospital they attended and associations with self-reported mood or well-being. Outpatients from three large metropolitan hospitals in Australia were mailed a self-report questionnaire and responded to statements about the treatment centr

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… Morales E. van Hoof J. Kort H.S.M. Healing environment: A review of the impact of physical environmental factors on users Build. Environ. 2012 58 70 80 10.1016/j.buildenv.2012.06.016 29. Hignett S. Masud T. …

Health Equity Among Black Women in the United States.

Black women in the United States have experienced substantial improvements in health during the last century, yet health disparities persist. These health disparities are in large part a reflection of the inequalities experienced by Black women on a host of social and economic measures. In this paper, we examine the structural contributors to social and economic conditions that create the landscape for persistent health inequities among Black women. Demographic measures related to the health status and health (in)equity of Black women are reviewed. Current rates of specific physical and mental

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… Saenz R , Morales MC . Demography of race and ethnicity . In: Poston DL , Micklin M , eds. Handbook of population . New York, NY : Kluwer Academic/Plenum Publishers , 2005 : 169 – 206 4. Waters M . The social construction of race and ethnicity: Some examples from demography . …

Outcomes and quality of life after major bile duct injury in long-term follow-up.

IntroductionRecently new standards for reporting outcomes of bile duct injury (BDI) have been proposed. It is unclear how these treatment outcomes are reflected in quality of life (QOL). The aim of this study was to report outcomes and QOL after repair of major BDI and compare repairs by hepatobiliary surgeon to repairs by non-hepatobiliary surgeons.MethodsThis was a retrospective study of patients treated for major (Strasberg E-type) BDI after cholecystectomy at a tertiary hepatobiliary center. Outcomes were assessed using Cho-Strasberg proposed standards. QOL was assessed using Short Form He

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… Cuendis-Velazquez A Trejo-Avila M Bada-Yllan O Cardenas-Lailson E Morales-Chavez C Fernandez-Alvarez L Romero-Loera S Rojano-Rodriguez M Valenzuela-Salazar C Moreno-Portillo M A new era of bile duct repair: robotic-assisted versus laparoscopic hepaticojejunostomy J Gastrointest Surg 2019 23 451 459 10.1007 …

Ensuring the Safety of Yellow Fever Vaccination in Travelers-The Experience at a Large U.S. Academic Medical Center in Colorado.

Background: Yellow fever (YF) virus has the potential to cause fatal outcomes among at-risk individuals visiting endemic areas. Vaccinating travelers who are at risk is necessary to prevent virus-related life-threatening complications. We lack data on the clinical features of persons seeking YF vaccination. We aim to describe the characteristics of a cohort of persons receiving the YF vaccine before travel. Methods: A retrospective analysis of 964 travelers receiving the YF vaccine (Stamaril®) from Oct 2016 to Jul 2019 was performed at the University of Colorado Hospital, U.S. Percentages, mea

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… Rodriguez-Morales A.J. Henao-Martínez A.F. Prevention of yellow fever in travellers: An update Lancet Infect Dis. 2020 20 e129 e137 10.1016/S1473-3099(20)30170-5 32386609 14. Nasidi A. Monath T.P. Vandenberg J. Tomori O. Calisher C.H. Hurtgen X. Munube G.R. Sorungbe A.O. Okafor G.C. Wali S. …