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Роль микробиомы в множестве миелом: новые знания и терапевтические возможности.

Множественная миелома — гематологический рак, описываемый распространением плазменных клеток в костном мозге, что вызывает иммунную дисфункцию и другие аномалии. Микробиом кишечника, микробное сообщество в желудочно-кишечном тракте, было обнаружено, что он модифицирует системный иммунитет, воспаление и метаболизм. Хотя взаимосвязь между кишечным микробиомом и множеством миелома была обнаружена в недавних исследованиях, существует пробел в знаниях, связывающий воздействие микробиома на патогенез и лечение множественной миеломы. Несбалансированность в кишечном микробиоме, дисбиозе, может влиять

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… Bacteroides fragilis has been shown to induce colitis in mice, interfere with E-cadherin junctions, and promote β-catenin signaling and IL-8 release in epithelial cells of the colon through its metalloprotease B. fragilis toxin [ 46 ]. … Colonization with enterotoxigenic Bacteroides fragilis is associated with early-stage colorectal neoplasia PLoS ONE 2017 12 e0171602 10.1371/journal.pone.0171602 28151975 PMC5289627 47. Gur C. Ibrahim Y. Isaacson B. Yamin R. Abed J. Gamliel M. Enk J. Bar-On Y. Stanietsky-Kaynan N. …

Redox Remodeling by Nutraceuticals for Prevention and Treatment of Acute and Chronic Inflammation.

Antioxidant-rich dietary regimens are considered the best practice to maintain health, control inflammation, and prevent inflammatory diseases. Yet, nutraceuticals as food supplements are self-prescribed and purchasable over the counter by healthy individuals for the purpose of beneficial effects on fitness and aging. Hence, the effectiveness, safety, and correct intake of these compounds need to be better explored. Since redox-modulating activity of these compounds appears to be involved in activation and or suppression of immune cells, the preventive use of nutraceuticals is very attractive

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… Indeed, intestinal fermentation supported by Bacteroides determined the increase of these postbiotics in the peripheral blood associated with a reduction of insulitis [ 34 ]. … EFF ▲ IL-10, IL-4, IL-13 | [ 70 ] Quercetin | Grapes Onion | Cell line NOD | Hypoglycemic | Antioxidant | ▲ NK | ▼ DC1 ▼ IL-6, IL-1β | [ 71 ] Adenosine-based (non-peptidyl compounds) | Fungi Plants | NOD | unknown | ROS scavengers | NOT DESCRIBED | ▲ DCreg ▲ Treg ▲ DC2 ▲ Th2 EFF ▼ Th1 EFF | [ 72 ] Bacteroides …

The Insider: Impact of the Gut Microbiota on Cancer Immunity and Response to Therapies in Multiple Myeloma.

The human microbiota is a unique set of microorganisms colonizing the human body and evolving within it from the very beginning. Acting as an insider, the microbiota provides nutrients, and mutualistically interacts with the host's immune system, thus contributing to the generation of barriers against pathogens. While a strong link has been documented between intestinal dysbiosis (i.e., disruption to the microbiota homeostasis) and diseases, the mechanisms by which commensal bacteria impact a wide spectrum of mucosal and extramucosal human disorders have only partially been deciphered. This is

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… Bacteroides , Clostriudium leptum and Rothia are enriched in MM patients when compared to family members, who usually share the microbiome ( 55 ). Interestingly, the level of Clostridium leptum positively correlates with ISS stage in MM patients. … Andrews et al. associated defined microbiota signatures and abundance of Bacteroides intestinalis with upregulation of mucosal IL-1β and IL-17 in patients with ICI-related gastrointestinal adverse events ( 127 ). …

Influence of gut microbial metabolites on tumor immunotherapy: mechanisms and potential natural products.

In recent years, tumor immunotherapy has made significant breakthroughs in the treatment of malignant tumors. However, individual differences in efficacy have been observed in clinical practice. There is increasing evidence that gut microbial metabolites influence the efficacy of distal tumor immunotherapy via the gut-liver axis, the gut-brain axis and the gut-breast axis, a process that may involve modulating the expression of immune cells and cytokines in the tumor microenvironment (TME). In this review, we systematically explore the relationship between gut microbial metabolites and tumor i

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… Vetizou ( 107 ) showed that Bacteroides fragilis and Bacteroides thetaiotaomicron can regulate specific T cell responses. FMT from ICI responders helped non-responders recover the anti-cancer effects of PD-1 and CTLA-4 immune checkpoint blockade ( 108 ). … Oral probiotics such as Bacteroides fragilis and Burkholderia cepacia can also help alleviate adverse effects ( 108 ). The impact of gut microbial metabolites on tumor immunity is not always beneficial and can sometimes promote the occurrence and progression of cancer. …

Female sex as an independent prognostic factor in the development of oral mucositis during autologous peripheral stem cell transplantation.

Oral mucositis (OM) is a frequent complication of stem cell transplantation-associated toxicity in haematological malignancies, contributing to mortality. Therapy still remains mainly supportive. We assessed risk factors in retrospective analysis of 192 autologous peripheral stem cell transplantation patients with lymphoma and multiple myeloma (MM), respectively. Futhermore, we examined the hormone levels both in serum and saliva during transplantation in 7 postmenopausal female patients with lymphoma compared to healthy controls using electrochemiluminescence immunoassay (ECLIA). Multivariabl

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… Bacteroides, Prevotella sp.). Progesterone also enhances inflammatory response to local irritative factors thereby increasing the risk and severity of OM 35 . … In the preengraftment stage there is often anaerob blood stream infection (ABI) with Fusobacterium and Porphyromonas species of oral and upper GI tract origin, whereas during postengraftment Bacteroides and Clostridium species of lower GI tract origin colonize 40 . …

Биоразлагаемый электроспун PLGA Nanofibers-Encapsolated Trichinella Sphiralis Antigens защищает от повторного использования экспериментального аутоиммунного энцефаломилита и связанного с ним микробиота дисбиоз.

ЦЕЛЬ: " Тричинелла спиралис " создала сложные механизмы иммуномодуляции при посредничестве экскременто-секретарских продуктов (ESL1), которые позволяют ей выжить в принимающей стране. Следовательно, антигены ESL1 обладают прекрасным потенциалом для лечения аутоиммунных заболеваний, таких, как множественный склероз (MS). Однако вопрос о том, могут ли своевременные контролируемые поставки антигенов ESL1 в vivo, как и в случае естественных инфекций, повысить его терапевтический потенциал в отношении MS, до сих пор неизвестен.Для этого мы ввели антигены ESL1 в полихлорированные (лактидно

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… Further analyses of taxa composition based on the bacterial 16S rRNA gene indicated the enrichment of species Bacteroides uniformis, Christensenellaceae R-7 group, genus Streptococcus , and several genera from the family Lachnospiraceae ( Blautia, Tyzzerella, Dorea ) in the EAE_ctrl group of animals … PLGA/ESL1-treated animals, which are known for their potential to induce Th17, intestinal inflammation, and EAE. 100–102 Moreover, several taxa were found to be enriched in the gut of MS patients, 97 , 103 , 104 or diseases associated with disturbance of gut barrier integrity, 105 , 106 including Bacteroides …

Anorectal Complications in Acute Leukaemia: A retrospective analysis of clinical characteristics, management and outcomes in a tertiary care setting in Oman.

OBJECTIVES: Anorectal complications are common and serious issues among patients with haematological malignancies, leading to significant morbidity and mortality. Limited data are available on their incidence, microbiology screening and management. This study aimed to improve the understanding of these complications in patients diagnosed with acute leukaemia in Oman. METHODS: This retrospective study was conducted at Sultan Qaboos University Hospital, Muscat, Oman and included patients diagnosed with acute leukaemia who developed anorectal complications over the past decade (2015-2024). RESU

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… Anaerobes such as bacteroides species are potential causative organisms in both current and previous studies and adding metronidazole is therefore recommended. 1 , 15 Other conservative treatments included painkillers and topical ointments to reduce pain and promote healing. …

The Impact of Human Microbiotas in Hematopoietic Stem Cell and Organ Transplantation.

The human microbiota heavily influences most vital aspects of human physiology including organ transplantation outcomes and transplant rejection risk. A variety of organ transplantation scenarios such as lung and heart transplantation as well as hematopoietic stem cell transplantation is heavily influenced by the human microbiotas. The human microbiota refers to a rich, diverse, and complex ecosystem of bacteria, fungi, archaea, helminths, protozoans, parasites, and viruses. Research accumulating over the past decade has established the existence of complex cross-species, cross-kingdom interac

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… For example, the relative abundance of several bacterial species belonging to the genera known to populate the gut microbiota, such as Faecalibacterum, Dorea, Blautia, Bacteroides, Parabacteroides , and Oscillospira , were observed to stabilize in enteral nutrition–fed individuals. … For instance, compared to the control mice, the tacrolimus-treated mice demonstrated an increase in the abundance of Bacteroides , Allobaculum , and Lactobacillus alongside a concomitant decrease in the abundance of Oscillospira, Ruminococcus, Rikenella , and Ruminococcaceae ( 154 ). …

Response to pneumococcal vaccination in multiple myeloma.

BackgroundStreptococcus pneumoniae infection causes morbidity and mortality in multiple myeloma patients. Pneumococcal vaccination is commonly given to immunocompromised myeloma patients; however response data are sparse. Here, we present longitudinal response data to pneumococcal vaccination in multiple myeloma patients.MethodTwenty-eight multiple myeloma patients were included, 25 of whom were newly diagnosed. All the patients received two vaccines Prevnar13® and Pneumo23®. Serotype-specific IgG was measured by ELISA for all 23 vaccine serotypes at baseline, and then sequentially at differen

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… Indeed, one patient presented with Staphylococcus haemolyticus and Enterococcus faecalis , another with Streptococcus oralis , Bacteroides fragilis , and Proteus mirabilis , and two other with Klebsiella pneumoniae and Streptococcus salivarius . …

Chinese expert consensus recommendations for the administration of immune checkpoint inhibitors to special cancer patient populations.

Immune checkpoint inhibitors (ICIs) targeting programmed cell death 1, programmed cell death ligand 1, and cytotoxic T lymphocyte-associated antigen-4 have shown significantly durable clinical benefits and tolerable toxicities and have improved the survival of patients with various types of cancer. Since 2018, the National Medical Products Administration of China has approved 17 ICIs as the standard treatment for certain advanced or metastatic solid tumors. As ICIs represent a broad-spectrum antitumor strategy, the populations eligible for cancer immunotherapy are rapidly expanding. However, t

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… Bacteroides thetaiotaomicron and Bacteroides fragilis increase the activity of specific T cells and improve the efficacy of CTLA-4 inhibitors. Gut microbiota heterogeneity is associated with primary resistance to PD-1 and CTLA-4 inhibitors. …

Short-chain fatty acids in the tumor microenvironment: from molecular mechanisms to cancer therapy.

Short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate, serve as pivotal metabolites within the tumor microenvironment (TME), playing essential roles in modulating tumor progression. Although the biological functions and mechanisms of SCFAs in the TME show some overlap, each SCFA also exerts some distinct regulatory effects on tumors and TME. Notably, even a single SCFA may exhibit pleiotropic effects across different cancer types or under varying conditions within the same malignancy. Consequently, according to the different metabolic microenvironment of patients, precis

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… Glucose and lactate serve as the main fermentative substrates, which are converted into propionate through three major pathways (Figure 3 ). (1) The genus Bacteroides can produce propionate via the succinate pathway using methylmalonyl-CoA 70 . (2) Soil bacterium Clostridium propionicum and Negativicutes … Pathway of succinate and propionate formation in Bacteroides fragilis. J Bacteriol. 1978;134:84–91. doi: 10.1128/jb.134.1.84-91.1978. 71. Hetzel M, Brock M, Selmer T, Pierik AJ, Golding BT, Buckel W. Acryloyl-CoA reductase from Clostridium propionicum. …

Sulopenem: An Intravenous and Oral Penem for the Treatment of Urinary Tract Infections Due to Multidrug-Resistant Bacteria.

Sulopenem (formerly known as CP-70,429, and CP-65,207 when a component of a racemic mixture with its R isomer) is an intravenous and oral pe … ly greater activity than imipenem against many Gram-positive and Gram-negative anaerobes, including Bacteroides fragilis. The pharmacokinetics of intravenous sulopenem appear similar to carbapenems such as imipenem-cilastatin, meropenem, and doripenem. In healthy subjects, reported volumes of distribution (Vd) ranged from 15.8 to 27.6 L, total drug clearances …

Methods of Topical Administration of Drugs and Biological Active Substances for Dental Implants-A Narrative Review.

Dental implants are, nowadays, established surgical devices for the restoration of lost teeth. Considered as an alternative for traditional prosthetic appliances, dental implants surpass them in reliability and patient feedback. Local drug delivery around the implants promotes osseointegration and reduces peri-implantitis. However, there are currently no methods of a multiple, precise topical administration of drugs to the implant area. Engineering coatings on the implants, drug application on carriers during implantation, or gingival pockets do not meet all requirements of dental surgeons. Th

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… Chlorhexidine reduces the number of anaerobic bacteria ( Porphyromonas gingivalis, Bacteroides forsythus, Prevotella intermedia ) and also prevents plaque build-up [ 29 , 71 , 72 ]. … This substance also reduces the frequency of detection of Prevotella intermedia/nigrescens, Fusobacterium sp., Bacteroides forsythus , and Campylobacter rectus [ 77 ]. …

Implementing Curcumin in Translational Oncology Research.

Most data published on curcumin and curcumin-based formulations are very promising. In cancer research, the majority of data has been obtained in vitro. Less frequently, researchers used experimental animals. The results of several clinical studies are conclusive, and these studies have established a good foundation for further research focusing on implementing curcumin in clinical oncology. However, the issues regarding timely data reporting and lack of disclosure of the exact curcumin formulations used in these studies should not be neglected. This article is a snapshot of the current status

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… An increase of Clostridium spp. and Bacteroides spp. was particularly strong [ 121 ]. An increase of Bacteroides spp. was also shown in mice fed a curcumin diet [ 122 ]. … If curcumin can induce increased abundance of Bacteroides spp. (which should be in accord with Reference [ 121 ]), then maybe the butyrate potentially benefited the participants in the study published back in 2005 [ 91 ]. …

Adult-Onset Hyperammonemia: Case Report and Review of Literature.

INTRODUCTION: Hyperammonemia is a life-threatening condition most associated with liver disease, though non-cirrhotic causes are increasingly recognized. CASE PRESENTATION: We report an 18-year-old female presenting with 1 week of progressive confusion, abdominal pain, and nausea. Initial evaluation showed normal routine laboratories but markedly elevated ammonia and respiratory alkalosis. She rapidly deteriorated, requiring intubation and intensive care. Ammonia peaked at 795 µg/dL and improved rapidly after urgent venous hemofiltration and medical therapy, with full neurological recovery by

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… Discussion Pathophysiology of HA: ammonia primarily originates from the gut via glutamine deamination, urea breakdown, nucleic acid degradation, and from microbes such as Escherichia coli and Bacteroides , and must be tightly regulated to avoid consequences like hepatic encephalopathy [ 4 ]. …

Purpura fulminans secondary to Capnocytophaga canimorsus bacteraemia following a dog bite: A case report and review of literature.

IntroductionInfection due to Capnocytophaga canimorsus may result in a wide variety of clinical presentations. We present a case of life-threatening Capnocytophaga canimorsus infection with evolution of ecchymosis to purpura fulminans.Case descriptionWe present a case of a 43-year-old male with a history of excessive alcohol consumption who presented with features of sepsis following a dog bite. This was associated with a striking, widespread purpuric rash. A causative pathogen, C. canimorsus was identified through blood culture and 16S RNA sequencing. His initially purpuric rash underwent bul

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… Dogs contain many pathogenic bacteria in their oropharynx, including Pasteurella canis , Streptococcus spp., Staphylococcus spp., Fusobacterium spp., Bacteroides spp., and Capnocytophaga canimorsus [ 3 ]. …

Машинное обучение выявляет микробиомы и клинические прогнозы устойчивой потери веса после продолжительного поста.

Длительное постирование может улучшить метаболическое здоровье, однако контролируемые данные по здоровым взрослым с более длительным последующим наблюдением и многомерным профилированием ограничены. Мы расследовали немедленное и 12-week ПОСЛЕДУЮЩИЕ ПОСЛЕДУЮЩИЕ ПОСЛЕДСТВИЯ 5-day Быстрое вмешательство в состав тела, кишечный микробиом и циркулирующие и фекальные метаболиты, а также оценка того, прогнозируют ли базовые характеристики индивидуальные реакции на потерю веса. В ходе случайного, контролируемого списка ожидания, 38 здоровые взрослые 5-day быстрого вмешательства с помощью 12-week :: пос

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… In overweight adults, a higher pretreatment Prevotella-to-Bacteroides ratio was associated with greater weight and fat loss during a 24-week energy-restricted diet, particularly at higher dietary fiber intake [ 47 ]. … Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis. Int J Obes (Lond). 2019;43:149–57. 10.1038/s41366-018-0093-2. 48. Grembi JA, et al. …

A narrative review of the epidemiological and mechanistic associations between ABO blood groups and diseases: focusing on cardiovascular diseases, cancers, diabetes, malaria, COVID-19 and rheumatic diseases.

BACKGROUND: The ABO blood group system is one of the most clinically significant human blood group systems and is closely associated with pathogenesis, progression, and prognosis of numerous diseases. This narrative review synthesizes recent epidemiological evidence and explores potential mechanisms linking ABO to cardiovascular diseases, malignancies, diabetes, Plasmodium falciparum malaria, COVID‑19, and rheumatic diseases. METHODS: We searched PubMed and CNKI up to September 2025. RESULTS: Epidemiological studies consistently show non‑O blood groups have significantly elevated cardiovascu

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… In secretor individuals, non-O blood types are associated with alterations in bacteria such as Bacteroides, while blood group A is linked to changes in microbial families like Lachnospiraceae [ 92 , 93 ]. …

Are patients with cancer with sepsis and bacteraemia at a higher risk of mortality? A retrospective chart review of patients presenting to a tertiary care centre in Lebanon.

ObjectiveMost sepsis studies have looked at the general population. The aim of this study is to report on the characteristics, treatment and hospital mortality of patients with cancer diagnosed with sepsis or septic shock.SettingA single-centre retrospective study at a tertiary care centre looking at patients with cancer who presented to our tertiary hospital with sepsis, septic shock or bacteraemia between 2010 and 2015.Participants176 patients with cancer were compared with 176 cancer-free controls.Primary and secondary outcomesThe primary outcome of this study was the in hospital mortality

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… †Others included: Bacteroides fragilis , Candida albicans , Citrobacter , Diphteroids spp., Enterobacter cloacae , Haemophilus influenzae (type B), Haemophilus parainfluenzae , Legionella pneumophila , Leuconostoc , Morganella morgani , Peptococcus spp., Providncia stuartii , Serratia marsescens , Stenotrophomonas …

Продольная стабильность микробиоты Гут в релапсирующих и излучающих множественных склерозах: перспективное исследование наблюдений.

Микробиота кишечника играет ключевую роль в регулировании иммунной системы в множестве склерозов (MS), однако продольные данные о динамике микробиома и их связи с инвалидностью и биомаркерами остаются ограниченными. Цель этого исследования заключалась в выявлении продольных микробиомных изменений кишечника у пациентов с повторно излучающимся множественным склерозом (RRMS) и их связи с инвалидностью и конкретными биомаркерами сыворотки, включая прогнозируемые метаболические пути. В ходе этого перспективного продольного исследования была проведена оценка 29 пациентов, проходящих курс лечения наи

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… At the genus level, Prevotella, Faecalibacterium, Phocaeicola and Bacteroides were among the most abundant taxa ( Supplementary Tables S1 and S2, Supplementary Figure S1 ). 3.2. …