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Abstracts

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Pediatric Acute Lymphoblastic Leukemia Emerging Therapies-From Pathway to Target.

Over the past 40 years, the 5-years-overall survival rate of pediatric cancer reached 75-80%, and for acute lymphoblastic leukemia (ALL), exceeded 90%. Leukemia continues to be a major cause of mortality and morbidity for specific patient populations, including infants, adolescents, and patients with high-risk genetic abnormalities. The future of leukemia treatment needs to count better on molecular therapies as well as immune and cellular therapy. Advances in the scientific interface have led naturally to advances in the treatment of childhood cancer. These discoveries have involved the recog

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… ClinicalTrials.gov Acute Lymphoblastic Leukemia Treatment Protocol Moscow-Berlin 2019 Pilot Available online: https://clinicaltrials.gov/ct2/show/NCT04723342?term=NCT04723342&draw=2&rank=1 (accessed on 15 January 2023) 95. Goto H. Ogawa C. Iida H. Horibe K. Oh I. Takada S. Maeda Y. Minami H. …

Abstracts cont.

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Deciphering transcriptomic changes in chemobrain: a comprehensive review.

Chemotherapy-induced cognitive impairments (CICI), colloquially known as "chemobrain," represents a profound and debilitating side effect experienced by a significant number of cancer survivors, impacting their memory, multitasking, and quality of life. This review critically evaluates the molecular mechanisms underlying CICI, with a particular focus on the insights gained from transcriptomic analyses. As cancer incidence rises globally, understanding the complex interplay between chemotherapy agents and their cognitive repercussions becomes increasingly vital. Key mechanisms implicated in CIC

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… Aluise CD, Sultana R, Tangpong J, Vore M, Clair DS, Moscow JA, Butterfield DA (2010) Chemo brain (chemo fog) as a potential side effect of doxorubicin administration: role of cytokine-induced, oxidative/nitrosative stress in cognitive dysfunction. …

Четвертое Международное совещание ИСЕВ, ISEV2015.

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Неделя ГЭЭ 2017 Презентации на плакате

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The 48th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians - Poster Session (P001 - P578).

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Proceedings to the 2020 Online Conference of the Particle Therapy Cooperative Group (PTCOG2020Online): 13-14 September 2020Organized by the Particle Therapy Cooperative Group (PTCOG), this special online meeting featured abstracts and programs that enabled the communication and cross fertilization for which PTCOG meetings are known.

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Polyphenols bind G4-Quadruplex structures and act as epigenetic modifiers with anti-cancer effects.

G4-quadruplexes (G4s) are non-canonical structures of nucleic acids that develop in guanine rich regions of DNA and RNA. Due to their presence in oncogenic promoters and telomeres, G4s represent attractive targets in anticancer drug designs. G4s have also been the subject of recent research regarding their role as epigenetic modulators, supporting their participation in epigenetic processes that control gene expression. The development of small compounds that preferentially target G4s have led to a better understanding of how G4s control these mechanisms. Natural products have greatly contribu

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… Biochemistry (Moscow) 2005;70:743–52. doi: 10.1007/s10541-005-0179-z. 88. Kjær TN, Ornstrup MJ, Poulsen MM, Jørgensen JOL, Hougaard DM, Cohen AS, et al. …

Burden of cancer in the Eastern Mediterranean Region, 2005-2015: findings from the Global Burden of Disease 2015 Study.

ObjectivesTo estimate incidence, mortality, and disability-adjusted life years (DALYs) caused by cancer in the Eastern Mediterranean Region (EMR) between 2005 and 2015.MethodsVital registration system and cancer registry data from the EMR region were analyzed for 29 cancer groups in 22 EMR countries using the Global Burden of Disease Study 2015 methodology.ResultsIn 2015, cancer was responsible for 9.4% of all deaths and 5.1% of all DALYs. It accounted for 722,646 new cases, 379,093 deaths, and 11.7 million DALYs. Between 2005 and 2015, incident cases increased by 46%, deaths by 33%, and DALYs

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… Vasiliy Victorovich Vlassov, MD, National Research University Higher School of Economics, Moscow, Russia. …

DNA-hydrolysing activity of IgG antibodies from the sera of patients with schizophrenia.

It is believed that damage to the membranes of brain cells of schizophrenia (SCZ) patients induces the formation of autoantigens and autoantibodies. Nevertheless, the importance of immunological changes leading to the loss of tolerance to self-antigens in the genesis of SCZ has not been established. The MALDI mass spectra of the IgG light chains of 20 healthy donors were relatively homogeneous and characterized by one peak with only one maximum. In contrast to the healthy donors, the MALDI mass spectra of IgG light chains corresponding to 20 SCZ patients demonstrated, similarly to 20 autoimmun

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… (Moscow) 29 , 727 – 749 . 7476940 63 Pihlaja H , Rantamaki T 2003 Linkage disequilibrium between the MBP tetranucleotide repeat and multiple sclerosis is restricted to a geographically defined subpopulation in Finland . …

Резюме ESPR 2013Европейское общество педиатрической радиологии 50th Ежегодное совещание и 36th Курсы для аспирантов. Июнь 3–7 2013. Будапешт, Венгрия.

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Mechanisms of chemotherapy-induced behavioral toxicities.

While chemotherapeutic agents have yielded relative success in the treatment of cancer, patients are often plagued with unwanted and even debilitating side-effects from the treatment which can lead to dose reduction or even cessation of treatment. Common side effects (symptoms) of chemotherapy include (i) cognitive deficiencies such as problems with attention, memory and executive functioning; (ii) fatigue and motivational deficit; and (iii) neuropathy. These symptoms often develop during treatment but can remain even after cessation of chemotherapy, severely impacting long-term quality of lif

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… Moscow J. A. . ( 2010 ). Chemo brain (chemo fog) as a potential side effect of doxorubicin administration: role of cytokine-induced, oxidative/nitrosative stress in cognitive dysfunction . Adv. Exp. Med. Biol . 678 , 147 – 156 . 10.1007/978-1-4419-6306-2_19 20738017 Angulo E. Casado V. Mallol J. …

Резюме книги: ISEV2017.

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The 46th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Oral Session (O010-O173).

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… Netherlands , 3 EBMT Data Office, Leiden, Netherlands , 4 Gaslini Children Research Hospital, Genova, Italy , 5 King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia , 6 First Affiliated Hospital of Soochow University, Suzhou, China , 7 Federal Research Center for Pediatric Hematology, Moscow … Pirogov, Moscow, Russian Federation , 2 Saint Petersburg State University Hospital, Saint-Petersburg, Russian Federation , 3 Multinational Center for Quality of Life Research, Saint-Petersburg, Russian Federation Background: At present high-dose immunosuppressive therapy with autologous hematopoietic …

Отчет о ДИД 1st Ежегодный Всемирный конгресс биомедицинской инженерии, проводимый в Сиане, Китай, 9-11 ноябрь 2017.

Мы рады представить на этом заседании резюме доклада "ДИД" 1st Всемирный конгресс биомедицинской инженерии 2017которая была проведена в Сиане в Китае [...].

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… for bioelectronic drugs (founded 2016); Founder and President of Wave Genome LLC, company producing bioelectronic devices and software for the distribution of bioelectronic drugs for rejuvenation only (founded 2010); Co-founder of “Matrix City” Consortium with the Institute for National Security in Moscow …

37th International Symposium on Intensive Care and Emergency Medicine (part 2 of 3) : Brussels, Belgium. 21-24 March 2017

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… Hypoxic and hyperoxic preconditioning in organ protection against ischemia-reperfusion injury: the experimental study I Mandel 1 , S Mikheev 2 , Y Podoxenov 2 , I Suhodolo 3 , A Podoxenov 2 , J Svirko 2 , A Sementsov 2 , L Maslov 2 , V Shipulin 2 1 City Clinical Hospital No 83 of FMBA of Russia, Moscow …

Melanoma and immunotherapy bridge 2015 : Naples, Italy. 1-5 December 2015.

MELANOMA BRIDGE 2015 KEYNOTE SPEAKER PRESENTATIONS Molecular and immuno-advances K1 Immunologic and metabolic consequences of PI3K/AKT/mTOR activation in melanoma Vashisht G. Y. Nanda, Weiyi Peng, Patrick Hwu, Michael A. Davies K2 Non-mutational adaptive changes in melanoma cells exposed to BRAF and MEK inhibitors help the establishment of drug resistance Gennaro Ciliberto, Luigi Fattore, Debora Malpicci, Luigi Aurisicchio, Paolo Antonio Ascierto, Carlo M. Croce, Rita Mancini K3 Tumor-intrinsic beta-catenin signaling mediates tumor-immune avoidance Stefani Spranger, Thomas F. Gajewski K4 Intra

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… Blokhin Russian Cancer Research Center, Moscow, Russia; 8 Department of Chemotherapy, Moscow City Oncology Hospital 62, Krasnogorsk, Russia; 9 Department of Dermatology, Centre Hospitalier Lyon Sud, Pierre-Bénite, France; 10 Department of Clinical Oncology, Hospital Universitario Virgen Macarena, Seville …

The 48th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians - Oral Sessions (O009-O155).

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… Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation, 2 Unit of Haematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 3 EBMT Paris Study Unit, Sorbonne Université, INSERM, CRSA, service d’hématologie …

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of risk factor exposure and attributable burden of disease. By providing estimates over a long time series, this study can monitor risk exposure trends critical to health surveillance and inform policy debates on the importance of addressing risks in context. METHODS: We used the comparative risk assessment framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years