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Disorders of the Spinal Cord

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… Drugs to consider include cefotaxime 30 to 40 mg/kg IV, IM, SC TID to QID and ceftazidime 20 to 50 mg/kg IV BID to TID. 3. Use metronidazole 10 mg/kg IV, PO TID for the treatment of anaerobic infections. 4. Trimethoprim-sulfadiazine 15 mg/kg SC, PO BID penetrates the CNS effectively. B. …

Boron Chemicals in Drug Discovery and Development: Synthesis and Medicinal Perspective.

A standard goal of medicinal chemists has been to discover efficient and potent drug candidates with specific enzyme-inhibitor abilities. In this regard, boron-based bioactive compounds have provided amphiphilic properties to facilitate interaction with protein targets. Indeed, the spectrum of boron-based entities as drug candidates against many diseases has grown tremendously since the first clinically tested boron-based drug, Velcade. In this review, we collectively represent the current boron-containing drug candidates, boron-containing retinoids, benzoxaboroles, aminoboronic acid, carboran

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… Compound 68 restored antibacterial activity of ceftazidime against Enterobacter cloacae P99-expressing AmpC, a class C β-lactamase enzyme. Scheme 19 Benzoxaboroles as a new class of β-lactamase inhibitors. …

Successful salvage of a severe COVID-19 patient previously with lung cancer and radiation pneumonitis by mesenchymal stem cells: a case report and literature review.

During the COVID-19 pandemic, elderly patients with underlying condition, such as tumors, had poor prognoses after progressing to severe pneumonia and often had poor response to standard treatment. Mesenchymal stem cells (MSCs) may be a promising treatment for patients with severe pneumonia, but MSCs are rarely used for patients with carcinoma. Here, we reported a 67-year-old female patient with lung adenocarcinoma who underwent osimertinib and radiotherapy and suffered from radiation pneumonitis. Unfortunately, she contracted COVID-19 and that rapidly progressed to severe pneumonia. She respo

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… kg VD+IV×4d With anti-thromboembolic | Remission | Discharged on day 40 Primorac 2021 ( 90 ) | Croatia | M | 50 | No | No | Azithromycin, Methylprednisolone, Amoxicillin/Clavulanic acid, Remdesivir, Enoxaparin, Moxifloxacin, Immunoglobulins | BM | 3×10 6 /kg VD With Colistin, Fosfomycin, Linezolid, Ceftazidime …

Infectious complications after hematopoietic stem cell transplantation: current status and future perspectives in Korea.

Hematopoietic stem cell transplantation (HSCT) is a treatment for hematologic malignancies, immune deficiencies, or genetic diseases, ect. Recently, the number of HSCTs performed in Korea has increased and the outcomes have improved. However, infectious complications account for most of the morbidity and mortality after HSCT. Post-HSCT infectious complications are usually classified according to the time after HSCT: pre-engraftment, immediate post-engraftment, and late post-engraftment period. In addition, the types and risk factors of infectious complications differ according to the stem cell

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… Except for the presence of definite infection foci, the broad-spectrum β-lactam antibiotics ceftazidime, cefepime, piperacillin/tazobactam, and carbapenem are recommended as they have activity against Gram-positive and -negative bacteria, including P. aeruginosa [ 13 , 15 , 43 , 44 ]. …

Essential oils and their constituents as anticancer agents: a mechanistic view.

Exploring natural plant products as an option to find new chemical entities as anticancer agents is one of the fastest growing areas of research. Recently, in the last decade, essential oils (EOs) have been under study for their use in cancer therapy and the present review is an attempt to collect and document the available studies indicating EOs and their constituents as anticancer agents. This review enlists nearly 130 studies of EOs from various plant species and their constituents that have been studied so far for their anticancer potential and these studies have been classified as in vitr

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… Journal of Cancer Prevention 2010 11 4 1045 1049 2-s2.0-78650705971 21133622 5 Jemal A Bray F Center MM Ferlay J Ward E Forman D Global cancer statistics CA Cancer Journal for Clinicians 2011 61 2 69 90 2-s2.0-79952232216 10.3322/caac.20107 21296855 6 Naumovski L Quinn JP Miyashiro D Outbreak of ceftazidime …

Drug Repurposing of Selected Antibiotics: An Emerging Approach in Cancer Drug Discovery.

Drug repurposing is a method of investigating new therapeutic applications for previously approved medications. This repurposing approach to "old" medications is now highly efficient, simple to arrange, and cost-effective and poses little risk of failure in treating a variety of disorders, including cancer. Drug repurposing for cancer therapy is currently a key topic of study. It is a way of exploring recent therapeutic applications for already-existing drugs. Theoretically, the repurposing strategy has various advantages over the recognized challenges of creating new molecular entities, inclu

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… . | ( 34 ) (b) Cefazolin (c) Cephalexin (d) Cefaclor (e) Cefotetan (f) Cefoxitin (g) Cefprozil (h) Cefuroxime (i) Cefotaxime (j) Ceftazidime (k) Cefdinir (l) Ceftriaxone (m) Cefpodoxime (n) Cefoperazone (o) Cefixime (p) Cefepime 13. | Chloramphenicol | (a) Chloromycetin | Chloramphenicol inhibits protein …

2020 ACVIM Forum On Demand Research Abstract Program.

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… | Fecal Extract From Obese Horses Induces Inflammation In Vitro E74 | Ana Berreta | Effect of the Proximal Gastrointestinal Tract on Viability of Equine Probiotics: An in vitro Study (ACVIM Resident Research Award eligible) E75 | Christina Marino | Pharmacokinetics of Intravenous and Intramuscular Ceftazidime …

Acute Pneumonia

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Abstracts from the 8th Drug Hypersensitivity Meeting (DHM)

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… Rifampicine: n = 1 Terbinafine: n = 2 Adiazine: n = 1 Isoniazide: n = 2 Biperidene: n = 1 Atovaquone: n = 2 Vancomycin: n = 1 Bactrim: n = 1 Bactrim: n = 1 Tazocillin: n = 1 Tazocillin: n = 1 Fluindione: n = 1 Fluindione: n = 1 Cefuroxime: n = 1 Raltegravir : n = 1 Cefpodoxime: n = 1 Fluconazole: n = 1 Ceftazidime … Terbinafine: n = 2 | Adiazine: n = 1 Isoniazide: n = 2 | Biperidene: n = 1 Atovaquone: n = 2 | Vancomycin: n = 1 Bactrim: n = 1 | Bactrim: n = 1 Tazocillin: n = 1 | Tazocillin: n = 1 Fluindione: n = 1 | Fluindione: n = 1 Cefuroxime: n = 1 | Raltegravir : n = 1 Cefpodoxime: n = 1 | Fluconazole: n = 1 Ceftazidime …

Unraveling the Anti-Cancer Mechanisms of Antibiotics: Current Insights, Controversies, and Future Perspectives.

Cancer persists as a significant global health challenge, claiming millions of lives annually despite remarkable strides in therapeutic innovation. Challenges such as drug resistance, toxicity, and suboptimal efficacy underscore the need for novel treatment paradigms. In this context, the repurposing of antibiotics as anti-cancer agents has emerged as an attractive prospect for investigation. Diverse classes of antibiotics have exhibited promising anti-cancer properties in both in vitro and in vivo studies. These mechanisms include the induction of apoptosis and cell cycle arrest, generation o

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… Several cephalosporins, including cefuroxime, cefotaxime, cefmetazole, and ceftazidime, selectively induced ferroptosis in nasopharyngeal carcinoma cells both in vitro and in vivo by upregulating HMOX1 , a gene involved in oxidative stress response. …

Cancer cachexia--pathophysiology and management.

About half of all cancer patients show a syndrome of cachexia, characterized by anorexia and loss of adipose tissue and skeletal muscle mass. Cachexia can have a profound impact on quality of life, symptom burden, and a patient's sense of dignity. It is a very serious complication, as weight loss during cancer treatment is associated with more chemotherapy-related side effects, fewer completed cycles of chemotherapy, and decreased survival rates. Numerous cytokines have been postulated to play a role in the etiology of cancer cachexia. Cytokines can elicit effects that mimic leptin signaling a

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… Commonly used empiric intravenous antibiotic monotherapies include carbapenems (e.g., imipenem/cilastatin, meropenem), and extended-spectrum antipseudomonal cephalosporins (e.g., ceftazidime, cefepime). …

Secondary Immunodeficiency in Hematological Malignancies: Focus on Multiple Myeloma and Chronic Lymphocytic Leukemia.

Secondary immunodeficiency is reported in most patients with hematological malignancies such as chronic lymphocytic leukemia and multiple myeloma. The aim of our review was to evaluate the existing literature data on patients with hematological malignancies, with regard to the effect of immunodeficiency on the outcome, the clinical and therapeutic approach, and on the onset of noninfectious complications, including thrombosis, pleural effusion, and orofacial complications. Immunodeficiency in these patients has an intense impact on their risk of infection, in turn increasing morbidity and mort

The Expanding Field of Secondary Antibody Deficiency: Causes, Diagnosis, and Management.

Antibody deficiency or hypogammaglobulinemia can have primary or secondary etiologies. Primary antibody deficiency (PAD) is the result of intrinsic genetic defects, whereas secondary antibody deficiency may arise as a consequence of underlying conditions or medication use. On a global level, malnutrition, HIV, and malaria are major causes of secondary immunodeficiency. In this review we consider secondary antibody deficiency, for which common causes include hematological malignancies, such as chronic lymphocytic leukemia or multiple myeloma, and their treatment, protein-losing states, and side

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… | | Early use of home back-up antibiotics | | Prophylactic antibiotics | Nebulized antibiotics | Early use of home back-up antibiotics | Nebulized Colomycin 1–2 mega units bd | Prophylactic antibiotics | Intermittent planned IVAB | Early use of home back-up antibiotics | Meropenem 2g IV tds and Ceftazidime …

50th ESCP Symposium on Clinical Pharmacy, Polypharmacy and ageing - highly individualized, interprofessional, person-centered care : 19–21 October 2022, Prague, Czech Republic

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Proceedings of Reanimation 2023, the French Intensive Care Society International Congress.

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Infections in Recipients of Hematopoietic Stem Cell Transplants

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… or relapse after 3 weeks of appropriate antimicrobial therapy, which suggests that prolonged antibiotic treatment is indicated for HSCT recipients with legionellosis. 138 Medical therapies for nocardiosis often consist of administration of sulfonamide in combination with a synergistic agent such as ceftazidime …

42nd International Symposium on Intensive Care & Emergency Medicine

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45th International Symposium on Intensive Care & Emergency Medicine.

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TB AND OTHER CHEST INFECTIONS

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… The most common organism found in lung abscess cases was Klebsiella pneumoniae, and they were sensitive to ceftazidime. …

The 20th Anniversary of Pegaptanib (MacugenTM), the First Approved Aptamer Medicine: History, Recent Advances and Future Prospects of Aptamers in Therapy.

In addition to classic small-molecule drugs and modern protein-based biologics, an intriguing class of medicines is the therapeutic oligonucleotides. Most approved drugs in this category are antisense oligomers or those acting via RNA interference, both of which use base hybridization. Aptamers, also known as chemical antibodies form a smaller, yet equally interesting group of oligonucleotides that can recognize a wide range of molecular targets. Despite their high potential, only two aptamers have been approved to date, pegaptanib (MacugenTM) and avacincaptad pegol (IzervayTM), both for the t

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… There was a report of an 84-year-old woman who experienced acute endophthalmitis following pegaptanib treatments, necessitating intravitreal antibiotic injections (vancomycin and ceftazidime) and vitrectomy [ 166 ]. …