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The protective mechanism of SIRT1 on cartilage through regulation of LEF-1.

BACKGROUND: Osteoarthritis (OA) is a chronic degenerative disease that suppresses middle-aged and older people worldwide. Silent information … emistry. Then, take 60 8-week-old female C57BL/6 J mice and apply the Destabilization of the medial meniscus (DMM) to induce OA. Mice were randomly divided into normal group (sham), model group (model), and post-modeling drug administration group (srt), and each group was further divided into 2 weeks after modeling (2 W) and 8 weeks after modeling (8 W) ac …

Allograft-Prosthesis Composites for the Reconstruction of the Distal Femur After the Resection of a Bone Tumor in Childhood.

BACKGROUND: The tibial physis is responsible for about 30% of the growth in the limb1. Therefore, preservation of this growth potential in s … on the MRI findings, the capsule, collateral ligaments, and cruciate ligaments are incised, and the meniscus on the tibial plateau is preserved, with consideration given to achieving a negative margin. An appropriately sized osteoarticular allograft with the retained capsule and ligaments is obtained from a standard bone bank. The femoral component of the …

[Correlation between osteopontin and cartilage oligomeric matrix protein levels in joint synovial fluid of patients with knee osteoarthritis and disease severity].

OBJECTIVE: To investigate the correlation between osteopontin(OPN) and cartilage oligomeric matrix protein (COMP) levels in synovial fluid o … ), and 18 cases in grade Ⅳ(K-L4 group). Eighteen patients who underwent arthroscopy for ligament or meniscus disease without cartilage damage were selected as control group, including 7 males and 11 females, age ranged 61 to 78 years old with an average of (64.88±1.60) years old, BMI ranged 22.8 to 29.9(25.89±1.49) kg/m2. Before treatment, synovial fluid s …

Coexistence of Autoantibodies against the Golgi Complex and Ro52 Antigen in a Patient with Nonspecific Interstitial Pneumonia.

Nonspecific interstitial pneumonia (NSIP) is often associated with connective tissue diseases (CTD). The diagnosis of NSIP was confirmed in a 63-year-old man by high-resolution computed tomography and an open lung biopsy. Anti-Golgi complex autoantibodies (AGA) and anti-Ro52 antibodies were simultaneously detected at high concentrations. Autoantibodies to aminoacyl-tRNA synthetases (ARS) were negative. The patient was treated with corticosteroids for six months. During the seven-year follow-up, NSIP had a slow progression and patient had not developed the clinical features of CTD. The present

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… Signs on Chest Radiographs Obliteration of the lateral costophrenic angle with a meniscus like arc at the interface between the fluid and the chest wall in PA radiographs (Meniscus sign) (Fig. 7.1.1 ). Obliteration of the posterior costophrenic angle in lateral radiographs (Fig. 7.1.1 ). … Fig. 7.1.1 Posteroanterior ( a ) and lateral ( b ) chest radiographs in two different patients with pleural effusion show meniscus sign with right pleural effusion obliterating the lateral costophrenic angle ( arrowhead ) in ( a ) and pleural effusion obliterating the posterior costophrenic angle in …

A Narrow Medial Femoral Condyle Width Is Associated With Anteromedial Rotatory Instability After Anterior Cruciate Ligament Injury.

PURPOSE: To identify bone morphological risk factors and injury patterns of medial structural injuries in patients with anteromedial rotator … vided into 3 groups: AMRI (n = 58), ACL-injured patients without AMRI (NAMRI, n = 25), and isolated meniscus tear patients (control, n = 58). The AMRI group exhibited significantly smaller MFCW (AMRI: 6.72 ± 0.55 vs control: 7.35 ± 0.51, P < .001) and notch width (AMRI: 1.79 ± 0.29 vs control: 2.01 ± 0.37, P = .001), whereas significantly larger lateral fe …

Spatiotemperal Dynamics of Osteoarthritis: Преобразование значений от стенда до Бедсайда.

Остеоартрит (OA) представляет собой многогранное дегенеративное совместное расстройство, вызванное различными факторами риска, такими, как возраст, механический стресс, воспаление и метаболическое воздействие. Эти элементы способствуют его разнообразным фенотипам и эндотипам, что подчеркивает имманентную сложность болезни. Участие нескольких тканей и их взаимодействие еще больше осложняет расследование ОА. Нынешние ограничения в области технологий пространственного фенотификации в сочетании со сложной сетью многофакторных взаимодействий препятствуют обнаружению надежных ранних диагностических

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… This model integrates radiological features of the meniscus and femorotibial cartilage derived from MRI and demonstrated high predictive accuracy, achieving an area under receiver operating characteristic curve (AUC) of 0.931, sensitivity of 84.4%, and specificity of 85.6% in a test cohort [ 83 ]. … The elements involved in the changes include cartilage, tidemark, proteoglycan, collagen integrity, subchondral bone plate, meniscus, synovium, and osteophytes, which can be seen via histopathological staining. …

CCN proteins in the musculoskeletal system: current understanding and challenges in physiology and pathology.

The acronym for the CCN family was recently revised to represent "cellular communication network". These six, small, cysteine-enriched and evolutionarily conserved proteins are secreted matricellular proteins, that convey and modulate intercellular communication by interacting with structural proteins, signalling factors and cell surface receptors. Their role in the development and physiology of musculoskeletal system, constituted by connective tissues where cells are interspersed in the cellular matrix, has been broadly studied. Previous research has highlighted a crucial balance of CCN prote

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… Mechanical stretch increases Smad3-dependent CCN2 expression in inner meniscus cells: STRETCH-INDUCED CCN2 IN THE MENISCUS. J Orthop Res. 2012;30:1738–1745. doi: 10.1002/jor.22142. Furumatsu T, Matsumoto E, Kanazawa T, Fujii M, Lu Z, Kajiki R, Ozaki T. … Role of mechanical-stress inducible protein Hcs24/CTGF/CCN2 in cartilage growth and regeneration: mechanical stress induces expression of Hcs24/CTGF/CCN2 in a human chondrocytic cell line HCS-2/8, rabbit costal chondrocytes and meniscus tissue cells. …

Skeletal stem cells, a new direction for the treatment of bone and joint diseases.

Skeletal stem cells (SSCs) are tissue-specific stem cells characterized by their capacity for self-renewal and their position at the apex of the differentiation hierarchy. They can generate mature bone cell types essential for bone development, maintenance, and repair. Lineage tracing experiments have demonstrated that SSCs reside in the bone marrow, periosteum, and the resting zone of the growth plate. These findings not only enhance our understanding of bone growth and development mechanisms but also offer novel therapeutic strategies for conditions such as epiphyseal injuries, fractures, os

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… Cartilage injuries, encompassing conditions such as degenerative joint disease, traumatic cartilage damage, meniscus avascular zone repair, chondromalacia patellae, and intervertebral disc degeneration, involve the destruction of cartilage or fibrocartilage structures[ 117 - 119 ]. … Meniscus Anatomy and Basic Science. Sports Med Arthrosc Rev. 2021;29:e18–e23. doi: 10.1097/JSA.0000000000000327. 119. Zhang H, Kong XQ, Cheng C, Liang MH. A correlative study between prevalence of chondromalacia patellae and sports injury in 4068 students. Chin J Traumatol. 2003;6:370–374. 120. …

Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases.

Bone serves to maintain the shape of the human body due to its hard and solid nature. A loss or weakening of bone tissues, such as in case of traumatic injury, diseases (e.g., osteosarcoma), or old age, adversely affects the individuals quality of life. Although bone has the innate ability to remodel and regenerate in case of small damage or a crack, a loss of a large volume of bone in case of a traumatic injury requires the restoration of bone function by adopting different biophysical approaches and chemotherapies as well as a surgical reconstruction. Compared to the biophysical and chemothe

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… Further, the developed scaffolds showed the regeneration of pig meniscus. The in vitro and in vivo studies show the potential use of BNC/collagen scaffolds in meniscus transplantation ( Bodin et al., 2007 ) and artificial cartilage ( Lopes et al., 2011 ) for treating articular joints. … Bacterial cellulose as a potential meniscus implant. J. Tissue Eng. Regen. Med. 1 406–408.. 10.1002/term.51 Cai Z., Hou C., Yang G., Kim J. (2011). Bacterial cellulose as a template for the formation of polymer/nanoparticle nanocomposite. J. Nanotechnol. Eng. …

[Anterior cruciate ligament reconstruction with semitendinosus tendon in children].

OBJECTIVE: To present the technique of arthroscopy-assisted anterior cruciate ligament (ACL) reconstruction in children with complete ACL ru … ry medial to the tibial tuberosity, entering the joint at the level of the anterior horn of lateral meniscus in the intercondylar notch. Optimal positioning confirmed by an intraoperative negative impingement test of the guiding pin before drilling. Femoral canal entry placed at the 10:00-10:30 o'clock position on the right side, and 01:30-02:00 o'clock po …

Каталоги оценок показателей качества жизни, связанных с здоровьем, по шкале EQ-5D-3L для 199 хронических заболеваний и рисков здоровья для использования в Великобритании и США.

СВОДНАЯ ИНФОРМАЦИЯ: В экономической оценке важное значение имеют связанные со здоровьем показатели качества жизни (HRQOL), однако в некоторых случаях отсутствуют первичные источники и требуется информация из вторичных источников. Существующие каталоги HRQOL Соединенного Королевства/США основаны, в частности, на предыдущих системах классификации диагнозов. Недавно опубликованный датский каталог объединился EQ-5D-3L Данные национальных обследований в области здравоохранения с использованием национальных регистров, содержащих информацию о пациентах ICD-10 - диагностика, медицинское обслуживание и

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… 0.767 0.816 0.860 131 Disorders of patella (kneecap) M22 496 36.0 3.3 0.1242 0.749 0.0154 0.691 0.796 1 0.813 0.0104 0.777 0.827 1 132 Internal derangement of knee M230, M231, M233, M235, M236, M238 128 44.5 4.0 0.2667 0.715 0.0244 0.691 0.796 0.796 0.790 0.0163 0.777 0.827 0.827 133 Derangement of meniscus … | 36.0 | 3.3 | 0.1242 | 0.749 | 0.0154 | 0.691 | 0.796 | 1 | 0.813 | 0.0104 | 0.777 | 0.827 | 1 132 | Internal derangement of knee | M230, M231, M233, M235, M236, M238 | 128 | 44.5 | 4.0 | 0.2667 | 0.715 | 0.0244 | 0.691 | 0.796 | 0.796 | 0.790 | 0.0163 | 0.777 | 0.827 | 0.827 133 | Derangement of meniscus …

Resveratrol: Molecular Mechanisms, Health Benefits, and Potential Adverse Effects.

Resveratrol (RES), a naturally occurring polyphenolic compound, has garnered significant attention due to its diverse biological activities, which include anti-inflammatory, antioxidant, and antiaging properties. This review synthesizes current evidence concerning the molecular mechanisms, therapeutic efficacy, and safety profile of RES across a variety of pathologies, with an emphasis on the latest research conducted in recent years. Mechanistically, RES is known to modulate critical signaling pathways such as the activation of sirtuin 1. These actions collectively contribute to the attenuati

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… It is important to note that research on the effects of RES on ligament degeneration and meniscus injury remains limited. … Given RES's anti‐inflammatory and antioxidant properties, including its ability to scavenge reactive oxygen species (ROS), there is considerable potential for further investigation into its application in meniscus replacement materials and the treatment of ligament degeneration. …

Arthrokinematic and Magnetic Resonance Imaging-Based Outcomes of Customized Lateral Wedge Insoles in Medial Compartment Knee Osteoarthritis: Six-Month Interim Findings of a Prospective Cohort Study.

INTRODUCTION: Knee osteoarthritis (OA) is a leading musculoskeletal disorder with a prevalence of 22-39% in India, representing approximatel … ion showed the greatest gain (+5.64°; P < 0.01); medial JSW widened (+0.40 mm; P < 0.01) and medial meniscus thickness increased (+0.16 mm; P = 0.05). Internal rotation (+1.56°; P = 0.06) and extension (+1.56°; P = 0.08) did not reach significance levels. In exploratory, non-prespecified sex-stratified analyses (male knees n = 10, female knees n = 12), mal …

The Role of Angiogenesis in Haemophilic Arthropathy: Where Do We Stand and Where Are We Going?

Haemophilia is an inherited bleeding disorder that can lead to degenerative joint arthropathy due to recurrent bleeding episodes affecting the musculoskeletal system of the patient. The cause of bleeding can be either traumatic or spontaneous. The pathogenesis of haemophilic arthropathy is unclear as many factors like iron, inflammatory cytokines, and angiogenic factors contribute to this process. Blood into joints can deteriorate the bone to such an extent that the patient experiences pain, reduction of the range of movement, and deformity of the joint, conditions that could have a great impa

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… The joint may be divided by an articular disc or meniscus, which is continuous in the periphery with the fibrous capsule while its free surfaces are covered by the synovial membrane. Synovial joints facilitate movement by bringing articulating bones into contact ( Figure 1 ). …

Zoledronic acid enhances lipopolysaccharide-stimulated proinflammatory reactions through controlled expression of SOCS1 in macrophages.

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious side effect of nitrogen-containing bisphosphonate (NBP) use. Many studies have shown that BRONJ is limited to the jawbone and does not occur in the other bones. We hypothesized that BRONJ is related to local bacterial iections and involves the innate immune system. To examine the relationship between BRONJ and innate immunity, we examined the effects of NBPs on macrophages, one of the important cell types in innate immunity. The expression of toll-like receptor-4 (TLR4) in cells after pretreatment with zoledronic acid (ZOL) d

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… Weinberg JB, Fermor B, Guilak F (2007) Nitric oxide synthase and cyclooxygenase interactions in cartilage and meniscus: relationships to joint physiology, arthritis, and tissue repair. Sub-cellular biochemistry 42: 31–62. 27. …

Neuropathic-like symptoms and central sensitization related signs and symptoms negatively affect the functional performance of patients with knee osteoarthritis - a cross-sectional study.

OBJECTIVE: This study aimed to compare the functional performance among participants with a neuropathic-like symptoms (NS) and central sensitization related signs and symptoms (CS), and their knee osteoarthritis (OA) counterparts. METHODS: A cross-sectional observational study was conducted with 125 participants with knee OA (94 females, mean age 63.1 ​± ​7.4 years). Participants completed a self-reported questionnaire with personal and clinical features and musculoskeletal pain characteristics, including NS (PainDETECT), CS (Central Sensitization Inventory, CSI), and conditioned pain modulat

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… OA arises from a complex biological process involving structural changes in the local tissues (i.e., cartilage, bone, ligaments, capsule, synovial membrane, meniscus, and periarticular muscles) [ 8 , 9 ]. …

Conjunctival HLA-DR and CD8 expression detected by impression cytology in ocular graft versus host disease.

PurposeTo assess the expression of human leucocyte antigen (HLA)-DR in epithelial cells and cluster of differentiation (CD8)-positive lymphocytes as possible markers of chronic ocular graft versus host disease (cGvHD) after hematological stem cell transplantation (HSCT).MethodsTwenty-seven consecutive patients with dry-eye symptoms following HSCT (24 [89%] with peripheral blood stem cell transplantation and 3 [11%] with bone marrow transplants; 17 [63%] familiar allogenic grafts) and 19 age-matched controls were included. Conjunctival impression cytology specimens were stained for HLA-DR, cyto

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… Other studies questioned the reproducibility and sensitivity of the Schirmer test in Sjögren’s syndrome and proposed the use of the anterior segment OCT as an alternative for quantification of the tear meniscus [ 26 ]. …

[Analysis of the clinical characteristics of dry eye patients with type 2 diabetes mellitus at different disease durations].

Objective: To investigate the clinical characteristics of symptoms and signs of ocular surface lesions in dry eye patients with type 2 diabe … by corneal sensitivity (CS), corneal fluorescein staining (CFS) score, Schirmer Ⅰ test (SⅠT), tear meniscus height (TMH), non-invasive first tear film break-up time (NIKf-BUT), non-invasive average tear film break-up time (NIKav-BUT), lipid layer thickness (LLT), and meibomian gland loss (MGL) grading score. Anterior segment optical coherence tomography w …

Early Operative Versus Delayed or Nonoperative Treatment of Anterior Cruciate Ligament Injuries in Pediatric Patients.

UNLABELLED: Reference: Ramski DE, Kanj WW, Franklin CC, Baldwin KD, Ganley TJ. Anterior cruciate ligament tears in children and adolescents: … of those who initially chose nonoperative treatment eventually needed surgery to repair the ACL or meniscus. Findings favor the early operative group over the delayed operative and nonoperative groups based on IKDC scores. One study reported a significant difference in operative patients, with an IKDC mean score of 95 compared with 87 in the nonoperative …

Mechanisms of bone pain: Progress in research from bench to bedside.

The field of research on pain originating from various bone diseases is expanding rapidly, with new mechanisms and targets asserting both peripheral and central sites of action. The scope of research is broadening from bone biology to neuroscience, neuroendocrinology, and immunology. In particular, the roles of primary sensory neurons and non-neuronal cells in the peripheral tissues as important targets for bone pain treatment are under extensive investigation in both pre-clinical and clinical settings. An understanding of the peripheral mechanisms underlying pain conditions associated with va

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… In an OA mouse model with a destabilization of the medial meniscus, aberrant subchondral bone angiogenesis was developed at the early stage of osteoarthritis, and selective knockout of the gene of PDGF-BB in the preosteoclasts attenuated both angiogenesis and sensory innervation 38 . … These tissues including synovium 106 , ligaments 107 , subchondral bone 108 – 110 , and meniscus are possible origins of joint pain 109 . Synovium inflammation (synovitis) mediated sensitization of primary afferent neurons was thought to be important to OA joint pain 111 . …